• The Journal of the Society of Korean Medicine Diagnostics
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• v.10 no.1
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• pp.141-152
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• 2006

Background and Objectives: The diagnosis of flood stasis pattern is one of the most important methods in oriental medicine. The aim of this study is to Develop clinically useful questionaire of Blood stasis(瘀血) and quantitative analysis. Methods: The questionnaire including symptoms and signs for diagnosis of Blood stasis pattern is studied by delphi method and statistical analysis. Result: By the delphi method and statistical analysis, 14 Items of questionnaries are choosen. Conclusion: Further research is necessary for improvement reliabilities and validities of the questionnaires of Blood stasis pattern.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.12 no.2
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• pp.74-83
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• 2008

Background and purpose : Health is characterized by variability, and the loss of variability is associated with aging and disease. Normal healthy respiratory patterns are characterized by breath to breath variability. Cold-Heat scores are quantified indices in Korean Medicine. The aim of this study is to analyze relations between 9 respiratory indices (including breath to breath variability) and HRV(heart rate variability). Method : Respiratory data were measured during a period of 15 minutes and transferred to text file. We calculated 9 respiratory parameters using MATLAB 7.1. Afterwards we did correlation analysis of the 9 respiratory indices and HRV. Results and conclusion : Respiratory variability showed significant correlation with HRV.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.12 no.2
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• pp.84-95
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• 2008

Background and purpose: Health is characterized by variability and a loss variability is associated with aging and disease. Normal healthy respiratory patterns are characterized by breath to breath variability. The aim of this study is to analyze Correlation Analysis of 10 respiratory indices(include breath to breath variability) and K-POMS factors score. Method: Respiratory data were measured during 15 minutes and transferred to text file. We calculated 10 respiratory parameters in use of MATLAB7.1. After then do correlation analysis of 10 respiratory indices and K-POMS factors score. Result and conclusion: Respiratory variability is showed significant correlation with vigor factor. Respiratory rate is showed significant correlation with depression factor.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.13 no.2
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• pp.78-87
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• 2009

Background and Objective: We previously developed questionnaire of subhealth status. Developed questionnaire was verified about reliability and validity, but there had a lack of concurrent validity study. On this study, we will verify concurrent Validity of the Korean Version of the Subhealth Questionnaire. Methods: Guibi-tang questionnaire, chalder questionnaire and subhealth questionnaire were applied to 113 college students. After then do correlation analysis, we calculate concurrent validity of that. Results and Conclusions: As a result, subhealth questionnaire between chalder questionnaire, and subhealth questionnaire between Guibi-tang questionnaire had a significant correlation respectively. The result of this study indicate that the developed questionnaire of subhealth status was verified about concurrent validity.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.13 no.1
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• pp.81-88
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• 2009

Purpose : To find out correlation between the Vocal indicators and the 'Buzhongyiqi-Tang questionnaire'. Method : The 'Buzhongyiqi-Tang questionnaire' is given to 83 healthy adults and collected their voice /a/ /e/ /i/ /o/ /u/. Analyze mean values of each factors of the Vocal indicators and the 'Buzhongyiqi-Tang questionnaire'. Conclusions : R square values of /i/ sound in factor 1 and factor 3 of 'Buzhongyiqi-Tang questionnaire' are noticeably high. The value of vocal diagnosis index F0, Fundamental Frequency, in Factor 1 and factor 3 of 'Buzhongyiqi-Tang questionnaire' are considerable. The research has shown conclusively that there is a link between The value of vocal diagnosis index F0 and Factor 3, lung deficiency factor, of 'Buzhongyiqi-Tang questionnaire'.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.11 no.2
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• pp.68-83
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• 2007

Background and Purpose: According to chaos theory, irregular signals of electroencephalogram can interpretated by nonlinear method. Chaotic nonlinear dynamics in EEG can be studied by calculating the correlation dimension. The aim of this study is to analyze EEG by correlation dimension and do Correlation Analysis of correlation dimension and K-POMS factors score. Method: EEG raw data were measured during 15 minutes and choosed 40 seconds. We calculated correlation dimension and used surrogate data method for checking nonlinear data. After then do correlation analysis. Result and Conclusion: Correlation dimension of channel 6, channel 7 and channel 8 are showed significant correlation with vigor factor.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.4
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• pp.417-424
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• 2014

