• Proceedings of the Zoological Society Korea Conference
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• 1998.10b
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• pp.166.2-166
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• 1998

No Abstract, See Full Text

• Journal of Korean Biological Nursing Science
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• v.22 no.4
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• pp.297-307
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• 2020

Purpose: The purpose of this research was to identify the relationships between stroke knowledge, health perception, exercise self-efficacy and stroke prevention behaviour and the factors influencing stroke prevention behaviour in middle-aged adults. Methods: A cross-sectional survey was conducted in 2 cities of Korea from May to July 2020, using structured questionnaire. The participants were 168 middle-aged adults without a history of stroke. Collected data were analyzed using descriptive statistics, independent t-test, one-way ANOVA, Pearson correlation coefficients, and multiple regression with SPSS/WIN 25.0. Results: There was significant correlations among degree of stroke prevention behaviour, stroke knowledge about warning sign (r= .20, p= .010), health perception (r= .35, p< .001) and exercise self-efficacy (r= .43, p< .001). The most important factor influencing stroke prevention behaviour was exercise self-efficacy (β= 0.38, p< .001), followed by health perception (β= 0.18, p= .008), body mass index (β= -0.17, p= .011), stroke knowledge about warning sign (β= 0.13, p= .045) in that order. These factors explained 37.7% of total variance in stroke prevention behaviour (F= 11.09, p< .001). Conclusion: The results of this study suggest that the development of nursing intervention for stroke prevention behaviour improvement is needed considering exercise self-efficacy and stroke knowledge.

• Journal of Korean Biological Nursing Science
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• v.2 no.1
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• pp.34-48
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• 2000

The purpose of this study was to analyse the factors associated with regular exercise in office workers based on the health belief model such as health belief, self efficacy and barrier among office workers. For the study, we surveyed 253 office workers and analysed using SAS package program. That results obtained were as follows; 1. There were significant differences in sex, age, marriage status. 2. Exercise showed a significant association according to 5-6 days/week exercise, used to fitness center in company, exercise before the attendances. 3. The health belief showed a significant association according to 20-29 years old, unmarried and non exerciser. 4. The self efficacy showed a significant association according to female, nondrinker, nonsmoker, regular exerciser, motivation of exercise is maintain health and weak exerciser. 5. The barrier of exercise was high in non exerciser. 6. A negative correlation was observed between the health belief, the self efficacy and the barrier of exercise. In conclusion, this study suggests that the effective exercise program to reinforce the factors based on health belief and self efficacy, have to be developed.

• Journal of Korean Biological Nursing Science
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• v.22 no.3
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• pp.184-191
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• 2020

Purpose: The purpose of this study was to validate the effects that the structured pamphlet and education through tablets regarding the daily life management and disease nursing education program has towards pneumonia patients in compliance, and self-efficacy. Methods: This study used the quasi-experimental study design based upon the nonequivalent control group pretest-posttest design. A total of 100 patients-50 patients who were hospitalized February 2020 as the control group and 50 patients who were hospitalized March 2020 as the experimental group - were used as material for the statistical analysis. These data were analyzed with a significance level of p< .05 using the SPSS WIN 21.0 program. Results: The patients' compliance, and self-efficacy had no significance difference between the two previous scores, meaning homogeneity in the two groups. Through verifying the experimental group who had disease and daily-life managing nursing education will have higher scores in compliance (t= 20.95, p< .001), and self-efficacy (t= 17.24, p< .001) than the control group who had not received those education, were statistically significantly different leading to all hypothesis being supported. Conclusion: For improving pneumonia patients' compliance, the methods should be simple, easy to understand, effective in numerous clinical situations, require constant education and reinforcement, and periodic nursing education program.

• Journal of Korean Biological Nursing Science
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• v.26 no.2
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• pp.123-135
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• 2024

Purpose: The purpose of this study was to examine the effects of self-care intervention using a mobile instant messenger on hemodialysis patient's knowledge, self-efficacy, self-care behavior and physiological indices. Methods: A non-equivalent control group pretest-posttest design was used. The participants consisted of 38 patients who had a regular hemodialysis of Seoul National University Hospital. They were assigned to one of two groups; an experimental group (n = 19) that had self-care intervention for 8 weeks and a control groups (n = 19) that had routine hemodialysis treatment. The data collection was conducted from September 5, 2022 to October 29, 2022. The date were analyzed by Chi-square test, Independent t-test, and Fisher's exact test using SPSS Win 29 program. Results: There was a significant difference in self-efficacy (t = 3.42, p = .002) between experimental and control groups. There was no significant differences between the two groups in knowledge (t = 0.80, p = .428), self-care behavior (t = 0.09, p = .929), potassium (t = -0.82 p = .416), phosphorus (t = -0.03, p = .974), weight gain (t = 0.16, p = .867). Conclusion: Based on above results, it was verified that self-care intervention in this study was an effective indicator in improving the self-efficacy. There is a requirement to formulate comprehensive interventions capable of enhancing various indicators.

