• 비파괴검사학회지
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• 제31권5호
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• pp.516-521
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• 2011

청각기관인 달팽이관에 존재하는 기저막의 중요한 기능은 등자뼈로부터 전달되는 진동에너지를 주파수별로 분리하는 것이다. 본 연구에서는 인간 기저막의 형상을 모사하여 설계한 매크로 스케일의 폴리머 박막을 사용하여 주파수 분리 특성을 연구하였다. 각각의 폴리머 박막상의 위치에 따른 변위 분포는 LDV (laser Doppler vibrometer) 스캐닝 기법을 이용하여 측정하였고, 측정된 결과는 후처리 과정을 거쳐 주파수별로 분리하였다. 인가된 주파수에 따른 최대 변위 발생 위치를 추출하여 각 박막에 대한 주파수-최대 변위 발생 위치 관계를 도식화하였다. 아울러 박막 두께 및 물성치가 주파수-최대 변위 발생 위치 관계에 미치는 영향에 대해서도 논하였다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 제13회 신호처리 합동 학술대회 논문집
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• pp.153-156
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• 2000

본 논문에서는 음성 인식률 향상을 위한 여러 가지방법들 중에서 음성특징 파라미터 추출 방법에 관한 한가지 방법을 제시하였다. 본 논문에서는 청각 특성을 기반으로 한 MFCC(met frequency cepstrum coef-ficients)와 성능 향상을 위한 방법으로 GFCC (gamma-tone filter frequency cepstrum coefficients)를 제시하고 음성 인식을 수행하여 성능을 분석하였다. MFCC에서 일반적으로 사용하는 임계 대역 필터로 삼각 필터(triangular filter) 대신 청각 구조의 기저막(basilar membrane)특성을 묘사한 gammatone 대역 통과 필터를 이용하여 특징 파라미터를 추출하였다. DTW 알고리즘으로 인식률을 분석한 결과 삼각 대역 필터를 이용한 것보다 gammatone 대역 통과 필터를 이용한 추출법이 약 2∼3%의 성능 향상을 보였다.

• 센서학회지
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• 제24권6호
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• pp.373-378
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• 2015

The structure of the human ear is divided into the outer ear, the middle ear, and the inner ear. The inner ear includes the cochlea that plays a very important role in hearing. Recently, the development of an artificial cochlear device for the hearing impaired with cochlear damage has been actively researched. Research has been carried out on the biomimetic piezoelectric thin film ABM (Artificial Basilar Membrane) in particular. In an effort to improve the frequency separation performance of the existing piezoelectric thin film ABM, this paper presents the design, fabrication, and characterization of the production and performance of a partially etched-type ABM material. $O_2$ plasma etching equipment was used to partially etch a piezoelectric thin film ABM to make it more flexible. The mechanical-behavior characterization of the manufactured partially etched-type ABM showed that the overall separation frequency range shifted to a lower frequency range more suitable for audible frequency bandwidths and it displayed an improved frequency separation performance. In addition, the maximum magnitude of the vibration displacement at the first local resonant frequency was enhanced by three times from 38 nm to 112 nm. It is expected that the newly designed, partially etched-type ABM will improve the issue of cross-talk between nearby electrodes and that the manufactured partially etched-type ABM will be utilized for next-generation ABM research.

• 대한의용생체공학회:의공학회지
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• 제14권2호
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• pp.125-136
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• 1993

The study of Cochlear biomechanics is to clearly define three biomechanical principles of the Cochlea : Activity, Nonlinearity and Feedback. In this article, the Cochlea is linearly and actively modelled in one dimensional time domain. The sharp tunning of the Basilar Membrane displacement is shown when the amplifying activity of hair cells is added to the model. The amplified energy of the travelling displacement wave is emitted throughout the Cochlear fluid, so that the model becomes unstable. A new technique is introduced to reduce strong echos fro the Helicotrema. It makes the model less unstable. Both pure and click tones are used as input stimuli onto the ear durm. When the model is normal, the click response of the model shows that the backward emission of the amplified fluid pressure has mainly the echos from the Helicotrema. However, when the linear and active model is assumed to be abnormal, that is, some of hair cells are damaged not to produce the active process, the effect of the hair cell damage is resulted in the Oto-acoustic emission. The frequency response of the abnormally emitted sound pressure shows that the Oto-acoustic emission has the information about the characteristic frequency of the damaged hair cell. The main aim of this paper is to demonstrate the active biomechanics of the Chchlea in the time domain.

