• Korean Journal of Agricultural Science
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• v.49 no.1
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• pp.11-18
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• 2022

A disrupted immune system during pregnancy is involved in pregnancy complications, such as spontaneous abortion, preeclampsia, and recurrent pregnancy loss. This study examined the role of toll-like receptor (TLR) 4 and ASC (apoptosis-associated speck-like protein containing a CARD [c-terminal caspase recruitment domain]) in pregnancy complications using a lipopolysaccharide (LPS)-induced miscarriage mice model. Incidences of miscarriage and embryonic resorption were examined at 9.5 days of pregnancy in wild-type (WT), ASC knockout (KO), and TLR4 KO mice after injecting them with LPS. The fetuses and placenta were obtained after sacrifice at 15.5 days of pregnancy. A significantly lower frequency of fetus absorption was found in TLR4 KO mice, whereas corresponding absorption outcomes were strongly induced in the WT and ASC KO mice upon an LPS injection. As expected, TLR4 KO mice were resistant to LPS-induced abortion. A histological analysis of the miscarried placenta showed increasing levels of the eosin staining of spongiotrophoblast cells without any obvious difference between WT and ASC KO mice. These results suggest that TLR4 KO mice are resistant to LPS, which affects pregnancy persistence, whereas WT and ASC KO mice show high miscarriage rates due to LPS. Moreover, the ASC adaptor is not directly involved in LPS-induced miscarriages, and the NLRP3 inflammasome can be activated by other proteins in the absence of ASC.

• Journal of Korean Society of Rural Planning
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• v.29 no.3
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• pp.15-24
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• 2023

The sense of crisis regarding regional extinction due to low birth rates and an aging population is expanding. Generally, the local extinction index is used to analyze local extinction. However, it is challenging to diagnose the actual situation of village extinction risk in rural areas, even though the regional extinction index can be analyzed in units such as Si-Gun-Gu and Eup-Myeon-Dong. This difficulty arises because the regional extinction index solely relies on natural population growth indicators (elderly population and female population aged 20-39). Therefore, the purpose of this study is to develop a village extinction index that can identify the disappearance of rural villages. Additionally, the aim is to apply the developed indicators to the village (administrative ri) spatial unit. The existing regional extinction index used only mortality-related indicators as factors for natural population decline and fertility-related indicators as factors for natural population growth. However, the developed village extinction index included not only the factors of natural population change but also incorporated social population growth factors and factors related to the pace of village extinction. This is the key difference between the developed village extinction index and the existing regional extinction index. In this study, the indicators of "total population," "number of young women aged 20-44," "number of elderly population aged 70 or older," and "number of incoming population" were selected to develop a village extinction index. The village extinction index was developed by incorporating both natural population growth indicators and social population growth indicators. The developed village extinction index was applied to administrative villages. This research is expected to provide a more accurate understanding of the current state of rural villages facing extinction.

• Journal of People, Plants, and Environment
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• v.22 no.6
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• pp.665-676
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• 2019

The Korean society is currently showing a decrease in the child population and a rapid increase in the elderly population due to low birth rates and aging, but the current park system does not reflect the changing population structure. This study aimed to find ways to plan and promote use of senior-friendly parks for the aging society. The results are as follows. First, the elderly mostly gathered in Tapgol Park and Jongmyo Park which were accessible to subways and close to amenities and traditional markets. The elders usually gathered around buffer zones or green spaces set up to protect cultural heritages. Second, many elderly users were observed in Osolgil Silver Park and Sinteuri Park which were renovated with senior-friendly concept. These parks were recognized as places that the elderly people could visit without minding users of other generations because the elderly users were ensured by words such as 'seniors only' or 'senior-friendly'. Third, the importance of the locational conditions for the senior-friendly parks should be mentioned. A senior-friendly park must be located in an urban center to have convenient access to transportation, secure large green spaces, and make elderly users feel at ease with social connectivity when they use the amenities there. Fourth, the survey results showed that elderly people visited parks to exerciseand take a walk (track),by age, older age groups visited the park to socialize with other elders around their age. Fifth, the most desired facilities for constructing senior-friendly parks were fitness equipment, and sports facilities like a trail, track, and gateball field, and in some cases, vegetable gardens and indoor rest area to avoid wind in cold weather.

