• Journal of Preventive Medicine and Public Health
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• v.56 no.4
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• pp.348-356
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• 2023

Objectives: We investigated trends in the incidence rate of macrosomia and its association with parental nationalities using Vital Statistics data in Japan. Methods: We used singleton birth data every 5 years from 1995 to 2020. The incidence rate of macrosomia was calculated according to specific attributes (maternal age, infant's sex, parental nationalities, parity, and household occupation) over time (years). In addition, a log-binomial model was used to investigate the relationship between the incidence of macrosomia and the attributes. This study compared Korea, China, the Philippines, Brazil, and other countries with Japan in terms of parental nationalities. "Other countries" indicates countries except for Japan, Korea, China, the Philippines, and Brazil. Results: The study included 6 180 787 births. The rate of macrosomia in Japan decreased from 1.43% in 1995 to 0.88% in 2020, and the decrease was observed across all parental nationalities. The rates for Japanese parents were the lowest values among parental nationalities during the timespan investigated. Multivariate regression analysis showed that mothers from Korea, China, the Philippines, Brazil, and other countries had a significantly higher risk of macrosomia than those from Japan (risk ratio, 1.91, 2.82, 1.59, 1.74, and 1.64, respectively). Furthermore, fathers from China, the Philippines, Brazil, and other countries had a significantly higher risk of macrosomia than those from Japan (risk ratio, 1.66, 1.38, 1.88, and 3.02, respectively). Conclusions: The rate of macrosomia decreased from 1995 to 2020 in Japan for parents of all nationalities, and the risk of macrosomia incidence was associated with parental nationality.

• Proceedings of the KSAR Conference
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• 2003.06a
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• pp.18-18
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• 2003

In human, sudden infant death syndrome(SIDS) is synonyms for the sudden, unexpected and unexplained death of an infant. The incidence of SIDS has been estimated to be from 1 to 3%. Cloning has a relatively high rate of late abortion and early postnatal death, particularly when somatic cells are used as donors of nuclei and rates as high as 40 to 70% have been reported. However, the mechanisms for SIDS in cloned animals are not known yet. To date, few reports provide detailed information regarding phenotypic abnormality of cloned pigs. In this study, most of the cloned piglets were alive at term and readily recovered respiration. However, approximately 82% of male cloned piglets (81/22) died within a week after birth. Significant findings from histological examinations showed that 42% of somatic cloned male piglets died earlier than somatic cloned female piglets, most probably due to severe congestion of lung and liver or neutrophilic inflammation in brain, which indicates that unexpected phenotypes can appear as a result of somatic cell cloning. No anatomical defects in cloned female piglets were detected, but three of the piglets had died by diarrhea due to bacterial infection within 15 days after birth. Although most of male cloned piglets can be born normal in terms of gross anatomy, they develop phenotypic anomalies that include leydig cell hypoplasia and growth retardation post-delivery under adverse fetal environment and depigmentation of hair- and skin-color form puberty onset. This may provide a mechanism for development of multiple organ system failure in some cloned piglets. Th birth weights of male cloned pig in comparison with those of female cloned piglets are significantly reduced(0.8 vs 1.4kg) and showed longer gestational day(120 vs 114). In conclusion, brain meningitis and hepatopneumonic congestion are a major risk factor for SIDS and such pregnancy in cloned animals requires close and intensive antenatal monitoring.

• Korean Journal of Agricultural Science
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• v.44 no.2
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• pp.254-260
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• 2017

The primary goals of this research were to evaluate the impact of diet supplemented with 25-hydroxyvitamin $D_3$ ($Hy{\cdot}D(R)$) on sow's body condition and reproduction performance. A total of sixteen multiparous sows [(Landrace ${\times}$ Yorkshire), average parity = $3.79{\pm}0.32$] and their litters were randomly allotted to 2 treatments to give 8 replicates per treatment. Diet treatments were randomized to receive a non-active (ND) or active 25-hydroxyvitamin $D_3$ (AD) diet (0.36 mg cholecalciferol/g) during pregnancy. The results of this experiment were observed at the gestation of d 58 - 75, d 76 - 95, d 96 - 110, and d 111 - 115. A corn-soybean meal-based diet was formulated to meet or exceed the nutrient requirements recommended by NRC (2012). Results indicated that the sows' farrowing duration was shortened (4.71, 5.38 h), and the average number of mummified fetuses decreased significantly (p < 0.05) in AD treatment compared with ND treatment (0.1, 0.5) while birth weight was significantly (p < 0.05) improved (1.44, 1.18 kg). There were no significant effects on body weight, backfat thickness, and fecal score during the gestation of sows in different phases (p > 0.05). And the total birth, stillbirth, live birth, and survival rates of the litter did not change (p > 0.05). The results of this study suggest that the farrowing duration of sow pigs will be shortened and the number of mummies will be decreased while their litters' body weight may be improved, if fed active 25-hydroxyvitamin $D_3$ (0.36 mg/g) during pregnancy phase.

