• Journal of Chest Surgery
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• v.47 no.3
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• pp.249-254
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• 2014

Background: Delirium after cardiac surgery is associated with serious long-term negative outcomes and high costs. The aim of this study is to evaluate neurobehavioral, hemodynamic, and sedative characteristics of dexmedetomidine, compared with the current postoperative sedative protocol (remifentanil) in patients undergoing open heart surgery with cardiopulmonary bypass (CPB). Methods: One hundred and forty two eligible patients who underwent cardiac surgery on CPB between April 2012 and March 2013 were randomly divided into two groups. Patients received either dexmedetomidine (range, 0.2 to $0.8\;{\mu}g/kg/hr$; n=67) or remifentanil (range, 1,000 to $2,500\;{\mu}g/hr$, n=75). The primary end point was the prevalence of delirium estimated daily via the confusion assessment method for intensive care. Results: When the delirium incidence was compared with the dexmedetomidine group (6 of 67 patients, 8.96%) and the remifentanil group (17 of 75 patients, 22.67%) it was found to be significantly less in the dexmedetomidine group (p<0.05). There were no statistically significant differences between two groups in the extubation time, ICU stay, total hospital stay, and other postoperative complications including hemodynamic side effects. Conclusion: This preliminary study suggests that dexmedetomidine as a postoperative sedative agent is associated with significantly lower rates of delirium after cardiac surgery.

• Korean Journal of Veterinary Research
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• v.36 no.4
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• pp.859-871
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• 1996

This study was conducted to elucidate the distribution of Aujeszky's disease viral nucleic acids and antigens in the central nervous system (CNS) of piglets. The first Korean isolate of Aujeszky's disease virus(ADV) that isolated from naturally infected piglets in Yang San, was inoculated into 32 day old piglets with $10^{5.9}TCID_{50}/ml$ through intranasal or intramuscular route. These piglets were sacrificed at every 24hrs for 8 days. The immunohistochemistry (IHC) was conducted to detect the viral antigens in paraffin-embedded tissue sections using avidin-biotin-peroxidase complex (ABC) method. The viral nucleic acids were detected by in situ hybridization (ISH) using ADV specific DNA probe labeled with digoxigenin. The ADV antigens were detected in reticuloendothelial cells of spleen, lymph nodes and tonsil, alveolar walls, leptomeningeal vascular walls, inflammatory foci of each organ, and nerve cells. The viral nucleic acids were detected in the spinal trigeminal nucleus and its tracts of the pons and medulla oblongata by the ISH technique. The pathways of AD viruses in CNS were determined by IHC and ISH. In the intranasally inoculated group, the viruses in nasal mucosa moved to medulla oblongata and pons through the trigeminal nerve. In case of intramuscullarly inoculated group, viruses moved to brain via lymphoid organs or spinal nerves from sciatic nerves.

• Korean Journal of Medicinal Crop Science
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• v.21 no.5
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• pp.372-379
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• 2013

The present study was investigated the effect of planting density on plant growth and yield of Panax ginseng C. A. Meyer. Sowing density is one of the most important factors affecting yield. The value of roots have affected by shape, color, weight and degree of disease injury in ginseng. Also, it needed to minimize elapsed time for 5 years including pre-planting field management and cultivation period. We were conducted to evaluate that planting densities and varieties on the growth, yield and missing rate. The direct sowing was treated seeds density as a four levels (seeds; 72, 90, 120, 144) and 10 different varieties with 3 years old ginseng roots. Root weight was significantly affected by planting density and variety, but the number of lateral root and yield were affected by only planting density. Growth index was related to variety and planting density. Also, Root shape index was affected by both varieties and planting densities. Suitable planting density and variety were 120 plant per 1.62 $m^2$ and Gopoong, respectively. Results showed that it was also a significant difference (p=5%) in variety of planting density on growth.

• The Journal of Internal Korean Medicine
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• v.27 no.3
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• pp.603-616
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• 2006

