• Title/Summary/Keyword: Bc1-2

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Lack of Association of the Cyclooxygenase-2 Gene 8473T>C Polymorphism with Breast Cancer Risk: a Meta-analysis

  • Yang, Xi;Zhao, Fen;Li, Yue-Hua;Huang, Min;Huang, Ying;Yi, Cheng
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.22
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    • pp.9693-9698
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    • 2014
  • Background: Associations between the 8473T>C polymorphism (rs5275) in the cyclooxygenase-2 (COX-2) gene and breast cancer (BC) risk are still inconclusive and ambiguous. The aim of this meta-analysis was to comprehensively estimate the genetic risk of 8473T>C polymorphism in the COX-2 gene for BC. Materials and Methods: We searched PubMed, Web of Science, Medline, Chinese biomedical (CBM), Weipu, China national knowledge infrastructure (CNKI), and Wanfang databases, covering all publications (last search was updated on Aug 17, 2014). Statistical analyses were performed using Revman 5.3 and STATA 10.0 software. Results: A total of 6,720 cases and 9,794 controls in 12 studies were included in this study. The results indicated no significant associations between the 8473T>C polymorphism of the COX-2 gene and BC risk for the CC+TC vs TT model (pooled odds ratio (OR)=0.97, 95% confidence interval (CI)=0.90-1.03, and p=0.29). On subgroup analysis, we also found that subdivision on ethnicity among Caucasians, Asians and others also revealed no relationship with BC susceptibility. With the study design (CC+TC vs TT), no significant associations were found in either population-based case-control studies (PCC), or hospital-based case-control studies (HCC). Conclusions: This present meta-analysis suggests that the 8473T>C polymorphism in the COX-2 gene is not a conspicuous low-penetrant risk factor for developing BC.

Optical Method for Measuring Deposition Amount of Black Carbon Particles on Foliar Surface

  • Yamaguchi, Masahiro;Takeda, Kenta;Otani, Yoko;Murao, Naoto;Sase, Hiroyuki;Lenggoro, I. Wuled;Yazaki, Kenichi;Noguchi, Kyotaro;Ishida, Atsushi;Izuta, Takeshi
    • Asian Journal of Atmospheric Environment
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    • v.6 no.4
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    • pp.268-274
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    • 2012
  • To perform quick measurements of black carbon (BC) particles deposited on foliar surfaces of forest tree species, we investigated an optical method for measuring the amount of BC extracted from foliar surfaces and collected on quartz fiber filters. The seedlings of Fagus crenata, Castanopsis sieboldii, Larix kaempferi and Cryptomeria japonica were exposed to submicron BC particles for one growing season (1 June to 7 December 2009). At the end of the growing season, the leaves or needles of the seedlings were harvested and washed with deionized water followed by washing with chloroform to extract the BC particles deposited on the foliar surfaces. The extracted BC particles were collected on a quartz fiber filter. The absorption spectrum of the filters was measured by spectrophotometer with an integrating sphere. To obtain the relationship between the absorbance of the filter and the amount of BC particles on the filter, the amount of BC particles on the filter was determined as that of elemental carbon (EC) measured by a thermal optical method. At wavelengths below 450 nm, the absorption spectrum of the filter showed absorption by biological substances, such as epicuticular wax, resulting in the low coefficient of determination ($R^2$) in the relationship between the amount of EC on the filter ($M_{EC}$, ${\mu}g\;C\;cm^{-2}$ filter area) and the absorbance of the filter. The intercept of the regression line between $M_{EC}$ and the absorbance of the filter at 580 nm ($A_{580}$) was closest to 0. There was a significant linear relationship between the $A_{580}$ and $M_{EC}$ ($R^2$=0.917, p<0.001), suggesting that the amount of BC particles collected on the filter can be predicted from the absorbance. This optical method might serve as a simple, fast and cost-effective technique for measuring the amount of BC on foliar surfaces.

Associations between single-nucleotide polymorphisms of the interleukin-18 gene and breast cancer in Iraqi women

