• Bioinformatics and Biosystems
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• v.1 no.1
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• pp.38-45
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• 2006

We present a client-server system architecture for inferring genetic interaction networks based on Bayesian networks. It is typical to take tens of hours when genome-wide large-scale genetic interaction networks are inferred in the form of Bayesian networks. To deal with this situation, batch-style distributed system architectures are preferable to interactive standalone architectures. Thus, we have implemented a loosely coupled client-server system for network inference and user interface. The network inference consists of two stages. Firstly, the proposed method divides a whole gene set into overlapped modules, based on biological annotations and expression data together. Secondly, it infers Bayesian networks for each module, and integrates the learned subnetworks to a global network through common genes across the modules.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.202-205
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• 2005

Cell phenotypes are determined by the concerted activity of thousands of genes and their products. This activity is coordinated by a complex network that regulates the expression of genes. Understanding this organization is crucial to elucidate cellular activities, and many researches have tried to construct gene regulatory networks from mRNA expression data which are nowadays the most available and have a lot of information for cellular processes. Several computational tools, such as Boolean network, Qualitative network, Bayesian network, and so on, have been applied to infer these networks. Among them, Bayesian networks that we chose as the inference tool have been often used in this field recently due to their well-established theoretical foundation and statistical robustness. However, the relative insufficiency of experiments with respect to the number of genes leads to many false positive inferences. To alleviate this problem, we had developed the algorithm of MONET(MOdularized NETwork learning), which is a new method for inferring modularized gene networks by utilizing two complementary sources of information: biological annotations and gene expression. Afterward, we have packaged and improved MONET by combining dispersed functional blocks, extending species which can be inputted in this system, reducing the time complexities by improving algorithms, and simplifying input/output formats and parameters so that it can be utilized in actual fields. In this paper, we present the architecture of MONET system that we have improved.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.164-169
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• 2003

In this paper, we propose the integrated Bayesian network framework to reconstruct genetic regulatory networks from genome expression data. The proposed model overcomes the dimensionality problem of multivariate analysis by building coherent sub-networks from confined gene clusters and combining these networks via intermediary points. Gene Shaving algorithm is used to cluster genes that share a common function or co-regulation. Retrieved clusters incorporate prior biological knowledge such as Gene Ontology, pathway, and protein protein interaction information for extracting other related genes. With these extended gene list, system builds genetic sub-networks using Bayesian network with MDL score and Sparse Candidate algorithm. Identifying functional modules of genes is done by not only microarray data itself but also well-proved biological knowledge. This integrated approach can improve there liability of a network in that false relations due to the lack of data can be reduced. Another advantage is the decreased computational complexity by constrained gene sets. To evaluate the proposed system, S. Cerevisiae cell cycle data [1] is applied. The result analysis presents new hypotheses about novel genetic interactions as well as typical relationships known by previous researches [2].

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2008.04a
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• pp.151-154
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• 2008

본 논문은 Bayesian Networks를 이용해서 EEG 신호를 분석해서 사람의 감정을 분석하는 방법을 제안하였다. 현제 연구자들은 Electroencephalogram(EEG) 신호를 기반으로 사람의 두뇌와 컴퓨터의 인터페이스에 관한 연구를 하고 있다. 기존에는 간질이나 발작 등을 의학 분야와 사람의 정서에 따라 뇌파분석을 하는 심리학의 영역에서 연구가 되어져 왔다. 최근에는 사람의 두뇌와 컴퓨터 간의 인터페이스를 통한 여러 가지 공학적인 접근이 이루어지고 있다. 본 논문에서는 사람의 감정에 따라 Brain-Computer Interface (BCI)를 통해서 EEG 신호를 분석하고 잡음을 제거해서 보다 정확한 신호를 추출한 다음 각각의 주파수 영역으로 분류를 하였다. 분류된 값들은 Bayesian Networks를 이용해서 피 실험자가 어떠한 감정을 나타내는지 확률 값으로 나타낸다. 확률 값에 의해서 피 실험자가 어떠한 감정인지를 인식하게 되는 것이다.

• Communications for Statistical Applications and Methods
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• v.9 no.1
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• pp.155-166
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• 2002

Neural networks have been studied as a popular tool for classification and they are very flexible. Also, they are used for many applications of pattern classification and pattern recognition. This paper focuses on Bayesian approach to feed-forward neural networks with single hidden layer of units with logistic activation. In this model, we are interested in deciding the number of nodes of neural network model with p input units, one hidden layer with m hidden nodes and one output unit in Bayesian setup for fixed m. Here, we use the latent variable into the prior of the coefficient regression, and we introduce the 'sequential step' which is based on the idea of the data augmentation by Tanner and Wong(1787). The MCMC method(Gibbs sampler and Metropolish algorithm) can be used to overcome the complicated Bayesian computation. Finally, a proposed method is applied to a simulated data.

