• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1833-1840
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• 2013

Metastasis is one of the hallmarks of malignant neoplasms and is the leading cause of death in many cancer patients. A major challenge in cancer treatment is to find better ways to specifically target tumor metastasis. In this study, the anti-metastatic potential of the methanolic extract of Rhizophora apiculata (R.apiculata) was evaluated using the B16F-10 melanoma induced lung metastasis model in C57BL/6 mice. Metastasis was induced in C57BL/6 mice by injecting highly metastatic B16F-10 melanoma cells through the lateral tail vein. Simultaneous treatment with R.apiculata extract (10 mg/kg b.wt (intraperitoneal) significantly (p<0.01) inhibited pulmonary tumor nodule formation (41.1 %) and also increased the life span (survival rate) 107.3 % of metastatic tumor bearing animals. The administration of R.apiculata extract significantly (p<0.01) reduced biochemical parameters such as lung collagen hydroxyproline, hexosamine, uronic acid content, serum nitric oxide (NO), ${\gamma}$-glutamyl transpeptidase (GGT) and sialic acid levels when compared to metastasis controls. These results correlated with lung histopathology analysis of R.apiculata extract treated mice showing reduction in lung metastasis and tumor masses. Taken together, our findings support that R.apiculata extract could be used as a potential anti-metastasis agent against lung cancer.

• 건축역사연구
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• 제22권6호
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• pp.47-58
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• 2013

The purpose of this study is to analyze the cause of damage to the three storied stone pagoda of Bulguksa temple in GyeongJu. This report is attempted to making reinforcement and conservation plan through investigating and analyzing the cause of damage to that. The damage is caused by occurring of stress, degrading of stone strength, changing of underground soil structure, natural disasters and so on. Compressive stress, shear stress, bending stress and lateral pressure affected to the pagoda since built up. Ultrasonic examination data tells the strength of the stone. According to this result, strength of the stereobate stone materials is enough to support the weight of the upper ones. But we could found many other factors of the damage could consider, for example the problems occurred on building the pagoda construction and the weakness of the stone material(soft rock). And many environmental factors being changed in soil structure(subsidence of soil and degradation of bearing power of soil and freezing and melting of soil) can be seen as the cause of the damage. Natural disasters like earthquake, lightning and heavy rain were also thought to give direct impact to the damage. At last Concentration of compressive stress caused the crack and exfoliation on the stone materials and shear stress, bending stress and lateral pressure were main causes of the stereobate stone materials shearing.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.1008-1013
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• 2003

This paper concerns the structural characteristic analysis and evaluation on the hydrostatic guide way and feeding system of a high precision centerless grinder for machining ferrules. In order to realize the required accuracy of ferrules with sub-micron order, the axial stiffness and motion accuracy of feeding system have to become higher level than those of existing centerless grinders. Under these points of view, the physical prototype of feeding system consisted of steel bed, hydrostatic guide way and ballscrew feeding mechanism is designed and manufactured for trial. Experimental results show that the axial and vertical stiffnesses of the physical prototype are very low as compared with those design values. In this paper, to reveal the cause of these stiffness difference, the structural deformations on the virtual prototype of feeding system are analyzed based on the finite element method under experimental conditions. The simulated results illustrate that the deformation of front ballscrew support-bearing bracket is the main cause of reduction in the axial stiffness of feeding system, and the deflection of bed structure and the bending deformation of hydrostatic guide rails are the main causes of reduction in the vertical stiffness of feeding system.

• 대한기계학회논문집A
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• 제28권7호
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• pp.896-903
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• 2004

This paper proposes the structural characteristic analysis and evaluation on the hydrostatic guide way and feeding system of a high-precision centerless grinder for machining ferrules. In order to realize the required accuracy of ferrules with sub-micron order, the axial stiffness and motion accuracy of feeding system have to become higher level than those of existing centerless grinders. Under these points of view, the physical prototype of feeding system composed of steel bed, hydrostatic guide way and ballscrew feeding mechanism is designed and manufactured for trial. Experimental results show that the axial and vertical stiffnesses of the physical prototype are very low as compared with those design values. In this paper, to reveal the cause of these stiffness difference, the structural deformations on the virtual prototype of feeding system are analyzed based on the finite element method under experimental conditions. The simulated results illustrate that the deformation of front ballscrew support-bearing bracket is the main cause of reduction in the axial stiffness of feeding system, and the deflection of bed structure and the bending deformation of hydrostatic guide rails are the main causes of reduction in the vertical stiffness of feeding system.

• 한국주조공학회지
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• 제30권4호
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• pp.130-136
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• 2010

Sulfide segregation behavior, characteristics of solidification microstructure and compositional distribution in the riser/castings junction of heavy-section main bearing support (MBS) steel castings were investigated; Sulfide streaks of A segregation were formed in the transitional region from columnar grain to coarse equiaxed grain and floated with aggregation of the dendritic free crystal. Solute segregation behaviors of elements Si, P and S were V shape negative segregation from the bottom of the castings to upper part of the riser with the reference of vertical center-line of the specimen block. Those of elements C and Mn were V shape negative segregation in the main body and A shape positive segregation in the riser of the casting. Just beneath the pipe shrinkage in the riser segregation ratio of each element was the highest, and that of S was 3.6 times higher, C 3.3 times, P 2.1 times, Si 1.6 times and Mn 1.0 times respectively. [Mn/S] ratio of the specimen block was distributed in the wide range of 20~275.

