• Korean Journal of Biological Psychiatry
• /
• v.2 no.1
• /
• pp.57-62
• /
• 1995

Objects : Clozapine, prototype of the atypical neuroleptics, was known to have unique antipsychotic effect with a few extrapyramidal effects. While most typical antipsychotic agents mainly block $D_2$ receptors, clozapine has higher affinity for dopamine $D_4$ receptor than for $D_2$ receptor. Many researchers have tried to find out the relationship between schizophrenia and the abnormality of the genes coding dopamine receptors. But no consistent findings were reported. Recently, dopamine $D_4$ receptor was fully sequenced, and the alleles of dopamine $D_4$ receptor gene was found in unusual form on the 48th base pair. Our study was performed to identify the distribution of the dopamine $D_4$ receptor alleles of schizophrenics and normal controls, and whether any difference between the dopamine $D_4$ receptor alleles of schizophrenics and that of normal controls exists. Methods : DNA was extracted from the blood of schizophrenic patients(N=60) and normal controls(N=60). Part of the dopamine $D_4$ receptor gene was amplified by PCR, and amplified DNA was electrophoresed. Authors compared the distribution of the alleles of dopamine $D_4$ receptor gene of normal controls and that of schizophrenic patients. Results : Six kinds of alleles of $D_4$ receptor were observed both groups. The fourth repeat form of alleles was the most common in both schizophrenic patients(75.8%) and normal controls(70.3%), so there was not significant difference between two groups. Conclusion : The Difference in the distribution of the dopamine $D_4$ receptor gene alleles is not thought to be responsible for the pathophysiology of the schizophrenia. However, the difference in the expression of the dopamine $D_4$ receptor gene between normal and schizophrenia is left to be scrutinized.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.26 no.6
• /
• pp.581-590
• /
• 2000

Alterations in the cellular genome affecting the expression or function of genes controlling cell growth and differentiation are considered to be the main cause of cancer. Over 30 oncogenes can be activated by insertional mutagenesis, single point mutations, chromosomal translocations and gene amplification. The ras oncogenes have been detected in $15{\sim}20%$ of human tumors that include some of the most common forms of human neoplasia and are known to acquire their transforming properties by single point mutations in two domains of their coding sequences, most commonly in codons 12 and 61. The ras gene family consists of three functional genes, N-ras, K-ras and H-ras which encode highly similar proteins of 188 or 189 amino acid residues generically known as P21. ras proteins have been shown to bind GTP and GTP, and possess intrinsic GTPase activity. Experimental study was performed to observe the mutational change of the ras gene family and apply the results to the clinical activity. 36 Golden Syrian Hamster each weighing $60{\sim}80g$ were used and painted with 0.5% DMBA by 3 times weekly on the right buccal cheek(experimental side) for 6, 8, 10, 12, 14 and 16 weeks. Left buccal cheek (control side) was treated with mineral oil as the same manner of the right side. The hamsters were sacrificed on the 6, 8, 10, 12, 14 & 16 weeks. Normal and tumor tissues from paraffin block were completely dissected by microdissection and DNA from both tissue were isolated by proteinase K/phenol/chloroform extraction. Segments of the K-ras and H-ras gene were amplified by PCR using the oligonucleotide primers corresponding to the homologous region (codon 12 and 61) of the hamster gene, and then confirmational change of ras genes was observed by SSCP and autosequencing analysis. The results were as follows : 1. Malignant lesion could be found in the experimental side from the experimental six weeks. 2. One hamster among six showed point mutation of the H-ras codon 12($G{\rightarrow}A$ transition) at the experimental 10 and 14 weeks. 3. One of six at 6 weeks, two of six at 8 weeks and one of six at 12 weeks revealed the confirmational change of the H-ras codon 61($A{\rightarrow}T$ transversion). 4. The incidence of point mutation of H-ras codon 12 and 61 were 5.5%(2 of 36) and 11%(4 of 36) respectively. 5. Point mutation of the K-ras could not be seen during the whole experimental period. Form the above results, these findings strongly support the concept that H-ras oncogenes may have the influence of the DMBA induced carcinoma of hamster buccal pouch.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.24 no.8B
• /
• pp.1518-1531
• /
• 1999

