• 대한화학회지
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• 제40권8호
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• pp.571-578
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• 1996

철 알킨일(에톡시)카르벤 착물과 아민의 반응에서 철 알킨일(아미노)카르벤 착물, (${\beta}$-아미노비닐)카르벤 착물, ${\eta}^3$-(2-(알킬카르보닐)비닐)카르벤 착물, 3-아미노알렌일리덴 착물의 생성을 관찰하였다. 각각 치환반응, Michael형 첨가반응, 첨가반응에 이은 자리옮김 반응, 첨가반응에 이은 에톡시기 이탈반응에 의해 생성되는 이들의 생성 비율은 반응온도, 알킨일기의 치환기, 아민의 종류에 영향을 받았다.

• 동의생리병리학회지
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• 제27권1호
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• pp.20-25
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• 2013

The education of traditional Korean medicine has been challenged for the lack of illustrated explanation of fundamental and pivotal concepts. The purpose of this study was to make suggestions for the diagrammatic concept on Qi. Thorough review was made performed to elucidate pictorial concept of Qi with medical classics and textbooks on the human physiology based on the central theories including Yin-Yang, five phase, and correspondence between nature and human. Medical terminology and its taxonomy for the Qi were examined here. We proposed more clarified terminology and related metabolic pathways for the design of schematic illustration of Qi. This study would contribute to the development of introductive drawings and educational materials fit for the apprentice.

• 동의생리병리학회지
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• 제27권1호
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• pp.112-117
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• 2013

We studied the modulation of pacemaker activities by Samchulkunbi-tang (SCKB) in cultured interstitial cells of Cajal (ICC) from murine small intestine with the whole-cell patch-clamp technique. Externally applied SCKB produced membrane depolarization in the current-clamp mode. The pretreatment with $Ca^{2+}$-free solution and thapsigargin, a $Ca^{2+}$-ATPase inhibitor in endoplasmic reticulum, abolished the generation of pacemaker potentials and suppressed the SCKB-induced action. The application of flufenamic acid (a nonselective cation channel blocker) abolished the generation of pacemaker potentials by SCKB. However, the application of niflumic acid (a chloride channel blocker) did not inhibit the generation of pacemaker potentials by SCKB. In addition, the membrane depolarizations were inhibited by not only GDP-${\beta}$-S, which permanently binds G-binding proteins, but also U-73122, an active phospholipase C inhibitor. These results suggest that SCKB modulates the pacemaker activities by nonselective cation channels and external $Ca^{2+}$ influx and internal $Ca^{2+}$ release via G-protein and phospholipase C-dependent mechanism. Therefore, the ICC are targets for SCKB and their interaction can affect intestinal motility.

• 대한예방한의학회지
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• 제14권2호
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• pp.105-120
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• 2010

Objectives : This study aims to evaluate the effects of expiration-to-inspiration time ratio (E/I-ratio) on heart rate, which represents cardiac autonomic function, and cold-heat in the healthy people. Methods : 49 healthy young volunteers(male : female = 32 : 17) were recruited in the study. The participants completed the questionnaire for yin-yang pattern identification and then we measured the chest plethysmogram for respiration signal and the electrocardiogram for NN intervals during different E/I-ratio from 1 to 2. We compared heart rate variability including RMS-SD, VLF, LF and HF, and the trend-cycle factors decomposed from NN interval data by time series analysis among the respective E/I-ratio. We also confirmed the difference on the trend-cycle factors according to the score of the questionnaire for cold and heat pattern identification. Results : There were differences on the trend-cycle factors from NN interval data, but no significant difference on heart rate variability, among the respective E/I-ratio. We also found significant relationship between the trend-cycle factors and the heat pattern identification scores. Conclusions : The results indicate that cardiac autonomic function can be modulated by the E/I-ratio and the modulation will be slower and more tendencious than respiratory sinus arrhythmia.

• 대한한의진단학회지
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• 제9권1호
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• pp.47-58
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• 2005

Background and purpose: The purpose of this study is to review the recent 10 year Chinese achievements on the objectification of traditional pulse diagnosis in clinical area. Methods: From the China Journal Full Text Database (中國學術期刊全文數据庫) we searched papers on pulse diagnosis by the keyword 'Maizhen'(脈診) Resulls: The researches are summarized into four parts; (1) the researches on the normal pulse in the physiological state (2) the clinical researches of pulse diagnosis on the symptom and disease diagnosis (3) the clinical researches of pulse diagnosis on the acupuncture treatment (4) the application of pulse diagnosis on the functional evaluation of the athlete. Conclusion: The undoubted principles of the traditional pulse diagnosis are evaluated by the objective clinical researches. And the researchers are trying to find a new application area over the traditional one.

