• BMB Reports
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• 제55권7호
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• pp.305-315
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• 2022

Transposable elements (TEs) are DNA sequences capable of mobilization from one location to another in the genome. Since the discovery of 'Dissociation (Dc) locus' by Barbara McClintock in maize (1), mounting evidence in the era of genomics indicates that a significant fraction of most eukaryotic genomes is composed of TE sequences, involving in various aspects of biological processes such as development, physiology, diseases and evolution. Although technical advances in genomics have discovered numerous functional impacts of TE across species, our understanding of TEs is still ongoing process due to challenges resulted from complexity and abundance of TEs in the genome. In this mini-review, we briefly summarize biology of TEs and their impacts on the host genome, emphasizing importance of understanding TE landscape in the genome. Then, we introduce recent endeavors especially in vivo retrotransposition assays and long read sequencing technology for identifying de novo insertions/TE polymorphism, which will broaden our knowledge of extraordinary relationship between genomic cohabitants and their host.

• 대한의생명과학회지
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• 제22권3호
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• pp.65-74
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• 2016

The critical aspects of biosafety and bio-containment have been increasingly important in recent years. Biological agents involved in biological research projects at the Nanyang Technological University (NTU) Singapore are usually those with low risks. Biosafety level 2 or BSL 2 laboratories are widely used. However, biosafety measures which refer to the implementation of laboratory practices and procedures, specific construction features of laboratory facilities and safety equipment must be in place to reduce the exposure of laboratory personnel, the public or the environment to potentially infectious agents or other biological hazards. It is also required to pay more attention to laboratory-acquired infections (LAIs) which may occur in research laboratories, clinical laboratories or animal facilities. BSL 2 audit and certification program is implemented as an internal exercise covering laboratories in the university where biological agents are handled or biological research works are carried out. We have put some efforts to raise biosafety standards university-wide in both laboratory infrastructure and laboratory practices to a higher level. Common audit findings are briefly discussed in this presentation.

• Journal of Mechanical Science and Technology
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• 제20권12호
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• pp.2265-2283
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• 2006

There is tremendous interest of research which surrounds the concept of 'osteoporosis,' as shown by the intense and growing research activity in the field. The urgency to advance knowledge in this area is motivated by the need to understand not only the causes, diagnosis and treatment but also need for early identification or detection of this silent disease. Despite the various researches work is going on, important issues remain unresolved. In this paper, Osteoporosis has also been discussed with respect to biological, engineering, biochemical and physical aspects. The diagnostic and therapeutic techniques have been described for osteoporosis, for better health care. The novelty of the review paper lies in clarifying several myths, explaining the disease in details with biomedical engineering aspects and focuses on the several detection techniques, providing a new direction for early diagnosis of this deadly disease and gives new directions for the POCT device for Osteoporosis.

• 생물정신의학
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• 제6권2호
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• pp.161-169
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• 1999

There are a number of approaches in developing experimental models for depression, but there is no such thing as a best model for depressive syndrome. Animal models are subject to the obvious limitations inherent in the assumption that human psychopathology can be represented accurately in lower animals. Recently, the concern increasingly is to develop a variety of experimental paradigms in animals to study selected aspects of human psychopathology, and animal models should be understood as basically experimental preparations that are developed to carry out these objects. Therefore, a battery of a variety of animal models should be applied to permit detailed pathophysiological studies and to develop new antidepressant treatments. Animal models of depression basically consider behavioral isomorphism with the human depression a plus, but not a req-uirement, and the model behavior should be defined operationally in order to be reproduced reliably by other researchers and be responsive to those agents possessing demonstrated clinical efficacy in human depression. In conclusion, animal models of depression have played a significant role in elucidating pathophysiology of depression and developing current treatments for depression, but there is no single comprehensive model for depression until now. Each of the proposed animal model has its advantages and limitations. In other words, certain paradigms are suitable for studying certain phenomena, whereas others are more suitable for studying other aspects. The best model for depression depends upon what the question is.

• 사상체질의학회지
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• 제11권1호
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• pp.159-168
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• 1999

Purpose : Sasang Constitutional Medicine explains the pathology peculiar to constitution and suggests treatment for each constitution. In Sasang Constitutional Medicine hwnan beings are classified on four groups; Taeyangin, Taeumin, 5oyangin, Soeumin. These four constitution has their's own symptoms and treatments. In treatment, control of mind inclination, that is to say, moderation takes a very important role. But the study on heredity in Sasang Constitutional Medicine has not done not biological study but also statistical study. So we used several statistical methods and analyzed 163 samples. Methods : We implemented Fishers exact test for adjusting chi-squared test, kappa coefficient to estimate agreement of parent's and children's constitutions, and finally plotted bi-plot using correspondence analysis. Results : From Fisher's exact test result, we could know that parent's and children'S constitution's distribution had significant difference. In kappa coefficient, mother and daughter's estimated value produced highest result. In correspondence analysis we only plotted the case of mother and son for easy interpretation. Conclusion : In the study of heredity of SaSang constitution, we cannot know exactly the heredity of constitution in terms of biology or genetics. But this research can be helpful for further analysis, that is, a study of biological or genetical aspects. And we could conclude that in statistical aspects the heredity in SaSang constitution is meaningful.

