• Journal of Biomedical Engineering Research
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• v.23 no.6
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• pp.477-484
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• 2002

A pacemaker autosense algorithm with dual thresholds. one for noise or tachyarrhythmia detection (noise threshold, NT) and the other for intrinsic beat detection (sensing threshold. ST), was developed to improve the sensing performance in single pass VDD electrograms. unipolar electrograms, or atrial fibrillation detection. When a deflection in an electrogram exceeds the NT (defined as 50% of 57), the autosense algorithm with dual thresholds checks if the deflection also exceeds the ST. If it does, the autosense algorithm calculates the signal to noise ratio (SNR) of the deflection to the highest deflection detected by NT but lower than ST during the last cardiac cycle. If the SNR 2, the autosense algorithm declares an intrinsic beat detection and calculates the next ST based on the three most recent intrinsic peaks. If the SNR $\geq$2, the autosense algorithm checks the number of deflections detected by NT during the last cardiac cycle in order to determine if it is a noise detection or tachyarrhythmia detection. Usually the autosense algorithm tries to set the 57 at 37.5% of the average of the three intrinsic beats, although it changes the percentage according to event classifications. The autosense algorithm was tested through computer simulation of atrial electrograms from 5 patients obtained during EP study, to simulate a worst sensing situation. The result showed that the ST levels for autosense algorithm tracked the electrogram amplitudes properly, providing more noise immunity whenever necessary. Also, the autosense algorithm with dual thresholds achieved sensing performance as good as the conventional fixed sensitivity method that was optimized retrospectively.

• Journal of Korea Society of Digital Industry and Information Management
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• v.7 no.1
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• pp.19-29
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• 2011

The u-Healthcare system, a new paradigm, provides healthcare and medical service anytime, anywhere in daily life using wired and wireless networks. It only doesn't reach u-Hospital at home, to manage efficient personal health in fitness space, it is essential to feedback process through measuring and analyzing a personal vital signs. MBAN(Medical Body Area Network) is a core of this technology. MBAN, a new paradigm of the u-Healthcare system, can provide healthcare and medical service anytime, anywhere on real time in daily life using u-sensor networks. In this paper, an ontology-based context-awareness in MBAN proposed system development methodology. Accordingly, ontology-based context awareness system on MBAN to Elderly/severe patients/aged/, with measured respiratory rate/temperature/pulse and vital signs having small variables through u-sensor network in real-time, discovered abnormal signs and emergency situations which may happen to people at sleep or activity, alarmed and connected with members of a family or medical emergency alarm(Emergency Call) and 119 system to avoid sudden accidents for early detection. Therefore, We have proposed that accuracy of biological signal sensing and the confidence of ontology should be inspected.

• Journal of Microbiology and Biotechnology
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• v.2 no.3
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• pp.174-182
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• 1992

The hemagglutinin-esterase glycoprotein (HE) gene of bovine coronavirus, coupled with a simian virus 40 early promoter and polyadenylation signal, was inserted into a human adenovirus transfer vector. The transfer vector was used to co-transfect 293 cells along with adenovirus genomic DNA. The hemagglutinin-esterase transcription unit was rescued into the adenovirus genome by homologous in vivo DNA recombination between the vector plasmid DNA and the adenovirus genomic DNA, and a recombinant adenovirus was isolated by several rounds of plaque assays. Thus the recombinant adenovirus carries the hemagglutinin-esterase gene in the early transcription region 3 (E3) of the adenovirus genome in the parallel orientation to the E3 transcription. The recombinant adenovirus synthesized the HE polypeptide in HeLa cells as demonstrated by immunoprecipitation with anti-coronavirus rabbit antisera. The recombinant HE polypeptide could be labelled by $[^3H]$glucosamine, demonstrating that the recombinant HE was glycosylated. Cells expressing the HE polypeptide exhibited hemadsorption activity when incubated with mouse erythrocytes. The HE was transported to the plasma membrane as shown by the cell surface immunofluorescence, indicating that the recombinant HE polypeptide retained its biological activities. Potential for the use of infectious recombinant adenovirus as a live virus-vectored vaccine candidate for bovine coronavirus disease is discussed.

• Journal of Biomedical Engineering Research
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• v.11 no.1
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• pp.147-156
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• 1990

A two-dimensional pulsed doppler system for ultrasonic blood velocity doppler signals is studied and implemented. The second-order sampling method and serial data processing procedures are utillized in the sys- tem, which eliminates the untuning problems at phase channels in the quadrature detection method as well as in the channels of parallel data processing. rho digital signal processor used in this system allows a hardware savings and flexible design options. The efficiency of the various mean frequency estimators in the second-order sampling system is examined by computer simulation as a function of the intersequence sample delay time. The temporal delay for the quadrature component is changed from $1/(4f_o){\;}to{\;}3/(4f_o){\;}and{\;}5/(4f_o)$ where to is the center frequency of the transducer, It is found that autocorrelator is the optimum frequency estimator for the second-order sampling: with !he intersequence sample delay of $1/(4f_o){\;}to{\;}3/(4f_o){\;}and{\;}5/(4f_o)$. The qualitative variation and information proportional to blood velocity in the vessel system are obtained in the VIVO experiments.

