• Asian Pacific Journal of Cancer Prevention
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• 제13권3호
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• pp.809-813
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• 2012

In spite of screening and early diagnostic tests, the upward trend of breast cancer has become a matter of great concern in both developed and developing countries. The data collected by Population Based Cancer Registry in Chittaranjan National Cancer Institute, a regional cancer centre in Kolkata, from 1997 to 2004 gives an insight about the scenario of Breast Cancer in this part of Eastern India.The total no of female breast cancer cases were steadily increasing from 1997 to 2001 and only slightly lower from 2002 to 2004. and majority were in the 40-49 year old age group during this period. The next most commonly affected age group was 50-59 years. Regarding the distribution according to treatment, the main modality was surgery and radiotherapy followed by combined surgery, chemotherapy and radiotherapy and then combined surgery and chemotherapy. The commonest type was ductal followed by lobular cancer. In this eight year study in CNCI, status of patients on last day of the respective year was assessed. Number of patients alive was 43.5% in 1997. The percentage gradually increased up to 2000 and then gradually decreased to 47.4% in 2004. Also with every passing year, percentage mortality gradually decreased from 25.7% in 1997 to 16.8% in 2004. Better pattern of care (diagnosis and treatment) was reflected in this picture. However, lost to follow up, which also implies non compliance to treatment, increased to 30.8% in 1997 to 35.8% in 2004. Due to the small number of male breast cancers, only female cases were considered. In conclusion, breast cancer continues to be a major problem in Kolkata, India.

• 대한암한의학회지
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• 제13권1호
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• pp.55-61
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• 2008

Nearly 800,000 new colorectal cancer cases are believed to be occur each year, which account for approximately 10% of all incident cancers, and mortality from colorectal cancer is estimated at nearly 450,000 per year. We report one patient with rectal cancer of stage III. The patient had a rectal cancer(StageIII T3N2M0) and underwent low anterior resection in 2004 followed by chemotherapy and radiotherapy. Lymph node metastases were found in 2005 and the patient was treated by palliative chemotherapy, which could not supress the lymph node metastases increase. The patient visited Kyunghee University East-West Neo Medical Center(KHNMC) in 2006 and was treated using allergen-removed Rhus Verniciflua Stokes(aRVS). Radiotherapy was done simultaneously in 2006. There was no evidence of recurrence since then. The patient showed no side effects. This case report brings forth the importance of a thorough study in rectal cancer in the traditional Korean medical point of view, along with the long-term effect of aRVS.

• 대한방사선기술학회지:방사선기술과학
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• 제38권4호
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• pp.463-475
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• 2015

본 논문은 상당히 진행된 중위 식도암의 동시항암화학 방사선치료에 대한 분석의 것이다. 사용한 항암제는 전통적으로 사용되어온 시스플라틴, 5-플루오로우라실에, 도쎄탁실을 추가 시행하였다. 과거 식도암의 방사선치료에서는 총 선량 50.4 Gy/28회를 처방하였다. 하지만 현대의 방사선치료기술의 비약적인 발전으로, 호흡동조치료와 세기변조방사선치료를 적용하여, 정상조직의 손상을 최대한 감소시키면서 총 선량을 50.4 Gy이상으로 증가시키는 것이 가능하다. 이에 우리는, 도쎄탁실, 시스플라틴, 5-플루오로우라실 이라는 새로운 3제 병합요법(DCF-R)에 추가하여, 4DCT 모의시뮬레이션을 기반으로 한 호흡동조 세기변조방사선치료(gated-IGRT) 총 선량 70.2 Gy/39회를 동시에 시도하였으며, 치료기간 동안, 그리고 치료 종료 후 임상적으로 환자에게 위중한 합병증 및 부작용 발생은 관찰되지 않았다. 또한 생존율 향상을 이루어 냈다. 이를 바탕으로, 식도암의 새로운 치료방법을 제안한다.