• Journal of the Korean Geographical Society
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• v.51 no.3
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• pp.367-380
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• 2016

This study reviewed and compared methods for mapping aggregated low birth weight (LBW) and geographic variations in LBW in South Korea. Based on this review, we produced LBW maps in South Korea. Standardized mortality/morbidity ratios (SMRs) and crude mortality rates have been widely used for many years in epidemiological research. However, SMR-based maps are likely to be affected by sample size of unit area. Therefore, this study adopted a model-based approach using Bayesian estimates to reduce noisy variability in the SMR. By using a Bayesian model, we can calculate a statistically reliable RR values. We used the full Bayes estimator, as well as empirical Bayes estimators. As a result, variations in the two Bayes models were similar. The SMR-based statistics had the largest variation. The result maps can be used to identify regions with a high risk of LBW in South Korea.

• The Journal of the Korea Contents Association
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• v.22 no.2
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• pp.379-389
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• 2022

This study analyzed 10,352 married women to find the correlation between marital equality felt by married women and additional childbirth intentions. Frequency analysis and chi-square test analysis were performed to analyze the general characteristics of the investigator, and studies were conducted through binary logistic regression analysis and interaction analysis to analyze the relevance between each variable and additional childbirth. As a result, the 4-point group based on the 0-point group that lowest marital equality had 2.01 times higher willingness to additional birth. And, the 3-point group and the 2-point group were 1.46 times and 1.41 times higher than 0-point group with marital equality and additional childbirth intentions. In addition, intention of additional childbirth was increased when the higher the number of children, if they own a house, and if wives are non-regular or unemployed. This study analyzed the relationship between married women's intention to give birth additionally, focusing on marital equality. It is suggested that specific and reasonable policies at the macro level are required to improve the fertility rate.

• Development and Reproduction
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• v.20 no.3
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• pp.219-225
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• 2016

Most of the commercial devices for vitrification are directly immersed into the warming solution (WS) for increasing of warming rate. However, the previous modified cut standard straw (MCS) which has reported is difficult to immerse into the WS. The aim of this study was to investigate whether the long cut straw (LCS) could be useful as a stable tool for vitrified-warmed human blastocysts. A total of 138 vitrified-warmed cycles were performed between November 2013 and November 2014 (exclusion criteria: women ${\geq}38$ years old, poor responder, surgical retrieval sperm, and severe male factor). The artificial shrinkage was conducted using 29-gauge needles. Ethylene glycol and dimethyl sulfoxide (7.5% and 15% (v/v)) were used as cryoprotectants. Freezing and warming were conducted using the LCS tool. The cap of LCS was removed using the forceps in the liquid nitrogen ($LN_2$) and then directly immersed into the first WS for 1 min at $37^{\circ}C$ (1 M sucrose). Only re-expanded blastocysts were transferred after it was cultured in sequential media for 18-20 h. A total of 294 blastocysts were warmed, and all were recovered (100%). Two hundred eighty-five embryos were survived (96.9%). The vitrified-warmed blastocysts of all patients were transferred without any cancellation. We were able to achieve a reasonable implantation (24.2%), following by clinical pregnancy (36.2%), which then continued to ongoing pregnancy (36.2%), and live birth (31.2%). Using LCS is achieved the acceptable rates of survival, pregnancy and live birth. Therefore, the LCS could be considered as a stable and simple tool for human embryo vitrificaton.

• Journal of Embryo Transfer
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• v.30 no.1
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• pp.45-50
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• 2015

The purpose of this study is to produce wanted sex progeny of genetically confined White Hanwoo (albinism) with preselected sex sperm. One bull of White Hanwoo was chosen for semen donor and X sperm was sorted by MoFlo XDP cell sorter. To compare the pregnancy and birth rates, KPN straw was used as control, total number of unsorted sperm was $20{\times}10^6/straw$. Sexed X frozen semen with $20{\times}10^6$ cells or $4{\times}10^6$ cells per straw were in seminated twice on Hanwoo heifers. The abnormality of the sexed X semen was $24.9{\pm}7.31%$ and distal reflex abnormality of mid piece was significantly (p<0.05) higher (11.7%) compared with that of KPN 768 (5.6%). There were no differences on the pregnancy and birth rates between $2{\times}10^6$ cells or $4{\times}10^6$ cells of X-sperm but KPN semen showed significant differences (p<0.05). The pregnancy rates of KPN 768, $2{\times}10^6$ cells and $4{\times}10^6$ cells X-sperm of White Hanwoo cattle were 85.0%, 26.3% and 50%. The birth rates were 80.0%, 15.8% and 21.4%, respectively. The female offspring rates of KPN 768, $2{\times}10^6$ cells and $4{\times}10^6$ cells X-sperm of White Hanwoo cattle were 43.8%, 100% and 100% (p<0.05). These results indicated that sex sorted White Hanwoo could be used for the production of wanted progeny with $2{\times}10^6$ cells/straw for AI. To increase the efficiency of calf production, the sperm number of sex sorted semen will be optimized for sex selection of White Hanwoo progeny.