  • Zakariya, Bilal Fadil;Almohaidi, Asmaa M. Salih;Simsek, Secil Akilli;Kamal, Areege Mustafa;Al-Dabbagh, Wijdan H.;Al-Waysi, Safaa A.
    • Genomics & Informatics
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    • v.20 no.2
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    • pp.18.1-18.7
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    • 2022
  • According to long-term projections, by 2030, the world's population is predicted to reach 7.5 billion individuals, and there will be roughly 27 million new cancer cases diagnosed. The global burden of breast cancer (BC) is expected to rise. According to the Ministry of Health-Iraqi Cancer Registry, cancer is the second largest cause of death after cardiovascular disease. This study investigated the interleukin-18 (IL18) single-nucleotide polymorphisms (SNPs) -607C/A rs1946518 and -137G/C rs187238 using the sequence-specific amplification-polymerase chain reaction approach. Regarding the position -607C/A, there was a highly significant difference between the observed and expected frequencies in patients and controls (χ2 = 3.16 and χ2 = 16.5), respectively. The AA and CA genotypes were associated with significantly increased BC risk (odds ratio [OR], 3.68; p = 0.004 and OR, 2.83; p = 0.04, respectively). Women with the A allele had a 5.03-fold increased susceptibility to BC. The C allele may be a protective allele against BC (OR, 0.19). Although position -137G/C showed no significant differences in the CC genotype distribution (p = 0.18), the frequency of the CC genotype was significantly higher in patients than in controls. In contrast, patients had a significantly higher frequency of GC genotypes than controls (p = 0.04), which was associated with an increased risk of developing BC (OR, 2.63). The G allele frequency was significantly lower in patients than in controls (55.0% vs. 76.2%, respectively). This SNP may be considered a common genotype in the Iraqi population, with the wild-type G allele having a protective function (OR, 0.19) and the mutant C allele having an environmental effect (OR, 2.63).

Studies on the Hereditary Properties of SSR Marker in Silkworm (Bombyx mori L.)

  • Li Muwang;Li Minghui;Miao Xuexia;Lu Cheng;Huang Yongping
    • International Journal of Industrial Entomology and Biomaterials
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    • v.11 no.1
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    • pp.49-55
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    • 2005
  • Two BC1 group, c108 $\times$ (p50 $\times$ c108) and p50 $\times$ (p50 $\times$ c108), one group of F$_{2}$ progeny, (p50 $\times$ c108) F$_{2}$ ,and 3 SSR markers, F10539, FlO626 and FlO618 were used to test the hereditary properties of SSR markers in silkworm. FI0539, FlO626 were proved to be linkage, and FlO618 was proved to be independent to those two markers. According to Mendel's law, the recombinant value between F10539, FlO626 was calculated in all of these groups, and they were 8.55$\%$ (c108BC1), 8.02$\%$ (p50BC1) and 7.81 $\%$ (F$_{2}$) respectively. There was dominant difference among the crossing-over value using paired-samples tests by SPSS 10.0 software. This research proved that SSR markers were co-dominant in B. mori too, and F 2 progeny could be used to construct SSR linkage map although B. mori lacked of crossing over in females.

Diurnal Size Distributions of Black Carbon by Comparison of Optical Particulate Measurements - Part I (광학 입자 측정기 비교 측정에 의한 입경별 일평균 블랙카본 분석 - Part I)

  • Park, Da-Jeong;Lee, Kwang-Yul;Park, Kihong;Bae, Min-Suk
    • Journal of Korean Society for Atmospheric Environment
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    • v.32 no.1
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    • pp.1-8
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    • 2016
  • Optical particle sizer (OPS), optical particle counter (OPC), and aethalomter were deployed to measure the particle number concentrations from 0.3 to $10.0{\mu}m$ and black carbon (BC) concentrations. Comparisons of particle number concentrations measured by OPS and OPC were conducted to evaluate the performance of the each optical instrument at the Gwangju sampling site ($35.23^{\circ}N$, $126.84^{\circ}E$) for 14 days from Dec. 27 in 2014. Although a good correlation ($r^2=0.99$) between the OPS and OPC was observed for both the particle number and volume concentrations, different relationships by BC concentrations can be associated with the intensities by different light scattering angles. In addition, based on diurnal patterns of size distributions in 24 hr running correlation coefficient determination, BC concentrations were highly related to the particles less than $0.3{\mu}m$ observed in the morning traffic hour.

A Dielectric Resonator Oscillator for DSRC with Improved Phase Noise Characteristic (위상잡음 특성을 개선한 DSRC용 운전체 공진 발진기)

  • Lee Young-Joon;Kim Hyun-Jin;Hong Ui-Seok
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.1 no.1
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    • pp.1-9
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    • 2002
  • In this paper, a DRO (Dielectric Resonator Oscillator) with high stability in DSRC(Dedicated Short Range Communication) is designed and fabricated. The DRO shows the phase noise characteristic of -109.3 dBc/Hz at 100 kHz offset from the fundamental frequency. The output power of 11.53 dBm, and the second harmonic suppression of 55.33 dBc for the DRO are obtained. This DRO with high stability of the phase noise characteristic can be used for the system in DSRC.

