• Journal of Biomedical Engineering Research
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• v.30 no.5
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• pp.428-437
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• 2009

The Performance research about EEG-BCI algorithm in BCI-naive subjects is very important for evaluating the applicability to the public. We analyzed the result of the performance evaluation experiment about the EEG-BCI algorithm in BCI-naive subjects on three different aspects. The EEG-BCI algorithm used in this paper is composed of the common spatial pattern(CSP) and the least square linear classifier. CSP is used for obtaining the characteristic of event related desynchronization, and the least square linear classifier classifies the motor imagery EEG data of the left hand or right hand. The performance evaluation experiments about EEG-BCI algorithm is conducted for 40 men and women whose age are 23.87${\pm}$2.47. The performance evaluation about EEG-BCI algorithm in BCI-naive subjects is analyzed in terms of the accuracy, the relation between the information transfer rate and the accuracy, and the performance changes when the different types of cue were used in the training session and testing session. On the result of experiment, BCI-naive group has about 20% subjects whose accuracy exceed 0.7. And this results of the accuracy were not effected significantly by the types of cue. The Information transfer rate is in the inverse proportion to the accuracy. And the accuracy shows the severe deterioration when the motor imagery is less then 2 seconds.

• Korean Journal of Clinical Pharmacy
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• v.27 no.4
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• pp.221-227
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• 2017

Background: As personalized healthcare industry has attracted much attention, big data analysis of healthcare data is essential. Lots of healthcare data such as product labeling, biomedical literature and social media data are unstructured, extracting meaningful information from the unstructured text data are becoming important. In particular, text mining for adverse drug reactions (ADRs) reports is able to provide signal information to predict and detect adverse drug reactions. There has been no study on text analysis of expert opinion on Korea Adverse Event Reporting System (KAERS) databases in Korea. Methods: Expert opinion text of KAERS database provided by Korea Institute of Drug Safety & Risk Management (KIDS-KD) are analyzed. To understand the whole text, word frequency analysis are performed, and to look for important keywords from the text TF-IDF weight analysis are performed. Also, related keywords with the important keywords are presented by calculating correlation coefficient. Results: Among total 90,522 reports, 120 insulin ADR report and 858 tramadol ADR report were analyzed. The ADRs such as dizziness, headache, vomiting, dyspepsia, and shock were ranked in order in the insulin data, while the ADR symptoms such as vomiting, 어지러움, dizziness, dyspepsia and constipation were ranked in order in the tramadol data as the most frequently used keywords. Conclusion: Using text mining of the expert opinion in KIDS-KD, frequently mentioned ADRs and medications are easily recovered. Text mining in ADRs research is able to play an important role in detecting signal information and prediction of ADRs.

• Journal of Genetic Medicine
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• v.1 no.1
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• pp.27-31
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• 1997

Steroid 21 hydroxylase deficiency is a major cause of congenital adrenal hyperplasia (CAH) and is caused by genetic impairment of the gene (CYP21B). In the human genome, CYP21B is located within the MHC class III region on the short arm of chromosome 6. Most of the genes in this region are highly polymorphic and crowded. Also the CYP21B gene is accompanied by its pseudogene (CYP21A) and tandemly arranged with two genes of fourth component of complement. This highly complex gene cluster in this area may predispose genetic instability of CYP21, i.e. mutations. In this study, tried to investigate the frequency of duplication and deletion of CYP21 and patterns of the genetic alterations of these genes.We also compared the genetic alteration in normal subjects with those of the CAH patients. The results showed that 15% of the normal korean population have duplication or deletion of CYP21. There was one normal subject with heterozygous deletion of CYP21B. Of the 5 CAH patients examined, 2 were found to show abnormal patterns. One was a large-scale gene conversion and the other a gene conversion associated with deletion involving both CYP21B and C4 locus II gene. Through this study, we carne to the conclusion that the duplication or even deletion of CYP21 and C4 might be quite a common event in the Korean population and these rearrangements must be regarded as polymorphisms. It could contribute to a high incidencs of CAH by providing a genetic pool of instable CYP21.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.12
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• pp.261-269
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• 2013

In this paper, the evoked potential(EP) was represented by additive delay model to comply with the variational noisy response of stimulus-event synchronization. The hybrid method of delay compensated-Wiener filtered-ensemble averaging(DWEA) was proposed to enhance the EP signal distortion occurred during averaging procedure due to synchronization timing mismatch. The performance of DWEA has been tested by surrogated simulation, which is composed of synthesized arbitrary delay and arbitrary level of added noise. The performance of DWEA is better than those of Wiener filtered-ensemble averaging and of conventional ensemble averaging. DWEA is endurable up to added noise gain of 7 for 10 % mean square error limit. Throughout the experimentation observation, it has been demonstrated that DWEA can be applied to enhance the evoked potential having the synchronization mismatch with added noise.

• Science of Emotion and Sensibility
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• v.16 no.4
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• pp.527-534
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• 2013

In this study, we analyzed spatial-frequency relationship related brain function for change of the time during attentional visual stimulus through the analysis of Coherence. With experimentation about ERP(Event Related Potential)data, it revealed that change of the phase synchronization between different scalp locations at ${\theta}$, ${\alpha}$ band. ERP between left and right frontal lobes, between the frontal and central lobes showed the phase synchronization at the P100, N200, ERP between the frontal and occipital lobes showed the phase synchronization at the P300 related information of visual stimulus. Compared to STFT using the window of a fixed length, CWT is able to multi-resolution analysis with the adjustment of parameters of mother wavelet. Thus, coherence results with CWT was found to be effective for analysis of time-varying spatial-frequency relationship in ERP. The phase synchronization for inattentional visual stimulus was not observed.

