• Transactions of the Korean Society of Mechanical Engineers B
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• v.33 no.1
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• pp.1-8
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• 2009

Recently microscale biofluid flows have been receiving large attention in various research areas. However, most conventional imaging techniques are unsatisfactory due to difficulties encountered in the visualization of microscale biological flows. Recent advances in optics and digital image processing techniques have made it possible to develop several advanced micro-PIV/PTV techniques. They can be used to get quantitative velocity field information of various biofluid flows from visualized images of tracer particles. In this paper, as new advanced micro-PIV techniques suitable for biofluid flow analysis, the basic principle and typical applications of the time-resolved micro-PIV and X-ray micro-PIV methods are explained. As a 3D velocity field measurement technique for measuring microscale flows, holographic micro-PTV method is introduced. These advanced PIV/PTV techniques can be used to reveal the basic physics of various microscale biological flows and will play an important role in visualizing veiled biofluid flow phenomena, for which conventional methods have many difficulties to analyze.

• International Journal of Vascular Biomedical Engineering
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• v.1 no.2
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• pp.42-47
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• 2003

• Journal of the Korean Society of Visualization
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• v.12 no.1
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• pp.7-10
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• 2014

• Parasites, Hosts and Diseases
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• v.53 no.4
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• pp.421-430
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• 2015

The parasite Plasmodium falciparum causes severe malaria and is the most dangerous to humans. However, it exhibits resistance to their drugs. Farnesyltransferase has been identified in pathogenic protozoa of the genera Plasmodium and the target of farnesyltransferase includes Ras family. Therefore, the inhibition of farnesyltransferase has been suggested as a new strategy for the treatment of malaria. However, the exact functional mechanism of this agent is still unknown. In addition, the effect of farnesyltransferase inhibitor (FTIs) on mitochondrial level of malaria parasites is not fully understood. In this study, therefore, the effect of a FTI R115777 on the function of mitochondria of P. falciparum was investigated experimentally. As a result, FTI R115777 was found to suppress the infection rate of malaria parasites under in vitro condition. It also reduces the copy number of mtDNA-encoded cytochrome c oxidase III. In addition, the mitochondrial membrane potential (${\Delta}{\Psi}m$) and the green fluorescence intensity of MitoTracker were decreased by FTI R115777. Chloroquine and atovaquone were measured by the mtDNA copy number as mitochondrial non-specific or specific inhibitor, respectively. Chloroquine did not affect the copy number of mtDNA-encoded cytochrome c oxidase III, while atovaquone induced to change the mtDNA copy number. These results suggest that FTI R115777 has strong influence on the mitochondrial function of P. falciparum. It may have therapeutic potential for malaria by targeting the mitochondria of parasites.

• Proceedings of the KSME Conference
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• 2005.11a
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• pp.257-261
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• 2005

Over the past 30 years, numerical methods and simulation tools for fluid dynamic problems have advanced as a new discipline, namely, computational fluid dynamics (CFD). Although a wide spectrum of flow regimes are encountered in many areas of science and engineering, simulation of compressible flow has been the major driver for developing computational algorithms and tools. This Is probably due to a large demand for predicting the aerodynamic performance characteristics of flight vehicles, such as commercial, military, and space vehicles. As flow analysis is required to be more accurate and computationally efficient for both commercial and mission-oriented applications (such as those encountered in meteorology, aerospace vehicle development, general fluid engineering and biofluid analysis) CFD tools for engineering become increasingly important for predicting safety, performance and cost. This paper presents the author's perspective on the maturity of CFD, especially from an aerospace engineering point of view.

• International Journal of Fluid Machinery and Systems
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• v.1 no.1
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• pp.121-139
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• 2008

For mechanical drive steam turbines, the investigation results of corrosion fatigue phenomena in the transient zone are introduced, including basic phenomena on expansion line and actual design and damage experience. These results were analyzed from the standpoint of stress intensity during the start of cracking. In order to resolve such problems, preventive coating and blade design methods against fouling and corrosive environments are developed. Detailed evaluation test results are given for coating performance using a unique test procedure simulating fouling phenomena and washing conditions. Finally, the results of the successful modification of internals and on-line washing results on site are introduced.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.178.6-178
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• 2001

Silicon-micromachined microneedle for a biofluid diagnosis system is developed. To fabricate microneedles, two sets of processes are used. One is making buried microchannels in silicon wafer using silicon isotropic etch with a SF6 plasma and then trench-refilling. The other is releasing the body of the microneedle by deep silicon etch. The microneedle has a 4 mm-length and about 12 $\mu\textrm{m}$ diameter buried microchannel, a 1.5 mm$\times$l.5 mm-area reservoir, and about 180 $\mu\textrm{m}$thickness body. Preliminary results indicate that microneedles are capable of flowing fluidic samples. The microneedle with a buried microchannel is expected to be integrated with in vitro diagnosis systems and microfluidic devices.

• 한국가시화정보학회:학술대회논문집
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• 2006.12a
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• pp.109-110
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• 2006

Osteoporosis is a deadly bone disease. Early detection of this disease is an important issue for better treatment. There is for a novel technique to identify the disease at early stage. Tremendous research is going on in this aspect. However, more work is required to be done to develop cheap and reliable early detection techniques. In the present study new optical technique has been explored using optical studies.

• Journal of the Korean Mathematical Society
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• v.59 no.3
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• pp.519-548
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• 2022

In this paper, a stabilized-penalized collocated finite volume (SPCFV) scheme is developed and studied for the stationary generalized Navier-Stokes equations with mixed Dirichlet-traction boundary conditions modelling an incompressible biological fluid flow. This method is based on the lowest order approximation (piecewise constants) for both velocity and pressure unknowns. The stabilization-penalization is performed by adding discrete pressure terms to the approximate formulation. These simultaneously involve discrete jump pressures through the interior volume-boundaries and discrete pressures of volumes on the domain boundary. Stability, existence and uniqueness of discrete solutions are established. Moreover, a convergence analysis of the nonlinear solver is also provided. Numerical results from model tests are performed to demonstrate the stability, optimal convergence in the usual L² and discrete H¹ norms as well as robustness of the proposed scheme with respect to the choice of the given traction vector.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2167-2172
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• 2013

Lung cancer remains a major cause of morbidity and mortality worldwide, accounting for more deaths than any other cause. All the clinical practice guidelines recommended against routine screening for lung cancer have cited lack of robust evidence, at least until a few years back. However, the potential to screen lung cancers has received renewed interest due to superior performance of low dose CT (LD-CT) in detecting early stage cancers. The incremental costs and risks involved due to the invasive procedures in the screened population due to a high false positivity rate questions the use of LD-CT scan as a reliable community based screening tool. There is therefore an urgent need to find a less invasive and a more reliable biomarker that is crucial to increase the probability of early lung cancer detection. This can truly make a difference in lung cancer survival and at the same time be more cost and resource utilization effective. Sampling blood serum being minimally invasive, low risk and providing an easy to obtain biofluid, needs to be explored for potential biomarkers. This review discusses the use of circulatory miRNAs that have been able to discriminate lung cancer patients from disease free controls. Several studies conducted recently suggest that circulating miRNAs may have promising future applications for screening and early detection of lung cancer.