• Journal of Biomedical Engineering Research
• /
• v.39 no.4
• /
• pp.153-160
• /
• 2018

3D ultrasound bladder scanners are getting popular in hospitals for the patients with bladder dysfunction. A current bladder scanner adopts a mechanical scan to acquire 3D images and requires two motors and complicated mechanical devices. In this paper, we propose a new ultrasound bladder scanner using hand-motion scan. Instead of two motors and mechanical devices, it has a motion sensor to record transducer positions during hand-motion scan. The experiments with a bladder phantom and volunteers showed similar measurement accuracy to a conventional 3D ultrasound bladder scanner. We expect that the proposed method will reduce the cost and size of the bladder scanner.

• Proceedings of the KIEE Conference
• /
• 2007.10a
• /
• pp.479-480
• /
• 2007

고령사회에 접어들면서 연속적으로 심전도를 관찰할 필요가 있는 만성 심장 질환 환자의 수가 증가함에 따라, 이동형 심전도 측정 모듈을 활용하여 심전도를 분석하는 진단 시스템의 필요성이 크게 증가하고 있다. 이에 따라서 본 연구에서는 무구속 패치형 심전도 측정 모듈을 이용하여 심전도를 획득하고, 획득한 심전도를 무선으로 전송받아 Matched Filter를 이용하여 잡음을 제거하고 R-peak 검출을 수행하여 심장활동을 모니터링하고자 하였다.

• Proceedings of the KOSOMBE Conference
• /
• v.1996 no.05
• /
• pp.126-129
• /
• 1996

Morphological changes of the heat treated dental procelain at toy have been investigated with SIM and TDX. The surface indium concentration of specimens increased as the heat treatment temperature and the oxygen partial pressure increased.

• Proceedings of the KOSOMBE Conference
• /
• v.1996 no.11
• /
• pp.57-60
• /
• 1996

A medical image management system was implemented using WWW(world wide web) technology. The Httpd server was designed using PC with Linux operating system. The client used Netscape as its network browser. The image processing module of the client part was programmed in Java. The database was constructed with Bicom3 format images and programmed using Perl. The present technique can be used to standardize the network and user environment of PACS and teleradiology.

• Proceedings of the KOSOMBE Conference
• /
• v.1996 no.11
• /
• pp.258-262
• /
• 1996

The physiological systems have nonlinear complex phenomena. Expecially, the flow of capillary blood vessel has a nonlinear dynamic system. Thus, this study analyzes nonlinear characteristics of the flow of capillary blood vessel in physiological systems using chaotic tools(phase space reconstruction, correlation dimension, largest lyapunov exponent). Experimental data have been acquired from examining 10 rabbits. The results of chaotic analysis showed a decreasing largest lyapunov exponent and correlation dimension according to increasement glocose index. And we also know the chaotic behavior.

• Journal of Biomedical Engineering Research
• /
• v.35 no.5
• /
• pp.111-118
• /
• 2014

As assessment of quantitative energy expenditure for effective exercise is becoming more important, many researches about the monitoring system for exercise status or result have been actively carried out. In this case, however, bicycle riders feel restrained and uncomfortable because the riders should wear a belt-type electrocardiograph or a watch-type accelerometer or GPS system during the assessment of bicycle exercise. In this study, therefore, an electrocardiograph based on textile electrode was developed for measuring ECG and calculating heart rate from the bicycle rider without feeling restraint, and smartphone application was also developed for monitoring the heart rate.

• Korean Journal of Acupuncture
• /
• v.27 no.4
• /
• pp.49-57
• /
• 2010

Objectives : The aim of this study is evaluation for significance of skin meridian-acupoints energy measurement system, and is verification of principle to measure the bio-ion charge on acupoints. Methods : To check a correlation between the MEP(Meridian Energy Potential) and bio-electric charge condition, ten acupoints(left/right BL meridian : BL13, BL15, BL18, BL20, BL23) were chosen. Based on basic theory concerning the upward trend of the bio-electric charge by cupping therapy, we measured MEP change before and after 600mmHg(80kPa) Negative pressure stimulation using cupping. Results : We could identify the correlation between MEP and the condition of bio-electric charge in acupoints. Also, we checked the balance or imbalance of left/right the MEP and unusual cases. Conclusions : We confirmed significance of proposed principle and meridian energy measurement system.

