• Bulletin of the Korean Chemical Society
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• v.30 no.9
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• pp.2039-2042
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• 2009

As a part of an ongoing effort to discover inhibitors of the Hepatitis C Virus RNA replication, we describe here the first synthetic route of 1'($\alpha$),2'($\beta$)-C-dimethyl carbocyclic adenine analogue. The key intermediate cyclopentenyl alcohol 8($\alpha$) was prepared from aldehyde 4 using ring-closing metathesis (RCM) as a key reaction. Coupling of 8($\alpha$) with nucleosidic base via the regioselective Mitsunobu reaction followed by stereoselective dihydoxylation and deprotection afforded the target carbocyclic adenine analogue 12.

• Bulletin of the Korean Chemical Society
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• v.25 no.2
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• pp.221-225
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• 2004

A series of 2',3'-dideoxy-3'-fluoro-D-apiosyl nucleosides 15, 16, 17 and 18 were synthesized enantiomerically with L-Gulonic- ${\gamma}$-lactone as the starting material. The reduction of butenolide 1 with DIBAL-H followed by the Luche procedure afforded the allylic alcohol 2. Ozonolysis and the reduction of compound 4 induced the cyclized lactol, which was acetylated to give the acetate 7. Condensation of the acetate 7 with silylated pyrimidine ($N^4$-benzoyl cytosine) and a purine base (6-chloropurine) under Vorbruggen conditions and deblocking afforded a series of fluorinated apiosyl nucleosides.

• Journal of the Korean Society of Safety
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• v.23 no.3
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• pp.12-16
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• 2008

For industrial centrifuges, the state of their welding areas, even with a naked-eye observation, offers potential safety problems such as inconsistent bead formation. STS304, which is used mainly in centrifuges, is made of metal alloys with chrome and nickel as the main ingredients, offering excellent corrosion resistance, thermal resistance, and high strength, and thus allowing it to be used for diverse purposes. This paper conducted tensile and fatigue tests of STS304 to improve the safety of centrifuges. In the findings, for the static behavior of the STS304 material, welded specimens increased their yield and tensile strength compared with the base test specimens, but decreased their elongation ratio. Also, the data dispersion phenomenon of welded specimens remarkably increased.

• The korean journal of orthodontics
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• v.19 no.1 s.27
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• pp.123-135
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• 1989

This study was undertaken to investigate the relationship between the depth of antegonial notch and the craniofacial morphology, and to predict the mandibular growth direction & potential in class III malocclusion. The computerized analyses were carried out on longitudinal lateral cephalometric radiographs of 50 children with class III malocclusion, divided into two groups ; 30 deep notch subjects (more than 2.6mm) and 20 shallow notch subjects (less than 1.5mm). The conclusions were as follows: 1. The mandibular growth direction in deep notch group was more vertically directed than in shallow notch group. 2. Deep notch group had shorter anterior & posterior cranial base than shallow notch group. 3. There was not significant difference between deep & shallow notch groups in the amount of mandibular growth during treatment period. 4. Notch depth increased in both deep & shallow notch groups during treatment period.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1998.06a
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• pp.268-271
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• 1998

this paper presents the potential application of fuzzy logic to the automatic incident detection system. While the conventional incident detection algorithms are based on a binary decision process, the algorithm using fuzzy logic can incorporate ambiguity which occurs in determining incidents. Since collecting good amount of data to construct data base for incidents is pretty expensive, a traffic simulator called FRESIM is used to simulate traffic condition in a freeway. Incident data are obtained by changing input parameters of the simulator and the fuzzy algorithm generates fuzzy rule for determining normal and incident traffic conditions. In this paper, various steps are described to test the algorithm and its results are summarized.

• 한국신재생에너지학회:학술대회논문집
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• 2008.05a
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• pp.613-616
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• 2008

Assessment of geothermal resources like other earth resources is a starting point for decision makers or stakeholders to set up basic plan on its development and R&D policies. In this context, there have been various works on world geothermal assessment, to report different estimates from each other. In this paper, we first introduce the definition of geothermal potential mainly adopted from the article by Muffler and Cataldi (1978) and then summarize the estimates made so far referring the work by Bertani (2003). An updated estimates by Stefansson (2005) are also reviewed in terms of identified resources separately for high-temperature resources for power generation and low-temperature ones for direct-use. Recent estimate of US geothermal resources by MIT (2006) using a volumetric method with extensively accumulated data base is discussed. Finally, we introduce the first geothermal assessment in Korea recently made and discuss its importance.

• BMB Reports
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• v.29 no.2
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• pp.133-136
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• 1996

The affinity cleavage reagent Methidiumpropyl-EDTA-Iron(II) is applied to the structural analysis of 5S rRNA. Analysis of cleavage sites induced by MPE-Fe(II) on 5S rRNA shows that MPE intercalates easily between the unstable base pairs or into the bulges, thereby it strongly cuts the nucleosides nearby. The stable helical stems A, B, D and E as well as loop d are weakly cut. Most of the single-stranded loops are not cleaved. Based on the cleavage pattern of the 5S rRNA by MPE-Fe(II) and RNase V1, we suggest that MPE-Fe(II) may be used as a potential chemical probe in searching for the unstable helical regions of RNA, and for the sequences that appear to be involved in folding and distorting 5S rRNA.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.312-316
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• 2004

In this study, a spatial 3-dof haptic mechanism is implemented. The implemented mechanism does not employ the gear transmissions as velocity reducers for all three joints but uses wire-based transmissions, thereby it is able to minimize the frictions significantly. Also, by employing the structure of the four-bar mechanism to drive third joint from close to the base, the mechanism is able to minimize the inertia effect from the third actuator very effectively. Its kinematic analysis such as position and velocity analyses are performed first. Then, its operating software development, hardware implementation, and the related interfaces between a PC and the implemented Haptic device are completed. To evaluate its potential and its performance as a haptic device, a experiment generating a virtual constraint in a operational task space is conducted and preliminary results are discussed.

• Proceedings of the KIEE Conference
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• 2003.04a
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• pp.128-132
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• 2003

The increase of vehicles stagnations leads to the increasing attention to the way customers pay and a large number of projects on electronic cash system. Transport system is comprised of a number of advanced technologies, including information processing, communications, control, and electronics. Recently many research on a system which provides contact in order to protect driver's vehicle passage have been carried out. And some potential problems from that system are being reviewed by electronic cash system. In this papers, we suggest RF protocol developing technology using the concept of electronic cash. ATM electronic cash developing is consist of component of pre-developed coin throw, integration of component using its, and production of more requirement-satisfactory ITS solution. Result increase 15-40% pre-type vehicles stagnations. Especially, we expect this proposed concept would be well adapted to our national environments

• Journal of the Korean Institute of Landscape Architecture
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• v.34 no.6 s.119
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• pp.101-110
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• 2007

This study is a base research for the restoration of village landscape of the Namhan-Sansung. The Namhan-Sansung has been recognized as a top destination for dining places. However, there have been increasing concerns about the village landscape and its rich historic and cultural heritages transformed into dining places. The village landscape of Namhan-Sansung should be reconstructed as a setting for education and loaming of Korean history and culture forgotten for a long time. The landscape also should be a space where resolute resistance and spirit of Korean people and a futuristic village space where environment friendly community environment harmonizes with daily lives. Restoration efforts of village landscape of the Namhan-Sansung can get to start from exploring the prototype of the village. In order to restore the prototype, it is important to review potential elements and setbacks. Based on the prototype of the Namhan-Sansung village, transitions of village landscape were reviewed and directions of restoration were proposed. Also, an improvement plan was proposed after reviewing problems in system and planning.