• Ecology and Resilient Infrastructure
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• v.1 no.1
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• pp.39-48
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• 2014

In order to establish fundamental data for stream restoration and environmental flow, we investigated optimal ecological flowrate (OEF) and riverine health condition in the Chogang Stream, a tributary to Geum River, Korea. The number of fish individuals sampled in this period were 4,669 in 36 species of 9 families. The most abundant species was Korean chub (Zacco koreanus, 34.0%) followed by pale chub (Z. platypus, 22.6%) and Korean shinner (Coreoleuciscus splendidus, 13.3%). Index of biological integrity (IBI) and qualitative habitat evaluation index (QHEI) values decreased from upstream to downstream along the stream. The estimated IBI value ranged from 27.9 to 38.6 with average 32.2 out of 50, rendering the site ecologically fair to good health conditions. OEF was estimated by the physical habitat simulation system (PHABSIM) using the habitat suitability indexes (HSI) of three fish species Z. koreanus, C. splendidus and Pseudopungtungia nigra selected as indicator species. In Z. koreanus, HSI for flow velocity and water depth were estimated at 0.1 to 0.4 m/s and 0.2 to 0.4 m, respectively. In P. nigra, HSI for flow velocity, water depth and substrate size were estimated at 0.2 to 0.5 m/s and 0.4 to 0.6 m and fine gravel to cobbles, respectively. OEF values increasing from up to downstream was found to increase, weighted usable area (WUA) values increased accordingly.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.2
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• pp.205-210
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• 2018

Salvianolic acid B, which is a compound in the Salvia miltiorrhiza, has diverse biological activities, In particular, the antioxidative effects were reported to be involved in the protection of hepatocytes, neurons, and various cell types. On the other hand, some phenolic compounds, such as ferulic acid, which is regarded as an antioxidant, plays a pro-oxidative role in the specific transitional metal environment, which could explain the anticancer effect. This study examined the pro-oxidative effects of salvianolic acid B in the presence of $Cu^{2+}$. Treatment with both salvianolic acid B and $Cu^{2+}$ induced the transition of supercoiled DNA to the open circular or linear form but not in the sole salvianolic acid B or $Cu^{2+}$ treatments. Salvianolic acid B reduced the $Cu^{2+}$ to $Cu^+$ using neocuproine, a $Cu^+$ specific chelator. In addition, catalase, an enzyme that breaks down the $H_2O_2$ to water and molecular oxygen, inhibited the DNA breakage. $H_2O_2$, a reactive oxygen species, has detrimental effects on biological molecules, particularly DNA. Overall, the reduction of $Cu^{2+}$ by salvianolic acid B could lead to the production of $H_2O_2$ followed by DNA breakage. These results suggest that the pro-oxidative effects could be the one of the anti-cancer mechanisms of salvianolic acid B, which remains to be explained.

• Applied Chemistry for Engineering
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• v.25 no.4
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• pp.401-408
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• 2014

In membrane bio-reactor (MBR), the aeration control is one of the important independent variables to decrease fouling and to save energy with shear stress change on the membrane surface. The paper was carried out for numerical simulation of 3-dimensional fluid flow phenomena of the cylindrical bioreactor with submerged flat membranes equipped in the center and supplied the air from the bottom by using the COMSOL program. The viscosity and temperature of solution were assumed to be constant, and the specific air demand based on permeate volume ($SAD_p$) defined as scouring air per permeate rates was used as a variable. The calculated CFD velocities were compared with those of the velocity meter measurement and video image analysis, respectively. The results were good agreement each other within 11% error. For fluid flow in the reactor the liquid velocity increased rapidly between the air diffuser and membrane module, but the velocity decreased during flowing of the membrane module. Also, the velocity increased as it was near from the reactor wall to the central axis. The calculated shear stress on the membrane surface showed the highest value at the center part of the module bottom side and increased as aeration rate increased. Especially, the wall shear stress increased dramatically as the aeration rate increased from 0.15 to 0.25 L/min.