• Journal of Biomedical Engineering Research
• /
• v.36 no.4
• /
• pp.109-114
• /
• 2015

In this study, joint angles of the lower extremity and tibial acceleration and angular velocity were measured during a snowboard simulator exercises in order to evaluate the skill of snowboarders. Ten unskilled and ten expert snowboarders were recruited for the study. A three-dimensional motion capture system and two inertial sensor modules were used to acquire joint movements, acceleration and angular velocity of the lower extremities during snowboard simulator exercises. Pattern variations were calculated to assess variations in the snowboard simulator motion of unskilled and expert snowboarders. Results showed that expert snowboarders showed greater range of motion in joint angles and greater peak to peak amplitude in acceleration and angular velocity for tibia than unskilled snowboarders. The unskilled snowboarders did not show symmetrical shape(same magnitude but opposite direction) in tibial angular velocity during two edge turns in snowboard simulator exercises. The expert snowboarders showed smaller pattern variations for joint angle of lower extremity, tibial acceleration and tibial angular velocity than unskilled snowboarders. Inertial sensor data and pattern variations during the snowboard simulator exercises could be useful to evaluate the skill of snowboarders.

• Food Science and Biotechnology
• /
• v.18 no.5
• /
• pp.1204-1211
• /
• 2009

Hericium erinaceus is an edible mushroom used as a medicinal food in Asian countries. In this study, the chemopreventive effects of H. erinaceus mycelia hot water extract (HEW) were evaluated. HEW remarkably induced the luciferase activity of the antioxidant response element (ARE), located in the promoter region of phase 2 and antioxidant genes and regulated by nuclear factor E2-related factor 2 (Nrf2). The up-regulation of ARE activity by HEW corresponded with the induction of Nrf2 and the antioxidant enzyme, hemeoxygenase-1. The inhibition of cyclooxygenase-2 (COX-2) activity is a promising effective approach in cancer chemoprevention, and HEW prominently suppressed COX-2 protein expression in HepG2 cells. Furthermore, HEW showed anti-inflammatory activity by modulating inflammatory mediators such as nitric oxide (NO), inducible NO synthase, tumor necrosis factor-${\alpha}$, interleukin-$1{\beta}$, and the transcription factor, nuclear factor-${\kappa}B$, in lipopolysaccharide-stimulated RAW 264.7 cells. These results suggest that H. erinaceus possessed anti-tumor and anti-inflammatory effects via the modulation of Nrf2/ARE and inflammatory signaling pathways, and may therefore have potential use as a natural chemopreventive agent.

• Biomolecules & Therapeutics
• /
• v.31 no.6
• /
• pp.599-610
• /
• 2023

According to recent evidence, ferroptosis is a major cell death mechanism in the pathogenesis of kidney injury and fibrosis. Despite the renoprotective effects of classical ferroptosis inhibitors, therapeutic approaches targeting kidney ferroptosis remain limited. In this study, we assessed the renoprotective effects of melatonin and zileuton as a novel therapeutic strategy against ferroptosis-mediated kidney injury and fibrosis. First, we identified RSL3-induced ferroptosis in renal tubular epithelial HK-2 and HKC-8 cells. Lipid peroxidation and cell death induced by RSL3 were synergistically mitigated by the combination of melatonin and zileuton. Combination treatment significantly downregulated the expression of ferroptosis-associated proteins, 4-HNE and HO-1, and upregulated the expression of GPX4. The expression levels of p-AKT and p-mTOR also increased, in addition to that of NRF2 in renal tubular epithelial cells. When melatonin (20 mg/kg) and zileuton (20 mg/kg) were administered to a unilateral ureteral obstruction (UUO) mouse model, the combination significantly reduced tubular injury and fibrosis by decreasing the expression of profibrotic markers, such as α-SMA and fibronectin. More importantly, the combination ameliorated the increase in 4-HNE levels and decreased GPX4 expression in UUO mice. Overall, the combination of melatonin and zileuton was found to effectively ameliorate ferroptosis-related kidney injury by upregulating the AKT/mTOR/ NRF2 signaling pathway, suggesting a promising therapeutic strategy for protection against ferroptosis-mediated kidney injury and fibrosis.