• Title/Summary/Keyword: Berber

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A Study on the Migration of the Berbers in France and their Current Status (프랑스 내 '베르베르인'의 이민 과정과 그 위상에 관한 연구)

  • Lim, Gi-Dae
    • Cross-Cultural Studies
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    • v.42
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    • pp.131-163
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    • 2016
  • The issue of migrants has always been a social problem in France. Particularly, migration issues from the Maghreb region to multicultural France are recognized as topics of confrontation and conflict. One of the many reasons would be that the Maghreb migrant issue is interpreted with a hostile or conflicting 'Arab-Islam' meaning in the West. Therefore, the naming of natives from this region as 'Arab-Maghrebis' has become a common phenomenon. However, deeper understanding of the Maghreb region will explain that such naming could produce a number of problems. This is because the native Maghrebis, not only in the Maghreb region but also in France, are Berbers. Among the various Berbers, the Kabyles are in many ways different from the Arabs in their language, culture, and way of thinking. Apart from the difference in their lifestyle, there is a deep anti-Arab sentiment within them that represents their resistance against the hundreds-of-years Arab domination. This feature has also been used as France's tool of colonial division policy during the colonization period. The purpose of this study is to discuss the settlement process of the Kabyles in France by paying attention to their features. The Kabyles were the first to migrate to France among the natives of the Maghreb region. This study focuses on the process of their migration and search for identity, as well as how they continued to form community and the Berber's cultural movement. Through these series of processes, it is possible to point out the fictitious claim in France and in Korea that Maghrebis are Arab-Muslims. Lastly, the current use of Berber language in France and Algeria is not a coincidental phenomenon, rather it has a connection with the prolonged cultural movement and the settlement process of the migrants in France.

microRNA Expression Profile in Patients with Stage II Colorectal Cancer: A Turkish Referral Center Study

  • Tanoglu, Alpaslan;Balta, Ahmet Ziya;Berber, Ufuk;Ozdemir, Yavuz;Emirzeoglu, Levent;Sayilir, Abdurrahim;Sucullu, Ilker
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.5
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    • pp.1851-1855
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    • 2015
  • Background: There are increasing data about microRNAs (miRNA) in the literature, providing abundant evidence that they play important roles in pathogenesis and development of colorectal cancer. In this study, we aimed to investigate the miRNA expression profiles in surgically resected specimens of patients with recurrent and non-recurrent colorectal cancer. Materials and Methods: The study population included 40 patients with stage II colorectal cancer (20 patients with recurrent tumors, and 20 sex and age matched patients without recurrence), who underwent curative colectomy between 2004 and 2011 without adjuvant therapy. Expression of 16 miRNAs (miRNA-9, 21, 30d, 31, 106a, 127, 133a, 133b, 135b, 143, 145, 155, 182, 200a, 200c, 362) was verified by quantitative real-time polymerase chain reaction (qRT-PCR) in all resected colon cancer tissue samples and in corresponding normal colonic tissues. Data analyses were carried out using SPSS 15 software. Values were statistically significantly changed in 40 cancer tissues when compared to the corresponding 40 normal colonic tissues (p<0.001). MiR-30d, miR-133a, miR-143, miR-145 and miR-362 expression was statistically significantly downregulated in 40 resected colorectal cancer tissue samples (p<0.001). When we compared subgroups, miRNA expression profiles of 20 recurrent cancer tissues were similar to all 40 cancer tissues. However in 20 non-recurrent cancer tissues, miR-133a expression was not significantly downregulated, moreover miR-133b expression was significantly upregulated (p<0.05). Conclusions: Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.

CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) Polymorphisms and Bladder Cancer Risk in a Turkish Population

  • Berber, Ufuk;Yilmaz, Ismail;Yilmaz, Omer;Haholu, Aptullah;Kucukodaci, Zafer;Ates, Ferhat;Demirel, Dilaver
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.6
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    • pp.3925-3929
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    • 2013
  • We aimed to investigate bladder cancer risk with reference to polymorphic variants of cytochrome p450 (CYP) 1A1, CYP1B1, glutathione S-transferase (GST) M1, and GSTT1 genes in a case control study. Polymorphisms were examined in 114 bladder cancer patients and 114 age and sex-matched cancer-free subjects. Genotypes were determined using allele specific PCR for CYP1A1 and CYP1B1 genes, and by multiplex PCR and melting curve analysis for GSTM1 and GSTT1 genes. Our results revealed a statistically significant increased bladder cancer risk for GSTT1 null genotype carriers with an odds ratio of 3.06 (95% confidence interval=1.39-6.74, p=0.006). Differences of CYP1A1, CYP1B1 and GSTM1 genotype frequencies were not statistically significant between patients and controls. However, the specific combination of GSTM1 null, GSTT1 null, and CYP1B1 codon 119 risk allele carriers and specific combination of GSTM1 present, GSTT1 null, and CYP1B1 432 risk allele carriers exhibited increased cancer risk in the combined analysis. We did not observe any association between different genotype groups and prognostic tumor characteristics of bladder cancer. Our results indicate that inherited absence of GSTT1 gene may be associated with bladder cancer susceptibility, and specific combinations of GSTM1, GSTT1 and CYP1B1 gene polymorphisms may modify bladder cancer risk in the Turkish population, without any association being observed for CYP1A1 gene polymorphism and bladder cancer risk.