• Industrial Engineering and Management Systems
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• v.16 no.1
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• pp.64-79
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• 2017

Identifying disease genes from human genome is a critical task in biomedical research. Important biological features to distinguish the disease genes from the non-disease genes have been mainly selected based on traditional feature selection approaches. However, the traditional feature selection approaches unnecessarily consider many unimportant biological features. As a result, although some of the existing classification techniques have been applied to disease gene identification, the prediction performance was not satisfactory. A small set of the most important biological features can enhance the accuracy of disease gene identification, as well as provide potentially useful knowledge for biologists or clinicians, who can further investigate the selected biological features as well as the potential disease genes. In this paper, we propose a new stepwise random forests (SRF) approach for biological feature selection and disease gene identification. The SRF approach consists of two stages. In the first stage, only important biological features are iteratively selected in a forward selection manner based on one-dimensional random forest regression, where the updated residual vector is considered as the current response vector. We can then determine a small set of important biological features. In the second stage, random forests classification with regard to the selected biological features is applied to identify disease genes. Our extensive experiments show that the proposed SRF approach outperforms the existing feature selection and classification techniques in terms of biological feature selection and disease gene identification.

• Journal of the Semiconductor & Display Technology
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• v.15 no.4
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• pp.27-32
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• 2016

In recent years, various researches have been conducted to improve process yields in accordance with miniaturization of semiconductor. APC(Advanced Process Control) is considered one of the methods to increase in process yields. APC is a process control technology that maintains optimal process conditions and improves the reliability of results by controlling and formulating the relationship among the various process parameters and results. We built up an optical diagnostic system with a three-channel spectrometer. The system detects signals those represent the changes of specific emission peaks intensity versus each reference and converts it into MFC control signals to get back the changes to the reference state. Controlling the MFC continues until the specific peak intensity changes into the normal state. Through this device, we tested a APC automatically responding to process changes during the plasma process. We could control gas flow while sputtering process on going and improve uniformity of plasma intensity with this system. Finally, we have got results those enhance the plasma intensity non-uniformity to 7.7% from 15.5%. Also, found unexpected oxygen flow what is estimated to be come out from IGZO target.

• Proceedings of the Korean Society for Applied Microbiology Conference
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• 2004.06a
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• pp.194-194
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• 2004

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.153-154
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• 2005

• Animal cells and systems
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• v.1 no.3
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• pp.425-427
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• 1997

One new species of the genus Myrmica was found from Mt. Moak in Chonbuk, Korea. It was named as Myrmica cadusa n. sp. on the basis of external shape of the antennal socket, which is jar-shaped. Accordingly Korean Myrmica now includes 13 species in total.

• Communications of the Korean Mathematical Society
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• v.24 no.2
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• pp.215-226
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• 2009

For a class of Holling type II food chain systems with biological and chemical controls, we give conditions of the local stability of prey-free periodic solutions and of the permanence of the system. Further, we show the system is uniformly bounded.

• Proceedings of the Polymer Society of Korea Conference
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• 2006.10a
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• pp.261-261
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• 2006

Membranes are a central feature of all biological systems and their ability to control many cellular processes is critically important. As a result, a better understanding of how molecules bind to biological membranes is an active area of research. In this report, the interaction between our biomimetic structures and different biological membranes is reported using both model vesicle and in vitro bacterial cell experiments. These results show that lipid composition is more important for selectivity than overall net charge. An effort is made to connect model vesicle studies with in vitro data and naturally occurring lipid compositions.

• Animal cells and systems
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• v.8 no.4
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• pp.255-265
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• 2004

While examining specimens collected in the shallow waters of Korea from 1995 to 2004, we found that Ampelisca bocki Dahl and A. naikaiensis Nagata were newly added to Korean fauna. We also provide description for A. brevicornis (Costa) based on materials collected from Korea. As a result, six species of Ampelisca are reported in Korea.

• Animal cells and systems
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• v.7 no.2
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• pp.93-103
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• 2003

Two diastylid species, Dimorphostylis manazuruensis Gamo(1960) and Dimorphostylis longicauda Gamo(1962), are recorded as new to Korea cumacean fauna. The subadult male of D. longicauda is described for the first time. As a result, the genus Dimorphostylis found in Korean waters now consists of eight species.

• Journal of Applied Biological Chemistry
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• v.57 no.3
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• pp.211-218
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• 2014

Polymethoxyflavones (PMFs) are a group of polymethoxylated bioactive flavones with diverse biological activities, including anticancer, anti-inflammatory, antibacterial, and antiviral activities. PMFs are found from various plants such as orange, tangerine, and krachaidum. To establish the simple quantitative analytical methods for PMFs, chromatographic analysis was applied to the selected krachaidum foods because krachaidum contains diverse PMFs compared to other PMF-containing foods. Krachaidum is the rhizome of Kaempferia parviflora, and many commercial krachaidum products, such as tea, juice and wine, are commercially available and consumed as health functional foods in Asian countries. Apart from the claimed health promoting benefits, reliable quality assurance and legal guideline for the registration of these products are not available yet. Twelve PMFs were analyzed from the commercial krachaidum foods by GC-FID and HPLC-DAD. No single chromatographic method could not analyze 12 PMFs simultaneously. HPLC-DAD method was found more sensitive to detect PMFs. Based on our analysis data, we proposed 5,7-dimethoxyflaone and 5,7,4'-trimethoxyflavone as index components for the food products.