• Journal of the Korean Society of Marine Environment & Safety
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• v.12 no.3 s.26
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• pp.171-177
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• 2006

To illustrate the characteristics of marine environment in coastal waters of stationary fisheries, field observations were carried out in August and November, 2001. Water temperatures in Jindong Bay compared with those in Masan Bay were about $2.0^{\circ}C$ higher in August and about $0.7^{\circ}C$ in November. Salinities were lowest in the western part of Jindong Bay. It was found that salinity increased gradually from the western part of Jindong Bay to Masan Bay. Sea water in Masan Bay can be characterised as lower temperature and higher salinity, compared with those in Jindong Bay. Concentrations of suspended solids in the inner parts of Jindong Bay were higher than 15mg/L in August. Suspended solids in both regions of Jindong Bay and Masan Bay showed contrastive distributions, especially in November. That is, higher concentrations of suspended solids were found in the inner parts of Jindong Bay and off Masan Bay. Concentration of chemical oxygen demand in Masan Bay was highest, 7mg/L.

• Food Science and Preservation
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• v.18 no.3
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• pp.414-422
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• 2011

The optimum condition for phenolics contents extraction from purple sweet potato was 12 hrs. in 50% ethanol. The electron donating scavenging activities (DPPH), ABTS radical cation decolorization (ABTS) and antioxidant protection factor (PF) of Jami, Yeonjami and Shinjami were higher than general sweet potato, and thiobarbituric acid reaction substance (TBARs) was below 30%. The minimum inhibitory concentration (MIC) against Staphylococcus aureus and Escherichia coli on skin were each 5,000 and 2,500 ppm in all purple sweet potatoes, and MIC of Jami was the lowest as 2,500 ppm against Staphlococcus epidermidis. The whitening (tyrosinase inhibitory) activity of purple sweet potatoes was the highest as 62.5% and 48.7% in Jami water and ethanol extracts. The anti-inflammation (hyaluronidase inhibitory) activity of purple sweet potatoes was the highest as 25.3% and 94.4% in Jami water and ethanol extracts. The safety of cosmetic with Jam; extracts was assessed by various safety profiles. pH and viscosity change of essence for 90 days was not detected. Cosmetic was stable to temperature and light for 90 days. The result to measure changes of skin color and pore size of the skin was that an aged skin was more effective than young skin.

• Journal of Plant Biotechnology
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• v.45 no.4
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• pp.289-298
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• 2018

The Biosafety Division of the National Academy of Agricultural Science has developed a 'Crop Composition DB' that provides analytical data on commercialized crops. It can be used as a reference in the 'Comparative Evaluation by Compositional Analysis' for the safety assessment of genetically modified (GM) crops. This database provides the composition of crops cultivated in Korea, and thus upgrades the data to check the extent of changes in the compositional content depending on the cultivated area, varieties and year. The database is a compilation of data on the antioxidant, nutrient and secondary metabolite compositions of rice and capsicum grown in two or more cultivation areas for a period of more than two years. Data analysis was conducted under the guidelines of the Association of Official Analytical Chemists or methods previously reported on papers. The data was provided as average, minimum and maximum values to assess whether the statistical differences between the GM crops and comparative non-GM crops fall within the biological differences or tolerances of the existing commercial crops. The Crop Composition DB is an open-access source and is easy to access based on the query selected by the user. Moreover, functional ingredients of colored crops, such as potatoes, sweet potatoes and cauliflowers, were provided so that food information can be used and utilized by general consumers. This paper introduces the feature and usage of 'Crop Composition DB', which is a valuable tool for characterizing the composition of conventional crops.

• Journal of the Korean Society of Marine Environment & Safety
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• v.23 no.7
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• pp.878-884
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• 2017

It is important to understand interactions in the sediment-water environment because nitrate (N) and phosphorus (P) nutrient fluxes released into overlying water can represent a significant fraction of the total nutrient requirement for primary productivity. In this study, we analyzed and estimated benthic nutrient fluxes at the sediment-water interface, investigating environmental conditions in Gomso and Geunso Bays. Also, we compared previously reported nutrient flux data to identify regional differences. As a result, benthic nutrient fluxes in Beopsan were DIN: $6.14mmol\;m^{-2}d^{-1}$ and DIP: $0.32mmol\;m^{-2}d^{-1}$ higher than other survey sites. Sediment COD were $4.0-10.8mg/g{\cdot}dry$, and environmental deterioration was observed due to organic pollution. If no solution is found for tidal flat farm management, problems such as a decrease in aquaculture production will follow. Therefore, long-term monitoring of tidal flat environments should be pursued to enable the sustainable use of biological resources.