• Fisheries and Aquatic Sciences
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• 제26권3호
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• pp.224-233
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• 2023

This research was conducted at Langgur City, Southeast Maluku Regency, Maluku Province, Eastern Indonesia from November 2020 to February 2021 to study biological aspects of roundscads (Decapterus spp.) which consist of species composition, sex ratio, gonad maturation level, size distribution, length-weight relationship and condition factor. Samples were collected at traditional fish market in Langgur City. Fish samples collected at the market were put into cool box and then brought to the laboratory for further examination. Fish samples were identified, separated based on species, dissected to determine their sex and gonad maturation stage and then measured. Totally, there were 290 specimen collected which consist of five species namely Decapterus kurroides, D. macarellus, D. macrosoma, D. muroadsi and D. russelli. Sex ratio between male and female for all species showed 1:1. Gonad maturation level showed that stage I and II have higher percentage than stage III and IV indicates immature fish more dominant compare to mature one. Among five species found, D. macarellus has larger size while the smaller belongs to D. muroadsi. Results of length-weight relationship analysis showed that roundscads inhabiting Southeast Maluku waters have isometric and negative allometric growth pattern with relative condition factor around 1.00.

• 수산경영론집
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• 제47권4호
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• pp.1-13
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• 2016

Fish mortality is the most important success factor in aquaculture management. To analyze the effect of mortality considering biological and economic condition is a important problem in land-based aquaculture. This study is aimed to analyze the effect of mortality for duration of cultivation in land-based aquaculture. This study builds the mathematical model that finds the value of decision variable to minimize cost that sums up the water pool usage cost, sorting cost, fingerling cost and feeding cost under critical standing corp constraint. The proposed mathematical model involves many aspects, both biological and economical: (1) number of fingerlings (2) timing and number of batch splitting event, based on (3) fish growth rate, (4) mortality, and (5) several farming expense. Numerical simulation model presented here in. The objective of numerical simulation is to provide for decision makers to analyse and comprehend the proposed model. When extensive biological and cost data become available, the proposed model can be widely applied to yield more accurate results.

• 생물정신의학
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• 제4권1호
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• pp.3-11
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• 1997

Disturbances in memory are the most common problem in patients with an organic mental syndrome. Other patients with significant psychiatric disorders also often have difficulty with memory. So it is very important in the clinical practice of psychiatry to understand the biological and neurocognitive mechanisms of memory proessing, and to develop the assessment tools with which memory function can be evaluated reliably and validly. Moreover, memory researches provide an important viewpoint from which we can understand the pathophysiological mechanisms of major neuropsychiatric illnesses. This article focuses on our understanding of memory functions in clinical and neurobiological aspects. The relevant material will be presented in four parts : 1) terminologies needed in defining major stages of various types of memory processing : 2) neurochemical and neuroanatomical basis of memory processing : 3) brief bed-side screening tests and more comprehensive neuropsychological tests for the evaluation of memory function : 4) the characteristics of memory dysfunction in several major psychiatric illnesses.

• 한국미생물·생명공학회지
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• 제25권4호
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• pp.396-402
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• 1997

Biocontrol of plant pathogens provides an alternative means of reducing the incidence of plant diseases without the negative aspects of chemical pesticides. Nowdays, as the resistant fungi about the chemical fungicides have revealed and the concern of environment has increased, the biological control of phytopathogenic fungi by the antagonistic microorganisms is very much indispensable. For the selection of strong antagonistic bacterium for biological control agent of rice leafblast and cucumber gray mold rot, the antifungal strain KL-3 strain was selected among 120 strains isolated from the rhizosphere soils. And the strain was identified to be a species of Bacillus subtilis or closely related strain. In several biochemical and in vitro antibiosis tests, antifungal substances of Bacillus sp. KL-3 were presumed heat stable, micromolecular antibiotic substances. In vivo test and vinyl house field test, the antifungal substances of Bacillus sp. KL-3 represented excellent biocontrol ability aganist Alternaria mali, Phyricularia oryzae, and Alternaria kikuchiana as well as broad spectrum of other fungi. In particular, Bacillus sp. KL-3 strain showed more predominant activity than some chemical fungicides against fungi shown to resist chemcal fungicides.

• 생물정신의학
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• 제8권2호
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• pp.203-207
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• 2001

The genome sequencing project has generated and will continue to generate enormous amounts of sequence data including 5 eukaryotic and about 60 prokaryotic genomes. Given this ever-increasing amounts of sequence information, new strategies are necessary to efficiently pursue the next phase of the genome project-the elucidation of gene expression patterns and gene product function on a whole genome scale. In order to assign functional information to the genome sequence, DNA chip(or gene microarray) technology was developed to efficiently identify the differential expression pattern of independent biological samples. DNA chip provides a new tool for genome expression analysis that may revolutionize many aspects of biotechnology including new drug discovery and disease diagnostics.