• Title/Summary/Keyword: Biomedical Applications

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3D Printing Application Cases for Medical Service (의료 서비스를 위한 3D 프린팅 기술 적용 사례)

  • Woo, Sung-hee;Kwak, Ji-yeon;Hong, Sung-won
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2015.10a
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    • pp.988-991
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    • 2015
  • 3D printing technology is instrument that can create real objects in three-dimensional space, as printed on paper, if the three-dimensional designs are made. 3D printing technology has been recently used in various field of medicine, and also biomedical application of three dimensional printing technology remains one of the most important research topics until now. 3D printing technology is causing a revolutionary change in the overall automotive manufacturing, aerospace, marine, medical and so on. The medical industry applications of current 3D printer are a virtual simulation, custom medical implants manufactured, practice of medical personnel. In this study, we analyzed 3D printing technology and application cases for medical services.

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Heat & Cool Injection Molded Fresnel Lens Solar Concentrators (가열-냉각 사출성형 방식을 적용한 집광형 프레넬렌즈)

  • Jeong, Byeong-Ho;Min, Wan-Ki;Lee, Kang-Yeon
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.63 no.4
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    • pp.283-289
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    • 2014
  • A Fresnel lens is an optical component which can be used as a cost-effective, lightweight alternative to conventional continuous surface optics. Fresnel lens solar concentrators continue to fulfill a market requirement as a system component in high volume cost effective Concentrating Photovoltaic (CPV) electricity generation. The basic principles of the fresnel lens are reviewed and some practical examples are described. To investigate the performance space of the Fresnel lens, a fast simulation method which is a hybrid between raytracing and analytical computation is employed to generate a cache of simulation data. Injection molders are warming up to the idea of cycling their tool surface temperature during the molding cycle rather than keeping it constant. Heat and cool process are now also finding that raising the mold wall temperature above the resin's glass-transition or crystalline melting temperature during the filling stage and product performance in applications from automotive to packaging to optics. This paper deals with the suitability of Fresnel lenses of imaging and non-imaging designs for solar energy concentration. The concentration fresnel lens confirmed machinability and optical transmittance and roughness measure through manufactured the prototype.

High Intensity Focused Ultrasound for Cancer Treatment: Current Agenda and the Latest Technology Trends (HIFU: 현황 및 기술적 동향)

  • Seo, Jong-Bum
    • The Journal of the Acoustical Society of Korea
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    • v.29 no.2E
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    • pp.55-63
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    • 2010
  • High Intensity Focused Ultrasound (HIFU) is a noninvasive surgical method mainly targeting deeply located cancer tissue. Ultrasound is generated from an extemally located transducer and the beam is focused at the target volume, so that selective damage can be achieved without harm to overlying or surrounding tissues. The mechanism for cell killing can be combination of thermal and cavitational damage. Although cavitation can be an effective means of tissue destruction, the possibility of massive hemorrhage and the unpredictable nature of cavitational events prevent clinical application of cavitation. Hence, thermal damage has been a main focus related to HIFU research. 2D phased array transducer systems allow electronic scanning of focus, multi-foci, and anti-focus with multi-foci, so that HIFU becomes more applicable in clinical use. Currently, lack of noninvasive monitoring means of HIFU is the main factor to limit clinical applications, but development in MRI and Ultrasound Imaging techniques may be able to provide solutions to overcome this problem. With the development of advanced focusing algorithm and monitoring means, complete noninvasive surgery is expected to be implemented in the near future.

Electrochemical Evaluation of Si-Incorporated Diamond-Like Carbon (DLC) Coatings Deposited on STS 316L and Ti Alloy for Biomedical Applications