The purpose of this study was to analyze the psychobiological traits of each Sasang typology based on the Sasang Digestive function Inventory (SDFI) which measures the Sasang type-specific pathophysiological digestive symptom. The SDFI, Temperament and Character Inventory (TCI) and NEO-Personality Inventory (NEOPI) were measured with 199 College students. The correlation coefficient was measured with Pearson correlation among SDFI, TCI, and NEOPI. The influence of TCI, sex and age on SDFI and its subscales were analyzed with regression analysis. We also compared the psychobiological features between high and low SDFI score groups to elucidate its psychobiological profiles. There was significant correlation between SDFI and TCI Harm-Avoidance (r=-0.192, p<0.001). The SDFI subscales were showed to have significant correlations with subscales of NEOPI and TCI. The regression model with TCI can explain 8-16% of type-specific pathophysiological digestive symptoms. The low SDFI score group ($39{\pm}9.3$) has significantly (p=0.007) higher than the high SDFI group ($33.6{\pm}12.2$) in TCI Harm-Avoidance which is considered important for the gastrointestinal dysfunction and So-Eum type differentiation. We found that the TCI may explain the mechanism underneath the Sasang type-specific pathophysiological symptom. It was suggested that the TCI Reward-Dependence would be useful for the study on Tae-Eum Sasang type, and its clinical meanings were discussed in the pathophysiological perspectives.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.6
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• pp.630-635
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• 2014

The purpose of this study was to investigate the effects of Naeso-san in interstitial cells of Cajal (ICCs) in murine small intestine. First, we isolated ICCs from murine small intestine. After that, we cultured these cells for 1 days. The patch-clamp technique was applied on ICCs that formed network-like structures in culture (1 days). Spontaneous rhythms were routinely recorded from cultured ICCs under current-clamp conditions, and the ICCs within networks displayed more robust electrical rhythms (pacemaker potentials). To understand the relationship between Naeso-san and pacemaker activity in ICCs, we examined the effects of Naeso-san on pacemaker potentials of ICCs. In current clamp mode (I = 0), the addition of Naeso-san (10 mg/ml - 50 mg/ml) decreased the amplitude and frequency of the pacemaker potentials of ICCs in a dose dependent manner. However, these effects were blocked by intracellular $GDP{\beta}S$, a G-protein inhibitor, and glibenclamide, a specific ATP-sensitive K+ channels blocker. Pretreatment with SQ-22536, an adenylate cyclase inhibitor, did not block the Naeso-san induced effects, whereas pretreatment with ODQ, a guanylate cyclase inhibitor, or L-NAME, an inhibitor of nitric oxide (NO) synthase blocked the Naeso-san induced effects. Our findings provide insight into unraveling the modulation of Naeso-san in pacemaker potentials of ICCs and developing therapeutic agents against gastrointestinal motility disorders.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.2
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• pp.155-159
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• 2012

The purpose of this study was to investigate the anti-cancer effects of Sophorae Radix and the effects of 5-Fluorouracil (5-FU) in human colorectal adenocarcinoma cells (HT-29). We used human colorectal adenocarcinoma cell line, HT-29 cells. We examined cell death by MTT assay and caspase 3 assay with Sophorae Radix. To examine the inhibitory effects of Sophorae Radix, cell cycle (sub G1) analysis was done the HT-29 cells after three days with Sophorae Radix. The reversibility of Sophorae Radix was examined on one day to five days treatment with $150{\mu}g$ Sophorae Radix. Sophorae Radix inhibited the growth of HT-29 cells in a dose-dependent fashion. Also we showed that Sophorae Radix induced apoptosis in HT-29 cells by MTT assay, caspase 3 assay and sub-G1 analysis. Sophorae Radix combined with 5-FU markedly inhibited the growth of HT-29 cells compared to Sophorae Radix or 5-FU alone. After 3 days treatment of HT-29 cells with Sophorae Radix, the fraction of cells in sub-G1 phase was much higher than that of the control group. Our findings provide insight into unraveling the effects of Sophorae Radix in human colorectal adenocarcinoma cells and developing therapeutic agents against colorectal cancer.

• Journal of Acupuncture Research
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• v.33 no.2
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• pp.117-133
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• 2016

Objectives : Traditional Korean Emergency Medicine (EM) has been developing for thousands of years, however its value was not properly considered after 19th century modernization. The purpose of this study was to review the current status of EM in Korean Medicine and suggest methods for improvement. Methods : We performed systematic reviews of the definition, current medical system, and educational curriculum of EM in Western Medicine, traditional Korean and Chinese Medicine, and integrated Western and traditional Chinese medicine with the use of medical classics and text books. We also analyzed the trends in published research articles to discuss the current situation in the field of traditional Korean EM, and to provide methods for its establishment and development with traditional Korean medicine. Results : The definition of EM as a treatment of acute disease shares common understanding among traditional Korean, Chinese, and Western medicine. We presented descriptions of EM in many medical classics, however current law and EM service does not include these. As for the review of publications during the last 20 years, we found 21 articles in several fields that confirmed the need for more investigation. Conclusion : Traditional Korean EM has a long history and clinical experiences that can be found in medical classics, textbooks and research articles. There is an urgent need for more studies on traditional Korean EM as an emergency medical service system, and in terms of educational curriculum and related policies to improve Evidence-Based teaching.