Transactions of the Society of Information Storage Systems (정보저장시스템학회논문집)

The Society of Information Storage Systems (정보저장시스템학회)
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High-resolution imaging of microneedles in biological tissue with optical coherence tomography

광간섭 단층 영상기술을 이용한 생체 내 microneedle 삽입 구조 영상

  • Kim, Hun (Department of Mechanical Engineering, Yonsei Univ.) ;
  • Heo, Jung (Department of Mechanical Engineering, Yonsei Univ.) ;
  • Lee, Kang Ju (Department of Mechanical Engineering, Yonsei Univ.) ;
  • Ryu, Su Ho (Department of Mechanical Engineering, Yonsei Univ.) ;
  • Ryu, Won Hyoung (Department of Mechanical Engineering, Yonsei Univ.) ;
  • Joo, Chulmin (Biomedical Optics & Instrumentation Laboratory (BOIL))
  • Received : 2013.03.15
  • Accepted : 2013.03.24
  • Published : 2013.03.25
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Abstract

Optical coherence tomography (OCT) allows non-invasive, cross-sectional optical imaging of biological tissue with high spatial resolution and acquisition speed. In principle, it is analogous to ultrasound imaging, but uses near-infrared light instead of ultrasound, measuring the time-delay of back-scattered light from within biological tissue. Compared to ultrasound imaging, it exhibits superior spatial resolution (1~10 um) and high sensitivity. Therefore, OCT has been applied to a wide range of applications such as cellular imaging, ophthalmology and cardiology. Here, we describe a novel application of OCT technology in visualizing microneedles embedded in tissue that is developed to deliver drugs into the dermis without the injection mark in the human skin. Detailed three-dimensional structural images of microneedles and biological tissues were obtained. Examining structural modification of microneedles and tissues during insertion process would enable to evaluate performance of various types of microneedles in situ.

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References

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