The reconstructed images from highly compressed MPEG or H.263 data have noticeable image degradations, such as blocking artifacts near the block boundaries, corner outliers at cross points of blocks, and ringing noise near image edges, because the MPEG or H.263 quantizes the transformed coefficients of 8$\times$8 pixel blocks. A post-processing algorithm has been proposed by authors to reduce quantization effects, such as blocking artifacts, corner outliers, and ringing noise, in MPEG-decompressed images. Our signal-adaptive post-processing algorithm reduces the quantization effects adaptively by using both spatial frequency and temporal information extracted from the compressed data. The blocking artifacts are reduced by one-dimensional (1-D) horizontal and vertical low pass filtering (LPF), and the ringing noise is reduced by two-dimensional (2-D) signal-adaptive filtering (SAF). A comparison study of the subjective quality evaluation using modified single stimulus method (MSSM), the objective quality evaluation (PSNR) and the computation complexity analysis between the signal-adaptive post-processing algorithm and the MPEG-4 VM (Verification Model) post-processing algorithm is performed by computer simulation with several MPEG-4 image sequences. According to the comparison study, the subjective image qualities of both algorithms are similar, whereas the PSNR and the comparison complexity analysis of the signal-adaptive post-processing algorithm shows better performance than the VM post-processing algorithm.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.17 no.6
• /
• pp.69-78
• /
• 2017

Shannon of the 5G smartphone and Fourier of the signal processing meet in the sampling theorem (2 times the highest frequency 1). In this paper, the initial Shannon Theorem finds the Shannon capacity at the point-to-point, but the 5G shows on the Relay channel that the technology has evolved into Multi Point MIMO. Fourier transforms are signal processing with fixed parameters. We analyzed the performance by proposing a 2N-1 multivariate Fourier-Jacket transform in the multimedia age. In this study, the authors tackle this signal processing complexity issue by proposing a Jacket-based fast method for reducing the precoding/decoding complexity in terms of time computation. Jacket transforms have shown to find applications in signal processing and coding theory. Jacket transforms are defined to be $n{\times}n$ matrices $A=(a_{jk})$ over a field F with the property $AA^{\dot{+}}=nl_n$, where $A^{\dot{+}}$ is the transpose matrix of the element-wise inverse of A, that is, $A^{\dot{+}}=(a^{-1}_{kj})$, which generalise Hadamard transforms and centre weighted Hadamard transforms. In particular, exploiting the Jacket transform properties, the authors propose a new eigenvalue decomposition (EVD) method with application in precoding and decoding of distributive multi-input multi-output channels in relay-based DF cooperative wireless networks in which the transmission is based on using single-symbol decodable space-time block codes. The authors show that the proposed Jacket-based method of EVD has significant reduction in its computational time as compared to the conventional-based EVD method. Performance in terms of computational time reduction is evaluated quantitatively through mathematical analysis and numerical results.

• Asian-Australasian Journal of Animal Sciences
• /
• v.33 no.11
• /
• pp.1725-1731
• /
• 2020

Objective: An initial RNA-Sequencing study revealed that UDP-galactose-4-epimerase (GALE) was one of the most promising candidates for milk protein concentration in Chinese Holstein cattle. This enzyme catalyzes the interconversion of UDP-galactose and UDP-glucose, an important step in galactose catabolism. To further validate the genetic effect of GALE on milk protein traits, genetic variations were identified, and genotypes-phenotypes associations were performed. Methods: The entire coding region and the 5'-regulatory region (5'-UTR) of GALE were re-sequenced using pooled DNA of 17 unrelated sires. Association studies for five milk production traits were performed using a mixed linear animal model with a population encompassing 1,027 Chinese Holstein cows. Results: A total of three variants in GALE were identified, including two novel variants (g.2114 A>G and g.2037 G>A) in the 5'-UTR and one previously reported variant (g.3836 G>C) in an intron. All three single nucleotide polymorphisms (SNPs) were associated with milk yield (p<0.0001), fat yield (p = 0.0006 to <0.0001), protein yield (p = 0.0232 to <0.0001) and protein percentage (p<0.0001), while no significant associations were detected between the SNPs and fat percentage. A strong linkage disequilibrium (D' = 0.96 to 1.00) was observed among all three SNPs, and a 5 Kb haplotype block involving three main haplotypes with GAG, AGC, and AGG was formed. The results of haplotype association analyses were consistent with the results of single locus association analysis (p<0.0001). The phenotypic variance ratio above 3.00% was observed for milk protein yield that was explained by SNP-g.3836G >C. Conclusion: Overall, our findings provided new insights into the polymorphic variations in bovine GALE gene and their associations with milk protein concentration. The data indicate their potential uses for marker-assisted breeding or genetic selection schemes.

• The Journal of the Korea Contents Association
• /
• v.7 no.12
• /
• pp.262-272
• /
• 2007

SAD (Sum of Absolute Difference) algorithm is the most frequently executing routine in motion estimation, which is the most demanding process in motion picture encoding. To enhance the performance of motion picture encoding on a VLIW processor, an optimal implementation of SAD algorithm on VLIW processor should be accomplished. In this paper, we propose an implementation of optimal scheduling of SAD algorithm with conditional branch on a VLIW-based high performance DSP. We first transform the nested loop with conditional branch of SAD algorithm into a single loop with conditional branch which has a large enough loop body to utilize fully the ILP capability of VLIW DSP and has a conditional branch to make the escape from loop to be achieved as soon as possible. And then we apply a modulo scheduling technique to the transformed single loop. We test the proposed implementation on TMS320C6713, and analyze the code size and performance with respect to processing time. Through experiments, it is shown that the SAD implementation proposed in this paper has small code size appropriate for embedded applications, and the H.263 encoder with the proposed SAD implementation performs better than other H.263 encoder with other SAD implementations.

