• 대한후두음성언어의학회지
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• 제30권1호
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• pp.34-38
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• 2019

Background and Objectives : The aim of this study is verify the correlation between benign laryngeal mucosal disease and metabolic syndrome. Materials and Method : Data for patients diagnosed with benign laryngeal mucosal disease and metabolic syndrome from 2006 to 2015 were selected for analysis from the National Health Insurance Service database. Results : The prevalence of Metabolic syndrome was 2,179,785 out of 6,437,051 patients (33.86%). The prevalence of benign laryngeal mucosal disease was 516,594 out of 6,437,051 patients (8.03%). Metabolic syndrome was a risk factor for benign laryngeal mucosal disease [hazard ratio: 0.99, 95% confidence interval: 0.984-0.997] after adjusting for age and other variables including age, gender, smoking status, alcohol intake, exercise, body mass index, and diabetes. The number of metabolic syndrome components was also risk factor. Conclusion : Metabolic syndrome was related to the incidence of benign laryngeal mucosal disease. However this correlation did not seem to be high.

• 대한후두음성언어의학회지
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• 제20권1호
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• pp.25-30
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• 2009

Introduction: 585 nm Pulsed dye laser (PDL) laryngeal surgery is based on the photodynamic characteristics of selective photothermolysis and photoangiolysis and recently considered to be the treatment for a variety of benign laryngeal disease. Objective: To review the indications and outcome of office-based 585nm PDL surgery and summarize new developments. Method: Retrospective study involving 402 patients was performed, The PDL surgery could be applied to various laryngeal diseases such as laryngeal papilloma, vocal fold dysplasia, laryngeal granuloma, vocal polyp, capillarectasia, scarred vocal fold and sulcus vocalis. Results : The physiologic properties of the vascular specificity of PDL provide many advantages and appear to be effective for laryngeal treatment. The PDL resulted in precise, selective coagulation of the microvasculature without damage to the surrounding tissue. Therefore PDL surgery is safe and effective for office-based treatment of benign laryngeal disease and for all patients regardless of their overall medical condition. Conclusion: PDL surgery provides potential benefits and advantage for treating common benign laryngeal disease.

• 대한후두음성언어의학회지
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• 제24권1호
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• pp.47-50
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• 2013

Background and Objectives:The purpose of this study is to find features in acoustics and to learn useful features of parameters in order to distinguish laryngeal diseases through many acoustic variables. Materials and Methods:The subjects of this study were 125-male patients who had been diagnosed with vocal nodule, vocal polyp, vocal cyst, Reinke's edema, leukoplakia. To research the features of each disease in acoustics, they are measured 34 parameters by using MDVP. Results:It is clear that in order to see a meaning result when distinguishing laryngeal diseases, $F_0$, $MF_0$, $T_0$, Fhi, Flo, PER variables are significant (p<.05). It means that variables related to fundamental frequency are important to anticipate which group will be diagnosed with Reinke's edema and leukoplakia. vAm had an effect on getting a significant result in terms of amplitude perturbation parameters, which is useful to distinguish between laryngeal polyp/cyst and other laryngeal disease (p<.05). ATRI made a significant result in related to tremor parameters, which is useful to distinguish between laryngeal polyp and other laryngeal disease (p<.05). Conclusion:$F_0$, $MF_0$, $T_0$, Fhi, Flo, PER, vAm, ATRI might be meaningful parameters distinguishing pathologic from benign laryngeal diseases. Especially, the vAm and ATRI are an important factor when forecasting which group would be diagnosed with vocal polyp.

• 대한기관식도과학회지
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• 제7권2호
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• pp.161-167
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• 2001

Background and Objectives： Total laryngectomy is often required for advanced cases. But this operation induced the many inconvenience of basic daily life. Early diagnosis of laryngeal cancer is very important to prevent from this disastrous condition. In this point of view, mass screening test for early detection of laryngeal cancer is necessary. Screening test using voice has many advantages such as simple, less interventional. Voice collection by Automatic Response System(ARS) is comfortable and easy to got acoustic sample. Thus author tried to got the acoustic parameters which can differentiate normal, benign. and malignant laryngeal diseases and also checked the availability of parameters on neural network system. Materials and Methods: Author has evaluated the voice from 17 laryngeal cancer patients and 45 benign laryngeal disease patients who visited at Department of Otolaryngology, Pusan National University Hospital from May 1998 to April 2001, and 15 normal control. Author chose the sir Parameters (Jitt. vFo, Shim, vAm, NHR, SPI) that was thought to be related with voice collected by ARS among thirty-three parameters analysed by a Multi-Dimensional Voice Program (MDVP). Two-step neural network was used for the availability of six parameters. Results: The detection rate of normal voice by ARS voice analysis is 78.5% and detection rate of abnormal voice was 97.1 o/o. Among abnormal voice, the detection rate of benign laryngeal diseases and laryngeal cancers were 82.4 o/o, 70.6% respectively. Conclusion: Author concluded that six parameters and Matlab based neural network software may be effective in development of acoustic screening system for laryngeal cancer and further study should be necessary for development of new acoustic parameters.

