• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제6권1호
• /
• pp.65-73
• /
• 1995

본 연구에서는 ADHD로 진단된 5세에서 11세 연령 범위의 임상 환아 집단을 대상으로 부모 훈련과 약물(메칠펜)을 병행한 치료와 약물만을 단독으로 사용한 치료 효과를 비교하였다. 8주간의 부모 훈련과 약물 치료를 실시한 결과, ADHD 아동들이 학교나 가정에서 보이는 주의산만함, 충동성, 과잉활동성 등 문제 행동을 감소시키고 부모의 양육 스트레스를 감소시키는데 부모 훈련과 약물 치료를 병행하는 것이 약물치료를 단독으로 사용하는 것보다 매우 효과적인 것으로 나타났다. 약물 치료만을 사용한 경우, 부모가 평정한 아동의 문제 행동 잠수와 양육 스트레스 점수상에서는 거의 변화가 없는 반면, 교사의 평정치와 TOVA 검사의 Reaction Time과 Variability 점수가 비록 통계적으로 유의미하지는 않았으나 약물 치료후에 정상 범위로 감소되는 경향이 있었다. 이러한 결과는 메칠펜이 주의력 결핍 중상의 치료에 효과적일 수 있으나, ADHD 아동이 학교나 가정에서 보이는 문제 행동을 변화시키고 부모나 교사가 ADHD 아동에 대해 가지고 있는 부정적인 인식을 변화시킬 뿐만 아니라 부모들의 자녀양육 스트레스를 감소시키기 위해서는 부모 훈련이 반드시 필요하다는 점을 시사해 주었다.

• 한국환경보건학회지
• /
• 제31권4호
• /
• pp.266-279
• /
• 2005

The present study was conducted to analyze the causes of stress on the part of Korean radiological technologists depending on their working environments. For this purpose, 890 questionnaires were distributed to and collected from radiological technologists who were working at 44 general hospitals in 16 cities and provinces of Korea during the period from the mid July to the end of August 2003. The collected data were compared between regions, divided into the capital, metropolitan, medium and small cities, whose results are as follows: 1. As factors affecting working conditions, drinking was found to exert more influence on radiological technologists in small- and medium-sized cities, while loyalty to immediate seniors and organizations was the one producing greater influence on them in metropolitan cities than other cities. Overall, position, job satisfaction and physical condition seemed to have a great effect on them (p<0.001).2. In terms of factors related to their roles, job satisfaction and physical condition played in general a greater role for radiological technologists (p<0.001). Immediate seniors and behavioral conducts were also found to have a lot influence on them (p<0.01).3. As for job conflicts, the kind of medical institutions seemed to exercise a great deal of impact on radiological technologists (p<0.05), while colleagues, immediate seniors, job satisfaction and physical conditions also produced a lot of influence on them as a whole (p<0.001).4. Regarding job autonomy, radiological technologists were found to have been less influenced by position in metropolitan cities and by immediate seniors in the capital city (p<0.01). As a whole, however, age and job satisfaction acted as decisive factors of influence on them (p<0.001). 5. Among factors related to job burden, gender played a bigger role for radiological technologists in metropolitan cities as the kind of medical institutions did in small- and medium-sized cities. Centrally, job satisfaction and behavioral conducts exercised a great impact on them (p<0.001).6. Job stability seemed to be more immensely linked to gender and physical conditions in metropolitan cities whereas position did more in the capital city. In general, how ever, job satisfaction produced a far-reaching (p<0.001).

• Molecules and Cells
• /
• 제40권2호
• /
• pp.133-142
• /
• 2017

Previous studies have shown that bone marrow mesenchymal stromal cell (MSC) transplantation significantly improves the recovery of neurological function in a rat model of intracerebral hemorrhage. Potential repair mechanisms involve anti-inflammation, anti-apoptosis and angiogenesis. However, few studies have focused on the effects of MSCs on inducible nitric oxide synthase (iNOS) expression and subsequent peroxynitrite formation after hypertensive intracerebral hemorrhage (HICH). In this study, MSCs were transplanted intracerebrally into rats 6 hours after HICH. The modified neurological severity score and the modified limb placing test were used to measure behavioral outcomes. Blood-brain barrier disruption and neuronal loss were measured by zonula occludens-1 (ZO-1) and neuronal nucleus (NeuN) expression, respectively. Concomitant edema formation was evaluated by H&E staining and brain water content. The effect of MSCs treatment on neuroinflammation was analyzed by immunohistochemical analysis or polymerase chain reaction of CD68, Iba1, iNOS expression and subsequent peroxynitrite formation, and by an enzyme-linked immunosorbent assay of pro-inflammatory factors (IL-$1{\beta}$ and TNF-${\alpha}$). The MSCs-treated HICH group showed better performance on behavioral scores and lower brain water content compared to controls. Moreover, the MSC injection increased NeuN and ZO-1 expression measured by immunochemistry/immunofluorescence. Furthermore, MSCs reduced not only levels of CD68, Iba1 and pro-inflammatory factors, but it also inhibited iNOS expression and peroxynitrite formation in perihematomal regions. The results suggest that intracerebral administration of MSCs accelerates neurological function recovery in HICH rats. This may result from the ability of MSCs to suppress inflammation, at least in part, by inhibiting iNOS expression and subsequent peroxynitrite formation.