• Journal of Korea Society of Industrial Information Systems
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• v.16 no.2
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• pp.19-29
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• 2011

Due to the development of web technologies and the increasing use of smart devices such as smart phone, in recent various web services are widely used in many application fields. In this environment, the topic of supporting personalized and intelligent web services have been actively researched, and an analysis technique on a web-click stream generated from web usage logs is one of the essential techniques related to the topic. In this paper, for efficient analyzing a web-click stream of sequences, a sequential pattern mining technique is proposed, which satisfies the basic requirements for data stream processing and finds a refined mining result. For this purpose, a concept of interesting sequential patterns with a time-interval constraint is defined, which uses not on1y the order of items in a sequential pattern but also their generation times. In addition, A mining method to find the interesting sequential patterns efficiently over a data stream such as a web-click stream is proposed. The proposed method can be effectively used to various computing application fields such as E-commerce, bio-informatics, and USN environments, which generate data as a form of data streams.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.12B
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• pp.1450-1458
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• 2011

The HPcN (Hybrid & high Performance Convergence Network) in research networks means environment which can provide both computing resource such as supercomputer, cluster and network resource to application researchers in the field of medical, bio, aerospace and e-science. The most representative research network in Korea, KREONET has been developing following technologies through the HERO (Hybrid Networking project for research oriented infrastructure) from 200S. First, we have constructed and deployed a control plane technology which can provide a connection oriented network dynamically. Second, the integrated resource management system technology has been developing for reservation and allocation of both computing and network resources, whenever users want to utilize them. In this paper, a testbed network is presented, which is possible to reserve and allocate network resource using the integrated resource management system. We reserve network resource through GNSI (Grid Network Service Interface) messages between GRS (Global Resource Scheduler) and NRM (Network Resource Manager) and allocate network resource through GUNI (Grid User Network Interface) messages between the NRM (network resource manager) and routers, based on reservation information provided from a user on the web portal. It is confirmed that GUNI interface messages are delivered from the NRM to each router at the starting of reservation time and traffic is transmitted through LSP allocated by the NRM.

• Korean Journal of Environmental Agriculture
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• v.26 no.2
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• pp.124-130
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• 2007

Excess application of paper mill sludge (PMS) in field can limit phosphorus uptake by crops because aluminum presented in the sludge can fix or adsorb available phosphorus which is necessary for crop growth. To investigate phosphorus (P) adsorption characteristics of PMS, we examined P adsorption maximum $(X_m)$ using Langmuir isotherm and P adsorption energy constant $(K_f)$ using Freundlich isotherm for PMS without alum, PMS with alum, and composted PMS with alum through a laboratory incubation test. The maximum P adsorption capacities were 800 ${\mu}g\;g^{-1}$ in soil, 47 $mg\;g^{-1}$ in PMS without alum and 61 $mg\;g^{-1}$ in PMS with alum. P adsorption capacity with alum treatment for PMS increased by 30%. That of PMS compost was 68 $mg\;g^{-1}$ and showed that composting increases 11% of P adsorption. Freundlich constant $K_f$ was 22 in check soil, while $K_f$ values in PMS without alum and in PMS with alum were 398 and 426, respectively. After composting, $K_f$ value of PMS compost significantly increased as 1,819. In conclusions, p adsorption capacity for PMS were increased by alum treatment or composting and therefore excess or continuous land application of alum-amended or composted PMS can limit P uptake for crops by reducing available P in sell.

• Archives of Pharmacal Research
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• v.22 no.5
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• pp.437-447
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• 1999

Type I diabetes, also known as insulin-dependent diabetes mellitus (IDDM) results from the destruction of insulin-producing pancreatic $\beta$ cells by a progressive $\beta$ cell-specific autoimmune process. The pathogenesis of autoimmune IDDM has been extensively studied for the past two decades using animal models such as the non-obese diabetic (NOD) mouse and the Bio-Breeding (BB) rat. However, the initial events that trigger the immune responses leading to the selective destruction of the $\beta$ cells are poorly understood. It is thought that $\beta$ cell auto-antigens are involved in the triggering of $\beta$ cell-specific autoimmunity. Among a dozen putative $\beta$ cell autoantigens, glutamic acid decarboxylase (GAD) has bee proposed as perhaps the strongest candidate in both humans and the NOD mouse. In the NOD mouse, GAD, as compared with other $\beta$ cell autoantigens, provokes the earliest T cell proliferative response. The suppression of GAD expression in the $\beta$ cells results in the prevention of autoimmune diabetes in NOD mice. In addition, the major populations of cells infiltrating the iselts during the early stage of insulitis in BB rats and NOD mice are macrophages and dendritic cells. The inactivation of macrophages in NOD mice results in the prevention of T cell mediated autoimmune diabetes. Macrophages are primary contributors to the creation of the immune environment conducive to the development and activation of $\beta$cell-specific Th1-type CD4+ T cells and CD8+ cytotoxic T cells that cause autoimmune diabetes in NOD mice. CD4+ and CD8+ T cells are both believed to be important for the destruction of $\beta$ cells. These cells, as final effectors, can kill the insulin-producing $\beta$ cells by the induction of apoptosis. In addition, CD8+ cytotoxic T cells release granzyme and cytolysin (perforin), which are also toxic to $\beta$ cells. In this way, macrophages, CD4+ T cells and CD8+ T cells act synergistically to kill the $\beta$ cells in conjunction with $\beta$ cell autoantigens and MHC class I and II antigens, resulting in the onset of autoimmune type I diabetes.