• 대한후두음성언어의학회지
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• 제19권2호
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• pp.142-145
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• 2008

Background and Object: The aim of this study is to evaluate the change of patient's subjective voice handicap index (VHI) and acoustic parameters before and after laryngeal microsurgery for benign vocal cord disease. Materials and Method: We analyzed 78 patients who received laryngeal microsurgery for benign vocal cord disease from January 2004 to February 2007 retrospectively. There were 28 vocal polyp, 40 vocal nodule, 5 intracordal cyst and 5 Reinke's edema. Jitter, shimmer, harmony to noise ratio (HNR) were analyzed before surgery and 2-3months after surgery using the Doctor's speech science program. The voice handicap index introduced by the Pittsburgh Voice Center was used to examine patient's subjective change of voice quality. Results: Acoustic parameters of jitter, shimmer and HNR were improved in patients with vocal polyp and vocal nodule after surgery. The acoustic parameters were not improved in patients with Reinke's edema, statistically. Only jitter was improved significantly in patients with intracordal cyst (p<0.05). The VHI was significantly improved after surgery. The change of jitter and shimmer was significantly correlated with the change of VHI after surgery. Conclusion: The acoustic parameters and VHI were significantly improved in patients with benign vocal disease after laryngeal microsurgery.

• 대한후두음성언어의학회지
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• 제14권1호
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• pp.16-25
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• 2003

후두암은 유병율이 높지만 조기에 발견하면 90% 이상의 치유율과 발성기능의 보존이 가능하며 현재 음성분석을 이용한 진단법이 시도되고 있으나 정립된 선별검사법은 없는 실정이다. 성문전도검사(electroglottography, EGG)는 성대의 진동양상을 알 수 있는 비침습적 검사로서 발성과 음성합성의 연구에 많이 사용되고 있다. 본 연구는 EGG에서 관찰되는 파라미터들을 다층 퍼셉트론(multilayer perceptron)구조의 신경회로망(artificial neural network)으로 감별하는 기법을 이용하여 후두암 감별법에 대한 연구로서 부산대학교병원을 내원한 후두암 환자 10명과 양성후두질환 26명을 대상으로 새로 고안한 Electroglottograph(v1.0)를 이용하여 검사하고 이의 임상적 유용성을 평가하였다. EGG 파라미터인 closed quotient(CQ), speed quotient(SQ), speed index(SI), fundamental frequency(F0), Jitter, Shimmer 등은 MATLAB 6.5 (Mathwork, Inc.)로 작성한 분석 프로그램을 이용하여 추출하였다. 각 환자에서 추출된 EGG 파라미터들을 다층 퍼셉트론 구조의 신경회로망으로 감별하였다. CQ는 각 질환군 간에 유의한 차이가 없었지만 SQ, SI, Jitter, Shimmer 등은 성대질환의 특성에 따라 유의한 차이를 보였다. 신경회로망에서 감별한 결과 CQ를 제외한 SQ, SI, Jitter, Shimmer 등에서 71.3-90%의 후두암의 감별율을 보였다. 또한 SQ, SI, Jitter, Shimmer를 3개씩 조합한 실험에서는 SQ-Jitter-Shimmer와 SQ-SI-Shimmer의 후두암의 감별율이 93%로 가장 높았고, SQ-SI-Jitter 90.9%, SI-Jitter-Shimmer 88.6%로 전체적으로 85% 이상의 높은 감별율을 나타내었다. 이러한 결과는 EGG검사와 신경회로망을 이용한 양성과 악성 후두질환의 감별이 가능함을 시사한다. 향후 성대 질환의 병태생리를 대변할 수 있는 파라미터가 추가로 개발되고 분류 알고리듬이 개선된다면 EGG를 이용한 성대질환의 감별 진단이 보다 정확해질 것으로 사료되었다.

