• Title/Summary/Keyword: Base Potential

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Antiviral Activity Enhancement through the SATE Prodrug of a 2'-Modified 5'-Norcarbocyclic Adenine Analogue

  • Li, Hua;Kim, Si-Wouk;Hong, Joon-Hee
    • Bulletin of the Korean Chemical Society
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    • v.31 no.8
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    • pp.2180-2184
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    • 2010
  • We synthesized and tested the anti-HIV activity of the SATE prodrug of a 2'-methyl 5'-norcarbocyclic adenine analogue. The introduction of a methyl group in the 2'-position was performed by the addition of a carbonyl using isopropenyl magnesium bromide. The adenine base was efficiently coupled using the Mitsunobu reaction. The chemical stability study of the bis(SATE) derivative 18 was measured at neutral (pH 7.2) and slightly acid (milli-Q water, pH 5.5) pH, and compounds 16 and 18 were evaluated as potential anti-HIV-1 agents.

Pulsed Corona Charging Characteristics of Aqueous Pesticide Spray (펄스 코로나 농약산포장치의 분무대전 특성)

  • 문재덕;이운태;배창환;권남열
    • The Transactions of the Korean Institute of Electrical Engineers C
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    • v.52 no.9
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    • pp.388-394
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    • 2003
  • Many toxic pesticides as aqueous-base sprays are dispensed for protection of food crops from pests into farm fields. When dispensed with conventional nozzles, a large portion of the spray is often lost by airborne drifts of droplets away and lack of deposition onto the plants due to rapid gravitational settling of droplets to the soil beneath. And target deposition efficiencies poorer than 20% are often encountered in agricultural pesticides. An electrostatic spraying technology offers a very favorable means to increasing pesticides droplets deposition onto biological surfaces of living crops. In this paper a corona type spray nozzle, utilizing a set of corona charging devices and a pulsed droplet-charging voltage applied, has been proposed and tested its potential experimentally. As a result, it exhibits a large current deposition of aqueous pesticide sprays on the sensing target, which, however, promise to be as one of the effective electrostatic spraying nozzle.

Active Controls of Flow Over a Sphere for Drag Reduction (능동제어를 이용한 구의 저항 감소)

  • Jeon, Seung;Choi, Hae-Cheon
    • 유체기계공업학회:학술대회논문집
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    • 2006.08a
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    • pp.199-202
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    • 2006
  • The objective of this study is to propose methods of controlling the wake behind a sphere for drag reduction using the suboptimal control theory and surrogate management framework, respectively. The Reynolds numbers considered is 300 at which the base flow is unsteady planar symmetric. Given the cost function defined as the square of the difference between the target pressure (potential-flow pressure) and real flow pressure on the sphere surface, the suboptimal control makes the flow steady axisymmetric and produces drag reduction. Based on the actuation profile from the suboptimal control, the optimal wavy actuation profile is obtained using the surrogate management framework and produces drag reduction.

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Study on the Manufacture of Resin Concrete of Machine Tool Bed with High Damping Capacity (고감쇠 레진 큰크리트 공작기계 베드 제작에 관한 연구)

  • 서정도;방경근;이대길;김태형;박보선
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 1997.10a
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    • pp.429-433
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    • 1997
  • High-speed and high-precision are trendy at present in the development of machine tools which are required for various fields of industry such as semiconductor, automobde, mold fabricat~on and so on. High damping capacity of the structure is an iniportant factor to ohtain precise products without vibration during manufacturing caused by rapid trarisportatm and rotation of spindle unit Resin concrete have high potential for machine tool bed due to its good damping characteristics. In this study, the statlc and dynamic characteristics of the machine tool bed were analysed. Also, the hybrid machine tool bed, made of steel base and polyester resin concrete material, was manufactured and its good dynamic characteristics were proved experimentally.

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Real-time simulation for fuzzy control of three fin torpedo (삼타어뢰의 퍼지제어를 위한 실시간 시뮬레이션)

  • 남세규;원태현;구본순;이만형;유완석
    • 제어로봇시스템학회:학술대회논문집
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    • 1992.10a
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    • pp.869-873
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    • 1992
  • A fuzzy controller is designed for compensating the cross-coupling effect of induced roll due to the dynamic characteristics of three fin torpedo. Since the utilization of fuzzy-coprocessor has many interfacing problems with typical microprocessors of the guidance and control unit, the simplified fuzzy inference method based on nonfuzzy-processor is proposed to implement fuzzy controllers of three fin torpedo. This method provides a flexible rule-base design to guarantee the robust control. The good potential of the proposed design is shown through real-time simulations using both a mathematical model on AD-100 computer and an implemented controller on Intel 80C186/80C 187 microprocessors employing 12bit A/D converter.