• Clinical and Experimental Otorhinolaryngology
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• v.11 no.4
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• pp.281-287
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• 2018

Objectives. Regenerative treatment using stem cells may serve as treatment option for empty nose syndrome (ENS), which is caused by the lack of turbinate tissue and deranged nervous system in the nasal cavity. We aimed to assess the efficacy and safety of the autologous stromal vascular fraction (SVF) in the treatment of ENS. Methods. In this prospective observational clinical study, we enrolled 10 ENS patients who volunteered to undergo treatment of ENS through the injection of autologous SVF. Data, including demographic data, pre- and postoperative Sino-Nasal Outcome Test-25 (SNOT-25) scores, overall patient satisfaction, and postoperative complications, were prospectively collected. Nasal secretion was assessed using the polyurethane foam absorption method, and the levels of biological markers were analyzed in both ENS group and control group using enzyme-linked immunosorbent assay. The SVF extracted from abdominal fat was diluted and injected into both inferior turbinates. Results. Among the 10 initial patients, one was excluded from the study. Subjective satisfaction was rated as "much improved" in two and "no change" in seven. Among the improved patients, the mean preinjection SNOT-25 score was 55.0 and the score at 6 months after injection was 19.5. However, the average SNOT-25 score of nine participants at 6 months after injection (mean${\pm}$standard deviation, $62.4{\pm}35.8$) did not differ significantly from the baseline SNOT-25 score ($70.1{\pm}24.7$, P>0.05, respectively). Among the various inflammatory markers assessed, the levels of interleukin $(IL)-1{\beta}$, IL-8, and calcitonin gene-related peptide were significantly higher in ENS patients. Compared with preinjection secretion level, the nasal secretions from SVF-treated patients showed decreased expressions of $IL-1{\beta}$ and IL-8 after injection. Conclusion. Although SVF treatment appears to decrease the inflammatory cytokine levels in the nasal mucosa, a single SVF injection was not effective in terms of symptom improvement and patient satisfaction. Further trials are needed to identify a more practical and useful regenerative treatment modality for patients with ENS.

• The Korean Society of Law and Medicine
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• v.22 no.4
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• pp.159-184
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• 2021

The significance of the enactment of the 「Act On The Safety Of And Support For Advanced Regenerative Medicine And Advanced Biological Products」 is to break away from the regulation of the Pharmaceutical Affairs Act and expand patient treatment opportunities through a medical technology approach to regenerative medicine, which is essentially a medical practice called 'transplantation'. However, more than a year after the law was enacted, clinical study has not been activated, with not a single high-risk study approved by the Ministry of Food and Drug Safety being approved. The reason is that despite the legal purpose of expanding patient treatment opportunities, the data requirements for clinical study approval are set in connection with drug development despite the insufficient legal basis, making it difficult for many researchers to meet the data requirements. Prior to the enactment of the Act, submitted data for clinical study on cell therapy products within the Pharmaceutical Affairs Act were cosiderably exempted from quality and non-clinical test data, but with the enforcement of the Advanced Regenerative Bio Act, quality and non-clinical test data are required in accordance with pharmaceuticals when applying for approval of a clinical study plan. To rectify this, when considering the identity of clinical study on advanced regenerative medicine to expand treatment opportunities, recognize that there are limitations in connection with drug development. And it is necessary to preserve the identity of clinical study on advanced regenerative medicine, and on the other hand, in the case of drug product approval, clinical study results should be utilized while specifying usage requirements. Therefore, with the power of the market and the voluntary motive of the clinical researcher, it is necessary to prepare the necessary data by themselves rather than the basic requirements for clinical study approval.

• Journal of the Korean Society of Marine Environment & Safety
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• v.28 no.5
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• pp.835-842
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• 2022

Several countries are establishing management systems for aquaculture environment, and fishery environment assessment is one of them. The fishery management law amended in 2013 stipulates that a fishery environment assessment should be performed when a fish cage farm's license is extended. The purpose of the fishery environment assessment is to promote sustainable fishery, increase the fishery production capacity, and increase the fishermen incoming by implementing evaluation and improvement measures through scientific methods. The analysis items of fishery environment assessment include the Benthic Health Index (BHI), which is a biological index based on the macrobenthic polychaetes community, and total organic carbon (TOC), and the two items are scored and used for evaluation as a single grade. This study explains the selection process of BHI and TOC, which are evaluation items for fishing ground, and ecological significance of the calculated evaluation grades.

