• 한국산업융합학회 논문집
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• 제12권1호
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• pp.27-33
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• 2009

In this paper, a computational analysis using a lumped system model is performed to investigate the hemodynamics of coronary circulation under the operation of T-PLS relevant to the cardiac arrest cases. The coronary circulation system is assumed to be comprised of three compartments: coronary arteries, coronary capillaries, and coronary veins. The effect of myocardial muscle contraction or relaxation is represented by temporal variations in the bias pressure. To verify the present method, we analyzed the coronary circulation for normal case and then compared the results with the existing data. Numerical results on the cardiac arrest model showed that T-PLS can increase LAD flow significantly.

• 보건의료산업학회지
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• 제9권2호
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• pp.33-46
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• 2015

This study was done on the basis that IT convergence-contents can help the elderly. The effects of IT convergence-contents were analyzed on the occupational performance of the elderly. This investigation was done with 100 elderly people above 65 years of age who lived in local community and two senior welfare centers in Busan and Kyeongbuk. The 100 elderly people were split into two groups of 50: the one group who has experience with IT convergence-contents was the experiment group, and the other group with no experience was the control group. In both groups, body functions, cognitive functions, activities of daily living and community participation were tested. The experimental group had higher scores for cognitive function, and activities of daily living than that of the control group. In conclusion, future studies can support continued IT convergence-contents at the local business community level rather than with smaller samples. This work lays the groundwork for follow-up studies to evaluate the effectiveness of IT convergence-contents.

• Korean Chemical Engineering Research
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• 제59권1호
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• pp.112-117
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• 2021

본 연구에서는 생물학적 공유결합인 다이타이로신 결합을 모방하여 비가역적 공유결합을 기반으로 한 펩타이드의 자기조립 방법을 연구하였다. 고밀도의 다이타이로신 결합을 달성하기 위해 Tyr-Tyr-Leu-Tyr-Tyr (YYLYY) 의 서열을 갖는 펩타이드 단량체를 선택하였다. 다이타이로신 결합으로 자기조립 된 펩타이드 나노입자는 가시광선 하에서 Ru(BPY)3Cl2 촉매를 사용하여 단일공정 광가교를 통해 합성되었다. 펩타이드 나노 입자의 크기에 대한 각 성분의 농도 효과는 동적 광산란, UV-Vis 분광법 및 투과 전자 현미경을 사용하여 확인하였다. 이를 통해 130 nm~350 nm범위의 펩타이드 나노입자의 크기별 최적의 합성 조건을 제시하였다.

• 대한의용생체공학회:의공학회지
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• 제38권4호
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• pp.205-210
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• 2017

The convergence healthcare industry in Korea has been stalled due to conflicts between stakeholders as well as a supplier-centered industry structure. This situation is caused by the structural contradiction in which the Korean industry has a prolonged conflict structure among stakeholders due to a strong regulation and an institutional inertia from the viewpoint of the sociotechnical system. Therefore, it is necessary to identify new system management plan that enhances social acceptability such as laws, customs and ideas while reducing conflicts between stakeholders. In this study, mainly adapting the stakeholder-oriented autopoiesis and focusing on publicness of healthcare, we propose the rationale and direction for policy making to harmonize various systems within the convergence healthcare industry.

• 한국건축시공학회지
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• 제19권1호
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• pp.19-29
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• 2019

본 연구에서는 공동주택 지하주차장 상부슬래브 등 주로 수평부에 적용되는 아스팔트 매스틱 도막재의 누유하자 원인을 바탕으로 제품의 누유안정성 확보 여부를 평가할 수 있는 평가방법을 개발 및 제시하였다. 본 연구에서 제시한 평가방법의 신뢰성을 검증하기 위하여 실제 현장에서 누유 발생 이력이 있는 3개 제품을 대상으로 누유안정성 평가를 진행하였으며, 진행 결과, 실제 발생하는 누유하자의 재연이 가능한 것으로 확인되었다. 재연성에 대한 정량적 검증을 위해 평가 중에 발생한 누유 시료를 채취하여 회분(Filler)함량을 측정한 결과, 정상시료 대비 최대 약 64%가 저하된 것을 확인하였는데, 이는 선행연구에서 규명한 누유원인과 일치하는 결과로 확인하여, 평가방법의 신뢰성이 검증되었다 할 수 있다.