• 대한간호학회지
• /
• 제27권1호
• /
• pp.128-140
• /
• 1997

When women are removed with their matrix which is a emotionally significant organ of symbol in psychologically adapting themselves to mother and woman, that is threatened and injured with woman role decisively. This study tried to find the efficient nursing intervention method to maintain and promote their health, to cope with health problem, and to inquire into the loss experience of women with hysterectomy by using the phenomenological method. The analysis of the data was made through the phenomenological analytic method suggested by Giorgi. The result of the study was as follows : The factors which have influence on the loss experience of the subjects are an offer of information, support system, age, occupation, economic situation, family history, character, season, the existence of ovary and religion. The loss experience of matrix was expressed in lingual, reactions to the loss of function, sex, body change and husband, in behavioral behaviors in emotion and body. The loss of matrix of the subjects was relived by religion. perineorrhapy, exercise, reading, watching video and diet. The subjects each showed ways of reaction of fatalism, giving-up, coping on the loss experience of matrix. In conclusion, since we ascertained that the nursing in the process of recovery decide the quality of life. though women with hysterectomy undergo various loss experience and adapt to it in the end, it is necessary to give them enough information and educate husband, having on important effect on the loss experience, to be a good supporter, And technically skilled nurses of consultant are thought to be able to contrive better qualitative life of women with hysterectomy as an important bridge between the subjects and their required information, since the nurses have their well-formed position of relationship of confidence through continuous contact with patients and their family.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 2005년도 춘계학술대회
• /
• pp.53-60
• /
• 2005

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting $1\%$ of the population above the age of 65 and is characterized by a selective loss of dopaminergic neurons in the substantia nigra pars compacta. Although the underlying cause of dopaminergic cell death or the mechanism by which these cells degenerate is still not clearly understood, oxidative stress, mitochondrial dysfunction, and protein misfolding are thought to play important roles in the dopaminergic degeneration in PD. Tetrahydrobiopterin (BH4) is synthesized exclusively in the monoaminergic, including dopaminergic, cells and serves as an endogenous and obligatory cofactor for syntheses of the potential oxidative stressors dopamine and nitric oxide. In addition to its contribution toward the syntheses of these two potentially toxic molecules, BH4 itself can directly generate oxidative stress. BH4 undergoes oxidation during the hydroxylation reaction as well as nonenzymatic autooxidation to produce hydrogen peroxide and superoxide radical. We have previously suggested BH4 as an endogenous molecule responsible for the dopaminergic neurodegeneration. BH4 exerts selective toxicity to dopamine-producing cells via generation of oxidative stress, mitochondrial dysfunction, and apoptosis. BH4 also induces morphological, biochemical, and behavioral characteristics associated with PD in vivo. BH4 as well as enzyme activity and gene expression of GTP cyclohydrolase I, the rate-limiting enzyme in BH4 synthesis pathway, are readily upregulated by cellular changes such as calcium influx and by various stimuli including stress situations. This points to the possibility that cellular availability of BH4 might be increased in aberrant conditions, leading to increased extracellular BH4 subsequent degeneration. The fact that BH4 is specifically and endogenously synthesized in dopaminergic cells, Is readily upregulated, and generates oxidative stress-related cell death provides physical relevance of this molecule as an attractive candidate with which to explain the mechanism of pathogenesis of PD.

• Journal of Nutrition and Health
• /
• 제16권4호
• /
• pp.243-252
• /
• 1983

This study was undertaken to invesigate the effect of early nutritional deprivation and environment on neurotransmitter concentrations and behavior in later life. The restoring process of rats fed foods ad libitum after 50% restriction of the casein or the Korean diet during the prenatal and/or the lactating periods was observed. There were two rearing conditions, isolated and enriched, after weaning. Behavioral development was measured by the Y- shaped water maze and the open field test. The neurotransmitters were analyzed after sacrifice at the age of 21 weeks. The results are summarized as follows. 1) The body weight impairment by dietary restriction during the prenatal and lactating periods could be restored within 18 weeks after weaning in case of living in a classical cage. The effect of quantitative restriction was bigger in the Korean diet than in the casein diet. 2) The brain weight was decreased by nutritional deprivation. Environmental enrichment increased it slightly. 3) The concentration of neurotransmitters, norepinephrine, dopamine, and serotonin, were not shown any traces of the dietary restriction at the age of 21 weeks. 4) In the maze test, the deprived rats made more errors than the nourished and the rats fed the Korean diet more than those fed the cascin dict. The environmental enrichment could decrease the number of errors. 5) In the open field test, the dietary deprived groups showed less reaction time, more squares entered in the field, and less number of fecal boli than the nourished among the environmentally isolated rats. However, rats living in the enriched cage without experience of nutritional stress showed the lowest emotionality and the elevated exploratory activity.