• 대한한의학회지
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• 제20권2호
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• pp.146-156
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• 1999

The present study was performed to investigate the effect of Yangkyuksanhoa-tang on the morphological changes of the basilar artery after experimentally induced subarachnoid hemonrrhages(SAH). Yangkyuksanhoa-tang has been used freguently for cerebrovascular accident Sprague Dawley rats weighing between 350-400 g were used. The 6 normal rats and 24 SAH elicited rats were used, The SAH induced by injection of the fresh autologus heart blood (0.3-0.4 ml) into the cisterna magna through the posterior atlanta-occipital membrane, Sample group was given 3.3 ml/kg/day of Yangkyuksanhoa-tang extracts for 2 days after SAH. The experimental animals were killed at 48hrs after SAH. The morphological changes of the arterial walls were examined by light and electron microscopy. Following are the obtained results: 1. In SAH elicited rats, the size of the lumen in basilar artery was diminished by about 45% and the thickness of arterial wall was increased by about 82%. In SAH elicited rats with Yangkyuksanhoa-tang treatment, the size of the lumen in basilar artery was merely diminished by about 18% and the thickness of arterial wall was merely increased by about 19%. 2. In light microscopic examination, the endothelium was swollen into a cuboid shape and the layer of smooth muscle was increased in the basilar artery of SAH elicited rats. In SAH elicited rats with Yangkyuksanhoa-tang treatment, the size of the lumen in basilar artery was enlarged and the thickness was decreased than in SAH elicited rats. The endothelium was flattened into a squamous shape and the layer of smooth muscle was decreased more than in SAH elicited rats. 3. In electron microscopic examination, the endothelial cells with fragmentation nuclei were changed into a cuboid shape and the internal elastic lamina were folded at the basilar artery of SAH elicited rat. The nuclei of smooth muscle cells were changed into a round or crumpled shape. The length of smooth muscle was shorten and thickness was increased. But all kinds of morphologic changes were diminished in SAH elicited rats with Yangkyuksanhoa-tang treatment. Conclusion : Yangkyuksanhoa-tang extracts were effective to treat cerebral vasospasm after experimentally induced subarachnoid hemorrhage in rats.

• 동국한의학연구소논문집
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• 제8권1호
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• pp.117-131
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• 1999

Yangkyuksanhoa-tang is frequently used for cerebrovascular accident(CVA). The present study was performed to investigate the effect of Yangkyuksanhoa-tang on the peri vascular immunoreactive nerve fiber of the basilar artery after experimentally induced subarachnoid hemorrhage(SAH). Sprague Dawley rats weighing between 350-400g were used. The SAH induced by injection of the fresh autologus heart blood(0.3-0.4ml) into the cisterna magna through the posterior atlanto-occipital membrane. Sample group was given a $3.3m{\ell}/kg/day$ of Yangkyuksanhoa-tang extracts for 2 days after SAH. The experimental animals divided into 48hrs after SAH. The changes of perivascular immunoreactive nerve fiber was examined by using indirect immunofluorescence method. The meshlike perivascular nerve fiber appeared in the basilar artery of normal rats. In basilar artery of SAH elicitated rat, the distribution of calcitonin gene-related peptide (CGRP)-immunoreactivity(IR) and vasoactive intestinal polypeptide(VIP)-IR of the perivascular nerve fiber were remarkably diminished, also dopamine beta hydroxylase(DBH)-IR, neuropeptide Y(NPY)-IR and serotonin-IR were diminished. In SAH elicitated rat with Yangkyuksanhoa-tang treatment, the CGRP-IR and VIP-IR degree were repaired as well as normal rat's, but DBH-IR, NPY-IR and serotonin-IR had no changes. These results provide the basic data to investigate the effect of Yangkyuksanhoa-tang on the vasospasm after SAH.