• 대한의용생체공학회:의공학회지
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• 제23권3호
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• pp.197-205
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• 2002

본 연구에서는 잡음이 존재하는 공간에서 획득한 음성신호로부터 후두질환을 감별진단 할 수 있는 분류기를 구현하였다. 이를 위해 후두질환 환자로부터 수집한 /아/ 모음에 잡음을 혼입하여 음성 신호를 획득하였고, 여러 가지 후두질환을 감별진단 할 수 있는 파라미터를 추출하였으며. 이를 입력으로 하는 계층적 신경회로망을 구성하여 후두질환을 감별진단 하도록 하였다. 감별진단용 분류기는 다섯 단계의 계층적 신경회로망으로 구성하였다 첫 번째 신경회로망은 정상 양성 후두질환과 악성 후두질환을. 두 번째 신경회로망은 정상과 양성 후두질환을 감별진단 하도록 하였다 그리고 세 번째 신경회로망은 양성 후두질환 중 후두용. 성대결절 후두마비를 감별진단 하도록 하였으며. 네 번째와 다섯 번째 신경회로망은 성문암 1-4기를 감별진단 하도록 구성하였다. 분류기에 적용된 신경회로망은 다층퍼셉트론 구조로써 역전파 알고리듬으로 학습시켰으며, 선형변환 표준점수변환 등 전처리과정을 적용하여 분류기의 성능을 개선하였다. 후두질환의 감별진단 결과 후두용 88.23%. 정상. 성대결절. 후두마비 100%. 성문암 1기 90%, 성문암 2-4기 100%의 감별진단율을 관찰할 수 있었다.

• 대한후두음성언어의학회지
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• 제7권1호
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• pp.27-31
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• 1996

The voice of aged persons is known generally to be somewhat different from that of other adults, suggesting that laryngeal change occurs with advancing age. However, because knowledge of the voice characteristics of aged persons is limited, it is difficult to judge whether their voices arc normal. Chart review and laryngoscopic examination from ninety-one patients with hoarseness over the age of 60(1st group) and one hundred sixteen patients with hoarseness below the age of 50(2nd group) were done to define aging related voice disorders. The following results were obtained. 1) Associated diseases related to laryngeal disease were hypertension(12%), pulmonary disease(4.4%), thyroid disease(1.1%) in 1st group and hypertension(9.5%), thyroid disease(1.7%) in 2nd group. 2) The underlying diseases causing hoarseness in order of frequency were benign vocal fold lesion(37.7%), inflammatory disease(36.8%), functional dysphonia(17%) in 1st group and benign vocal fold lesion(43.6%), functional dysphonia(26.3%), inflammatory disease(16.5%) in 2nd group. 3) In stroboscopic findings, atrophy and sulcus of vocal cords are more prevalent in males than in females and edema of vocal cords is more common in females. Generally the voice characteristics of aged persons depend on the mass of the vocal folds which may be decreased through atrophy or be increased by edema. However, other factors such as systemic diseases, drug side effects and compensatory mechanism to presbylaryngis must be taken into account in diagnosing and treating voice disorders in aged persons.

• 대한기관식도과학회지
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• 제2권1호
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• pp.135-139
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• 1996

Laryngeal amyloidosis is a rare benign disease. It is characterized by extracellular deposition of homogeneous and eosinophilic protein material in the form of fibrils. Diagnosis of this disease is made by histologic examination of involved tissue. It is ususlly primary or localized but rarely associated with a systemic or generalized disease. We present a case of primary laryngeal amyloidosis that was treated with KTP 532 laser vaporization.

• 대한후두음성언어의학회지
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• 제26권1호
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• pp.34-39
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• 2015

후두 미세 수술을 받은 환자에서 수술 전과 후 전체적인 음성 장애 지수를 비교했을 때 모두 호전이 있는 것으로 나타났다. 영역별로는 기능적, 물리적 영역에서는 남녀간의 차이가 없었으나 감성적 영역에서는 여자보다 남자에서 수술 후 만족도가 큰 것으로 나타났다. 이번 연구를 통해 음성 장애 지수가 음성의 상태를 모두 대변할 수는 없지만 객관적인 음향, 공기역학적 검사로 평가할 수 없었던 음성 장애에 대한 환자의 인식 정도를 정량화하여 평가할 수 있는 편리한 도구임을 확인 할 수 있었다.