• 한국인지과학회:학술대회논문집
• /
• 한국인지과학회 2005년도 춘계학술대회
• /
• pp.151-153
• /
• 2005

We investigated the brain substrate of repetition priming on the implicit memory taskusing low-resolution electromagnetic tomography (LORETA) with high-density 128 channel EEG and individual MRI as a realistic head model. Thirteen right-handed, healthy subjects performed a word/nonword discrimination task, in which the words and nonwords were presented visually,and some of the words appeared twice with a lag of one or five items. All of the subjects exhibited repetition priming with respect to the behavioral data, in which a faster reaction time was observed to the repeated word (old word) than to the first presentation of the word (new word). The old words elicited more positive-going potentials than the new words, beginning at 200 ms and lasting until 500 ms post-stimulus. We conducted source reconstruction using LORETA at a latency of 400 ms with the peak mean global field potentials and used statistical parametric mapping for the statistical analysis. We found that the source elicited by the old words exhibited a statistically significant current density reduction in the left inferior frontal gyrus. This is the first study to investigate the generators of repetition priming using voxel-by-voxel statistical mapping of the current density with individual MRI and high-density EEG.

• 한국도서관정보학회지
• /
• 제43권4호
• /
• pp.139-159
• /
• 2012

이 연구는 태도에 대한 이해를 높이고 여러 학자들이 개발한 독서태도 모형의 비교와 분석을 통하여 독서태도 조사를 위한 설문 내용을 개발하고자 한 것이다. 태도는 개인이 어떠한 사건이나 문제, 사람이나 사물 등에 대하여 어떤 인식과 감정을 가지고 있으며, 또한 그 대상에 대해 가지고 있는 반응의 준비상태를 말하는 것이다. 태도는 정서, 인지, 행동으로 구성되어 있으며, 태도는 경험이나 학습에 의하거나 가치판단에 의해서 형성되는 것이다. 독서태도는 독서에 대한 신념이나 의견을 나타내는 인지적 요소와 독서에 대한 감정이나 평가를 나타내는 정의적 요소, 실질적으로 독서하려는 행동이나 의도를 나타내는 행동적 요소의 3가지 요소로 구성되어 있다. 독서태도 모형의 구성요소를 분석해보면 독서태도 형성에 영향을 미치는 요인은 독서경험, 독서결과에 대한 신념, 타인의 기대에 대한 신념, 독서환경 등을 들 수 있다. 따라서, 독서태도 조사를 위한 설문의 내용은 독서경험, 독서결과에 대한 신념, 타인의 기대에 대한 신념, 독서환경 등이 포함되어야 한다.

• 한국실내디자인학회논문집
• /
• 제22권3호
• /
• pp.61-69
• /
• 2013

The conventional boundaries between art and technology are being torn down by the development of science in the 21st century. It is fulfilling the convergence to emphasize two-way communication. This research is to study the aesthetic experience of the space design which appeared in the playful space of art and technology. The purpose of this study is to analyze the expression and characteristics of the art and technology applied for the playful space, to present the intrinsic value of aesthetic experience, and finally to focus on the necessity of aesthetic experience in modern society. In the Playful space of art and technology, research methods and settings of the range to study the aesthetic experience are as follows: First, establish a theoretical consideration about the concept and characteristics of the aesthetic experience, based on Philosophical theories. Second, analyze the meaning of art and the expression elements and characteristics by using technology. Third, discuss the concept of play and features of aesthetic experience in the playful space. Fourth, investigate analysis of the case studies, focused on the architecture and space design announced through the media recently. Finally, proposes the value for the applicability of aesthetic experience that appears playful space works affect us. I saw the aesthetic experience that appears playful space independent reaction and lead to behavioral changes and physical experience to maximize the effectiveness of participation. and it is to maximize a pleasurable experience, while increasing the commitment to participate in the space. Expressions using art and technology are activated by stimulation of the emotional experience, creating a new aesthetic experience. In the modern, the new environment is being created by the convergence of art and technology and it stimulates the imagination of art. Also, it has been newly regulated the meaning of human emotions and consciousness in the new space, surrounded by technology.

• 대한치과마취과학회지
• /
• 제12권2호
• /
• pp.105-109
• /
• 2012

The gag reflex is a physiological reaction, but, an exaggerated gag reflex can be a severe limitation not only to treat dental caries but also to do oral exam. Procedures such as surface anesthesia of the palate and pharyngeral area, sedation, or general anesthesia can be options as behavioral management. But, there are no golden rule for the sever gag reflex patients. We present a case report of propofol intravenous sedation using TCI pump for simple dental treatment. A 44-year-old man, who had past history of general anesthesia for dental treatment because of severe gag reflex, was scheduled intravenous sedation for simple dental treatment. After 8 hour fasting he entered the clinic for persons with disabilities. We explained about intravenous deep sedation and got informed consent. First, we kept intravenous catheter (22G) in the arm and started monitoring ECG, non-invasive blood pressure, pulse oximetry and end-tidal $CO_2$ through nasal cannula. We started propofol infusion with TCI pump at the target concentration of 3 mcg/ml. The patient became sedated, but he showed involuntary movement during dental treatment, so we increased the target concentration to 4 mcg/ml. We finished the dental treatment without complications during 30 min. And after 40 min recovery room stay he was discharged without any complications.