• Journal of Nutrition and Health
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• v.56 no.3
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• pp.330-347
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• 2023

Purpose: This study identified words closely associated with the keyword "dietary supplement" (DS) using big data in Korean social media and investigated consumer perceptions and trends related to DSs before (2019) and after the coronavirus disease 2019 (COVID-19) pandemic (2021). Methods: A total of 37,313 keywords were found for the 2019 period, and 35,336 keywords were found for the 2021 period using blogs and cafes on Daum and Naver. Results were derived by text mining, semantic networking, network visualization analysis, and sentiment analysis. Results: The DS-related keywords that frequently appeared before and after COVID-19 were "recommend", "vitamin", "health", "children", "multiple", and "lactobacillus". "Calcium", "lutein", "skin", and "immunity" also had high frequency-inverse document frequency (TF-IDF) values. These keywords imply a keen interest in DSs among Korean consumers. Big data results also reflected social phenomena related to DSs; for example, "baby" and "pregnant woman" had lower TD-IDF values after the pandemic, suggesting lower marriage and birth rates but higher values for "joint", indicating reduced physical activity. A network centered on vitamins and health care was produced by semantic network analysis in 2019. In 2021, values were highest for deficiency and need, indicating that individuals were searching for DSs after the COVID-19 pandemic due to a lack an awareness of the need for adequate nutrient intake. Before the pandemic, DSs and vitamins were associated with healthcare and life cycle-related topics, such as pregnancy, but after the COVID-19 pandemic, consumer interests changed to disease prevention and treatment. Conclusion: This study provides meaningful clues regarding consumer perceptions and trends related to DSs before and after the COVID-19 pandemic and fundamental data on the effect of the pandemic on consumer interest in dietary supplements.

• Clinical and Experimental Reproductive Medicine
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• v.51 no.1
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• pp.75-84
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• 2024

Objective: The purpose of this study was to evaluate the impact of preimplantation genetic testing for aneuploidy (PGT-A) on clinical outcomes among high-risk patients. Methods: This retrospective study involved 1,368 patients and the same number of cycles, including 520 cycles with PGT-A and 848 cycles without PGT-A. The study participants comprised women of advanced maternal age (AMA) and those affected by recurrent implantation failure (RIF), recurrent pregnancy loss (RPL), or severe male factor infertility (SMF). Results: PGT-A was associated with significant improvements in the implantation rate (IR) and the ongoing pregnancy rate/live birth rate (OPR/LBR) per embryo transfer cycle in the AMA (39.3% vs. 16.2% [p<0.001] and 42.0% vs. 21.8% [p<0.001], respectively), RIF (41.7% vs. 22.0% [p<0.001] and 47.0% vs. 28.6% [p<0.001], respectively), and RPL (45.6% vs. 19.5% [p<0.001] and 49.1% vs. 24.2% [p<0.001], respectively) groups, as well as the IR in the SMF group (43.3% vs. 26.5%, p=0.011). Additionally, PGT-A was associated with lower overall incidence rates of early pregnancy loss in the AMA (16.7% vs. 34.3%, p=0.001) and RPL (16.7% vs. 50.0%, p<0.001) groups. However, the OPR/LBR per total cycle across all PGT-A groups did not significantly exceed that for the non-PGT-A groups. Conclusion: PGT-A demonstrated beneficial effects in high-risk patients. However, our findings indicate that these benefits are more pronounced in carefully selected candidates than in the entire high-risk patient population.

• Industry Promotion Research
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• v.9 no.1
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• pp.103-111
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• 2024

In this study, the problem of child care gaps has arisen due to the expansion of women's entry into the workforce and the increase in working couples, and the care cliff phenomenon after children enter elementary school has been identified as one of the causes of women's career disconnection and low birth rates, and child care services have been initiated to solve care problems and balance work and family. The importance of childcare services to the safety and well-being of children has been highlighted by the restrictions on school attendance and the absence of caregivers during the COVID-19 pandemic. The government has been making policy efforts to reduce the gap in child care, but problems with the effectiveness and efficiency of the child care system have arisen due to unstable target selection and delivery systems by ministries and projects in the implementation of child care services. Therefore, this study examines the child care services implemented by each ministry to reduce the blind spots of after-school care services in the community and prepare efficient operation plans for various delivery systems, and seeks directions for the development of child care services.

• Convergence Security Journal
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• v.23 no.4
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• pp.153-158
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• 2023

Massacres of civilians are being committed in the Russia-Ukraine war, and the war is becoming a long-term war due to a lack of support for reserve combat forces. Considering the reality that South Korea is experiencing a rapid population decline and is rapidly entering an aging society, we are at a point where the nature of the war with North Korea must change. Among them, if private security guards are placed under the control of the police as regular security and crime prevention personnel and used as an alternative resource for reserve forces to ensure the safety of wartime areas and residents and prepare for long-term wars, it will help preserve combat power and maintain sustainability.Regarding private security, considering Japan's further development, we compared it with ours and looked into ways to utilize it as a reserve force for a divided country. In a future where low birth rates will lead to a decrease in military strength, if private security guards are used in local security vacuums during peacetime and participate in local defense during wartime, it could help improve the Korean military's reserve force.

