• 수산해양기술연구
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• 제45권4호
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• pp.223-233
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• 2009

It has been considered that fishing areas for shrimp beam trawl have been in ruin because Korean local governments have permitted trawling into the areas limited by the fisheries local regulations from 1994. Physical and biological effects of the trawling were investigated in the study. Physical effects were investigated by optical methods such as trawling tracking by side scan sonar and comparing the gear both before and after trawling. Biological aspects were investigated by grab sampling of benthic animals, concentration of trace metals in sediment and a flux evaluation of ${NH_4}^+,\;{PO_4}^-,\;and\;SiO_2$ by coring. The fishing activity had physical impacts on the seabed but these recovered naturally in less than fourty days naturally, which increased the benthic biodiversity, increases the trace metal concentration of and nutrient flux into the seawater, especially phosphate and silicate. This method and these results can help in further studies looking for disturbances by fishing.

• 대한의용생체공학회:의공학회지
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• 제39권5호
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• pp.188-207
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• 2018

Recently, three-dimensional (3D) printing of biological tissues and organ has become an attractive interdisciplinary research topic that combines a broad range of fields including engineering, biomaterials science, cell biology, physics, and medicine. The 3D bioprinting can be used to produce complex tissue engineering scaffolds based on computer designs obtained from patient-specific anatomical data. It is a powerful tool for building structures by printing cells together with matrix materials and biochemical factors in spatially predefined positions within confined 3D structures. In the field of the 3D bioprinting, three major categories of the 3D bioprinting include the stereolithography-based, inkjet-based, and dispensing-based bioprinting. Some of them have made significant process. Each technique has its own advantages and limitations. Compared with non-biological printing, the 3D bioprinting should consider additional complexities: biocompatibility, degradability of printing materials, cell types, cell growth, cell viability, and cell proliferation factors. Numerous 3D bioprinting technologies have been proposed, and some of them have been making great progress in printing several tissues including multilayered skin, cartilaginous structures, bone, vasculature even heart and liver. This review summarizes basic principles and key aspects of some frequently utilized printing technologies, and introduces current challenges, and prospects in the 3D bioprinting.

• 대한의생명과학회지
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• 제21권4호
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• pp.181-187
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• 2015

Osteoporosis is one of the diseases caused by accumulation of effects from complex interactions between genetic and environmental factors. Aging is the major cause for osteoporosis, which normally increases skeletal fragility and bone fracture especially among the elder. "Omics" refers to a specialized research field dealing with high-throughput biological data, such as genomics, transcriptomics, proteomics or metabolomics. Integration of data from multi-omics has been approved to be a powerful strategy to colligate biological phenomenon with multiple aspects. Actually, integrative analyses of "omics" datasets were used to present pathogenesis of specific diseases or casual biomarkers including susceptible genes. In this study, we evaluated the proposed relationship of novel susceptible genes (TREML2, HTR1E, and GLO1) with osteoporosis, which genes were obtained using multi-omics integration analyses. To this end, SNPs of the susceptible genes in the Korean female cohort were analyzed. As a result, one SNP of HTR1E and five SNPs of TREML2 were identified to associate with osteoporosis. The highest significant SNP was $rs6938076^*$ of TREML2 (OR=0.63, CI: 0.45~0.89, recessive P=0.009). Consequently, the susceptible genes identified through the multi-omics analyses were confirmed to have association with osteoporosis. Therefore, multi-omics analysis might be a powerful tool to find new genes associated with a disease. We further identified that TREML2 has more associated with osteoporosis in females than did HTR1E.

• 동의생리병리학회지
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• 제26권3호
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• pp.306-313
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• 2012

Herbal medicines are medicinal products containing a single or a mixture of two or more different herbal substances or herbal preparations as active principles. Recently, much attention has been paid to developing various kinds of fermented herbal extracts, a new type of traditional herbal medicine in the field of Korean traditional medicine. The fermentation of medicinal herbs is intended to exert a favorable influence on bioestability, bioavaliablilty and pharmacological activity of herbal extract in the gastrointestinal tract as well as intensifying the nutritional and pharmacological aspects of the medicinal herbs. The purpose of this study was to investigate biological activities of fermented Rehmanniae Radix by lactic acid bacteria at $30^{\circ}C$ for 3 days in comparison with those for Rehmanniae Radix The fermented Rehmanniae Radix exhibited different chemical profile to Rehmanniae Radix generated with HPLC, indicating production of new ingredients during fermentation. Rehmanniae Radix served as good nutritional sources for the growth of lactic acid bacteria showing increased number of bacteria during fermentation. Toxic effect of the fermented Rehmanniae Radix to cells were not seen judged by the MTT assay. The fermented Rehmanniae Radix exhibited better antioxidant effect than non-fermented Rehmanniae Radix analyzed by a SOD-likely assay. Both hypoglycemic and hypotensive effects of the fermented Rehmanniae Radix were also detected and better than those for Rehmanniae Radix in showing dose-dependent inhibitory effects on alpha-glucosidase and ACE, respectively. In conclusion, fermented Rehmanniae Radix appears to have more biological activities than non-feremented Rehmanniae Radix showing not only antioxidant effect but also cardiovascular protection.