• Journal of Biomedical Engineering Research
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• v.23 no.4
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• pp.301-308
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• 2002

This research was performed to analyze quantitatively how spiritual stress affects some ERPs on human through sight stimulus after the settlement of visual and auditory integration environment in three dimension space. We measured ERPs in the normal state and spiritual stress sessions separately. The subjects were 10 normal men and women and vital signs was recorded from Fpl, Fz, Cz, Pz, O1, O2's scalps. The experiment was done in isolated room where electro-magnetic effect do not affect. The result showed that P300's amplitude was a little higher under stress session and latent period in this resulted in longer time. We recorded through voltage variation the activity of brain which is in charge of human's perception. cognition, process of action and evaluated the effect of spiritual stress. We expected that the result of this research can be used to evaluate the malfunction of brain.

• Journal of Biomedical Engineering Research
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• v.41 no.1
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• pp.35-41
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• 2020

In this study, we examined whether the systematic literature review method used in the field of evidence-based medicine could be used for post-market clinical evaluation of medical devices by modifying them to fit the regulatory perspective of medical devices in Korea. For this purpose, systematic literature review was modified and applied to conduct a clinical literature survey on the ophthalmic electrosurgical system(Trabectome^®, NeoMediX Corp) used for the treatment of glaucoma. A total of six documents were finally selected, and clinical safety and efficacy information on the indications of the ophthalmic electrosurgical system were effectively presented. In addition, general safety information and unexpected safety information could be distinguished through comparison with medical device adverse event reporting cases. The method used in this study is expected to be used in various ways throughout post-market medical device safety management system and for the purpose of regulation improvement, especially in the field of ophthalmic electrosurgical system.

• Journal of Biomedical Engineering Research
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• v.43 no.6
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• pp.375-381
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• 2022

Brain-computer interface (BCI) is a technology that allows users with motor disturbance to control machines by brainwaves without a physical controller. Motor imagery (MI)-BCI is one of the popular BCI techniques, but it needs a long calibration time for users to perform a mental task that causes high fatigue to the users. MI is reported as showing a similar neural mechanism as motor execution (ME) and motor observation (MO). However, integrative investigations of these three tasks are rarely conducted. In this study, we propose a new paradigm that incorporates three tasks (MI, ME, and MO) and conducted a comparative analysis. For this study, we collected Electroencephalograms (EEG) of motor imagery/execution/observation from 28 healthy subjects and investigated alpha event-related (de)synchronization (ERD/ERS) and classification accuracy (left vs. right motor tasks). As result, we observed ERD and ERS in MI, MO and ME although the timing is different across tasks. In addition, the MI showed strong ERD on the contralateral hemisphere, while the MO showed strong ERD on the ipsilateral side. In the classification analysis using a Riemannian geometry-based classifier, we obtained classification accuracies as MO (66.34%), MI (60.06%) and ME (58.57%). We conclude that there are similarities and differences in fundamental neural mechanisms across the three motor tasks and that these results could be used to advance the current MI-BCI further by incorporating data from ME and MO.

• Journal of Biomedical Engineering Research
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• v.45 no.1
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• pp.26-36
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• 2024

Functional brain imaging techniques have been used to diagnose psychiatric disorders such as dementia, depression, and autism. Recently, these techniques have also been actively used to study hearing loss. The present study reviewed the application of the functional brain imaging techniques in auditory research, especially those focusing on hearing loss, over the past decade. EEG, fMRI, fNIRS, MEG, and PET have been utilized in auditory research, and the number of research studies using these techniques has been increasing. In particular, fMRI and EEG were the most frequently used technique in auditory research. EEG studies mostly used event-related designs to analyze the direct relationship between stimulus and the related response, and in fMRI studies, resting-state functional connectivity and block designs were utilized to analyze alterations in brain functionality in hearing-related areas. In terms of age, while studies involving children mainly focused on congenital and pre- and post-lingual hearing loss to analyze developmental characteristics with and without hearing loss, those involving adults focused on age-related hearing loss to investigate changes in the characteristics of the brain based on the presence of hearing loss and the use of a hearing device. Overall, ranging from EEG to PET, various functional brain imaging techniques have been used in auditory research, but it is difficult to perform a comprehensive analysis due to the lack of consistency in experimental designs, analysis methods, and participant characteristics. Thus, it is necessary to develop standardized research protocols to obtain high-quality clinical and research evidence.

• Science of Emotion and Sensibility
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• v.14 no.2
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• pp.269-278
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• 2011

This paper illustrates the inter-relationship between the theta/alpha ratio of the EEG signal and multiple HRV related parameters associated with the cardiovascular system response during event-related stimuli. Both EEG and PPG signals were simultaneously recorded in 21 healthy subjects. All subjects had their attention focused on the CNT program for nine minutes. Time-frequency analysis was applied to the EEG and PPG signals. The theta/alpha ratio was extracted from the EEG results, and the HRV features, including beat interval(1), SDNN(2), RMSSD(3), NN50(4), LF(5), HF(6), and LFIHF(7), were extracted from the PPG. Through multiple linear regression, the relationship ($R^2$) between the multiple combined features and the theta/alpha rhythm was identified. As a result, the combinations of $R^2$($R^2=0.253$; seven dimensions) and the theta/alpha ratio indicated a higher inter-relationship value than those of other combinations. The combinations of features that were greater than three dimensions, based on {SDNN(2), HF(6)}, generally showed higher $R^2$ value. We demonstrate that the high dimensional combinations had a higher correlation than did the low dimensional combinations.