• 한국소음진동공학회논문집
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• 제18권5호
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• pp.572-581
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• 2008

The performance of a barrel stave flextensional transducer is determined by the properties of its constituent materials and the effects of many structural parameters. In this study, with the finite element method, the structure of a barrel stave flextensional transducer was optimized to achieve the widest bandwidth while satisfying the requirements on pressure and center frequency. The optimization was carried out with the SQP-PD method for multi-variable minimization. The optimized barrel stave flextensional transducer satisfied all the required specifications.

• BMB Reports
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• 제38권5호
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• pp.507-516
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• 2005

Antimicrobial peptides (AMPs) have been isolated and characterized from tissues and organisms representing virtually every kingdom and phylum. Their amino acid composition, amphipathicity, cationic charge, and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of AMP activity, their relevance to resolving how peptides damage and kill microorganisms still needs to be clarified. Moreover, many AMPs employ sophisticated and dynamic mechanisms of action to carry out their likely roles in antimicrobial host defense. Recently, it has been speculated that transmembrane pore formation is not the only mechanism of microbial killing by AMPs. In fact, several observations suggest that translocated AMPs can alter cytoplasmic membrane septum formation, reduce cell-wall, nucleic acid, and protein synthesis, and inhibit enzymatic activity. In this review, we present the structures of several AMPs as well as models of how AMPs induce pore formation. AMPs have received special attention as a possible alternative way to combat antibiotic-resistant bacterial strains. It may be possible to design synthetic AMPs with enhanced activity for microbial cells, especially those with antibiotic resistance, as well as synergistic effects with conventional antibiotic agents that lack cytotoxic or hemolytic activity.

• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.173-173
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• 2006

We have explored a strategy to control the supramolecular nano-structures self-assembled from rigid segments through attachment of flexible chains through microphase separation and anisotropic arrangement. Supramolecular structures formed by self-assembly of rigid building blocks can be precisely controlled from 1-D layered, 3-D bicontinuous cubic to 2-D cylindrical structures by systematic variation of the type and relative length of the respective blocks. Furthermore, depending on the individual molecular architectures, rigid building blocks self-assemble into a wide range of supramolecular structures such as honeycomb, disk, cylinder, helix, tube, barrel stave, and nano-cage.

• Journal of Microbiology and Biotechnology
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• 제25권6호
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• pp.759-764
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• 2015

Antimicrobial peptides (AMPs) are one of the critical components in host innate immune responses to imbalanced and invading microbial pathogens. Although the antimicrobial activity and mechanism of action have been thoroughly investigated for decades, the exact biological properties of AMPs are still elusive. Most AMPs generally exert the antimicrobial effect by targeting the microbial membrane, such as barrel stave, toroidal, and carpet mechanisms. Thus, the mode of action in model membranes and the discrimination of AMPs to discrepant lipid compositions between mammalian cells and microbial pathogens (cell selectivity) have been studied intensively. However, the latest reports suggest that not only AMPs recently isolated but also well-known membrane-disruptive AMPs play a role in intracellular killing, such as apoptosis induction. In this mini-review, we will review some representative AMPs and their antimicrobial mechanisms and provide new insights into the dual mechanism of AMPs.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 1999년도 춘계종합학술대회
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• pp.307-312
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• 1999

결합형 유한요소-경계요소 기법을 사용하여 압전체 유연형 쏘나 변환기를 시뮬레이션하였다. 쏘나 변환기의 역학적 구동을 3차원적으로 모델링하였고 전기적 외부 부하 조건을 가지고 분석하였다. 정상 상태 변위 모드와 방향 패턴과 같은 결과들을 보여준다. 본 논문의 술통 형태의 압전 재질 쏘나 변환기는 유연형 변위를 발생시키며, 다른 형태의 쏘나 변환기와 달리 고출력, 낮은 Q-factor, 향상된 전방위성을 가지도록 해준다.

• Journal of Yeungnam Medical Science
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• 제10권2호
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• pp.493-505
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• 1993

저자들은 1예의 선천성 피부결손증을 경험하고 국소피판술과 피부이식으로써 치료하고 술후 발생된 부분적 괴사는 습윤치료로써 자연치유시켜 만족스러운 결과를 얻었고, 4예의 craniosynostosis 환자를 진단하고 modified Marchac's method, Persing's method를 이용하고 교정하였고 CT를 이용한 뇌용적 측정으로 예후를 판정할 수 있었다.