• 한국음향학회지
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• 제4권3호
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• pp.8-15
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• 1985

본 논문에서는 코클리어 기저막 운동에 관한 전기적 모델링을 래더회로를 이용하여 구현하였다. Budak 의 이론에 근거한 이득이 1보다 큰 RC 수동회로를 이용하여 귀에서의 Place Principle을 만족시 키는 특성을 갖는 모델을 제시하였으며 이는 간단한 회로를 첨가시킬시에 이득이 1보다 큰 주파수를 검 지해낼 수도 있다. 컴퓨터 Simulation을 이용한 전달함수 분석에서는 특이한 형태 의 전압전달함수를 얻 을 수 있었으며, 연구결과, 본 모델은 코클리어 기저막운동을 표현하기에 적합하다는 결론을 얻을 수 있 었다. 본 모델은 임상의학이나 그 외의 공학분야등에 이용이 가능하리라고 본다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 ITC-CSCC -3
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• pp.1717-1720
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• 2002

Objective quality measurement schemes that in- corporate properties of the human auditory system. The basilar membrane(BM) acts as a spectrum analyzer, spatially decomposing the signal into frequency components. Each filterbank is an implementation of the ERB, gam-machirp function. This filterbank is level-dependent asymmetric compensation filters. And for the validation of the auditory model, we calculate the CPD. Quality measurement is obtained from the result.

• The Korean Journal of Physiology and Pharmacology
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• 제6권1호
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• pp.33-39
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• 2002

It has been suggested that $Ca^{2+}$ sensitization mechanisms might contribute to myogenic tone, however, specific mechanisms have not yet been fully identified. Therefore, we investigated the role of protein kinase C (PKC)- or RhoA-induced $Ca^{2+}$ sensitization in myogenic tone of the rabbit basilar vessel. Myogenic tone was developed by stretch of rabbit basilar artery. Fura-2 $Ca^{2+}$ signals, contractile responses, PKC immunoblots, translocation of PKC and RhoA, and phosphorylation of myosin light chains were measured. Stretch of the resting vessel evoked a myogenic contraction and an increase in the intracellular $Ca^{2+}$ concentration $([Ca^{2+}]_i)$ only in the presence of extracellular $Ca^{2+}$. Stretch evoked greater contraction than high $K^+$ at a given $[Ca^{2+}]_i.$ The stretch-induced increase in $[Ca^{2+}]_i$ and contractile force were inhibited by treatment of the tissue with nifedipine, a blocker of voltage-dependent $Ca^{2+}$ channel, but not with gadolinium, a blocker of stretch-activated cation channels. The PKC inhibitors, H-7 and calphostin C, and a RhoA-activated protein kinase (ROK) inhibitor, Y-27632, inhibited the stretch-induced myogenic tone without changing $[Ca^{2+}]_i.$ Immunoblotting using isoform-specific antibodies showed the presence of $PKC_{\alpha}$ and $PKC_{\varepsilon}$ in the rabbit basilar artery. $PKC_{\alpha},$ but not $PKC_{\varepsilon},$ and RhoA were translocated from the cytosol to the cell membrane by stretch. Phosphorylation of the myosin light chains was increased by stretch and the increased phosphorylation was blocked by treatment of the tissue with H-7 and Y-27632, respectively. Our results are consistent with important roles for PKC and RhoA in the generation of myogenic tone. Furthermore, enhanced phosphorylation of the myosin light chains by activation of $PKC_{\alpha}$ and/or RhoA may be key mechanisms for the $Ca^{2+}$ sensitization associated with myogenic tone in basilar vessels.

• 한국음향학회지
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• 제9권3호
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• pp.42-47
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• 1990

음성처리 및 인식기기의 기능을 향상시키기 위해서는 생체공학적인 방법을 이용한 인체의 청각신경 정보처리 시스템의 연구가 중요하다. 그래서 본 논문에서는 와우각의 메카니즘을 분석한 기저막의 IIR 디지털 필터 모델링이 연구되었다. 특히 음소검출필터와 측징 추출을 위한 변별기능을 이용한 자음인식의 다층신경 모델을 구성한다. 이 모델은 자음인식에 있어서 90% 이상의 높은 감지율을 나타내고 있다.