• 대한한의진단학회지
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• 제16권2호
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• pp.33-46
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• 2012

Purpose : Nowadays excrement-related disease that repeats constipation and diarrhea is on the increase due to the change of dietary and lack of exercise, etc. We analyzed Bangyakhappyeon in order to find out the materia medica which is used for the excrement patterns. Methods : The database used in present thesisis consist of disease pattern, nature of medicinals and materia medica from Bangyakhappyeon was constructed. We analyzed the nature of medicinals of excrement patterns(or symptom) by frequency analysis and network analysis, and also searched main materia medica of excrement patterns(or symptom) by frequency analysis and rule mining. Results : We analyzed the nature of medicinals of excrement patterns(or symptom) in Bangyakhappyeon. And we researched the high frequency materia medica, high specificity materia medica and high frequent paired-drugs as main materia medica of excrement patterns(or symptom). Conclusion : This study found the information about frequency relationship between excrement patterns(or symptoms) and materia medica.

• 대한한의진단학회지
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• 제12권1호
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• pp.93-102
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• 2008

Purpose: To review the Scale Measurement studies on Traditional Chinese Medicine and it's prospection. Method: The papers reviewed in this study were searched through internet search engines such as China National Knowledge Infrastructure(www.cnki.net). we searched papers on Scale studies by the keyword "量表"(Scale) and "中醫"(TCM). Results: 263 papers which is truly related on "Scale" were collected. All the papers were reviewed briefly under the subtitle of diagnosis, evaluation of curative value, development of scale, reverse of overseas questionnaire to chinese literature and etc. Conclusions: Scale measurement studies on TCM proceeded so much but their medical application was on small and narrow field. Also Scale study had TCM's characteristics were only 18% of them. Neverthless, productions from China were precious and valuable to Korean Oriental Medicine and we have to learn their success on scale measurement studies.

• Food Science and Biotechnology
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• 제18권6호
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• pp.1330-1335
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• 2009

Although beneficial effects of dietary plant proteins on lipid metabolism are well documented, not much information exists on the influence of different seafood proteins on the lipid metabolism. The present study evaluated the effect of 2 marine proteins (tuna protein and scallop ovary proteins) in comparison to casein and soy protein in male Wistar rats. The concentration of total lipids in the plasma of rats fed experimental diets was significantly lower from that of control (278.2 mg/dL) group (p<0.05); and, the liver lipid content was not significantly different (p>0.05). Fecal excretion of cholesterol and bile acids was significantly higher in marine proteins and soy protein fed groups compared to casein only fed control (6.1 and 6.4 mg/day, respectively) group (p<0.05). No significant differences were observed in the mRNA concentrations of different transcriptional factors (p>0.05).

• 동의생리병리학회지
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• 제23권6호
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• pp.1273-1281
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• 2009

To research the trends of study and the guidelines of investigation and management about gastrointestinal (GI) disease in oriental medicine, we reviewed and analysed articles published in Korea from 2004 to 2009. The western medicine in medical treatments of GI tract is notorious for their side effects. But, in oriental medicine, we couldn't find any side effects. Although we treat or manage clinical practices of the GI disease every day, however, we do not have abundant evidences about scientific mechanisms of those treated with oriental medicine therapy. Therefore, we suggest that the upward of qualities of life and the improvement of health-care system through the development of oriental medicine therapies in Korea will be need.

• 대한한의진단학회지
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• 제16권3호
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• pp.23-32
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• 2012

Objectives: The objective of this study is to investigate and valuate currently provided database management systems (DBMS) of traditional Korean medical knowledge. Methods: We searched DBMS on the web and smart device application markets (Apple App Store and Google Play Store). Key words for searching were 'traditional medicine', 'acupuncture', 'moxibustion', 'herbal medicine', and '한의학'. We looked into each DBMS to find out its scopes and limits, and each was valuated according to its functionality, accessibility, and utility. Results: 186 DBMS of traditional Korean medical knowledge were investigated and 91% of them were applications for smart devices. Almost all DBMS provided acupuncture and herb information, and a small amount of DMBS provided prescription and research paper information. Functionality, accessibility, and utility valuation were performed by using scoring system from 0 to 2. Mean values of functionality, accessibility, and utility were 0.86, 1.29, and 1.09. Conclusions: On the whole, high accessibility and low functionality were found, and various data-calculating functions were not implemented. Further researches and developments about traditional Korean medical knowledge DBMS are necessary to provide correct traditional Korean medical information and to support the studies about Korean medicine.

