• Nutrition Research and Practice
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• 제18권1호
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• pp.62-77
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• 2024

BACKGROUND/OBJECTIVES: Colorectal cancer (CRC) is the third most common cancer worldwide with a high recurrence rate. Oxaliplatin (OXA) resistance is one of the major reasons hindering CRC therapy. β-Carotene (BC) is a provitamin A and is known to have antioxidant and anticancer effects. However, the combined effect of OXA and BC has not been investigated. Therefore, this study investigated the anticancer effects and mechanism of the combination of OXA and BC on CRC. MATERIALS/METHODS: In the present study, the effects of the combination of OXA and BC on cell viability, cell cycle arrest, and cancer stemness were investigated using HCT116, HT29, OXA-resistant cells, and human CRC organoids. RESULTS: The combination of OXA and BC enhanced apoptosis, G₂/M phase cell cycle arrest, and inhibited cancer cell survival in human CRC resistant cells and CRC organoids without toxicity in normal organoids. Cancer stem cell marker expression and self-replicating capacity were suppressed by combined treatment with OXA and BC. Moreover, this combined treatment upregulated apoptosis and the stem cell-related JAK/STAT signaling pathway. CONCLUSIONS: Our results suggest a novel potential role of BC in reducing resistance to OXA, thereby enhances the anticancer effects of OXA. This enhancement is achieved through the regulation of cell cycle, apoptosis, and stemness in CRC.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• 제16권6호
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• pp.231-237
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• 2016

This paper presents a multiband low phase noise CMOS VCO with wide frequency tunability using switched bondwire inductor bank. The combination of bondwire inductor and CMOS switch transistor enhances frequency tunability and improves phase noise characteristics. The proposed multiband VCO operates from 2.3GHz to 6.3GHz with phase noise of -136dBc/Hz and -122dBc/Hz at 1 MHz offset frequency, respectively. Switched bondwire inductor bank shows high quality factor(Q) at each frequency band, which allows better tradeoff between phase noise and power consumption. The proposed VCO is designed in TSMC 0.18um CMOS process and consumes 7.2 mW power resulting in figure of merit(FOM) of -189.3dBc/Hz at 1 MHz offset from 6GHz carrier frequency.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• 제29권4호
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• pp.464-476
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• 2019

Objectives: This study aimed to assess the exposure levels of tollbooth workers to diesel particulate matter using black carbon (BC) and to find the correlations among variables associated with BC using the motor vehicle management act regulated by the Ministry of Land, Infrastructure and Transport. Methods: This study was performed over 14 days at a university in Seoul. BC levels were monitored using an aethalometer and were conducted around the breathing zones of the workers. There were three sampling locations: inside the tollbooth (front gate and rear gate) and an office as a control group. T-test, correlation, and multiple linear regression analysis were performed using SPSS. Results: The geometric mean (GM) of BC_30min concentrations in the exposure group was 2.44 ㎍/㎥, approximately 1.4 times higher than the control group (1.75 ㎍/㎥). The GM of BC_30min concentrations was 2.75 ㎍/㎥ during the heavy traffic time (9-10 am) and 2.30 ㎍/㎥ during non-heavy traffic times (p<0.001). The multiple linear regression analysis shows that the number of all types of vehicles and PM_2.5 concentrations in the atmosphere were factors increasing the GM of BC(ln(BC_30min)) concentrations (adjusted R²=0.42, p<0.001). The workers were constantly exposed to low concentrations (GM of BC_30min=2.44 ㎍/㎥), but they were exposed to peak concentrations instantly (BC_10sec=3545.04 ㎍/㎥). When the GM of BC_30min concentrations was momentarily represented as high, it was identified that a vehicle mainly using diesel fuel or an aging vehicle had passed. Conclusions: A ventilation system should be installed in the closed tollbooth or aging vehicles should be controlled so as not to pass tollbooths.

• Journal of the Institute of Electronics Engineers of Korea TC
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• 제41권10호
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• pp.79-86
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• 2004

This paper proposes a dual band Voltage Controlled Oscillator(VCO) with a standard 0.3${\mu}{\textrm}{m}$ CMOS process to generate 1.07GHz and 2.07GHz. The proposed VCO architecture with 50% duty cycle circuit and a half adder(HA) was capable of producing a frequency two times higher than that of the conventional VCOs. The measurement results demonstrate that the gain of VCO and power dissipation are 561MHz/V and 14.6mW, respectively. The phase noises of the dual band VCO are measured to be -102.55dBc/Hz and -95.88dBc/Hz at 2MHz offset from 1.07GHz and 2.07GHz, respectively.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• 제23권5호
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• pp.97-102
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• 2023

In this paper, we fabricated transmitting and receiving antennas to realize the low cost radar using two receiving antennas and investigated their characteristics. The antennas are designed with MPA(Microstrip Patch Array) structure for the beam concentration in horizon direction and low cost and used Taylor array pattern synthesis to suppress sidelobes. As a results of measurement in the 24GHz ISM band(24.0-24.25GHz), our using band, antenna gains are placed between 15.2 dBi and 16.26 dBi which are satisfied with the design specification of higher than 15dBi and lower than 17dBi. The sidelobes are -13.15 dBc, -13.1 dBc and -12.8 dBc at the operating frequencies of 24.0 GHz, 24.125 GHz and 24.25 GHz repectively, which are satisfied with the specification of lower than -10 dBc.