• 한국지반신소재학회논문집
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• 제6권2호
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• pp.9-15
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• 2007

콘크리트 표면 차수벽형 석괴댐(CRFD)에서의 표층부기초지반은 콘크리트 차수벽을 균등하게 지지할 수 있는 지지력과 사면안정을 위한 소요강도를 확보하여야 하며, 콘크리트 차수벽의 누수시 세립토의 유실을 억제할 수 있는 차수성을 유지하여야 한다. 본 연구에서는 사면부 표층기초지반에 대하여 시험시공을 실시하여 다짐회수에 대한 제체의 변위량과 현장다짐밀도의 변화, 살수량에 따른 함수비 변화 등을 측정하여 효율적인 다짐관리기준을 마련하고자 하였다. 일련의 현장다짐시험결과 CFRD에서의 표층부기초지반은 층별 포설두께 및 다짐회수에 따라 영향 받고 있음을 확인할 수 있었다.

• Structural Engineering and Mechanics
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• 제50권1호
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• pp.19-36
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• 2014

This paper focuses on a model order reduction (MOR) for large-scale rotordynamic systems by using finite element discretization. Typical rotor-bearing systems consist of a rotor, built-on parts, and a support system. These systems require careful consideration in their dynamic analysis modeling because they include unsymmetrical stiffness, localized nonproportional damping, and frequency-dependent gyroscopic effects. Because of this complex geometry, the finite element model under consideration may have a very large number of degrees of freedom. Thus, the repeated dynamic analyses used to investigate the critical speeds, stability, and unbalanced response are computationally very expensive to complete within a practical design cycle. In this study, we demonstrate that a Krylov subspace-based MOR via moment matching significantly speeds up the rotordynamic analyses needed to check the whirling frequencies and critical speeds of large rotor systems. This approach is very efficient, because it is possible to repeat the dynamic simulation with the help of a reduced system by changing the operating rotational speed, which can be preserved as a parameter in the process of model reduction. Two examples of rotordynamic systems show that the suggested MOR provides a significant reduction in computational cost for a Campbell diagram analysis, while maintaining accuracy comparable to that of the original systems.

• 설비공학논문집
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• 제17권4호
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• pp.325-332
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• 2005

This paper addresses the development of a scroll expander for power generation from relatively low temperature steam source. It has a double-sided orbiting scroll member so that no thrust bearing is needed to support the base plate of the orbiting scroll. Three power transmission shafts are placed at the periphery of the orbiting scroll base plate, and these shafts can also function as anti-rotation devices. Final output is obtained from the main central shaft engaged with the three power transmission shafts through gear assembly. The clearance between the fixed and orbiting scroll elements was estimated by comparing measurement of the mass flow rate with calculation results of a computer simulation. Due to large clearance, the expander total and volumetric efficiencies were measured to be $34\%\;and\;43\%$, respectively. It has been shown through the computer simulation that the total and volumetric efficiencies could be improved to $65\%\;and\;83\%$, respectively, if the current clearance is reduced by half.

• Archives of Pharmacal Research
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• 제29권2호
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• pp.165-171
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• 2006

Osteoarthritis is thought to be induced by the ageing-related loss of homeostatic balance between degeneration and repair mechanism around cartilage tissue in which inflammatory mediators such as reactive oxygen species, cytokines and prostaglandins are prone to overproduction under undesirable physiological conditions. Phlorotannins are unique polyphenolic compounds bearing dibenzo-1,4-dioxin skeleton which are not found in terrestrial plants but found only in some brown algal species such as Ecklonia and Eisenia families. Phlorotanninrich extracts of Ecklonia cava including LAD103 showed significant antioxidant activities such as DPPH radical scavenging, ferric ion reduction, peroxynitrite scavenging, and inhibition of LDL oxidation, indicating their possible antioxidative interference both in onset and downstream consequences of osteoarthritis. LAD103 also showed significant down regulation of $PGE_2$ generation in LPS-treated RAW 246.7 cells, and significant inhibition of human recombinant interleukin-$1{\alpha}$-induced proteoglycan degradation, indicating its beneficial involvement in pathophysiological consequences of osteoarthritis, the mechanism of which needs further investigation. Since LAD103 showed strong therapeutic potentials in arthritic treatment through several in vitro experiments, it is highly encouraged to perform further mechanistic and efficacy studies.

• 한국생산제조학회지
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• 제25권4호
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• pp.245-252
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• 2016

Girth gears are applied in the mining, cement, and mineral processing industries and used in various types of horizontal mills, rotary dryers and kilns, and other heavy-gear ring applications. The large ring gears are normally fitted outside mills or kilns to provide the primary rotational drive. Recently, an external pinwheel gear set (e-PGS) was introduced to overcome manufacturing problems associated with girth gears. e-PGS is also suitable for low-speed, heavy-duty mechanical transmission and dusty and poor-lubrication conditions. This paper first presents a new profile modification of root relief for the e-PGS cam pinion. We then investigate load-stress factors to estimate the surface fatigue life by varying the shape design parameters. The results show that the contact fatigue life of an e-PGS can be extended significantly by increasing the profile shift coefficient. However, support bearing life of the pinwheel depends more on the contact force distribution than the profile shift coefficient.