• 동아시아식생활학회지
• /
• 제14권6호
• /
• pp.634-639
• /
• 2004

An eight-week-old male ICR mouse, which was induced with acute alcohol and sub-acute alcohol poisoning condition, was administered with bohee tea(Camelia sinensis L) extract. After oral administration of bohee tea and inducement of acute alcohol poisoning condition, the mouses blood alcohol concentration became as low as that of the normal control group. Its decrease rate was 87.26%, in comparison with that of the positive control group. Moreover, its blood GOT activity decreased with a rate of 93.1 % until it reached the normal level, as opposed to that of the positive control group. In addition, the GOT activity, despite rising after the alcohol intake, decreased(p<0.05) significantly after administration of each sample and reached the normal level. The bohee tea group experienced a significant decrease in the GOT activity, compared with the A1codex group and the Drink group. The GPT activity of the Alcodex group decreased by 11 % compared with that of the positive control group. The CTP activity of the bohee tea group decreased by 8.2%, while that of the Drink group decreased by 6.5%(P<0.05). However, there were no significant differences between the results in the control group and those of the test group. The bohee tea group's hepatic ADH activity increased by 22.7% compared with that of the positive control group. On the other hand, the hepatic ADH activity of the Drink group increased by 33.6% while that of the A1codex group increased by 20.4%. On the contrary, the bohee tea extract, the hepatic ALDH did not manifest any significant difference as compared with the normal control group. However, its decrease rate was about 16.67% as compared with that of the positive control group. The Drink group, meanwhile, obtained a decrease rate of about 21.59%.

• 한국식품과학회지
• /
• 제29권1호
• /
• pp.167-172
• /
• 1997

1. 정상 성인 남자를 대상으로 한 25%의 알콜 100 ml 섭취시 DWP715는 전 대상인에서 $C_{max}$ 및 AUC 등의 감소와 다소 지연된 반감기($T_{1/2}$)를 나타내었으며 2시간에서 최대의 알콜농도 감소효과를 보여 주었다. 2. 3시간 구속스트레스를 통한 피로모델에서 DWP715는 피로부여시 증가된 LDH 수치, GOT수치 및 비장의 무게 등을 정상상태로 유지시켰다. 3. 과산화지질 생성을 위해 $CC1_4$로 유도된 항산화효과 측정 모델에서 DWP715는 대조군에 비해 유의적인 MDA감소를 보여주었다. 이상의 결과로 볼 때 DWP715는 알콜섭취 후 유도되는 간기능 저하에 따른 피로 상태와 아세트알데히드에 의해 형성되는 라디칼에 의한 간조직 손상을 보호해 주며 알콜섭취시 혈중으로의 알콜 흡수를 저하시키는 효능을 갖고 있는 것으로 판단된다. 따라서 DWP715는 혈중 알콜농도 감소와 함께 알콜섭취 후 발생되는 비특이적인 생체반응들에 의한 체내 불균형 상태를 효과적으로 회복시켜 줄 수 있을 것으로 생각된다.

• Natural Product Sciences
• /
• 제21권1호
• /
• pp.54-58
• /
• 2015

The protective effect of EtOAc fraction of Limonium tetragonum extract (EALT) against alcohol-induced hepatotoxicity was assessed following acute ethanol intoxication in Spraque-Dawley rats. EALT (200 mg/kg p.o.) was administrated once before alcohol intake (8 g/kg, p.o.). Blood ethanol concentration, and the activities of alcohol metabolic enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the liver were measured. Also, the formation of malondialdehyde (MDA) and the activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GSH-px), catalase were determined after acute alcohol exposure. Pretreatment of rats received ethanol with EALT significantly decreased blood ethanol concentration and elevated the activities of ADH and ALDH in liver. The increased MDA level was decreased, and the reduced activities of SOD, GSH-px and catalase were markedly preserved by the treatment with EALT. This study suggests that EALT prevent hepatic injury induced by acute alcohol which is likely related to its modulation on the alcohol metabolism and antioxidant enzymes activities.