• Journal of Korean Biological Nursing Science
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• v.15 no.3
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• pp.107-114
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• 2013

Purpose: This study was aimed to describe the level of medication adherence and to identify the impact of cognitive function and self-efficacy on medication adherence of elderly patients with chronic disease. Methods: The descriptive study included 303 patients over 65 years with chronic diseases from two medical centers in Cheonan city. Data were collected from July to November 2011. A questionnaire including questions on the Korean version of mini-mental state examination (MMSE-K), self-efficacy and medication adherence were completed by the subjects. Data were analyzed using the SPSS/WIN 20.0 program. Results: The mean score of medication adherence was $1.4{\pm}1.6$. In univariate analysis, exercise (t=2.85, p=.005), type of disease (F=3.91, p=.001) and self-efficacy (r=-.57, p<.001) were the significant factors related to medication adherence. Linear regression analysis demonstrated that self-efficacy (${\beta}$=-.57, p<.001) was a significantly associated factor with medication adherence. Self-efficacy explained about 33% of the total variance of the medication adherence in elderly patients. Conclusion: The results suggest that self-efficacy to medication can be a facilitator to medication adherence in elderly patients. However, these results indicate that there remains much work to be done in identifying other predictors of medication adherence of elderly patients with chronic diseases.

• Journal of Korean Biological Nursing Science
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• v.21 no.1
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• pp.46-53
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• 2019

Purpose: This study was conducted to identify the effects of organizational culture for the infection control and self-efficacy on compliance with standard precautions of emergency room nurses. Methods: This cross-sectional descriptive study was conducted from 1st July to 3rd August, 2017. The participants were 200 nurses working in emergency rooms. The data was collected using structured self-report questionnaires. Results: The average scores for the organizational culture for infection control, self-efficacy and compliance with standard precautions were 5.54, 3.65, and 4.31, respectively. The organizational culture for infection control (r = .59, p< .001) and self-efficacy (r= .28, p< .001) were found to have a positive, meaningful correlation with compliance with the standard precautions. Multiple regression analysis showed that compliance with standard precautions was significantly affected by the organizational culture for infection control (${\beta}=0.55$, p< .001) and self-efficacy (${\beta}=0.13$, p= .033). Conclusion: The results for this study indicate that the organizational culture for infection control and self-efficacy were highly influential factors affecting compliance with standard precautions of emergency room nurses. Therefore, in order to improve the nurses' use of the standard precautions, it was necessary to develop and evaluate a program that considers the environmental factors and self-efficacy.

• International Journal of Oral Biology
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• v.49 no.1
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• pp.18-25
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• 2024

Despite advancements in therapeutic approaches, radiotherapy and cisplatin-based chemotherapy remain primary noninvasive treatments for patients with oral squamous cell carcinoma (OSCC). Moreover, the 5-year survival rate for patients with OSCC has remained almost unchanged for several decades, and many side effects of chemotherapy still exist. In this study, three-dimensional (3D) models of OSCC were established using fibroblasts, and the efficacy of various biological inhibitors was evaluated. A culture of epithelial cells with two types of fibroblasts (hTERT-hNOFs and cancer-associated fibroblasts) within a type I collagen matrix resulted in the formation of a continuous layer of tightly packed cells compared to models without fibroblasts. Furthermore, the effects of biological chemicals, including Y27632, latrunculin A, and verteporfin, on these models were investigated. The stratified formation of the epithelial layer and invasion in OSCC 3D-culture models were effectively inhibited by verteporfin, whereas invasion was weakly inhibited by Y27632 and latrunculin. Collectively, the developed OSCC 3D-culture models established with fibroblasts demonstrated the potential for drug screening, with verteporfin showing promising efficacy.

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.319-329
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• 2003

Ursolic acid (UA) and oleanolic acid (OA) are pentacyclic triterpenoids which are widely distributed in plants, and their derivatives are aglycones of many naturally occurring saponins. It is known that pentacyclic acids may possibly enhance the mechanical barrier functions of cell membranes in plants. Recently, it has been reported that OA and UA have interesting biological activities on skin, such as anti-inflammatory and anti-wrinkle activities. Since triterpenoids are extremely insoluble and their solubility problem limits skin-care application, OA and UA were encapsulated in liposomes via micelle-to-vesicle transition to overcome poorly soluble property and enhance biological efficacy. Optimal molar ratio of OA to lecithin was found to exist for producing liposomes of small hydrodynamic size and liposomal suspensions without recrystallized precipitation of OA. From electron micrograph and dynamic light scattering studies, reconstituted OA-containing liposomes without severe mechanical treatment showed small hydrodynamic size about 150 nm. Wide-angle X-ray diffraction coupled with dynamic light scattering revealed that optimal amount of OA in liposome was 25.4 mole %. In biological evaluation, OA-containing liposome significantly increased filaggrin and transglutaminase as markers of keratinocyte differentiation in epidermal layer of hairless mouse, whereas ursolic acid-containing liposome did not show noticeable increase of filaggrin and transglutaminase compared to empty liposome. It is concluded that nano-scaled liposomes containing triterpenoids were spontaneously prepared by vesicular transition from mixed micelle and liposomal triterpenoids can enhance skin absorption of triterpenoid and biological efficacy.

• The Korean Journal of Pharmacology
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• v.11 no.1 s.17
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• pp.61-79
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• 1975

The recent knowledge about the effects and the biological roles of prostaglandins(PGs) in the female reproductive system were reviewed on the following view points in detail and the authors also argued on the efficacy and reliability for the induction of labour and therapeutic abortions in midtrimester pregnancy. 1. The actions of PGs on the myometrium in vivo and in vitro and the effects of ovarian hormones on the actions of PGs. 2. The actions of PGs on the fallopian tube. 3. The role of PGs in the initiation of menstrual bleeding and dysmenorrhea. 4. The biological action of PGs on the mechanism of labour and parturition. 5. The efficacy and reliability of PGs for therapeutic abortion in the first and midtrimester pregnancy. 6. The biological role of PGs in the activity and life-span of corpus luteum.