• Journal of Digital Contents Society
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• v.17 no.1
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• pp.51-57
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• 2016

Distributed Computing attempts to harness a massive computing power using a great numbers of idle PCs resource distributed linked to the internet and processes a variety of applications parallel way such as bio, climate, cryptology, and astronomy. In this paper, we develop internet-distributed computing environment, so that we can analyze High Resolution Rainfall Prediction application in meteorological field. For analyze the rainfall forecast in Korea peninsula, we used QPM(Quantitative Precipitation Model) that is a mesoscale forecasting model. It needs to a lot of time to construct model which consisted of 27KM grid spacing, also the efficiency is degraded. On the other hand, based on this model it is easy to understand the distribution of rainfall calculated in accordance with the detailed topography of the area represented by a small terrain model reflecting the effects 3km radius of detail and terrain can improve the computational efficiency. The model is broken down into detailed area greater the required parallelism and increases the number of compute nodes that efficiency is increased linearly.. This model is distributed divided in two sub-grid distributed units of work to be done in the domain of $20{\times}20$ is networked computing resources.

• Journal of Life Science
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• v.23 no.7
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• pp.913-918
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• 2013

The applicability of the ultrasonic wave method to the extraction of useful components from seaweeds was investigated. Extracts from freeze-dried Ecklonia cava powder were prepared with hot water ($65^{\circ}C$), water ($24^{\circ}C$), 50% ethanol, and 100% ethanol, and ultrasonic extraction was also performed. The content of phenolic compounds and the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and tyrosinase inhibitory activity of the extracts were analyzed, and differences in the data obtained by the ultrasonic extraction and the traditional extraction methods were compared. The phenolic content in the E. cava extract by ultrasonic extraction (142.80 mg/g) was approximately 14 times higher than the phenolic content in the hot water extract (10.03 mg/g). The DPPH radical scavenging and the tyrosinase inhibitory activities of the ultrasonic extract were approximately 4 times and 14 times higher than the hot water extracts, respectively. The correlation between the phenolic content and the DPPH radical scavenging activity ($R^2$=99.47) and between the phenolic content and the tyrosinase inhibitory activity ($R^2$=99.99) was very high. These results indicate that ultrasonic extraction is more suitable than traditional extraction for the extraction of useful components from E. cava.

• Journal of Wetlands Research
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• v.16 no.2
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• pp.251-259
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• 2014

Recently, wetland and paddy wetland are being highlighted as the international environmental issues. However, research system which can assess paddy wetland is lacking. Thus, the purpose of this study is to assess the value of paddy wetland by applying RAM to paddy wetland. In addition, we would like to use this study as the data to establish assessment method for paddy wetland. 16 sites were selected as research targets based on altitude and soil. As the results of wetland assessment, 16 research target sites had total score of 212~227 and the average of 2.17~2.50. It was similar to those of Lacustrine Wetlands, Palustrine Wetland and Riverine Wetland which were sites in previous studies. The value could be recognized as the wetland. However, there was no difference in assessment results based on altitude and soil. It was found that all conservation values were the same. The factor the most closely affecting conservation value was the area. However, there was limitation to apply existing wetland assessment system to paddy wetland. In order to assess paddy wetland, factors such as rice farming methods, topography, vegetation, growth environment and biodiversity should be added. It was thought to supplement wetland assessment system through various further studies.