• Progress in Medical Physics
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• v.25 no.3
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• pp.157-166
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• 2014

ATP in quantity co-stored with neurotransmitters in the secretory vesicles of neurons, by being co-released with the neurotransmitters, takes an important role to modulate the stimulus-secretion response of neurotransmitters. Here, in this study, the modulatory effect of ATP was studied in $Ca^{2+}$ channels of cultured rat adrenal chromaffin cells to investigate the physiological role of ATP in neurons. The $Ca^{2+}$ channel current was recorded in a whole-cell patch clamp configuration, which was modulated by ATP. In 10 mM $Ba^{2+}$ bath solution, ATP treatment (0.1 mM) decreased the $Ba^{2+}$ current by an average of $36{\pm}6%$ (n=8), showing a dose-dependency within the range of $10^{-4}{\sim}10^{-1}mM$. The current was recovered by ATP washout, demonstrating its reversible pattern. This current blockade effect of ATP was disinhibited by a large prepulse up to +80 mV, since the $Ba^{2+}$ current increment was larger when treated with ATP ($37{\pm}5%$, n=11) compared to the control ($25{\pm}3%$, n=12, without ATP). The $Ba^{2+}$ current was recorded with $GTP{\gamma}S$, the non-hydrolyzable GTP analogue, to determine if the blocking effect of ATP was mediated by G-protein. The $Ba^{2+}$ current decreased down to 45% of control with $GTP{\gamma}S$. With a large prepulse (+80 mV), the current increment was $34{\pm}4%$ (n=19), which $25{\pm}3%$ (n=12) under control condition (without $GTP{\gamma}S$). The $Ba^{2+}$ current waveform was well fitted to a single-exponential curve for the control, while a double-exponential curve best fitted the current signal with ATP or $GTP{\gamma}S$. In other words, a slow activation component appeared with ATP or $GTP{\gamma}S$, which suggested that both ATP and $GTP{\gamma}S$ caused slower activation of $Ca^{2+}$ channels via the same mechanism. The results suggest that ATP may block the $Ca^{2+}$ channels by G-protein and this $Ca^{2+}$ channel blocking effect of ATP is important in autocrine (or paracrine) inhibition of adrenaline secretion in chromaffin cell.

• Journal of the Korea Computer Graphics Society
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• v.14 no.3
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• pp.11-17
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• 2008

Many methods which represent complex surfaces using height map without a number of vertex have been researched. However, a single layer height map cannot present more complex objects because it has only one height value on each position. In this paper, we introduce the new approach to render more complex objects, which are not generated by single layer height map, using multi layer height map. We store height values of the scene to each texture channel by the ascending order. A pair of ordered height values composes a geometry block and we use this property. For accurate ray search, we store the highest value in odd channels and the lowest value in even channels to generate quad tree height map. Our ray search algorithm shows accurate intersections between viewing ray and height values using quad tree height map. We solve aliasing problems on grazing angles occurred in previous methods and render the result scene on real-time.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.5
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• pp.421-427
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• 2009

This paper has proposed 1-2-1 coded cooperative communication that is a combination of STBC and ARQ. Coded cooperative communication is a protocol that integrates channel coding with cooperative communication. In this paper consider convolution encoder. ARQ method can increase the spectral efficiency than conventional cooperative communication because if the received signal from source node is satisfied by the destination preferentially, the destination transmits ACK message to both relay node and source node and then recovers the received signal. Where each relay 1, 2 forwards a punctured portion of receive data. When relay transmit to destination apply STBC the reliability to increase. Moreover this protocol can get better BER performance of receiver using simple comparator. We verified BER performance for the proposed protocol through Monte-Carlo simulation over Rayleigh fading plus AWGN.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.1
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• pp.133-138
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• 2020

This paper introduces a method for improving accuracy using the first convolution layer, which is not used in most modified CNN(: Convolution Neural Networks). In CNN, such as GoogLeNet and DenseNet, the first convolution layer uses only the traditional methods(3×3 convolutional computation, batch normalization, and activation functions), replacing this with RGB-csb. In addition to the results of preceding studies that can improve accuracy by applying RGB values to feature maps, the accuracy is compared with existing CNN using a limited number of images. The method proposed in this paper shows that the smaller the number of images, the greater the learning accuracy deviation, the more unstable, but the higher the accuracy on average compared to the existing CNN. As the number of images increases, the difference in accuracy between the existing CNN and the proposed method decreases, and the proposed method does not seem to have a significant effect.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.43 no.9 s.351
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• pp.31-37
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• 2006

Low-density parity-check (LDPC) codes are recently emerged due to its excellent performance. The standard for European high definition satellite digital video broadcast, DVB-S2 has adopted LDPC codes as a channel coding scheme. This paper proposes a DVB-S2 LDPC decoder architecture using a hybrid parity check matrix which is efficient in hardware implementation for both decoders and encoders. The hybrid H-matrices are constructed so that both the semi-random technique and the partly parallel structure can be applied to design encoders and decoders. Using the hybrid H-matrix scheme, the architecture of LDPC decoder for DVB-S2 can be very practical and efficient. In addition, we show a new Variable Node processor Unit (VNU) architecture to reuse the VNU for various code rates and optimized block memory placement to reuse. We design a DVB-S2 LDPC decoder of code rate 1/2 usng the proposed architecture. We estimate the performance of the DVB-S2 LDPC decoder and compare it with other decoders.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.4
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• pp.17-25
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• 2013