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Design of S-Band Phased Array Antenna with High Isolation Using Broadside Coupled Split Ring Resonator

  • Hwang, Sungyoun;Lee, Bomson;Kim, Dong Hwan;Park, Joon Young
    • Journal of electromagnetic engineering and science
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    • v.18 no.2
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    • pp.108-116
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    • 2018
  • In this paper, a method of designing a Vivaldi type phased array antenna (PAA) which operates at S-band (2.8-3.3 GHz) is presented. The presented antenna uses broadside coupled split ring resonators (BC-SRRs) for high isolation, wide field of view, and good active S-parameter characteristics. As an example, we design a $1{\times}8$ array antenna with various BC-SRR structures using theory and EM simulations. The antenna is fabricated and measured to verify the design. With the BC-SRR implemented between the two radiating elements, the isolation is shown to be enhanced by 6 dB, up to 23 dB. The scan angle is shown to be within ${\pm}53^{\circ}$ based on a -10 dB active reflection coefficient. The operation of the scan angle is possible within ${\pm}60^{\circ}$ with a little larger reflection coefficient (-7 dB to -8 dB). The proposed design with BC-SRRs is expected to be useful for PAA applications.

Production of Bacterial Cellulose by Gluconacetobacter hansenii PJK Isolated from Rotten Apple

  • Park, Joong-Kon;Park, Youn-Hee;Jung, Jae-Yong
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.8 no.2
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    • pp.83-88
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    • 2003
  • A cellulose-producing strain isolated from rotten apples was identified as Gluconacetobacter hansenii based on its physiological properties and the 16S rDNA complete sequencing method, and specifically named Gluconacetobacter hansenii PJK. The amount of bacterial cellulose (BC) produced by G. hansenii PJK in a shaking incubator was 1.5 times higher than that produced in a static culture. The addition of ethanol to the medium during cultivation enhanced the productivity of bacterial cellulose, plus the supplementation of 1% ethanol into the culture medium made the produced BC aggregate into a big lump and thus protected the bacterial-cellulose-producing G. hansenii PJK cells in the shear stress field from being converted into non-cellulose-producing (Cel) mutants. Cells subcultured three times in a medium containing ethanol retained their ability to produce BC without any loss in the production yield.

Block-chain based Secure Data Access over Internet of Health Application Things (IHoT)

  • A. Ezil Sam, Leni;R. Shankar;R. Thiagarajan;Vishal Ratansing Patil
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.17 no.5
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    • pp.1484-1502
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    • 2023
  • The medical sector actively changes and implements innovative features in response to technical development and revolutions. Many of the most crucial elements in IoT-connected health services are safeguarding critical patient records from prospective attackers. As a result, BlockChain (BC) is gaining traction in the business sector owing to its large implementations. As a result, BC can efficiently handle everyday life activities as a distributed and decentralized technology. Compared to other industries, the medical sector is one of the most prominent areas where the BC network might be valuable. It generates a wide range of possibilities and probabilities in existing medical institutions. So, throughout this study, we address BC technology's widespread application and influence in modern medical systems, focusing on the critical requirements for such systems, such as trustworthiness, security, and safety. Furthermore, we built the shared ledger for blockchain-based healthcare providers for patient information, contractual between several other parties. The study's findings demonstrate the usefulness of BC technology in IoHT for keeping patient health data. The BDSA-IoHT eliminates 2.01 seconds of service delay and 1.9 seconds of processing time, enhancing efficiency by nearly 30%.

Application of Synergistic Solvent Extraction by Formation of Ternary Complex for Determination of Trace Zn(II) in Water Samples

  • Choi, Jong-Moon;Park, Hyun-Mo;Choi, Sun-Do
    • Bulletin of the Korean Chemical Society
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    • v.27 no.4
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    • pp.563-567
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    • 2006
  • The application of a synergistic solvent extraction by the formation of ternary complex with pyrocatechol violet (PV) and benzalkonium chloride (BC) was studied for determination of trace Zn(II) in water samples. The pH of sample solution and the amount of PV and BC added were optimized for the formation of the stable complex, a proper solvent was selected for the effective extraction, and the concentration of nitric acid was fixed for the back extraction of the complex from the solvent. After the ionic strength of 100 mL sample solution was adjusted to 0.1 M by adding NaCl and the pH was fixed at 9 with a carbonate buffer, 1.0 mL of 2% PV solution was added to form Zn(II)-PV complex then the Zn(II)-PV/BC ternary complex was made by adding 1.0 mL of 10% BC solution. The ternary complex was extracted into 10 mL of MIBK. And the ternary complex was back-extracted with 10 mL of 1.0 mol/L nitric acid to determine Zn(II) by a flame atomic absorption spectrophotometer (flame-AAS). The interference of concomitant ions on the extraction of Zn(II) was investigated. This procedure was applied to the analysis of three real samples such as Dalbang-dam water, laboratory tap water and Jungnajin seawater. The recoveries of Zn(II) in spiked samples were 86.58-104.1%.