• Korean Chemical Engineering Research
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• 제57권4호
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• pp.455-460
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• 2019

수소화 처리 촉매공정은 정유공정에서 다양한 유분 내 황, 질소, 산소 및 미량 금속성분들의 헤테로 원자를 제거함과 동시에 불포화 탄화수소의 포화를 목적으로 진행되는 수소화공정이다. 대부분의 정유 공정은 납사, 중간유분, 가스오일을 포함하여 중질 잔사유의 업그레이드용 수소화 처리 공정을 포함하고 있다. 언급된 유종 중, 잔사유의 수소화 처리 촉매공정은 원료자체의 복잡성으로 인해 정유공정의 핵심으로 받아들여지고 있는 만큼 기타 유종에 대한 업그레이드 공정 대비 상당히 비중 있게 다루어 지고 있는 실정이다. 따라서, 본 총설은 수소화 처리에 의한 잔사유의 업그레이드 공정 중, 중요한 이슈의 최근 동향을 수첨탈금속 (Hydrodemetallization, HDM) 및 수첨탈황(Hydrodesulfurization, HDS) 공정에 대해 화학적 관점으로 고찰하고자 한다. 더불어, 수소화 처리용 촉매의 기능과 조성은 물론, 개선방향도 살펴보았다.

• 한국환경생태학회지
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• 제36권6호
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• pp.684-692
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• 2022

본 연구는 새만금 농생명용지와 주변 지역의 간척 전후 생태계서비스를 평가하고 증진방안을 마련하기 위해 수행하였다. 새만금 지역의 생태계서비스 기능은 토지 유형에 따라 다르게 나타났다. 간척 전 새만금은 공급, 조절, 문화, 지지서비스 기능이 모두 높았으나 간척 후에는 공급, 조절, 지지서비스 기능이 하락했다. 따라서 새만금 농생명 용지의 생태계서비스를 증진하려면 논 습지, 저수지 등의 반(半)자연생태계가 가지는 공급, 조절, 지지서비스를 강화하는 것이 필요하다. 현재 남아 있는 산림, 도서 지역 등의 자연생태계와 광활한 농경지를 농촌관광 및 생태관광을 특화하고, 농업과 관련된 교육.연구 위주의 문화서비스 기능을 강화할 필요가 있다. 이를 위해 넓은 농경지와 농업 기반을 활용하여 농업생산, 농촌관광 등을 활성화하고 고령화가 진행되고 있는 지역에 대한 정부의 지원이 필요하다.

• 한국과학교육학회지
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• 제29권5호
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• pp.513-530
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• 2009

과학과 기술 분야에서 발생하는 윤리적 논쟁거리를 가르치기 위해 많은 방법들이 사용되어 왔다. 그러나 그런 생명윤리 교수법이 윤리학 이론을 근거로 정당화되지 않았으며, 실용적 효용도 대부분 확인되지 않았다. 이 논문의 목적은 중 고등학교의 생명과학에 관련된 사회과학적 논쟁거리와 윤리적 이론에 적절한 생명윤리 교수법을 제안하고자 함이다. 이 논문에서는 지금까지 제시된 13가지의 생명윤리 교수-학습 방법 가운데에서 윤리학 이론에 비추어 타당하며 현행 우리나라 교육적 여건에 대한 실용성도 높다고 판단되는 아홉 가지의 생명윤리 교수-학습 방법의 특성을 적용하기 적절한 생명윤리 논쟁거리 또는 상황, 교수-학습 방법을 잘 설명하는 윤리학 이론과 법칙, 실례 등으로 기술하였다.

• BMB Reports
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• 제47권8호
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• pp.417-423
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• 2014

MicroRNAs (miRNAs) are a large family of post-transcriptional regulators, which are 21-24 nt in length and play a role in a wide variety of biological processes in eukaryotes. The past few years have seen rapid progress in our understanding of miRNA biogenesis and the mechanism of action, which commonly entails a combination of target degradation and translational repression. The target degradation mediated by Argonaute-catalyzed endonucleolytic cleavage exerts a significant repressive effect on target mRNA expression, particularly during rapid developmental transitions. This review outlines the current understanding of the mechanistic aspects of this important process and discusses several different experimental approaches to identify miRNA cleavage targets.

• 한국환경과학회지
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• 제8권3호
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• pp.355-361
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• 1999

The aim of this study is to develop the water quality simulation model (BAYQUAL) that deal with the physical, chemical and biological aspects of fate/behavior of pollutants in the bay. BAYQUAL is a two dimensional, time-variable finite element water quality model based on the flow simulation model in bay(BAYFLOW). The algorithm is composed of a hydrodynamic module which solves the equations of motion and continuity, a pollutnat dispersion module which solves the dispersion-advection equation. The applicability and feasibility of the model are discussed by applications of the model to the Kwangyang bay of south coastal waters of Korea. Based on the field data, the BAYQUAL model was calibrated and verified. The results were in good agreement with measured value within relative error of 14% for COD, T-N, T-P. Numerical simulations of velocity components and tide amplitude(M2) were agreed closely with the actual data.

• 환경생물
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• 제23권2호
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• pp.93-97
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• 2005

Zooplankton dynamics were investigated based on samples collected monthly during the period between November 1998 and October 1999 at 15 stations in Gwangyang and Sachon Bay. Zooplankters were quantitatively collected with horizontal towing through the surface and oblique hauling from the bottom to surface at each station, simultaneously. A total of 88 taxa of zooplankton were distributed and 60 taxa were identified to species. Copepods showed the prosperity in species number of 52 species. Number of taxa occurred in samples hauled obliquely always showed $2\~5$ more species than those captured in the surface except for stations near the Namhae bridge. In waters near Namhae bridge, fast current seemed to mix waters vertically. Seasonally these differences were more distinct in the spring and summer than those in other seasons possibly due to the stratification in warmer seasons. In quantitative aspects, differences between two layers seemed to be obscure. Spatial and temporal variations in species diversity of copepods showed more prosperity in pelagic realm than those in the surface. Our collection carrying out in day time might be one of the important reason to cause these differences in zooplankton dynamics between two layers.