• Journal of Chest Surgery
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• 제32권1호
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• pp.27-31
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• 1999

배경: 최근 항암화학요법의 발달에도 불구하고 전이성폐암에 대한 예후는 불량하다. 이에비해 전이성폐암에 대한 외과적 요법후 좋은 결과를 보이는 보고가 증가하고 있다. 그래서 전이성 폐암에 대한 치료에 도움이 되고자 본원의 경우를 관찰하였다. 대상 및 방법: 1983년부터 1997년까지 수술적 치료를 했던 17례를 분석하였고 Kaplan-Meier 방법으로 5년생존률을 구하였다. 결과: 평균연령은 42.8세였고 남녀비는 10:7이었다. 수술은 단일폐엽절제술이 8례, 전폐적출술이 3례, 부분절제술이 1례, 쌍폐엽절제술이 1례, 폐엽절제술 및 부분절제가 3례있었다. 술후 5명이 사망하였고 이중 재발로 인한 것은 3례였다. 나머지 12례의 환자들중 3명은 재발하여 현재 외래추적관찰중이며 9명은 재발없이 건강한 상태로 외래추적 관찰중에 있다. 술후 평균 생존기간은 40.5개월이었다. Kaplan-Meier 방법으로 구한 5년생존율은 60.4%였다. 결론: 앞으로 더많은 경험이 필요하지만 전이성폐암에 대해서 더 적극적인 수술적치료를 하는 것이 필요하다고 생각한다.

• 대한소아치과학회지
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• 제28권2호
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• pp.287-292
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• 2001

Burkitt림프종은 중앙아프리카 지역의 어린이 악골에서 흔하게 나타나는 악성 종양으로 림프조직으로부터 발생되며 매우 빠른 성장 양상을 보인다. 임상적으로는 3~8세 아동에 주로 호발하며 악골에 발생하는 경우 안면부 종창이 나타날 수 있으며 유치의 비정상적 동요 및 구치부 조기 맹출등이 나타날 수 있다. 방사선 소견으로는 경계가 불규칙한 방사선투과성 병소로 나타나며 조직학적으로는 종양세포들 사이에 대식세포가 분포되어 "starry-sky" appearance의 특징적인 양상이 관찰된다. 본 증례는 좌측 안면부 종창을 동반한 유구치의 심한 동요도를 주소로 내원한 3세 남환아에서 임상 및 방사선 검사와 조직학적 검사를 통해 Burkitt림프종으로 진단하였고 항암 화학요법에 의해 치료중이며 양호한 치료 결과를 얻고 있다.

• Radiation Oncology Journal
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• 제35권4호
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• pp.349-358
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• 2017

Purpose: This study aimed to evaluate whether prophylactic extended-field pelvic radiotherapy (EF-PRT) yields better results than standard whole pelvic radiotherapy (WPRT) in patients with pelvic lymph node-positive cervical cancer treated with concurrent chemoradiotherapy (CCRT). Materials and Methods: A total of 126 cases of stage IB-IVA cervical cancer that had pelvic lymph node involvement in magnetic resonance imaging and were treated with CCRT between 2000 and 2016 were reviewed. None of the patients had para-aortic lymph node (PALN) metastases. The patients were classified to two groups, namely, those treated with EF-PRT, including prophylactic para-aortic radiotherapy, and those treated only with WPRT. The median dose to the PALN area in patients treated with EF-PRT was 45 Gy. All patients received concurrent cisplatin-based chemotherapy. Results: Overall, 52 and 74 patients underwent EF-PRT and WPRT, respectively. Patient characteristics and irradiated dose were not significantly different, except the dose to the para-aortic area, between the two groups. The median follow-up period was 75.5 months (range, 5 to 195 months). The 10-year cumulative recurrence rate of PALN for EF-PRT vs. WPRT was 6.9% and 10.1% (p = 0.421), respectively. The 10-year disease-free survival and overall survival for EF-PRT vs. WPRT were 69.7% vs. 66.1% (p = 0.748) and 71.7% vs. 72.3% (p = 0.845), respectively. Acute gastrointestinal complications were significantly higher in EF-PRT (n = 21; 40.4%) than WPRT (n = 26; 35.1%) (p = 0.046). Late toxicities were not significantly different in both groups. Conclusion: In this study, prophylactic radiotherapy for PALN does not have an additional benefit in patients with pelvic lymph node-positive cervical cancer treated with CCRT.