• 대한한의진단학회지
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• 제15권1호
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• pp.77-86
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• 2011

Objectives: With increased rate of chronic disease, concerns about preventive medicine has raised. Therefore questionnaire of subhealth status was developed and analysed in our previous study. A large number of chronic diseases is related to emotional issues. This study was to confirm a relationship between mood state and health status in terms of modern people's healthcare. Methods: Subhealth Questionnaire and Korean version of Profile of Mood States(k-POMS) were putted by 113 college students. And correlation and regression analysis was conducted. Results: Subhealth questionnaire and k-POMS proved a significant correlation. In particular, subhealth factor 3(mood) had a significant correlation with all factors of k-POMS. Subhealth factor 1(body), subhealth factor 2(life) and subhealth factor 6(society) had significant correlations with 5 factors of k-POMS. Subhealth factor 4(energy) and subhealth factor 5(heredity) did not show significant results. 'Fatigue' factor of k-POMS was proved to be the most important factor influencing the subhealth status and illness, indicating high correlations with all of subhealth status.

• 대한한의진단학회지
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• 제17권1호
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• pp.1-16
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• 2013

Objectives Iridology is a field of study that diagnoses various systemic diseases through analysis of colors, structural characteristics and changes in iris. The purpose of this study was to review previously published study results of the iridology. Methods The studies were searched with the keyword "iridology" through search engines such as SCOPUS, Pub med, RISS, and NDSL. Total of 36 iridology-related studies published from 1980 to 2012 were analyzed. Results Most diagnoses of systemic disease through iris markings were insignificant. The studies on relevance of gene polymorphism and iris constitution were highly significant. The studies on relevance of Sasang constitution and iris constitution varied in results depending on diagnosis methods. The studies on relevance of iris constitution and diseases had significant results. The structural characteristics of iris were related to certain personality. Conclusions The studies on utility of iris diagnosis and diagnostic markings were negative, but the relevance of constitution, heredity, and iris diagnosis was positive. A persistent in-depth study on relevance of iris and constitution is needed in the future.

• 대한한의진단학회지
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• 제19권1호
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• pp.1-10
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• 2015

Objectives The purpose of this study was to survey the status of clinical use of a computerized tongue diagnosis system (CTDS) Methods We searched domestic/international articles using the CTDS from online medical databases including OASIS, NDSL and pubmed. We selected articles on clinical application or reliability of CTDS but excluded articles on mechanical design or software programming for developing a new CTDS. Finally we found 15 articles and classified the articles according to the study purpose. Results Out of the 15 articles, 8 were focused on the clinical application including halitosis, cold/heat syndrome, lung cancer, xerostomia etc. Other 5 articles were aimed at evaluating and improving reliability of CTDS. The other 2 articles were studied for development of differential diagnostic criteria on tongue coating thickness. Conclusion We found out that until now the researches on clinical application of CTDS mainly had been performed for producing a variety of CTDSs. Considering the importance of the tongue color in the traditional Korean medicine, we suggest that at first standard operating procedure for CTDS be developed and researches to develop differential diagnostic criteria on tongue body/coating color be performed and then explore its applications.

• 동의생리병리학회지
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• 제30권6호
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• pp.419-425
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• 2016

This study analyzed research methodologies based on network pharmacology to build a new system architecture optimized for Korean Medicine research. Results form studies using network pharmacology were collected and analyzed to evaluate the strength and weakness. Finally, an improved system architecture was proposed. Whether the predicted effects of drugs or herbs from network pharmacological analyses were in agreement with those from conventioanl knowledge of Korean Medicine was evaluated. These results were used to verify the applicability of research methodologies to the modern pharmacology and Korean Medicine respectively. Eighteen papers using TCMSP were collected and analyzed. The results suggest that the research methodology based on network pharmacology is appropriate only for the modern pharmacology but not for Korean Medicine. Information about compound-compound, herb-herb and drug-compound interactions need to be considered. We propose the modified system architecture with those information.

• 대한한의진단학회지
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• 제16권2호
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• pp.33-46
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• 2012

Purpose : Nowadays excrement-related disease that repeats constipation and diarrhea is on the increase due to the change of dietary and lack of exercise, etc. We analyzed Bangyakhappyeon in order to find out the materia medica which is used for the excrement patterns. Methods : The database used in present thesisis consist of disease pattern, nature of medicinals and materia medica from Bangyakhappyeon was constructed. We analyzed the nature of medicinals of excrement patterns(or symptom) by frequency analysis and network analysis, and also searched main materia medica of excrement patterns(or symptom) by frequency analysis and rule mining. Results : We analyzed the nature of medicinals of excrement patterns(or symptom) in Bangyakhappyeon. And we researched the high frequency materia medica, high specificity materia medica and high frequent paired-drugs as main materia medica of excrement patterns(or symptom). Conclusion : This study found the information about frequency relationship between excrement patterns(or symptoms) and materia medica.