• Journal of Ginseng Research
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• v.41 no.1
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• pp.1-9
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• 2017

Panax ginseng Meyer, belonging to the genus Panax of the family Araliaceae, is known for its human immune system-related effects, such as immune-boosting effects. Ginseng polysaccharides (GPs) are the responsible ingredient of ginseng in immunomodulation, and are classified as acidic and neutral GPs. Although GPs participate in various immune reactions including the stimulation of immune cells and production of cytokines, the precise function of GPs together with its potential receptor(s) and their signal transduction pathways have remained largely unknown. Animal lectins are carbohydrate-binding proteins that are highly specific for sugar moieties. Among many different biological functions in vivo, animal lectins especially play important roles in the immune system by recognizing carbohydrates that are found exclusively on pathogens or that are inaccessible on host cells. This review summarizes the immunological activities of GPs and the diverse roles of animal lectins in the immune system, suggesting the possibility of animal lectins as the potential receptor candidates of GPs and giving insights into the development of GPs as therapeutic biomaterials for many immunological diseases.

• YAKHAK HOEJI
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• v.47 no.6
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• pp.432-437
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• 2003

It has been known that quercetin, a bioflavonoid widely distributed in fruits and vegetables as dietary-derived flavonoid and exert significant multiple biological effects such as antioxidant and anti-inflammatory, anti-tumor effects. In addition, it has been shown to have a chemoprotective role in cancer, though complex effects on signal transduction involved in cell proliferation and angiogenesis. The present study investigated whether quercetin can enhance antioxidant enzyme activity (glutathione peroxidase: GPx, superoxide dismutase: SOD, catalase: CAT) and regulate the reactive oxygen species (ROS) generation in the presence of vitamin E, L-ascorbic acid, reduced glutathione (GSH) on B16F10 murine melanoma cells. After 48h treatment of cells with quercetin in the presence of vitamin E, L-ascorbic acid, GSH, we measured the cytotoxicities by MTT assay. The cells exhibited a dose-dependent inhibition in their proliferation in the presence of vitamin E, L-ascorbic acid, GSH respectively. We also investigated the effects of antioxidant enzyme activity and ROS generation. The antioxidant enzyme activity of quercetin in the presence of vitamin E was stronger than GSH, L-ascorbic acid, the same treatments decreased ROS generation in B16F10 murine melanoma cells. Taken together, these result demonstrate that the antioxidant effect of quercetin can enhanced in the presence of vitamin E and it might plays an important role in anti-oxidative effects.

• Journal of Biomedical Engineering Research
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• v.19 no.5
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• pp.539-546
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• 1998

The purpose of this study is to estimate human emotion quantitatively under colors and music stimuli and to examine the for correlation between color and music sensibility. Physiological signals(electroencephalogram, electrocardiogram, Galvanic skin conductivity and respiration rate) were measured to compare color with music sensibilities. The personality of the subject were investigated using factor analysis and semantic differential method of 20 items(7 interval scaled). The results showed that red, yellow and violets color provoked active and exciting senses mainly as dance, rock and blues music. While blue, cyan and pink colors ware involved in tranquil and resting emotions deeply as classic and ballade music.

• Journal of Biomedical Engineering Research
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• v.16 no.1
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• pp.17-24
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• 1995

This paper presents a new compression method (or ECG data using iterated contractive transformations. The method represents any range of ECG signal by piecewise self-afrine fractal Interpolation (PSAFI). The piecewise self-afrine rractal model is used where a discrete data set is viewed as being composed of contractive arfine transformation of pieces of itself. This algorithm was evaluated using MIT/BIH arrhythmia database. PSAFI is found to yield a relatively low reconstruction error for a given compression ratio than conventional direct compression methods. The compression ratio achieved was 883.9 bits per second (bps) - an average percent rms difference (AFRD) of 5.39 percent -with the original 12b ECG samples digitized at 400 Hz.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.11a
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• pp.36-39
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• 2000

A small electrical potential difference which appears on any solid body when subjected to illumination by a modulated light beam generated by laser is called photocharge voltage(PCV)[1,2]. This voltage is proportional to the induced change in the surface electrical charge and is capacitatively measured on various materials such as conductors, semiconductors, ceramics, dielectrics and biological objects. The amplitude of the detected signal depends on the type of material under investigation, and on the surface properties of the sample. In photocharge voltage spectroscopy measurements[3], the sample is illuminated by both a steady state monochromatic bias light and the pulsed laser. The monochromatic light is used to created a variation in the steady state population of trap levels in the surface and space charge region of semiconductor samples which does result in a change in the measured voltage. Using this technique the spatial variation of PCV can be utilized to evaluate the surface conditions of the sample and the variation of the PCV due to the monochromatic bias light are utilized to characterize the surface states. A qualitative analysis of the proposed measurement is present along with experimental results performed on amorphous silicon samples. The deposition temperature was varied in order to obtain samples with different structural, optical and electronic properties and measurements are related to the defect density in amorphous thin film.

