• 대한화장품학회지
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• 제30권3호
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• pp.415-418
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• 2004

알부틴은 glycosylated hydroquinone으로 여러 식물들에서, 고농도로 발견되며 비교적 안정한 물질이다. 이는 멜라닌화를 억제하는 작용이 있는 것으로 보고되어 있고, 베타-글루코시다제에 의해 포도당과 hydroquinone으로 쉽게 가수분해된다. Hydroquinone 역시 우수한 항멜라닌화 작용을 가지나, 여러 가지 부작용들로 인해 그 사용이 제한적이거나 주의를 요한다. 이 연구는 알부틴과 베타-글루코시다제를 포함하는 미백 화장품이 자외선 조사로 유도된 색소 침착을 억제하는 효과를 알아보고자 하였다. 대상은 10명의 건강한 성인으로 등 부위에 자외선 B를 조사하여 색소 침착 병변을 만들었고 이 병변들은 세 그룹: 알부틴과 베타-글루코시다제를 함유하는 미백 화장품 도포군, vehicle 대조군, no-application 대조군으로 나누었다. 알부틴과 베타-글주코시다제를 함유하는 미백 화장품 도포군은 no-application 대조군에 비교하여 색소 침착을 $50.17\%$ 억제하였다(N = 10:P<0.05). 따라서 알부틴과 베타-글루코시다제를 함유하는 미백 화장품이 기미 등 자외선 조사로 유도되거나 악화되는 과색소성 질환에 효과적으로 사용될 수 있겠다.

• 생태와환경
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• 제35권4호통권100호
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• pp.326-330
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• 2002

습지토양을 두 가지 방법으로 멸균한 후, 미생물 효소활성도의 변화를 알아보았다. 단기 멸균의 효과는 톨루엔을 가하여 알아 보았고, 장기적인 효과는 감마선 조사를 이용하였다. 처리된 시료에서 ${\beta}$-glucosidase, ${\beta}$-xylosidase, cellobiohydrolase, phosphatase, arylsulfatase, N -acetylglucosaminidase 활성도를 methylumbelliferyl 계열의 인공기질을 사용하여 측정한 후 공시료와 비교하였다. 톨루엔을 가한 경우 효소에 따라 다른 반응을 보였다. 예를 들어, 처리에 의하여phosphatase의 활성은 증가하였으나 반대로 ${\beta}$-glucosidase와 arylsulfatasem의 활성도는 감소하였다. 감마선 조사는 모든 효소의 활성을 40-80%정도 감소시켰다. 본 연구의 전반적인 결과에 의하면, 적어도 단기적으로는 다량의 효소가 미생물 체외에서 안정적으로 존재하나, 장기적으로는de-novo 합성이 중요함을 알 수 있었다.

• The Korean Journal of Physiology and Pharmacology
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• 제17권4호
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• pp.267-274
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• 2013

A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties, could ameliorate radiation-induced pulmonary inflammation and fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior to a single irradiation and for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage accumulation, interstitial edema, alveolar septal thickness, perivascular fibrosis, and collapse in radiation-treated lungs were inhibited by curcumin administration. Radiation-induced transforming growth factor-${\beta}1$ (TGF-${\beta}1$), connective tissue growth factor (CTGF) expression, and collagen accumulation were also inhibited by curcumin. Moreover, western blot analysis revealed that curcumin lowered radiation-induced increases of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), TNF receptor 1 (TNFR1), and cyclooxygenase-2 (COX-2). Curcumin also inhibited the nuclear translocation of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) p65 in radiation-treated lungs. These results indicate that long-term curcumin administration may reduce lung inflammation and fibrosis caused by radiation treatment.