• 대한한의진단학회지
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• 제13권2호
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• pp.117-128
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• 2009

Object : The purpose of this study is to reveiew recent 10 years chinese achievements on the use of digestive system on the utilization of Erchentang. Methods : From the China Journal Full Text Detabase we searched paper on the use of Erchentang by Keyword "二陳湯" Results : The researches are summarised into 7parts. (1) The Effect of Erchentang utilized in liver diseases, (2) The Effect of Erchentang utilized in constipation, (3) The Effect of Erchentang utilized in emesis, (4) The Effect of Erchentang utilized in Bile reflux gastritis, (5) The Effect of Erchentang utilized in gastroesophageal reflux disease, (6) The Effect of Erchentang utilized in gastralgia, (7) The Effect of Erchentang utilized in gastritis. Conclusion : The Effect of Erchentang's utilization has been estabalished for its usefulness in various chinese medical researches.

• 대한한의진단학회지
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• 제11권2호
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• pp.128-140
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• 2007

Purpose: We performed this study to examine the correlationship between EEG complexity and impedance cardiography data using correlation analysis. Method: This study performed on 30 healthy subjects(16 males, 14 females). Before and after natural respiration, ICG data were recorded, and EEG raw data were measured by moving windows during 15 minutes. The correlation dimension(D2) was calculated from 15 minutes data. 8 channels EEG data were analysed with 9 index of ICG data by correlation analysis. Result: 1. ACI of impedance cardiography had significant correlationship with ch.4 of EEG complexity(p=0.03). 2. VI of impedance cardiography had significant correlationship with ch.3 of EEG complexity(p=0.034) and ch.4 of EEG complexity(p=0.017). 3. HR, TFC, PEP, LVET, STR of impedance cardiography had no significant correlationship with all of 8 channel EEG complexity. Conclusions: These results suggest that nonlinear analysis of EEG and impedance cardiography have some significant correlationship. And it can make out relationship between brain system and cardiovascular system. In the future, therefore, more study of these fields are necessary.

• 한방비만학회지
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• 제17권2호
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• pp.61-67
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• 2017

Objectives: The purpose of this study was to investigate the effects of Socheongryong-tang, a traditional herbal medicine, on gastrointestinal (GI) motility disorders (inflammatory and diabetic models) in mice. Methods: The in vivo effects of Socheongryong-tang on GI motility were investigated by calculating percent intestinal transit rates (ITR) and gastric emptying (GE) values using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). GMD models were induced by acetic acid and streptozotocin. Results: In normal ICR mice, ITR and GE values were significantly and dose-dependently increased by the intragastric administration of Socheongryong-tang (0.0025~0.25 g/kg). The ITR values (%) of GMD mice were significantly lower than those of normal mice, and these reductions were significantly and dose-dependently inhibited by Socheongryong-tang. Conclusions: These results suggest that Socheongryong-tang is a good candidate for the development of a prokinetic agent that may prevent or alleviate GMD.

• Applied Biological Chemistry
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• 제44권2호
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• pp.122-128
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• 2001