• Journal of KIISE:Computing Practices and Letters
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• v.15 no.1
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• pp.72-76
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• 2009

Recently, as the interest of ubiquitous computing has been increased there has been lots of research about recognizing human activities to provide services in this environment. Especially, in mobile environment, contrary to the conventional vision based recognition researches, lots of researches are sensor based recognition. In this paper we propose to recognize the user's activity with multi-modal sensors using hierarchical dynamic Bayesian networks. Dynamic Bayesian networks are trained by the OVR(One-Versus-Rest) strategy. The inferring part of this network uses less calculation cost by selecting the activity with the higher percentage of the result of a simpler Bayesian network. For the experiment, we used an accelerometer and a physiological sensor recognizing eight kinds of activities, and as a result of the experiment we gain 97.4% of accuracy recognizing the user's activity.

• Journal of Institute of Control, Robotics and Systems
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• v.22 no.2
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• pp.104-109
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• 2016

In this paper, a localization method for multiple robots based on Bayesian inference is proposed when multiple robots adopting multi-RAT (Radio Access Technology) communications exist in cognitive radio networks. Multiple robots are separately defined by primary and secondary users as in conventional mobile communications system. In addition, the heterogeneous spectrum environment is considered in this paper. To improve the performance of localization for multiple robots, a realistic multiple primary user distribution is explained by using the probabilistic graphical model, and then we introduce the Gibbs sampler strategy based on Bayesian inference. In addition, the secondary user selection minimizing the value of GDOP (Geometric Dilution of Precision) is also proposed in order to overcome the limitations of localization accuracy with Gibbs sampling. Via the simulation results, we can show that the proposed localization method based on GDOP enhances the accuracy of localization for multiple robots. Furthermore, it can also be verified from the simulation results that localization performance is significantly improved with increasing number of observation samples when the GDOP is considered.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.11
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• pp.4913-4916
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• 2016

Objective: As a source of information, medical data can feature hidden relationships. However, the high volume of datasets and complexity of decision-making in medicine introduce difficulties for analysis and interpretation and processing steps may be needed before the data can be used by clinicians in their work. This study focused on the use of Bayesian models with different numbers of nodes to aid clinicians in breast cancer risk estimation. Methods: Bayesian networks (BNs) with a retrospectively collected dataset including mammographic details, risk factor exposure, and clinical findings was assessed for prediction of the probability of breast cancer in individual patients. Area under the receiver-operating characteristic curve (AUC), accuracy, sensitivity, specificity, and positive and negative predictive values were used to evaluate discriminative performance. Result: A network incorporating selected features performed better (AUC = 0.94) than that incorporating all the features (AUC = 0.93). The results revealed no significant difference among 3 models regarding performance indices at the 5% significance level. Conclusion: BNs could effectively discriminate malignant from benign abnormalities and accurately predict the risk of breast cancer in individuals. Moreover, the overall performance of the 9-node BN was better, and due to the lower number of nodes it might be more readily be applied in clinical settings.

• International Journal of Computer Science & Network Security
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• v.23 no.4
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• pp.85-94
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• 2023

Image halftoning is a technique for varying grayscale images into two-tone binary images. Unfortunately, the static representation of an image-half toning, wherever each pixel intensity is combined by its local neighbors only, causes missing subjective problem. Also, the existing noise causes an instability criterion. In this paper an image half-toning is represented as a dynamical system for recognizing the global representation. Also, noise is reduced based on a probabilistic model. Since image half-toning is considered as 2-D matrix with a full connected pass, this structure is recognized by the dynamical system of Cellular Neural Networks (CNNs) which is defined by its template. Bayesian Rough Sets is used in exploiting the ideal CNNs construction that synthesis its dynamic. Also, Bayesian rough sets contribute to enhance the quality of the halftone image by removing noise and discovering the effective parameters in the CNNs template. The novelty of this method lies in finding a probabilistic based technique to discover the term of CNNs template and define new learning rules for CNNs internal work. A numerical experiment is conducted on image half-toning corrupted by Gaussian noise.

• Journal of the Korean Statistical Society
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• v.36 no.3
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• pp.435-445
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• 2007

This paper addresses for the first time the use of complete data information criteria in unsupervised learning of the Naive-Bayes model. A Monte Carlo study sets a large experimental design to assess these criteria, unusual in the Bayesian network literature. The simulation results show that complete data information criteria underperforms the Bayesian information criterion (BIC) for these Bayesian networks.