• Journal of Biomedical Engineering Research
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• v.8 no.1
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• pp.41-48
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• 1987

In estimating the freguency-dependent attenuation coefficient, we analyzed the range-dependent ultrasonic beam and proposed the method of calculating the experimental equation of beam pattern in order to reduce the error on the influence of beam pattern. These experimental equations are divided into the spectral centroid and the spec ural standard deviation slope according to axial propagation length. These are repnesented by the first-order equation in the near field of the beam and the second- order eqLlatlon In the far field. In order to prove the validity of this method, the attenuation coefficients of the non-corrected ease and the corrected case are compared. Using the reflected signal from acryle plate, the attenuation coefficients were estimated by the spectral shift method ann the spectral difference method. The result shows attenuation coeffi talents after correction are better than attenuation coefficients before correction. And this method can be applied In vivo measurement.

• Proceedings of the KOSOMBE Conference
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• v.1991 no.11
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• pp.142-144
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• 1991

In this study, we have developed 64 channel computerized cardiac mapping system using micro-computer for basic research of electrophysiology and electrical propagation in cardiac arrhythmias. The significant problems of this study are the simultaneous acquisition of large amount data at 64 sites, the need of accurate and rapid analysis, and the effective display of the analyzed data. To solve these problems, we made 64 channel signal pre-processing board in order to amplify and filter the raw signals. And the software for cardiac isochronous mapping which were presented immediately via computer-generated graphics has been developed. This system is expected to enable us to study pathophysiology of cardiac arrhythmia and to improve the results of diagnosis and surgical treatment for cardiac arrhythmia.

• Journal of Biomedical Engineering Research
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• v.9 no.1
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• pp.93-100
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• 1988

The Auto Regressive Parameter Estimation and Pattern Classification of EKG Signal for Automatic Diagnosis. This paper presents the results from pattern discriminant analysis of an AR (auto regressive) model parameter group, which represents the HRV (heart rate variability) that is being considered as time series data. HRV data was extracted using the correct R-point of the EKG wave that was A/D converted from the I/O port both by hardware and software functions. Data number (N) and optimal (P), which were used for analysis, were determined by using Burg's maximum entropy method and Akaike's Information Criteria test. The representative values were extracted from the distribution of the results. In turn, these values were used as the index for determining the range o( pattern discriminant analysis. By carrying out pattern discriminant analysis, the performance of clustering was checked, creating the text pattern, where the clustering was optimum. The analysis results showed first that the HRV data were considered sufficient to ensure the stationarity of the data; next, that the patern discrimimant analysis was able to discriminate even though the optimal order of each syndrome was dissimilar.

• Journal of Biomedical Engineering Research
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• v.26 no.6
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• pp.373-381
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• 2005

The respiratory and heart beat signals are the fundamental physiological signals for sleep monitoring in the home. Using the air mattress sensor system, the respiration and heart beat movements can be measured without any harness or sensor on the subject's body which makes long term measurement difficult and troublesome. The differential measurement technique between two air cells is adopted to enhance the sensitivity. The concept of the balancing tube between two air cells is suggested to increase the robustness against postural changes during the measurement period. With this balancing tube, the meaningful frequency range could be selected by the pneumatic filter method. The mathematical model for the air mattress and balancing tube was suggested and the validation experiments were performed for step and sinusoidal input. The results show that the balancing tube can eliminate the low frequency component between two cells effectively. This technique was applied to measure the respiration and heart beat on the bed, which shows the potential applications for sleep monitoring device in home. With the analysis of the waveform, respiration intervals and heart beat intervals were calculated and compared with the signal from conventional methods. The results show that the measurement from air mattress with balancing tube can be used for monitoring respiration and heart beat in various situations.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.125-126
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• 1998

Pulse conduction velocity is determined by areterial compliance, which is changed by lateral pressure of arterial wall. Hydrostatic pressure of the limb vessel is changed by body position, especially in elevated arm. The arterial pulse in the finger causes the blood volume to change, changing the optical density of the blood. Photoplethysmograph of index finger was obtained by LED and phototransistor. Pulse transmission time(PTT) was measured by the interval between the peak of ECG R wave and the peak of the finger plethysmogram. PTT was increased by upward position of arm, and decreased by downward position of the arm compared to horizontal position. This result suggests that relationship between finger plethysmography and postural change could be applied to evaluate clinical cardiovascular status.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.121-122
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• 1998

To induce perturbed magnetic field variations in the range of auto prescans permitted, we chose artificially shim values and applied manualy as DC offsets to X, Y, Z gradient amplifiers. The STEAM spectra were obtained from a localized region (8ml) of phantom's center and a Marquart Algorithm is employed to quantify MRS spectra. Results indicated that Creatine (Cr) which had a good correlation between a signal intensity and an area, changed little bit and showed extremly a stabilized state in perturbed magnetic field variations. Therefore, during the MRS experiments, to minimize the SNR reduction by means of unavoidable inhomogeneous magnetic fields, the present study suggested that the quantification method of relative ratios produced by replacing Cr concentration with standard quantify was most desirable.