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Synthesis of Naftifine-Related Allylamine as a Potential Antimycotics (항진균제 Naftifine 구조와 관련된 알릴아민류의 합성)

  • Kim, Wook;Park, Eun-Ju;Seo, Hee-Kyong;Shin, Boo-Ahn;Choi, Bo-Gil;Chung, Byung-Ho
    • YAKHAK HOEJI
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    • v.37 no.3
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    • pp.247-253
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    • 1993
  • Eight new derivatives of allylamine which are related to naftifine and expected to have antifungal activity were synthesized. Schiff base 2a-2d and 2'e-2'h were obtained by conventional methods using trans-cinnamylamine or trans-cinnamaldehyde. The reduction of azomethine linkage with NaBH$_{4}$ yielded secondary amine 3a-3h, which were then methylated by means of HCHO and excess NaBH$_{4}$ or HCOOH to give 4a-4h.

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Hypokalemic Muscular Paralysis Causing Acute Respiratory Failure in a Chronic Glue Sniffer (만성 본드 흡입 환자에게 발생한 호흡부전 1례)

  • Choi, Yoon-Hee;Lee, Dong-Hoon;Eo, Eun-Kyung
    • Journal of The Korean Society of Clinical Toxicology
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    • v.3 no.1
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    • pp.63-66
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    • 2005
  • Toluene is an aromatic hydrocarbon found in glues, cements, and solvents. It is known to be toxic to the nervous system, hematopoietic system, and causes acid-base and electrolyte disorders. Acute respiratory failure with hypokalemia and rhabdomyolysis with acute renal failure should be considered as potential events in protracted glue sniffing. We reported the case of 26-year-old woman was admitted to the emergency department with the development of respiratory failure and altered mentality due to hypokalemia after chronic glue sniffing. She was weaned from the ventilator 3 days later after potassium and sodium bicarbonate replacement and was discharged without respiratory symptoms and other complications.

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PERFORMANCE NEEDS OF TOMORROW'S DRIVELINE LUBRICANTS

  • Hong, Hyun-Soo
    • Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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    • 2002.10a
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    • pp.21-24
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    • 2002
  • There is a trend with driveline lubricants toward improved thermal stability, vehicle component durability and fuel efficiency. These improvements can significantly reduce vehicle operating costs and improve customer satisfaction. Of these improvements, the fuel efficiency is getting a substantial attention due to recent focus on $CO_2$ emission control in Europe, Japan and $CAF{\'{E}}$ requirement in U.S.A. Lower viscosity axle oils and transmission fluids are currently being evaluated as potential solutions since these lubricants tend to reduce the churning losses and can improve the fuel efficiency. However, these lubricants should provide adequate gear and bearing protection, while increasing the overall efficiency of the driveline components. In this paper, the development of new fuel efficient axle was discussed with the focus on the effect of base oils, additives, and viscosity modifiers on the fuel efficiency of driveline components.

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Study on the Corrosion Charactristics and its Corrosion Protection of Steel Fishing Banks (강제어촌의 부식특성과 그 방식에 관한 연구)

  • Lim, Uh-Joh;Lee, Jong-Rark
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.28 no.2
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    • pp.216-227
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    • 1992
  • The corrosion rate, behavior of corrosion fatigue and characteristic of cathodic protection for SB41 were investigated by corrosion and corrosion control tests in seawater at laboratory and coast. The main result obtained are as the following; 1) The corrosion rate of base metal (BM) is about 28-37 mg/dm super(2) day in seawater of coast. 2) The correlation between the stress intensity factor range $\Delta$K and crack propagation rate da/dN for weldment follows paris' rule in seawater : da/dN=C($\Delta$K) super(m) where m is the slope of the correlation, and is 2.02 for BM and 1.75 for heat affected zone (HAZ) respectively. 3) The corrosion sensitivity of HAZ is more sensitive than that of BM under the low region of $\Delta$K. 4) With increase of bared surace area of cathode, cathodic protection potential is increased sharply.

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Knowledge-Based Control via the Internet

  • Tang, Kok-Zuea;Goh, Han-Leong;Tan, Kok-Kiong;Lee, Tong-Heng
    • International Journal of Control, Automation, and Systems
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    • v.2 no.2
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    • pp.207-219
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    • 2004
  • This paper presents the development of a knowledge-based control system operating via the Internet. With the synergy provided by the Internet, the central expert controller with its knowledge-base has the potential to serve a multitude of front-end clients located anywhere in the world provided they have Internet access. In this way, the operational span of the knowledge-based control system can be expanded to virtually anyplace within the reach of the Internet. This configuration has positive implications in improving the efficiency of distributed operations, thereby enabling plantwide optimization and costs savings. Datasocket technology is adopted to facilitate a more efficient data exchange between the knowledge-based central server and the front-end clients. A specific application in the remote monitoring and fault diagnosis of machines using the proposed control configuration is presented in the paper.