• Journal of Life Science
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• v.33 no.1
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• pp.91-101
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• 2023

Bacteriocins are antimicrobial peptides synthesized on ribosomes, produced by bacteria, that inhibit the growth of similar or closely related bacterial strains. Since the discovery of nisin, many bacteriocins with unique structures and various modes of antibacterial activity have been described, and genes encoding production, secretion, and immunity have been reported. Nisin is one of the bacteriocins applied in cheese, liquid eggs, sauces and canned foods. Many of the bacteriocins of the genus Bacillus belong to lantibiotics, which are modified peptides after translation. Other genus Bacillus also produce many non-lantibiotic bacteriocins. Bacteriocins of the genus Bacillus are sometimes becoming more important because of their broader antibacterial spectrum. Bacteriocins are considered attractive compounds in the food and pharmaceutical industries to prevent food spoilage and growth of pathogenic bacteria. Bacteriocins can be used as biological preservatives in a variety of ways in the food system. Biopreservation refers to extending shelf life and improving safety of foods using microorganisms and/or their metabolites. The demand for new antimicrobial compounds has generated great interest in new technologies that can improve food microbiological safety. Applications of bacteriocins are expanding from food to human health. Today, many researchers are shifting their interest in bacteriocins from food preservation to the treatment of bacteria that cause infections and antibiotic-resistant diseases. This exciting new era in bacteriocin research will undoubtedly lead to new inventions and new applications. In this review, we summarize the various properties and applications of bacteriocins produced by the genus Bacillus.

• Journal of the Korean Society of Marine Environment & Safety
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• v.29 no.5
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• pp.520-524
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• 2023

Regalecus russellii, which spends most of its life in the deep sea, occasionally appears in coastal waters. However, the reasons for its appearance remain unclear. In Korea, R. russellii mainly appears along the eastern coastal waters, and most of them are caught in fishing gear, such as gill nets, or are stranded on the shore; nevertheless, the frequency of appearance is extremely low. Even if found, this species is often identified to be morphologically similar to Trachipterus ishikawae, and comprehensive analysis to identify the species through sample collection is limited. Consequently, information on the biological characteristics of R. russellii appearing in the coastal waters of Korea is scarce. Herein, the anatomical characteristics of R. russellii caught in a gill net off the Gangwon-do coast on March 14, 2023, were analyzed, and coastal water temperature was measured using an ocean buoy. Our results showed that the individual was male, its total length was 320 cm, body weight was 27.52 kg, body length was 26.62 cm, gonad weight was 619.45 g, and liver weight was 218.71 g. The stomach was full of euphausiids. The water temperature changed drastically at 15-30 m roughly a week before the R. russellii individual was caught, and the subsurface water temperature was lower than 10 ℃. Our findings provide baseline data to understand the ecological characteristics of R. russellii appearing along the eastern coast of the Korea.

• Annals of Occupational and Environmental Medicine
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• v.35
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• pp.39.1-39.14
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• 2023

Background: Diseases affecting the lungs and airways contribute significantly to the global burden of disease. The problem in low- and middle-income countries appears to be exacerbated by a shift in global manufacturing base to these countries and inadequate enforcement of environmental and safety standards. In Ghana, the potential adverse effects on respiratory function associated with occupational wood dust exposure have not been thoroughly investigated. Methods: Sixty-four male sawmill workers and 64 non-woodworkers participated in this study. The concentration of wood dust exposure, prevalence and likelihood of association of respiratory symptoms with wood dust exposure and changes in pulmonary function test (PFT) parameters in association with wood dust exposure were determined from dust concentration measurements, symptoms questionnaire and lung function test parameters. Results: Sawmill workers were exposed to inhalable dust concentration of 3.09 ± 0.04 mg/m³ but did not use respirators and engaged in personal grooming habits that are known to increase dust inhalation. The sawmill operators also showed higher prevalence and likelihoods of association with respiratory symptoms, a significant cross-shift decline in some PFT parameters and a shift towards a restrictive pattern of lung dysfunction by end of daily shift. The before-shift PFT parameters of woodworkers were comparable to those of non-woodworkers, indicating a lack of chronic effects of wood dust exposure. Conclusions: Wood dust exposure at the study site was associated with acute respiratory symptoms and acute changes in some PFT parameters. This calls for institution and enforcement of workplace and environmental safety policies to minimise exposure at sawmill operating sites, and ultimately, decrease the burden of respiratory diseases.