• 동아시아식생활학회지
• /
• 제1권3호
• /
• pp.299-304
• /
• 1991

In this study the effects of water extracts of endocarps and seeds of omija(Schizandra chinensis Baillon)on alcohol metabolism in rats were investigated. 25% alcoholic solution(v/v,0.75g/200g B.W.)and 40% alcoholic solution(v/v,0.80g/200g B.W.)were orally administered to rats for 2 hours. The levels of metabolites and enzyme activities both on serum and liver were not changed by acute oral adminiatration of 25% and 40% alcoholic solution. Blood alcohol levels were significantly lowered by treatment of water extracts of endocarps and seeds of omija in rats administered with 25% and 40% alcohol. In 25% alcohol treated group, serum GPT level was decreased but hepatic G-6-P DH and pyruvate levels were increased. In 40% alcohol treated group, water extracts of endocarps and seeds of omija resulted in a significant decreased in serum levels of FFA, GPT but increased in serum glucose level. Hepatic levels of cytosolic protein, glycogen and pyruvate were increased by water extracts of omija parts in 40% alcohol treated group.

• 약학회지
• /
• 제40권1호
• /
• pp.78-83
• /
• 1996

An ethanol administration causes hepatic triglyceride accumulation in rats. To assess whether the herbal extract containing Phaseoli radiati semen(herbal extract) inhibit s the triglyceride accumulation in the liver, we determined the hepatic triglyceiide levels in rats fed ethanol and the herbal extract. In addition, the blood ethanol concentrations and the activities of hepatic alcohol dehydrogenase(ADH) and aldehyde dehydrogenase(ALDH) were measured to determine the effects of the herbal extract on alcohol metabolism in rats. The administration of the herbal extract markedly reduced the triglyceride levels elevated by ethanol in the liver as well as in the serum. The herbal extract remarkably lowered blood ethanol concentrations in a dose-dependent manner. The ADH activities decreased by ethanol were recovered to the normal level by the herbal extract treatment. Moreover, the ALDH activities slightly decreased by ethanol increased beyond the normal level by the herbal extract treatment. We conclude that the herbal extract inhibits the hepatic triglyceride accumulation and stimulates alcohol metabolism by preventing ADH and ALDH from inhbition by the ethanol administration in the rat liver.

• 보건교육건강증진학회지
• /
• 제30권1호
• /
• pp.83-93
• /
• 2013

Objectives: The objective of this study was to assess the gender differences in the relationship between alcohol use behaviors and the risk of metabolic syndrome among Korean adult population. Methods: Data from the Korean National Health and Nutrition Examination Survey (5th, 2010) was analyzed. Using the Alcohol Use Disorders Identification Test, subjects were classified into 4 groups including non-drinking, low-risk drinking, medium-level alcohol problem, and high-level alcohol problem group. Metabolic syndrome and its components were compared among the alcohol behavior groups by gender. Results: The odds ratio vs. non-drinking group for metabolic syndrome was significantly higher in male medium and high-level alcohol problem group. In female, high-level alcohol problem group showed significantly higher odds ratio for metabolic syndrome. Blood pressure and HDL-cholesterol were likely to be higher with the excessive drinking behaviors in both men and woman. Triglyceride level in men was significantly higher in the medium and high-level alcohol problem group than non-drinking group. Although fasting glucose level did not show differences among drinking groups, the odd ratios vs. non-drinking group for the hyperglycemia (${\geq}$ 100mg/dl) were significantly higher in female drinking groups. Conclusions: Problematic alcohol drinking is likely to increase the risk of metabolic syndrome in Korean adults.

• Journal of Preventive Medicine and Public Health
• /
• 제25권2호
• /
• pp.141-147
• /
• 1992

신체나 정신적으로 건강한 남자 대학생 15명을 대상으로 시판 소주(25%)를 식사 후 $3{\sim}4$시간 지나서 체중 kg당 ethyl alcohol 1ml(60kg 체중의 경우 소주 4잔, (240ml 또는 맥주 $2\frac{1}{5}$병 정도)되도록 마시게 한 후 시간별(5, 30, 60, 90분)로 Alcohol Sensor 100을 사용하여 호기로 혈중알를농도를 측정하고 선택반응시간검사(교통 신호등 반응시간검사), 눈과 손의 협동능력기능검사 및 연속가산에 의한 계산능력기능검사를 술을 마신 후 시간별로(5, 30, 60, 90분) 실시하여 다음과 같은 결과를 얻었다. 1. 술을 마셨을 때의 호기로 측정한 혈중알콜농도는 술(소주)을 마신 후 5, 30, 60, 90분에 중량백분율로서 각각 0.16%($160{\pm}57mg/100ml$), 0.10%($100{\pm}42mg/100m1$), 0.08%($80{\pm}36mg/100m1$), 0.03%($30{\pm}24mg/100m1$)로서 음주직후인 5분후에 0.16%로서 가장 높은 농도를 보였고 그 후는 점차 떨어져 30분, 60분에는 0.10%와 0.08%로 나타났다. 그리고 술을 마신 직후 호기로 혈중알콜농도를 측정할 경우 실제 혈중알콜농도보다 높게 나타날 가능성이 있다. 2. 선택반응시간검사(교통신호반응시간 검사 : 즉 빨간 정지신호를 보고 브레이크를 밟는 시간)에서는 혈액중 알콜농도가 증가함에 따라 반응시간이 길어졌으며, 술을 마신후 혈중농도가 0.16%, 0.10%, 0.08%를 보인 5분, 30분, 60분에서는 음주전보다 유의하게 늦어졌으며, p<0.01, 음주후 5분과 30분 후에는 0.46초 및 0.44초로서 음주전의 0.40초보다 0.06초와 0.04초 늦어졌다. 3. 눈과 눈의 협동능력검사에서는 혈중알콜농도가 높아감에 따라 작업수행의 정확도가 떨어졌는데 혈중농도가 0.08% 이상을 보인 음주후 5분과 30분, 60분후(p<0.05)에는 유의하게 협동능력이 떨어졌다. 4. 연속가산검사에서는 계산능력이 혈중농도가 0.08% 이상에서 계산의 정확성과 속도가 유의하게 떨어졌다.