  • Kim, Jung-Gu;Lee, Kwang-Ryeol;Kim, Young-Sik;Hwang, Woon-Suk
    • Corrosion Science and Technology
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    • v.6 no.1
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    • pp.18-23
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    • 2007
  • DLC coatings have been deposited onto substrate of STS 316L and Ti alloy using r.f. PACVD (plasma-assisted chemical vapor deposition) with a mixture of $C_{6}H_{6}$ and $SiH_{4}$ as the process gases. Corrosion performance of DLC coatings was investigated by electrochemical techniques (potentiodynamic polarization test and electrochemical impedance spectroscopy) and surface analysis (scanning electron microscopy). The electrolyte used in this test was a 0.89% NaCl solution of pH 7.4 at temperature $37^{\circ}C$. The porosity and protective efficiency of DLC coatings were obtained using potentiodynamic polarization test. Moreover, the delamination area and volume fraction of water uptake of DLC coatings as a function of immersion time were calculated using electrochemical impedance spectroscopy. This study provides the reliable and quantitative data for assessment of the effect of substrate on corrosion performance of Si-DLC coatings. The results showed that Si-DLC coating on Ti alloy could improve corrosion resistance more than that on STS 316L in the simulated body fluid environment. This could be attributed to the formation of a dense and low-porosity coating, which impedes the penetration of water and ions.

Improved Mechanical and Durability Properties of PVC Sheet by Designing Three-Layered Structures

  • Park, Jun-Young;Kim, Woo-Sang;Kang, Hae-Cheon;Bae, Seokhu;Yoon, Jeong-Hwan;Yun, Juho;Lee, Eun-Kyoung;Kim, Namil
    • Elastomers and Composites
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    • v.54 no.4
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    • pp.294-298
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    • 2019
  • A three-layered PVC sheet consisting of polyvinyl chloride (PVC) and woven polyester fabric was prepared by extrusion and calendering. The flexibility and durability of the PVC were tuned by adding plasticizers, additives, and surface coatings. The tensile and tear strengths of the three-layered PVC sheet were higher than those of commercial two-layered sheet, while exhibiting low weight. The concentrations of the total volatile organic compounds (TVOCs) and formaldehyde (HCHO) emitted from the sheet were also lowered. The PVC sheet remained stable after prolonged exposure to UV light, signifying that the PVC sheet is suitable for cargo screen applications.

Slender piezoelectric beams with resistive-inductive electrodes - modeling and axial wave propagation

  • Schoeftner, Juergen;Buchberger, Gerda;Benjeddou, Ayech
    • Smart Structures and Systems
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    • v.18 no.2
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    • pp.335-354
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    • 2016
  • This contribution presents an extended one-dimensional theory for piezoelectric beam-type structures with non-ideal electrodes. For these types of electrodes the equipotential area condition is not satisfied. The main motivation of our research is originated from passive vibration control: when an elastic structure is covered by several piezoelectric patches that are linked via resistances and inductances, vibrational energy is efficiently dissipated if the electric network is properly designed. Assuming infinitely small piezoelectric patches that are connected by an infinite number of electrical, in particular resistive and inductive elements, one obtains the Telegrapher's equation for the voltage across the piezoelectric transducer. Embedding this outcome into the framework of Bernoulli-Euler, the final equations are coupled to the wave equations for the longitudinal motion of a bar and to the partial differential equations for the lateral motion of the beam. We present results for the wave propagation of a longitudinal bar for several types of electrode properties. The frequency spectra are computed (phase angle, wave number, wave speed), which point out the effect of resistive and inductive electrodes on wave characteristics. Our results show that electrical damping due to the resistivity of the electrodes is different from internal (=strain velocity dependent) or external (=velocity dependent) mechanical damping. Finally, results are presented, when the structure is excited by a harmonic single force, yielding that resistive-inductive electrodes are suitable candidates for passive vibration control that might be of great interest for practical applications in the future.

High-resolution imaging of microneedles in biological tissue with optical coherence tomography (광간섭 단층 영상기술을 이용한 생체 내 microneedle 삽입 구조 영상)

  • Kim, Hun;Heo, Jung;Lee, Kang Ju;Ryu, Su Ho;Ryu, Won Hyoung;Joo, Chulmin
    • Transactions of the Society of Information Storage Systems
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    • v.9 no.1
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    • pp.17-21
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    • 2013
  • Optical coherence tomography (OCT) allows non-invasive, cross-sectional optical imaging of biological tissue with high spatial resolution and acquisition speed. In principle, it is analogous to ultrasound imaging, but uses near-infrared light instead of ultrasound, measuring the time-delay of back-scattered light from within biological tissue. Compared to ultrasound imaging, it exhibits superior spatial resolution (1~10 um) and high sensitivity. Therefore, OCT has been applied to a wide range of applications such as cellular imaging, ophthalmology and cardiology. Here, we describe a novel application of OCT technology in visualizing microneedles embedded in tissue that is developed to deliver drugs into the dermis without the injection mark in the human skin. Detailed three-dimensional structural images of microneedles and biological tissues were obtained. Examining structural modification of microneedles and tissues during insertion process would enable to evaluate performance of various types of microneedles in situ.