• Journal of Radiation Protection and Research
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• 제46권4호
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• pp.194-203
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• 2021

Background: Surface soil radiation monitoring around nuclear facilities is important to classify and characterize the contaminated areas. A scanning and direct measurement technique can survey the sites rapidly before starting sampling analysis. Materials and Methods: Regarding this, we test and suggest a measurement technique for gross alpha/beta and ⁹⁰Sr activities in surface soil based on a mobile ZnS(Ag)/PVT (polyvinyltoluene) array and a handheld PVT rod, respectively. To detect ⁹⁰Sr selectively in soil mixed with naturally occurring radioactive materials, chosen energy channel counts from the multichannel analyzers were used instead of whole channel counts. Soil samples contaminated with exempt liquid ⁹⁰Sr with 1 Bq·g^-1, 3 Bq·g^-1, and 10 Bq·g^-1 were prepared and hardened by flocculation. Results and Discussion: The mobile ZnS(Ag)/PVT array could discriminate gross alpha, gross beta, and gamma radiation by the different pulse-shaped signal features of each sensor material. If the array is deployed on a vehicle, the scan minimum detectable concentration (MDC) range will be about 0.11-0.17 Bq·g^-1 at 18 km·h^-1 speed, highly sensitive to actual sites. The handheld PVT rod with 12 mm (Φ) × 20 mm (H) size can directly measure ⁹⁰Sr selectively if channels on which energies are from 1,470 and 2,279 keV are gated, minimizing crossdetection of other radionuclides. These methods were verified by measuring soil samples fabricated with homogeneous ⁹⁰Sr concentrations, showing static MDC of 2.16 Bq·g^-1 at a measurement time of 300 seconds. Conclusion: Based on the results, comprehensive procedures using these detectors are suggested to optimize soil sites survey.

• Radiation Oncology Journal
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• 제29권4호
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• pp.219-227
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• 2011

Purpose: This study evaluated the treatment effectiveness and proper radiation dose of helical tomotherapy (HT) in spine oligometastases from gastrointestinal cancers. Materials and Methods: From 2006 to 2010, 20 gastrointestinal cancer patients were treated with HT for spine oligometastases (31 spine lesions). The gross tumor volume (GTV) was the tumor evident from magnetic resonance imaging images fused with simulation computed tomography images. Clinical target volume (CTV) encompassed involved vertebral bodies or dorsal elements. We assumed that the planning target volume was equal to the CTV. We assessed local control rate after HT for 31 spine metastases. Pain response was scored by using a numeric pain intensity scale (NPIS, from 0 to 10). Results: Spine metastatic lesions were treated with median dose of 40 Gy (range, 24 to 51 Gy) and median 5 Gy per fraction (range, 2.5 to 8 Gy) to GTV with median 8 fractions (range, 3 to 20 fraction). Median biologically equivalent dose (BED, ${\alpha}/{\beta}$ = 10 Gy) was 52 $Gy_{10}$ (range, 37.5 to 76.8 $Gy_{10}$) to GTV. Six month local control rate for spine metastasis was 90.3%. Overall infield failure rate was 15% and outfield failure rate was 75%. Most patients showed pain relief after HT (93.8%). Median local recurrence free survival was 3 months. BED over 57 $Gy_{10}$ and oligometastases were identified as prognostic factors associated with improved local progression free survival (p = 0.012, P = 0.041). Conclusion: HT was capable of delivering higher BED to metastatic lesions in close proximity of the spinal cord. Spine metastases from gastrointestinal tumors were sensitive to high dose radiation, and BED (${\alpha}/{\beta}$ = 10 Gy) higher than 57 $Gy_{10}$ could improve local control.