감귤류 유래 플라보노이드인 hesperidin 및 naringin과 이들의 agIycone 형태인 hesperetin 및 naringenin의 생리기능 활성에 대하여 동물(흰쥐 및 햄스터)실험을 통한 지질대사,인체 간종양 세포주 HepG2 세포를 이용한 암세포 생육 및 지질대사, 노화와 질병의 원인이 되는 불포화 지방산의 지질 과산화 억제 작용을 중심으로 고찰하였다. 이들 감귤류 플라보노이드는 흰쥐에서의 콜레스테롤 농도 저하작용 및 햄스터에서의 중성지질 농도 저하작용을 나타내었다. 이러한 대사 기작으로서 콜레스테를 및 중성지질 합성의 중요 조절효소로 알려진 acyl-CoA: cholesterol acyltransferase(ACAT) 및 phosphatidate phosphohydrolase(PAP) 활성이 in vivo 및 in vitro 실험계에서 현저히 저해되었으며, 특히 aglycone 형태의 플라보노이드에서 그 효과가 강하게 나타났다. 또한,이들 플라보노이드는 인체 간종양 세포주 HepG2 세포를 이용한 실험에서 암세포 생육 억제 및 세포내 콜레스테롤과 중성지질 농도를 저하시키는 효과도 인정되었다. Hesperetin은 실험적으로 유도한 간질환을 개선시켰다. 노화 및 질병의 발생과 깊이 관련된 것으로 알려진 불포화지방산 과산화 반응을 억제시키는 항산화 효과도 확인되었는데, hesperetin에서 좋은 효과를 나타내었다. 이상의 결과에서 감귤류 유래 플라보노이드는 동물의 혈중 콜레스테롤 및 중성지질 억제작용에 의한 혈관계 질환 개선효과, 지방간을 비롯한 간질환 개선효과, 암세포 증식억제 작용, 노화 및 질병의 원인이 되는 지질 과산화 억제 작용 등 건강에 관련된 다양한 생리기능 활성이 존재하는 것을 확인하여 기능성 성분의 연구로 일정의 효과를 얻었다. 따라서 이러한 감귤류 유래의 생리활성 성분의 연구목적은 건강증진 효과를 높이는 식품의 개발과 식품 첨가물의 신규 수요를 증대시켜 국민의 건강을 향상시키는데 있다.

• 대한약침학회지
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• 제19권1호
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• pp.51-58
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• 2016

Objectives: Oldenlandia diffusa is traditionally used to relieve the symptoms of and to treat various diseases, but its anti-cancer activity has not been well studied. In the present study, the authors investigated the anti-cancer effects of an ethanol extract of Oldenlandia diffusa (EOD) on HT-29 human adenocarcinoma cells. Methods: Cells were treated with different concentrations of an EOD, and cell death was assessed by using a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Analyses of the sub G1 peak, the caspase-3 and -9 activities, and the mitochondrial membrane depolarizations were conducted to confirm cell death by apoptosis. Also, intracellular reactive oxygen species (ROS) generation was determined using carboxy-H2DCFDA (5-(and-6)-carboxy-20,70-dichlorodihydrofluorescein diacetate). Results: EOD inhibited the proliferation of HT-29 cells for 24 hours by $78.6%{\pm}8.1%$ at $50{\mu}g/mL$, $74.4%{\pm}4.6%$ at $100{\mu}g/mL$, $65.9%{\pm}5.2%$ at $200{\mu}g/mL$, $51.4%{\pm}6.2%$ at $300{\mu}g/mL$, and by $41.7%{\pm}8.9%$ at $400{\mu}g/mL$, and treatment for 72 hours reduced the proliferation at the corresponding concentrations by $43.3%{\pm}8.8%$, $24.3{\pm}5.1mV$, $13.5{\pm}3.2mV$, $6.5{\pm}2.3mV$, and by $2.6{\pm}2.3mV$. EOD increased the number of cells in the sub-G1 peak in a dose-dependent manner. The mitochondrial membrane depolarization was elevated by EOD. Also, caspase activities were dose-dependently elevated in the presence of EOD, and these activities were repressed by a pan-caspase inhibitor (zVAD-fmk). The ROS generation was significantly increased by EOD and N-acetyl-L-cysteine (NAC; a ROS scavenger) remarkably abolished EOD-induced cell death. In addition, a combination of sub-optimal doses of EOD and chemotherapeutic agents noticeably suppressed the growth of HT-29 cancer cells. Conclusion: These results indicate that EOD might be an effective chemotherapeutic for the treatment of human colorectal cancer.