In this paper, a coding algorithm is proposed for multi-user multi-input multi-output (MU-MIMO) systems to improve the reception performance in fading conditions without reducing the bandwidth efficiency. The space division multiple access (SDMA) scheme that is one of the commonly used for MU-MIMO systems is vulnerable to the fading. The space time block code (STBC) scheme that is used to overcome the fading has a disadvantage of reduced throughput. The proposed MU-MIMO system first encodes transmitted symbols by linear dispersion code (LDC) which is less vulnerable to the fading and increases the throughput in proportional to the number of transmit antennas. Then, the LDC coded symbols are pre-coded by the result of singular value decomposition (SVD) of the estimated channel gain. We evaluate the performance of the proposed scheme compared with the conventional algorithms by computer simulations.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.2
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• pp.169-177
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• 2017

Lamotrigine is an antiepileptic drug widely used to treat epileptic seizures. Using whole-cell voltage clamp recordings in combination with a fast drug application approach, we investigated the effects of lamotrigine on 5-hydroxytryptamine $(5-HT)_3$ receptors in NCB-20 neuroblastoma cells. Co-application of lamotrigine ($1{\sim}300{\mu}M$) resulted in a concentration-dependent reduction in peak amplitude of currents induced by $3{\mu}m$ of 5-HT for an $IC_{50}$ value of $28.2{\pm}3.6{\mu}M$ with a Hill coefficient of $1.2{\pm}0.1$. These peak amplitude decreases were accompanied by the rise slope reduction. In addition, $5-HT_3$-mediated currents evoked by 1 mM dopamine, a partial $5-HT_3$ receptor agonist, were inhibited by lamotrigine co-application. The $EC_{50}$ of 5-HT for $5-HT_3$ receptor currents were shifted to the right by co-application of lamotrigine without a significant change of maximal effect. Currents activated by 5-HT and lamotrigine co-application in the presence of 1 min pretreatment of lamotrigine were similar to those activated by 5-HT and lamotrigine co-application alone. Moreover, subsequent application of lamotrigine in the presence of 5-HT and 5-hydroxyindole, known to attenuate $5-HT_3$ receptor desensitization, inhibited $5-HT_3$ receptor currents in a concentration-dependent manner. The deactivation of $5-HT_3$ receptor was delayed by washing with an external solution containing lamotrigine. Lamotrigine accelerated the desensitization process of $5-HT_3$ receptors. There was no voltage-dependency in the inhibitory effects of lamotrigine on the $5-HT_3$ receptor currents. These results indicate that lamotrigine inhibits $5-HT_3$-activated currents in a competitive manner by binding to the open state of the channels and blocking channel activation or accelerating receptor desensitization.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.41 no.11
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• pp.1341-1348
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• 2016

In this paper, we propose method to enhance security performance using HT-STBC with artificial noise under Wier-Tap channel model that exist with legitimate receiver and illegal eavesdropper. Conventional STBC with artificial noise scheme has a weakness that a limited increase in the BER of the difference between the receiver and an eavesdropper, when used over QPSK modulation. To solve this problem, we suggest HT-STBC combining hadamard transform and STBC with artificial noise for reduce BER of receiver than the conventional scheme and demonstrated through simulation that also increased BER difference between the receiver and an eavesdropper. By the simulation results, when used proposed scheme, showed approximately 3dB improvement in performance compared to the conventional scheme.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.11
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• pp.2113-2120
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• 2015

This paper presents an integrated receiver to support multimode broadcasting standards such as DVB-T2, DVB-C2, and DVB-S2 in a single platform. The integrated receiver consists of a tuner block, a receiver engine, a frame processor, and an A/V decoder. The receiver engine includes a channel decoding engine and a demodulation engine to perform OFDM and APSK demodulations. The frame processor performs deinterleaving and BB frame decoding functions. The demodulator engine and the frame processor are implemented in two FPGA devices and DSP-based embedded software, respectively. To verify the functionality of the integrated receiver, it is tested in the laboratory. Commercial PC-based modulators are used to generate the DVB-T2, DVB-C2, and DVB-S2 modulated signals. The integrated receiver was tested under various operation modes as specified in the standards such as DVB-T2, DVB-C2, and DVB-S2 and showed successful operation in all the scenarios tested.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.10
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• pp.31-40
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• 2013

In this paper, the spatial modulation (SM) multi-input multi-output (MIMO) system is proposed for indoor wireless local area networks (WLANs) with improved spectral efficiency. SM is suitable for high speed WLANs with avoiding the inter channel interference (ICI). Only one transmit antenna is activated in SM at each symbol interval. Therefore, it fails to attain the maximum coding gain of MIMO. The space time block code (STBC)-SM MIMO system can attain the maximum diversity gain at the expense of spectral efficiency. The proposed Golden-SM MIMO system uses the Golden code to improve the coding gain and spectral efficiency at the same time. The Golden code is adapted for STBC-SM and it makes the new code book for transmission symbols. The performance of the proposed system is compared with the conventional systems with computer simulations.