• Journal of Biomedical Engineering Research
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• v.17 no.4
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• pp.469-478
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• 1996

In the conventional digital ultrasound scanner, the reflected signal is sampled either in polar coordinates of R-$\theta$ method, or in Cartesian coordinates of uniform ladder algorithm (ULA). The R-$\theta$ scan method necessitates a coordinate transform process which makes hardware complex in comparison with ULA scan mrthoA In spite of this complexity, R-$\theta$ method has a good resolution in ultrasonographic (US) image, since scan direction of the US imaging is a radial direction. In this paper, a new digital scan converter is proposed, which is named the radius uniform ladder algorithm (RULA). The RULA has the rome scan direction as the US scanning in the radial direction and as the display space in the $\theta$ direction. In tllis new approach, sampled points we uniformly distributed in each horizontal line i.n well as in each radial ray so that the data are displayed in the Cartesian coordinates by the 1-D interpolation process. The propped algorithm has an uniform resolution in the periphery and the center field in comparison with equi-angle ULA and equi-interval ULA. To extend the scan angle, concentric square raster sampling (CSRS) is adopted with reduction of discontinuities on the junctions between horizontal scan and vertical scan. The discontinuities are reduced by using the hmction filtering along the $\theta$ direction.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.179-183
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• 1996

Most of the conventional electrocardiogaphies fail to detect signals other than P-QRS-T due to the limited SNR and bandwidth. High-resolution electrocardiography (HRECG) provides better SNR and wider bandwidth for the detection of micro-potentials with higher frequency components such as ventricual late potentials(LP). In this paper, we developed a HRECG using uncorrected XYZ lead. The overall gain of the amplifier is 4000 and the bandwidth is $0.5{\sim}300Hz$ without using 60Hz notch filter. Three 16-bit AH converters sample X, Y, and Z signals simultaneously with a sampling frequency of 2000Hz. Sampled data are transmitted to PC via a DMA-controlled serial communication channel using RS-485 and HDLC protocol. The noise level of the developed HRECG is less than $5{\mu}V_{rms,\;RTI}$. In order to further reduce the noise level, signal averaging technique is implemented utilizing template matching method. The SNR of the developed HRECG is high enough for the detection of LP.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.139-142
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• 1996

A remotly controlled interactive magnetic resonance imaging (MRI) has been tried using the World Wide Web. For this purpose, an HTTP server is developed on the host computer of the MRI system. Video and audio conferencing capability is also included for the experiment. Using the developed system, MRI imaging has been successfully carried out at the Signal Processing Lab in the Kwangwoon University with the remote MRI system located at the Medical Image Research Center in the KAIST in Daejon.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.90-94
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• 1996

We studied the problem of driver's low vigilance state which is related to the one reason of traffic accidents. In this paper, we developed the drowsiness warning system for a drowsy driver. To extract the eyes and mouth from the driver's facial image in real time, a computer vision method was used. The eye blink duration and yawning were used as measurement parameters of drowsiness detection. When the drowsy state of a driver was detected, the driver was refreshed by the scent generator and the alarm. Also, the driver's bio-signal was acquired and analyzed to measure the vigilance state.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.307-309
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• 1996

A new design scheme of actively-shielded x,y-gradient coils for Magnetic Resonance Imaging(MRI) is proposed. An actively-shielded x-gradient coil has been designed as an example and the results are presented. In MRI, gradient coils are needed for spatial selection and position coding to obtain the position information of the NMR signal. They are usually switched on and off during imaging and the eddy current induced by the current switching usually degrades the final image quality To reduce or remove this kind of problems, the active shielding has been proposed few years ago. In this paper, a new design scheme for actively-shielded x,y-gradient coils, namely, a minimum-power design scheme using current-loop elements, has been proposed. Its utility in designing MRI gradient coils has been shown by using simulation. The design scheme seems to be useful for actively-shielded transverse gradient coils, even of non-cylindrical or of arbitrary-selected shapes.