• 한국약용작물학회지
• /
• 제6권2호
• /
• pp.126-130
• /
• 1998

Spraque-Dawley계 웅성흰쥐에 계통분획한 소엽의 각 분획물을 경구투여하고 혈청 Ethanol농도와 간의 ADH활성에 미치는 효과를 검색 추적한 결과 알코올대사를 촉진시키는 성분은 주로 에탄올가용부에, 억제시키는 성분은 에탄올불용부에 주로 존재함을 추정할 수 있었고 현재 활성성분을 분리중에 있다.

• 한국자원식물학회지
• /
• 제10권4호
• /
• pp.319-323
• /
• 1997

Spraque-Dawley계 응성흰쥐에 계통분획한 cornsilk의 각 분획물을 경구투여하고 혈청 Ethanol농도와 간의 Alcohol dehydrogenase활서에 미치는 효과를 검색 추적한 결과 알코올대사를 촉진시키는 성분은 주로 에탄올가용부에, 억제시키는 성분은 에탄올불용부에 주로 존재함을 추정할 수 있었다.

• Journal of Ginseng Research
• /
• 제1권1호
• /
• pp.59-78
• /
• 1976

알코을 마취작용 및 독작용에 미치는 인삼(백삼 및 홍삼)의 영향을 보기 위하여 다음과 같은 실험을 시행하였다. 실험동물로는 백색 가토, 마우스, 및 잡견을 사용하였고, 백색 가토 및 잡견에 대한 알코올의 마취작용을 관찰하기 위하여 마취의 유도시간, 마취시간, 회복시간과 마취의 유도로부터 완전회복까지의 전시간을 각각 계정하였으며, 마우스에 대한 알코올의 독작용($LD_{50}$)을 측정하였다. 아울러 혈중 알코올 농도, 혈당량, 혈청 transaminase(GOT 및 GDT)활성도 및 혈청 alkaline phosphatase활성도를 각각 측정하였다. 그리고 건강한 대학생에 대한 임상실험으로는 code substitution, response time 및 muscle coordination을 각각 관찰하였다. 실험결과로는 1. 인삼 전처치로 알코올 마취의 유도시간은 지연되었고, 회복시간과 마취가 시작하 여 회복될때 까지의 전시간은 현저히 단축되었다. 2. 혈중 알코을 농도는 인삼 전처치로 백색 가로에 있어서는 감소되었으나. 잡견에서는 별 영향이 없었다. 3. 인삼 전처치로 헐당량, 혈청transaminase(GOT 및 GDT)활성도 및 쳔청 alkaline phosphatase활성도는 다소 변동이 있었으나, 각각 경상 범위 내에서의 변동이 였기 때문에 의의 있는 변화라고 할 수 없다. 4. 가토간 내 알코올 dehydrogenase활성도는 인삼 투여로 상승하였는데 특히 홍삼 투여로 더욱 현저하였다. 5. 마우스에 대한 알코올의$LD_{50}$은 인삼 전처치로 증가되었는데 홍삼 전처치로 더욱 현저히 증가되었다. 6. 학생에 대한 임상 실험에서는 알코올 투여 후 3시간에 측정하였는데 혈중 알코올 농도는 인삼 전처치로 변동이 없었으나 혈당량은 증가되었다. 7. 인삼 전처치로 알코을에 의한 response time은 현저히 단축되었으나 code substitution이나 muscle coordination에는 영향이 없었다.