• Journal of Korean Society of Water and Wastewater
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• v.37 no.6
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• pp.363-373
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• 2023

Numerous studies have established a correlation between sociodemographic characteristics and water usage, identifying population as a primary independent variable in mid- to long-term demand forecasting. Recent dramatic sociodemographic changes, including urban concentration-rural depopulation, low birth rates-aging population, and the rise in single-person households, are expected to impact water demand and supply patterns. This underscores the necessity for operational and managerial changes in existing water supply systems. While sociodemographic characteristics are regularly surveyed, the conducted surveys use aggregate units that do not align with the actual system. Consequently, many water demand forecasts have been conducted at the administrative district level without adequately considering the water supply system. This study presents an upward water demand forecasting model that accurately reflects real water facilities and consumers. The model comprises three key steps. Firstly, Statistics Korea's SGIS (Statistical Geological Information System) data was reorganized at the DMA level. Secondly, DMAs were classified using the SOM (Self-Organizing Map) algorithm to consider differences in water facilities and consumer characteristics. Lastly, water demand forecasting employed the PCR (Principal Component Regression) method to address multicollinearity and overfitting issues. The performance evaluation of this model was conducted for DMAs classified as rural areas due to the insufficient number of DMAs. The estimation results indicate that the correlation coefficients exceeded 0.9, and the MAPE remained within approximately 10% for the test dataset. This method is expected to be useful for reorganization plans, such as the expansion and contraction of existing facilities.

• Journal of Animal Science and Technology
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• v.54 no.6
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• pp.395-400
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• 2012

This study was conducted to estimate the growth curve parameters for the body weight (BW) and body length (BL) of miniature pigs in Korea. Growth curve parameters were estimated through a nonlinear regression model using Gompertz, Logistic, and von Bertalanffy methods. A total of 25 piglets were measured monthly from birth up to 15 months of age to estimate both body weight and length. Results showed that the estimated average values for the body weight (body length) were 31.83 kg (58.77 cm) for the mature weight (A), 3.06 (1.74) for the growth ratio (${\beta}$), and 0.28 (0.52) for the maturing rate (${\kappa}$). Average inflection points showing maximum growth rate estimated each month for body weight were 3.97 kg and 11.70 cm, while for the body length were 1.06 kg and 21.61 cm. Moreover, the estimated maturation rates of the body weight and length for the group of Sire 1 were 0.22 and 0.40 respectively, whereas for the group of Sire 2 these values were 0.34 and 0.39. On the other hand, for the groups of Dam 1, Dam 2, and Dam 3, maturation rates for their body weights were 0.26, 0.28 and 0.33 respectively, while for their body lengths these values were 0.43, 0.37, and 0.38, respectively. The study also indicated a negative relationship between the values of mature weight and maturity rate for the body weight will result to a higher inflection point which is in contrast for the body length where results show that a positive relationship between the values of mature length and the maturity rate will result to a higher inflection point. Furthermore, the growth performance of miniature pig varies across stages but using these estimated growth curve parameters could improve the genetic traits of miniature pig.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.21 no.3
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• pp.153-160
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• 2010

Objectives: The purpose of this study was to evaluate the prenatal, perinatal, and infancy history of children with autism spectrum disorder (ASD) as compared to unaffected siblings (SIB) and typically developing children (TC). Methods: Subjects with ASD, their SIB, and TC were recruited. All subjects were assessed using both the Korean version of Autism Diagnostic Interview-Revised (K-ADI-R) and the Korean version of Autism Diagnostic Observation Schedule (K-ADOS) and were subsequently identified as affected or unaffected. Prenatal, perinatal, and infancy history was obtained from the primary caregivers and each facet was compared in those with ASD, the SIB, and the TC groups using SPSS ver. 17.0 (p<.05). Results: 70 individuals with ASD (63 males, 87.94${\pm}$37.8months), 53 SIB (27 males, 85.4087.94${\pm}$48.06 months), and 32 TC (19 males, 104.1987.94${\pm}$23.409 months) were analyzed. The ASD group showed significantly higher rates of insufficient vaccination as they aged age ($x^2$=15.54, p=.000). Among the scheduled vaccinations, the DPT vaccination ($x^2$=10.08, p=.006) was insufficient in ASD groups. The ASD group also showed higher rates of sleep disturbances from infancy. Differences in maternal/paternal age at conception, gestational age, and growth parameters at birth were not significantly difference among the three groups. Conclusion: These results do not support the previous controversies regarding the relationship between prenatal/perinatal complications and ASD. However, these results indicate that perinatal and prenatal factors may contribute to the development of ASD.