• 한국음향학회:학술대회논문집
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• 한국음향학회 1999년도 학술발표대회 논문집 제18권 1호
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• pp.218-223
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• 1999

A piezoelectric flextentional deep-water sonar transducer has been simulated using a coupled FE-BEM. The dynamics of the sonar transducer is modelled in three dimensions and is analyzed with extern리 electrical excitation conditions as well as external acoustic pressure loading conditions. Different results are available such as steady-state frequency response for RX and TX, displacement modes, directivity patterns, back-scattering patterns, resonant frequencies, bandwidths, quality factors, transmitting voltage (TV) responses, input receiving sensitivity (RS) responses. White the present barrel-stave typed sonar transducer of the piezoelectric material is being simulated, the external surface of the transducer is modified in order to allow the same water pressure to be applied to the inner and the outer surfaces of the transducer. With this modification for deep-water application, the resonance frequency of the modified flextentional sonar transducer becomes much lower than that of the unmodified flextentional sonar transducer. The results of the present sonar transducer modelling are also compared with those of a commercial package such as ATILA.

• 한국정보통신학회논문지
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• 제3권3호
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• pp.559-567
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• 1999

결합형 유한요소-경계요소 기법을 사용하여 압전체 유연형 쏘나 변환기를 시뮬레이션하였다. 쏘나 변환기의 역학적 구동을 3차원적으로 모델링하였고 전기적 외부 부하 조건을 가지고 분석하였다. 정상 상태 변위 모드, 방향 패턴, 공진 주파수, 대역,0-factor, 출력 압력, TV 응답과 같은 결과들을 보여준다. 본 논문의 술통 형태의 압전 재질 쏘나 변환기는 유연한 변위를 발생시키며, 다른 형태의 쏘나 변환기와 달리 고출력, 낮은 Q-factor, 향상된 전방위성을 가지도록 해준다. 본 연구에서 개발된 쏘나 변환기 모델링의 결과를 ATILA와 같은 상업적 소프트웨어와 비교하였다.

• 센서학회지
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• 제8권5호
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• pp.377-387
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• 1999

결합형 유한요소-경계요소 기법을 사용하여 심해저용 유연형 압전체 쏘나 트랜스듀서를 설계하였다. 쏘나 트랜스듀서의 역학적 구동을 3차원적으로 모델링하였고 전기적 외부 부하 조건을 가지고 분석하였다. 쏘나 트랜스듀서의 정상 상태 변위 모드, 지향성, 공진 주파수, TVR과 같은 결과들을 보였다. 본 논문의 술통 형태의 압전체 쏘나 트랜스듀서를 설계하면서, 심해저용으로 사용하기 위해 쏘나 트랜스듀서의 내외부에 동일한 수압이 가해지도록 쏘나 트랜스듀서의 외부 표면 구조를 새롭게 변형시킨 결과 낮은 주파수의 새로운 공진 모드가 발생하였으나 그 크기는 외부 표면 구조 변형의 정도에 따라 조절될 수 있다.

• Archives of Plastic Surgery
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• 제38권5호
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• pp.683-686
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• 2011

Purpose: Craniosynostosis of three or more cranial sutures was not common. "Mercedes Benz pattern," named by Moore1 was a rare form of craniosynostosis and had an atypical pattern of premature closure of cranial suture. It was not reported in Republic of Korea. We report this case with literature review. Methods: A 13-months-old male patient visited our clinic due to exophthalmos. He showed normal developmental course. Other neurological tests were normal but he was Crouzon syndrome patient. CT scans showed bilateral lambdoid and posterior sagittal sutures were fused and the length of the skull was extended. Cranioplasty with pi craniotomy & Barrel-Stave osteotomy and recombination of the bone flap was performed. Results: The patient was discharged after post operative 10 days without any complications. In follow up visit after 2.7 years, he was in good state without recurrence and functional abnormality of skull. Conclusion: This was the first case of Mercedes Benz pattern craniosynostosis with Crouzon syndrome in Korea. This type of craniosynostosis has to be considered differently from single type of craniosynostosis or typical syndromic craniosynostosis clinically and surgically.