• 대한의용생체공학회:의공학회지
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• 제38권5호
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• pp.271-276
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• 2017

Cancer biomarkers are using in the diagnosis, staging, prognosis and prediction of disease progression. But, there are not sufficiently profiled and validated in early detection and risk classification of prostate cancer. In this study, we have devoted to finding a panel of serum biomarkers that are able to detect the diagnosis of prostate cancer. The serum samples were consisted of 111 prostate cancer and 343 control samples and examined. Eleven biomarkers were constructed in this study, and then nine biomarkers were relevant to candidate biomarkers by using t test. Finally, four biomarkers, PSA, ApoA2, CYFRA21.1 and TTR, were selected as the prostate cancer biomarker panel, logistic regression was used to identify algorithms for diagnostic biomarker combinations(AUC = 0.9697). A panel of combination biomarkers is less invasive and could supplement clinical diagnostic accuracy.

• 한국융합학회논문지
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• 제11권10호
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• pp.355-361
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• 2020

스쿼트는 장소에 제약 없이 효과적으로 하체 근력을 증진시킬 수 있는 운동이다. 스쿼트 시 잘못된 자세로 인한 부상이 빈번하게 발생하고 있으며, 부상을 예방하기 위해서는 적절한 각도를 유지하며 운동하는 것이 중요하다. 본 연구에서는 허벅지에 착용된 단일 관성 센서 모듈을 이용하여 스쿼트 각도를 측정할 수 있는 시스템을 개발하고 검증하였다. 스쿼트 각도를 측정하기 위해 각 관성 센서(가속도 센서, 자이로 센서)의 장단점을 상호 보완 하는 상보필터 알고리즘을 사용하였고, 임상 실험을 통해 각 상보필터 계수에 따른 스쿼트 각도의 정확도를 평가하였다. 분석 결과, 최적의 상보필터 계수를 기반으로 계산된 스쿼트 각도는 측각기에서 측정한 각도와 상관 계수 0.623와 편향 오차 -5.6°로 유의한 상관관계를 보였다.

• Nuclear Engineering and Technology
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• 제56권6호
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• pp.2247-2257
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• 2024

To investigate the impact of the recently released pediatric reference voxel phantoms (0-, 1-, 5-, 10-, 15-year-old males and females) of the International Commission on Radiological Protection (ICRP) on organ dose estimates for radioactive iodine (RAI) treatment in pediatric patients, we calculated and analyzed pediatric-specific iodine131 S values (r_T ← thyroid) for the 30 radiosensitive organs by conducting Monte Carlo simulations using the Geant4. The gender dependency in the S values was frequently seen for the 15-year-old phantoms with higher S values of female than male. In addition, the age dependency in the S values was observed for most target organs; that is, the S values tend to decrease for older ages (e.g., ~120 times for the gonads between the adult and newborn) due mainly to the inter-organ distances generally longer for older ages. Moreover, we observed that the iodine-131 S values tend to be significantly greater by up to ~145.5 times than those of the stylized phantoms that have been widely used for organ dose estimates of pediatric RAI patients. We believe that the pediatric-specific iodine-131 S values (r_T ← thyroid) of the ICRP pediatric reference voxel phantoms should be beneficial to improve the dosimetry of pediatric RAI patients.

• 대한전자공학회논문지SD
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• 제46권1호
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• pp.59-67
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• 2009

본 논문에서 생체신호의 적응잡음을 제거하기 위해 개선된 비적적응필터(IMADF) 알고리즘을 제안한다. IMADF 구조는 DPCM과 Sign 알고리즘을 사용한 MADF에 1차 예측 필터를 사용한다. 그때 생체신호를 시험하기 위해서 MCG(심자도)에 기반한 심장팬텀 모델을 사용하고 신호를 분석한다. 심장팬텀의 기능들은 다극점 전류원으로부터 만들어진다. 이것은 인간의 심장과 똑같은 기능을 수행하는 역할을 한다 실험결과 IMADF 알고리즘은 곱셈동작이 없고 덧셈동작만 MADF 알고리즘보다 2개 더 늘어났으나, 훨씬 안전한 수렴특성을 나타냈고, 계산상을 복잡성도 줄이는 결과를 얻었다.

• BMB Reports
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• 제50권11호
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• pp.535-536
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• 2017

A novel approach has been used to identify functional interactions relevant to human disease. Using high-throughput human-yeast genetic interaction screens, a first draft of disease interactome was obtained. This was achieved by first searching for candidate human disease genes that confer toxicity in yeast, and second, identifying modulators of toxicity. This study found potentially disease-relevant interactions by analyzing the network of functional interactions and focusing on genes implicated in amyotrophic lateral sclerosis (ALS), for example. In the subsequent proof-of-concept study focused on ALS, similar functional relationships between a specific kinase and ALS-associated genes were observed in mammalian cells and zebrafish, supporting findings in human-yeast genetic interaction screens. Results of combined analyses highlighted MAP2K5 kinase as a potential therapeutic target in ALS.