• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.229-235
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• 2015

Purpose: This study was undertaken to study on visual function before and after prescription of vertical prism. Methods: 80 subjects (10-30ages) who had been precribed vertical prism and 1 year after they were represcribed vertical prism. Results: Phoria (p=0.000), supra vergence (p=0.000), NPC (p=0.003), NPA (right eye) (p=0.005), NPA(left eye) (p=0.000) showed a significant change. Conclusion: Vertical prism prescription was reduced during revisit. Supra vergence, NPC, NPA(right eye), NPA(left eye) showed a significant change. Binocular Accommodative lag was not associated with vertical prism prescription and binocular vision findings.

• Clinics in Orthopedic Surgery
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• v.10 no.4
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• pp.468-478
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• 2018

Background: The restriction of wrist motion results in limited hand function, and the evaluation of the range of wrist motion is related to the evaluation of wrist function. To analyze and compare the wrist motion during four selected tasks, we developed a new desktop motion analysis system using the motion controller for a home video game console. Methods: Eighteen healthy, right-handed subjects performed 15 trials of selective tasks (dart throwing, hammering, circumduction, and winding thread on a reel) with both wrists. The signals of light-emitting diode markers attached to the hand and forearm were detected by the optic receptor in the motion controller. We compared the results between both wrists and between motions with similar motion paths. Results: The parameters (range of motion, offset, coupling, and orientations of the oblique plane) for wrist motion were not significantly different between both wrists, except for radioulnar deviation for hammering and the orientation for thread winding. In each wrist, the ranges for hammering were larger than those for dart throwing. The offsets and the orientations of the oblique plane were not significantly different between circumduction and thread winding. Conclusions: The results for the parameters of dart throwing, hammering, and circumduction of our motion analysis system using the motion controller were considerably similar to those of the previous studies with three-dimensional reconstruction with computed tomography, electrogoniometer, and motion capture system. Therefore, our system may be a cost-effective and simple method for wrist motion analysis.

• BMB Reports
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• v.57 no.6
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• pp.287-292
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• 2024

Hepatocellular Carcinoma (HCC), the predominant primary hepatic malignancy, is the prime contributor to mortality. Despite the availability of multiple surgical interventions, patient outcomes remain suboptimal. Immunotherapies have emerged as effective strategies for HCC treatment with multiple clinical advantages. However, their curative efficacy is not always satisfactory, limited by the dysfunctional T cell status. Thus, there is a pressing need to discover novel potential biomarkers indicative of T cell exhaustion (Tex) for personalized immunotherapies. One promising target is Cyclin-dependent kinase inhibitor 2 (CDKN2) gene, a key cell cycle regulator with aberrant expression in HCC. However, its specific involvement remains unclear. Herein, we assessed the potential of CDKN2 expression as a promising biomarker for HCC progression, particularly for exhausted T cells. Our transcriptome analysis of CDKN2 in HCC revealed its significant role involving in HCC development. Remarkably, single-cell transcriptomic analysis revealed a notable correlation between CDKN2 expression, particularly CDKN2A, and Tex markers, which was further validated by a human cohort study using human HCC tissue microarray, highlighting CDKN2 expression as a potential biomarker for Tex within the intricate landscape of HCC progression. These findings provide novel perspectives that hold promise for addressing the unmet therapeutic need within HCC treatment.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.8
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• pp.1051-1057
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• 2013

In this study, an automatic surface-strain measurement system called "ASIAS-bio" has been developed. This system can be used even in cases in which it is very difficult to apply a regular grid pattern necessary for measuring surface-strain, such as curved or uneven surfaces; surfaces damaged by corrosion or contamination; or soft materials such as rubber, foam, and biological tissues. This system works independently of the measurement conditions including the material and its surface condition, grid pattern and size, grid marking method, and degree of deformation. A comparison between the strain distributions of the sheet metal parts measured by using this system and those obtained by a commercial system showed that this system was sufficiently reliable. In addition, the deformation of the swine joint capsule and human knee skin was measured by using this system to demonstrate its usefulness.

• Journal of the Institute of Electronics and Information Engineers
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• v.49 no.9
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• pp.322-327
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• 2012

Parallel-plate-type scanning sensors have been commercially used for X-ray imaging sensors. In this study, we manufactured the scan typed 1D X-ray image sensor that can be used to obtain scanning images, by using the plasma display panel (PDP) fabrication process. We fabricated drift and pixel electrodes in the glass chamber and injected Xe gas at atmospheric pressure. We evaluated the intensity of a pixel signal depending on the bias voltage on the drift electrode and investigated the characteristics of shielding effect on the single pixel using lead (Pb). The adsorption rate of X-ray photon is low (4%) on the soda lime glass (1.1mm) and the electrical signal detected on the X-ray sensor was increased in the high bias voltage. We acquired digital X-ray scanning image with our DAS (data acquisition system) and sensor scanning system.