• Journal of Broadcast Engineering
• /
• v.15 no.3
• /
• pp.380-390
• /
• 2010

The most recent standard video codec, H.264/AVC achieves significant coding efficiency by using a rate-distortion optimization(RDO). The RDO is a measurement for selecting the best mode which minimizes the Lagrangian cost among several modes. As a result, the computational complexity is increased drastically in encoder. In this paper, a method for fast intra prediction mode decision is proposed to reduce the RDO complexity. To speed up Intra$4{\times}4$ and Chroma Intra encoding, the proposed method decides the case that MPM (Most Probable Mode) is the best prediction mode. In this case, the RDO process is skipped, and only MPM is used for encoding the block in Intra$4{\times}4$. And the proposed method is also applied to the chroma Intra prediction mode in a similar way to the Intra$4{\times}4$. The experimental results show that the proposed method achieves an average encoding time saving of about 63% with negligible loss of PSNR (Peak Signal-to-Noise Ratio).

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.14 no.12
• /
• pp.1239-1247
• /
• 2003

OFDM(orthogonal frequency division multiplexing) communications system is very attractive for the high data rate transmission in the frequency selective lading channel. Since OFDM has high PAPR(peak-to-average power ratio), OFDM signal may be distorted by the nonlinear HPA(high power amplifier). In this paper, we propose the DSI(dummy sequence insertion) method for OFDM communication system. Some sub-carriers are inserted for PAPR reduction. They carry the specified dummy data sequence which are used for only PAPR reduction and do not work as side information like the conventional PTS(partial transmit sequence) or SLM(selected mapping) method. We use the complementary sequence and the combination of the correlation sequence as the dummy sequence. Flipping technique is used for the DSI method to get the effective PAPR reduction. It is important that BER of the proposed method is independent of the damage of the dummy data sequence. And DSI method has better spectral efficiency than the conventional block coding. On the other hand, threshold PAPR method is applied to cut down the processing time. However, this DSI method is not better than the conventional PTS method in the respect of the PAPR reduction performance. The DSI method includes the threshold PAPR lower than the PAPR of the OFDM signal, reduces the processing time and improves the BER performance.

• Journal of the Institute of Electronics Engineers of Korea CI
• /
• v.39 no.5
• /
• pp.11-20
• /
• 2002

Based on regularization principles, we propose a new dequantization scheme on DCT-based transform coding for reducing of blocking artifacts and minimizing the quantization error. The conventional image dequantization is simply to multiply the received quantized DCT coefficients by the quantization matrix. Therefore, for each DCT coefficients, we premise that the quantization noise is as large as half quantizer step size (in DCT domain). Our approach is based on basic constraint that quantization error is bounded to ${\pm}$(quantizer spacing/2) and at least there are not high frequency components corresponding to discontinuities across block boundaries of the images. Through regularization, our proposed dequantization scheme, sharply reduces blocking artifacts in decoded images. Our proposed algorithm guarantees that the dequantization process will map the quantized DCT coefficients will be evaluated against the standard JPEG, MPEG-1 and H.263 (with Annex J deblocking filter) decoding process. The experimental results will show visual improvements as well as numerical improvements in terms of the peak-signal-to-noise ratio (PSNR) and the blockiness measure (BM) to be defined.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.32 no.2C
• /
• pp.181-188
• /
• 2007

This paper proposed a watermark embedding/extracting method using CABAC(Context-based Adaptive Binary Arithmetic Coding) which is the entropy encoder for the main profile of MPEG-4 Part 10 H.264/AVC. This algorithm selects the blocks and the coefficients in a block on the bases of the contexts extracted from the relationship to the adjacent blocks and coefficients. A watermark bit is embedded without any modification of coefficient or with replacing the LSB(Least Significant Bit) of the coefficient with a watermark bit by considering both the absolute value of the selected coefficient and the watermark bit. Therefore, it makes it hard for an attacker to find out the watermarked locations. By selecting a few coefficients near the DC coefficient according to the contexts, this algorithm satisfies the robustness requirement. From the results from experiments with various kinds and various strengths of attacks the maximum error ratio of the extracted watermark was 5.02% in maximum, which makes certain that the proposed algorithm has very high level of robustness. Because it embeds the watermark during the context modeling and binarization process of CABAC, the additional amount of calculation for locating and selecting the coefficients to embed watermark is very small. Consequently, it is highly expected that it is very useful in the application area that the video must be compressed right after acquisition.