• 분석과학
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• 제24권6호
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• pp.414-420
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• 2011

본 연구에서는 알파선, 베타선 및 감마선 방출 핵종에 대한 검출기를 선정하여, 방사성 시료의 핵종분석을 위한 방사선 측정 시스템을 연구하고 구성하였다. 그리고 알파, 베타 및 감마 측정 시스템에 대한 검출효율을 교정하였다. 방사선 검출기에 대한 안정도를 확보하기 위해 품질관리 프로그램이 확립되었다. 또한 분석결과에 대한 신뢰도를 확보하기 위해 시료유형에 따른 최소검출방사능을 구하였다.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1999년도 제38차 춘계학술대회
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• pp.209-221
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• 1999

Coronary restenosis is still regarded as Achilles' Hill of interventional cardiology despite relentless efforts of many investigators. Recent experimental and clinical studies have suggested that both gamma and beta radiation can reduce restenosis after angioplasty. Currently, intracoronary brachytherapy for the prevention of restenosis has become a new evolving treatment modality in interventional cardiology. This report discusses a physical aspect of gamma and beta radiation, initial clinical results and delivery systems used in intracoronary brachytherapy. We shall take a brief overview of methods and their advantages in intra-coronary brachytherapy. Future work should provide further insight for the best way of treating restenosis.

• Carbon letters
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• 제15권4호
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• pp.262-267
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• 2014

Pyrolized fuel oil (PFO) was reformed by novel electron beam (E-beam) radiation, and the elemental composition, chemical bonds, average molecular weight, solubility, softening point, yields, and density of the modified patches were characterized. These properties of modified pitch were dependent on the reforming method (heat or E-beam radiation treatment) and absorbed dose. Aromaticity ($F_a$), average molecular weight, solubility, softening point, and density increased in proportion to the absorbed dose of E-beam radiation, with the exception of the highest absorbed dose, due to modification by free radical polymerization and the powerful energy intensity of E-beam treatment. The H/C ratio and yield exhibited the opposite trend for the same reason. These results indicate that novel E-beam radiation reforming is suitable for the preparation of aromatic pitch with a high ${\beta}$-resin content.

• Nuclear Engineering and Technology
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• 제5권2호
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• pp.83-86
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• 1973

Acetylbenzoylaconine, 2-aminoethylisothiouronium bromide hydrobromide (AET), $\beta$-mercaptoethylamine HCI (MEA), L-thiazolidine-4-carboxylic acid (thioproline)의 Co-60 감마선에 대한 방어효과를 5-6주된 백색마우스를 이용하여 연구하였다. 백색마우스에 대한 acetylbenzoylaconine의 독성실험 결과 LD$_{50}$은 2.5mg/kg이었다. 위의 4종 실험약제를 백색마우스 복강내에 주사한 후 Co-60 감마선 800 rad를 전신조사하고 30일간 계속 관찰하여 실험군들에 대한 생존계수를 계산하였다. 이 생존계수치로 방사선장해에 대한 방어계수를 계산한 결과 acetylbenzoylaconine AET, MEA, thioproline에 대해 각각 2.24, 2.95, 2.78, 1.23 으로, acetylbenzoylaconine은 백색마우스를 Co-60 감마선장해로 부터 방어할 수 있는 능력이 있음을 알았다.

• Journal of Radiation Protection and Research
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• 제19권3호
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• pp.179-188
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• 1994

생쥐의 난소에 미치는 방사선의 조직학적 및 기능적 영향을 조사하기 위하여 2.88Gy 및 7.2Gy의 방사선(Co-60)을 전신조사하였다. $7{\mu}m$ 두께의 조직절편을 제작하여 조직학적 관찰을 하였고, 방사면역측정 법을 이용하여 난소마쇄현탁액내 프로게스테론, 테스토스테론 및 에스트라디올을 정량하였다. 방사선조사로 유강소난포 및 무강소난포가 공히 높은 폐쇄율을 보였고, 난포내 프로게스테론의 농도가 증가되었으며 테스토스테론 및 에스트라디올의 농도는 감소되었다. 즉, 방사선을 조사함으로써 난소내 난포세포인 협막세포에 영향이 미친 결과 $3{\beta}-HSD(3{\beta}-hydroxysteroid\;dehydrogenase) $ 및 isomerase의 활성이 억제 혹은 둔화되어 테스토스테론 및 에스트라디올의 합성이 저하되었고 그 결과 난포의 폐쇄가 가속화되었다고 사료된다.