• Journal of the Institute of Convergence Signal Processing
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• v.20 no.2
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• pp.105-110
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• 2019

People sleep about one-third of their lives and their sleep time varies according to age. Adult usually sleep 8 hours a day. However, that dose not guarantee good sleep. The cause of this is due to sleep disorders like snoring and sleep apnea. In this paper, the smart pillow for detecting snoring among sleep disorders is investigated. This pillow consists of two microphones located on the left and right side of the pillow. For simple detecting, the snoring signal was converted into the pulse using a peak detection circuit. The decision of the snoring occurrence was by pulse duration. The accuracy of the snoring detection was about 97%. The research results show that the smart pillow can be use to detect the snoring during sleeping.

• Journal of the Institute of Convergence Signal Processing
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• v.20 no.4
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• pp.199-204
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• 2019

In the boundary layer, vortical system has been analyzed by the statistical methods to identify the vortex interaction. However, there are the limitations in explaining vortices by the mean velocity or the standard deviation. This paper proposed a method to establish a frequency analysis by Fourier transform in order to simultaneously investigate various scale vortices. For this purpose, the flow visualization conducted to reveal a standing vortex, a hairpin vortex and a wake region around a hemisphere attached on a flat plate in a water channel. In addition, the velocity where the hairpin vortex was being generated in the wake region was measured by a hot-film anemometer. To observe changes in the vortex interaction, suction was applied through a hole in front of the hemisphere. For the evaluation of the proposed frequency analysis, the existing statistical results were compared to the frequency analysis that corresponds to the qualitative results of the flow visualization.

• Journal of the Institute of Convergence Signal Processing
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• v.20 no.4
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• pp.212-217
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• 2019

In this paper, a sleep management pillow system for snoring detection and respiration measurement is investigated. The sleep management pillow system consists of four force sensing resistor(FSR) sensors, two microphones(MIC), a pillow, a measurement system. Four FSR sensors attached at the bottom part of the pillow are used for respiration measurement and snoring detection. Two microphones located at the middle left and right of the pillow are utilized for only snoring detection. The respiration and the snoring of ten young people were measured using the sleep management pillow system composed of a data acquisition board, interface circuit, and personal computer. The measurement accuracy of the respiration was about 98% and the measurement accuracy of the snoring was about 97%. The experiment results show that the sleep management pillow system can be used for snoring detection and respiration rate measurement during sleeping.

• Journal of the Institute of Convergence Signal Processing
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• v.19 no.4
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• pp.167-173
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• 2018

We propose an air purification system that utilizes aerial plant parts and root zone of indoor plants where light is insufficient and air circulation is bad. In order to maximize the air purification effect of the plant, the aerial plant parts illuminates mixed light combining blue and green LED and CRI(Color Rendering Index) LEDs close to natural light, respectively. And the root zone was forcibly circulated by the fan to use the soil as a filter. The indoor air purification system combined with the light source and the fan removed most polluted air in the shortest. In the case of mixed light and CRI LEDs of indoor air purification system, fine dust decreased by 14%, 14.2%, and TVOC(Total volatile organic compounds) decreased by 7.5% and 9.4%, respectively. In the experiment in which the fan was operated for 15 minutes, the TVOC decreased to 97.8%. The photosynthesis of the plant and the use of soil as a filter were able to purify polluted air in a short time. And the fan's temporary operation gave the similar effect of continuous operation.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.10a
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• pp.1000-1002
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• 2012

The material with superior biocompatibility and physical-chemical stability is required to fabricate high sensitive biosensors. Many kinds of biomaterials have been evaluated to apply for bioindustry. Recently, carbon based diamond and graphene thin films have been focal pointed as bio applications and their possibility is partially evaluated. Diamond thin film has many advantages for electrochemical and biological applications, such as wide potential window (3.0~3.5V), low background current and chemical-physical stability. And graphene film has many advantages as biomaterial, chemical-physical stability and conductivity. In this work, we have cultured human nerve cell (SH-SY5Y) on the nanocrystalline diamond, mirocrystalline diamond, graphene film and cell culture dish. We use MTT assay to evaluate the characteristics of cell culture on the substrates. As a result, nerve cell is well cultured on the carbon based diamond and graphene films as similar as cell culture dish. We expect that carbon materials have been applied for bioindustry such as biosensors.