• Neonatal Medicine
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• v.17 no.1
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• pp.94-101
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• 2010

Purpose:In recent years, Korea has showed a steady increase in the frequency of teenage birth, while the overall birth rate has declined. As the teenage birth is known as a high risk pregnancy itself, we examined perinatal complications of teenage mothers and whose neonates in aspects of medical problem, and social status and support. Methods:We examined the perinatal characteristics of teenage mothers and whose babies, who were hospitalized at Korea University Ansan Hospital from January 2004 to July 2009 using medical records retrospectively. Twenty-seven teenage mothers and their 28 babies were enrolled in this study. Results:Teenage mothers were all unmarried and showed high rates of preterm labor, maternal anemia, and unexpected delivery. Among them, 11 (40.7%) were from families that were separated. Eleven mothers (40.7%) did not have any antenatal care. There were high rates of prematurity and low birth weight (60.7% and 64.3%, respectively). The complication included: respiratory distress syndrome, patent ductus arteriosus and necrotizing enterocolitis. Fourteen babies (51.9%) were not going to be brought up by their biological parents. Conclusion:Teenage pregnancy had high rates of preterm labor and associated complications, often caused by the lack of proper antenatal care. Babies from unmarried mothers were likely to be adopted and this could be a social burden. Therefore, to reduce unplanned teenage pregnancy and births, sex education and social supports should be provided to all teenagers.

• Research in Community and Public Health Nursing
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• v.15 no.1
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• pp.84-94
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• 2004

Purpose: The purpose of this study was to examine the health care management status of preschoolers depending on the children's characteristics. Methods: The sample of this study were 212 mothers of preschoolers attending Child Care Centers in three cities, Seoul, Daejon, and Suwon, in Korea. A self administered questionnaire developed by investigators was used to collect data from September 15 to October 31, 2002. Data was analyzed with SPSS 11.5 Win program. Results: 5.7% of the children had not completed their vaccination programs. Children who were second or later birth order showed less complete vaccination rates than firstborn babies. Children who had working mothers showed less complete vaccination rates than those whose mothers did not work. Among the various vaccinations, the DPT and MMR booster vaccination rates were the lowest. Home safety scores were higher when mothers have younger children. higher monthly incomes and reside in apartment type houses. Forty one(41%) of the preschoolers experienced accidents, and the accident rate was higher in boys and children with easy temperament. The most frequently experienced accident was laceration. Twenty eight point eight percent(28.8%) of the children experienced hospitalization because of various diseases. Most of the mothers perceived their children healthy. However, children who were second or third born were perceived less as healthy. Children in families with less monthly income were perceived as less healthy. Conclusions: This study provided basic data about preschoolers' health care management status focusing on vaccinations and accident rates. More attention should be paid to preschoolers' health and safety. Related factors found in this study should be considered when providing anticipatory guidance for parents.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2125-2129
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• 2016

Background: Stomach cancer is an aggressive malignancy that is difficult to detect at an early stage and therefore is characterized by poor survival rates. Over the last two decades, there has been no report of gastric cancer survival in Khon Kaen province, Thailand. The aim of this retrospective cohort study was to provide up-to-date information about the survival of gastric cancer patients in this province. Materials and Methods: Data from Khon Kaen population-based cancer registry, Faculty of Medicine, Khon Kaen University were newly obtained on 650 patients who were diagnosed with stomach cancer during the period 1 January, 2000 to 31 December, 2012. These were then followed up until death or the end of the study (31 December 2014). We calculated the observed survival with the actuarial life table method, and relative survival, defined as the ratio of observed survival in the group of the stomach cancer patients to the expected survival in the entire Thai population from the estimated generation life tables for Thailand of five-year birth cohorts from 1900 - 2000. Results: The 5 year observed and 5 year relative survival rates were 17.2 % (95% CI: 13.54-21.14) and 18.2 % (95% CI: 14.3-22.4), respectively. The highest 5 year relative survival rates were demonstrated among patients aged 45-65, with stage I or II lesions, with adenocarcinomas, with a body of stomach location, well differentiated and receiving surgery and/or chemotherapy. Conclusions: The observed and relative survival rates were close to each other. Our findings provide basic information beneficial to development of an effective treatment system and appropriately improved population-based cancer registration.