• 한국임상수의학회지
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• 제20권4호
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• pp.489-492
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• 2003

구강내에 출혈을 동반한 크기 $5{\times}6$ 센티미터의 종괴가 있는 종양을 가진 12년령의 거세되지 않은 수컷 래브라도 리트리버가 건국대학교 부속동물병원에 의뢰되었다. 임상증상은 2년전부터 시작되었고, 점진적인 진행양상을 보여왔다. 총백혈구검사에서 백혈구증가증과 경도의 빈혈증상이 관찰되었다. 구강 종양의 폐장으로의 전이는 흉부 방사선 검사에서 발견되었으며 왼쪽 하악 주위의 흑색 괴저성의 종괴는 흡인도말검사 및 조직병리학적 검사에 의해 악성 흑색종으로 진단되었다. 치료는 외과적으로는 반하악절제술과 항암제인 carboplatin을 이용한 화학요법이 시행되었다. Carboplatin투여후 심한 신장의 괴사는 관찰되지 않았지만 이차감염으로 투여 3개월 후 폐사하였다.

• 대한암한의학회지
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• 제26권1호
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• pp.39-48
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• 2021

Objective: The purpose of this study is to report effects and potential of Integrative Cancer Treatment (ICT) on metastatic pancreatic cancer patient. Methods: A 79-year-old pancreatic cancer patient diagnosed with metastasis on liver visited the Daejeon Korean medicine hospital of Daejeon university East West Cancer Center (EWCC) on May 2021. The patient has been received chemotherapy (gemcitabine plus abraxane) and concurrently treated with ICT since May 2021. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (CEA, CA19-9) and numeric rating scales (NRS). Laboratory analysis and National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0 were used to evaluate the safety of ICT. Results: After treatment, constipation was relieved from NRS 5-6 to 2, both leg numbness was improved from NRS 9 to 2. Tumor size was generally decreased accompanying by reducing the levels of tumor markers. There were no severe adverse events induced by ICT based on NCI CTCAE version 5.0. Conclusion: This case study suggests that ICT in combination with chemotherapy may help in the treatment of patients with metastatic pancreatic cancer.

• 대한암한의학회지
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• 제24권1호
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• pp.19-28
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• 2019

Objective : The purpose of this study is to report and observe effects of Integrative Cancer Treatment (ICT) on metastatic breast cancer patient. Method : A left breast cancer patient diagnosed with recurrence on liver and bones April 2018. The patient had received paclitaxel chemotherapy for two months and discontinued it because of tumor progression and side effects. The patient has been treated with ICT since March 2018 and has been taking capecitabine since October 2018. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (CEA, CA15-3). The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (CEA, CA15-3), liver function test (AST, ALT), Eastern Cooperative Oncology Group performance status (ECOG PS), and numeric rating scales (NRS). Results : After the ICT, tumor size was partially decreased accompanying by reducing the levels of tumor markers. Major clinical symptoms induced by paclitaxel chemotherapy were improved. There were no severe adverse events induced by ICT based on National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5.0. Conclusion : This case suggests that ICT may have synergistic effect for the treatment of metastatic breast cancer patient in conjunction with capecitabine.

• 동서간호학연구지
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• 제27권1호
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• pp.43-50
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• 2021

Purpose: The purpose of this study was to identify the influence of depression, optimism and posttraumatic growth on health-related quality of life in female breast cancer survivors received adjuvant chemotherapy. Methods: In total, 115 female breast cancer survivors participated in this descriptive correlational study. The participants answered self-report questionnaires. Data were collected from 1 June 2020 to 10 June 2020, and were analyzed using descriptive statistics, the t-test, one-way ANOVA, Pearson correlation coefficients, and stepwise multiple regression with SPSS for Windows ver. 24.0. Results: The mean age of the breast cancer survivors was 45.83 years. The mean score for the degree of health-related quality of life was 81.85 out of 148 points. Participants' scores for health-related quality of life differed significantly based on economic status (F=5.36 p=.006) and hobbies (t=-3.37, p=.001). Health-related quality of life was negatively correlated with depression (r=-.73, p<.001), and positively correlated with optimism (r=.65, p<.001) and posttraumatic growth (r=.28, p=.002). Depression (𝛽=-.55, p<.001) was the most significant factor that affects health-related quality of life, followed by optimism (𝛽=.29, p<.001), and post-traumatic growth (𝛽=.12, p=.048), which together accounted for 62.2% (F=63.61, p<.001) of the variance. Conclusion: It is necessary to develop educational programs for breast cancer survivors to reduce depression, increase optimism and post-traumatic growth, and improve the health-related quality of life. By adapting these programs, positiveness may increase and this may lead to improvement of health-related quality of life for breast cancer survivors.