Advances in Rapid Detection Methods for Foodborne Pathogens

  • Zhao, Xihong;Lin, Chii-Wann;Wang, Jun;Oh, Deog Hwan
    • Journal of Microbiology and Biotechnology
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    • v.24 no.3
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    • pp.297-312
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    • 2014
  • Food safety is increasingly becoming an important public health issue, as foodborne diseases present a widespread and growing public health problem in both developed and developing countries. The rapid and precise monitoring and detection of foodborne pathogens are some of the most effective ways to control and prevent human foodborne infections. Traditional microbiological detection and identification methods for foodborne pathogens are well known to be time consuming and laborious as they are increasingly being perceived as insufficient to meet the demands of rapid food testing. Recently, various kinds of rapid detection, identification, and monitoring methods have been developed for foodborne pathogens, including nucleic-acid-based methods, immunological methods, and biosensor-based methods, etc. This article reviews the principles, characteristics, and applications of recent rapid detection methods for foodborne pathogens.

Identification of Research Areas and Evolution of 2D Materials by the Keyword Mapping Methodology (키워드 매핑 기반 2차원 물질 연구 영역 탐지와 발전 과정 분석)

  • Ahn, Sejung;Lee, June Young
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.31 no.1
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    • pp.11-18
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    • 2018
  • Two-dimensional (2D) materials such as transition metal dichalcogenides have attracted tremendous scientific interests owing to their potential of solving the zero band-gap issue of graphene. In this work, the research areas and technology evolutionary dynamics of the 2D materials were identified using the scientometric method focusing on keyword mapping and clustering. The time-series analysis showed that the technological progress of 2D material is in the early growth period. The overlay mapping analysis were carried out to investigate the technology evolution of 2D materials with time. The strategic diagram of co-word analysis classifying the topological positions of keyword was derived to support the analysis results. It is conjectured that extensive research will be conducted widely on the application of 2D materials not only in electronic and optoelectronic devices, but also in various other fields such as biomedical applications, and that their development will be more rapid based on accumulated results of extant graphene research.

Preparation of Polymeric Self-Assembly and Its Application to Biomaterials

  • Cho, Chong-Su;Park, In-Kyu;Nah, Jae-Woon;Toshihiro Akaike
    • Macromolecular Research
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    • v.11 no.1
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    • pp.2-8
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    • 2003
  • The self-assembly of polymers can lead to supramolecular systems and is related to the their functions of material and life sciences. In this article, self-assembly of Langmuir-Blodgett (LB) films, polymer micelles, and polymeric nanoparticles, and their biomedical applications are described. LB surfaces with a well-ordered and layered structure adhered more cells including platelet, hepatocyte, and fibroblast than the cast surfaces with microphase-separated domains. Extensive morphologic changes were observed in LB surface-adhered cells compared to the cast films. Amphiphilic block copolymers, consisting of poly(${\gamma}$-benzyl L-glutamate) (PBLG) as the hydrophobic part and poly(ethylene oxide) (PEO) [or poly(N-isopropylacrylamide) (PNIPAAm)] as the hydrophilic one, can self-assemble in water to form nanoparticles presumed to be composed of the hydrophilic shell and hydrophobic core. The release characteristics of hydrophobic drugs from these polymeric nanoparticles were dependent on the drug loading contents and chain length of the hydrophobic part of the copolymers. Achiral hydrophobic merocyanine dyes (MDs) were self-assembled in copolymeric nanoparticles, which provided a chiral microenvironment as red-shifted aggregates, and the circular dichroism (CD) of MD was induced in the self-assembled copolymeric nanoparticles.