• 전자공학회논문지 IE
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• 제45권4호
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• pp.1-6
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• 2008

A fast-hopping frequency synthesizer that reduces complexity and power consumption is presented for MB-OFDM UWB applications. The proposed architecture uses 3960 MHz LC VCO, 528 MHz ring oscillator, passive mixer and LC-tuned Q-enhancement BPF to generate Band Group 1 frequencies. The adjacent channel rejection ratio is less than -40 dBc for 3432 MHz and -H dBc for 4488 MHz. A fast switching SCL-tpre MUX is used to produce the required channel output signal and it takes less than 2.2 ns for band switching. The total power consumption is 47.9 mW from a 1.8 V supply.

• Research in Plant Disease
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• 제29권2호
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• pp.188-192
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• 2023

Abiotic and biotic stresses have been a serious threat to crop growth and productivity in the agricultural system. In this study, four strains (HS1, H30-3, KJ40, and BC42), which have biological activities related to disease suppression or alleviation of salinity and drought stresses, were tested for broad-spectrum biocontrol activity against anthracnose caused by Colletotrichum orbiculare, a bacterial fruit blotch caused by Acidovorax citrulli, and Fusarium wilt caused by Fusarium oxysporum in cucumber plants. As a result of test, when the four strains were drenched into the soil, anthracnose in cucumber leaves significantly decrease; strain KJ40 suppressed disease incidence by A. citrulli; strain BC42 significantly reduced bacterial fruit blotch and Fusarium wilt compared to control. Therefore, strain KJ40 could be a biocontrol candidate for controlling anthracnose through induced systemic resistance and the disease caused by A. citrulli as well as alleviating drought stress; strain BC42 has broad-spectrum biocontrol activity against anthracnose, Fusarium wilt, and bacterial fruit blotch.

• JSTS:Journal of Semiconductor Technology and Science
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• 제2권1호
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• pp.41-48
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• 2002

This paper presents a 18-mW, 2.5-㎓ fractional-N frequency synthesizer with l-bit $4^{th}$-order interpolative delta-sigma ($\Delta{\;}$\sum$)modulator to suppress fractional spurious tones while reducing in-band phase noise. A fractional-N frequency synthesizer with a quadruple prescaler has been designed and implemented in a $0.5-\mu\textrm{m}$ 15-GHz $f_t$ BiCMOS. Synthesizing 2.1 GHzwith less than 200 Hz resolution, it exhibits an in-band phase noise of less than -85 dBc/Hz at 1 KHz offset frequency with a reference spur of -85 dBc and no fractional spurs. The synthesizer also shows phase noise of -139 dBc/Hz at an offset frequency of 1.2 MHz from a 2.1GHz center frequency.

• Journal of the Korea Institute of Information and Communication Engineering
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• 제5권4호
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• pp.653-660
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• 2001

In this paper, we designed 2303.15MHz frequency synthesizer for the purpose of the phase noise prediction. For the modeling of phase noise generated in the designed system through introducing the noise-modeling method suggested by Lascari we analyzed a variation of phase noise as according as that of offset frequency. Especially, for the third-order system of the PLL among some kinds of phase noise generated from VCO we analyzed the aspect of 1/f-noise appearing troubles in the low frequency band. Since it is difficult to analyze mathematically 1/f-noise in the third-order system of the PLL, introducing the concept of pseudo-damping factor has made an ease of the access of the 1/f-noise variance. we showed a numerical formula of 1/f-noise variance in the third-order system of the PLL which is compared with that of 1/f-noise variance in the second-order system of the PLL. As a result, In case of txco we found the reduce rapidly along the offset frequency after passed through that phase-noise was -160dBc/Hz before passed through a loop at 10kHz offset frequency and -162.6705dBc/kHz after passed through the loop, -180dBc/Hz at 100kHz offset frequency and -560dBc/kHz after passed through the loop. We can notice that the variance of third-order system more occurs (or the variance of second-order system in connection with noise bandwidth and variance factor of second-order and third-order system.

• Proceedings of the IEEK Conference
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• 대한전자공학회 2003년도 통신소사이어티 추계학술대회논문집
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• pp.37-40
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• 2003

The 1.63㎓, 2.33㎓ dual-band PLL frequency synthesizer has been developed for applications to the miniature repeater. The miniature dual-band repeater will be used at shopping mall, basements and underground parking lots. The in-loop 1.63㎓, 2.33㎓ dual-band PLL frequency synthesizer has been developed by designing Si BJT VCO and PLL loop circuits with Colpitts. The prototype of 1.63㎓, 2.33㎓ dual-band PLL frequency synthesizer of size 19${\times}$19${\times}$8(mm) has shown operating frequencies of 1.63㎓, 2.33㎓ ranges, RF output of 1dBm(PCS), 1dBm(IMT-2000), phase noise of -100 dBc/Hz(PCS), -95dBc/Hz(IMT-2000) at 10KHz offset, harmonics suppression of -24dB c(PCS), -15dBc(IMT-2000).