The water extract of Gamiyaengshinhwan (GYH), has been used in vitro tests for its beneficial effects on neuronal survival and neuroprotective functions, particularly in connection with CT105-related dementias and Alzheimer's disease(AD). CT105 derived from proteolytic processing of the $\beta$-amyloid precursor protein (APP), including the amyloid-$\beta$ peptide ($A{\beta}$), plays a critical role in the pathogenesis of Alzheimer's dementia. We determined that transfected overexpressing APP695 and $A{\beta}$ CT105 have a profound attenuation in the Increase in CT105 expressing neuro2A cells from GYH. Experimental evidence indicates that GYH protects against neuronal damage from cells, but its cellular and molecular mechanisms remain unknown. Using a neuroblastoma cell line stably expressing CT105-associated neuronal degeneration, we demonstrated that GYH inhibits formation of amyloid-$\beta$ fragment ($A{\beta}$ CT105). which are the characteristic, and possibly causative, features of AD. The decreased CT105 $A{\beta}$ in the presence of GYH was observed in the conditioned medium of this CT105-secreting cell line under in vitro. In the cells, GYH significantly attenuated mitochondrion-initiated apoptosis and decreased the activity of Bax, a key enzyme in the apoptosis cell-signaling cascade. These results suggest that neuronal damage in AD might be due to two factors: a direct CT05 toxicity and the apoptosis initiated by the mitochondria. Multiple cellular and molecular neuroprotective mechanisms, including attenuation of apoptosis and direct inhibition of CT105 aggregation, underlie the neuroprotective effects of GYH.

• Journal of Biomedical Engineering Research
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• v.26 no.1
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• pp.9-16
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• 2005

One of the most important roles of a brain atlas is providing a spatial reference system in which multiple images can be interpreted in a consistent way. The brain atlase based on Western populations such as the International Consortium for Brain Mapping's 452 T-1 Weighted Average Atlas was widely used; however, they may not be the optimal choice for use with brain images from other ethnic groups, because structural differences between occidental and oriental brains have been reported. Therefore, in this study, we created an average brain atlas from 100 healthy Koreans (100 cases (M/F=53/47), 39.0±17.0 years). The purpose of this study was to make a Korean average-brain atlas and to measure its differences from a widely accepted average brain atlas built on an occidental population. The average brain atlas for Koreans was developed using widely accepted tools and procedures. The comparison between the Korean and occidental averages was performed using tissue probability maps and a registration tool, and it was shown that the global pattern of differences between the two average brains found in this work agreed with previously reported differences: Korean brains are wider and shorter in size, and smaller in volume, yet no hemispheric volume asymmetry was found.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.9
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• pp.3802-3807
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• 2011

In this study, in-plane and out-plane compression tests of aluminum foam and honeycomb sandwich composites were carried out. Through these tests, the relationships of load-displacements were analyzed and the compression characteristics were compared with each other. The specimens were compressed with the speed of 1mm/min by using the universal testing machine. Experimental procedures were taken with photograph by the camera and load cell data were stored into computer. Test results showed that buckling was occurred at the aluminum foam core and honeycomb core according to the increase of load. In the in-plane compression test, the maximum load of aluminum foam specimen was similar with that of honeycomb sandwich. The property of honeycomb was better than that of the foam in consideration of specific gravity. In the out-plane compression test, compression maximum load of aluminum honeycomb sandwich composite was higher than that of aluminum foam sandwich composite.

• Journal of the Korea institute for structural maintenance and inspection
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• v.24 no.1
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• pp.108-115
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• 2020

In this study, the flexural performance of Highly Ductile Cement Composites(HDCC) mimicking boundary conditions of shellfish skin layer was evaluated. To improve ductility by mimicking the boundary skin layer structure of shellfish, the method of stratification by charging between precast panels using HDCC and the method of distributing PE-mesh to the interface surface were applied. Evaluation of flexural performance of layered cement composite materials mimicking boundary conditions of shellfish skin layer resulted in increased ductility of all test specimens applied with stratified cross-section compared to typical bending test specimens. The layered method by inserting PE-mesh showed excellent ductility. This is most likely because the inserted PE-mesh made an interface for separating the layers while the HDCC pillars in the PE-mesh gave adhesion between layers.

• Journal of Yeungnam Medical Science
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• v.26 no.1
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• pp.24-29
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• 2009

Background : The aims of medical education have recently been changing in Korea, which has been accompanied by efforts to modify the rotating clerkship courses, improve the quality of clinical education, and make global doctors. We report the experiences of medical students going through an international elective clerkship for during past two years. Materials and Methods: Third year medical students could apply to the international elective clerkship course during a 4 week period alter their third-year rotating clerkship at a university hospital. This was done twice - in 2008 and in 2009. Applicant students were allowed to select hospitals anywhere in the world. We analyzed their choices including data on nation, state or city, hospital or institute, contacted hospitals by medical college, differences of two years, etc. Results : Twelve students (10.9%) of a total of 75 third-year students applied to 3 nations and 4 hospitals in 2008. Nine students applied to the Tampa General Hospital at the University of South Florida (USF) in the USA, which was arranged by their medical college. In 2009, a total of five (4.2%) of 77 students applied to 2 nations and 3 hospitals, including three at the University of South Florida, one in another city in the USA, and one in another nation because of the increased financial burden due to a higher exchange rate. Conclusion: Medical students started their first international elective clerkship courses during the past two years. Experiences were interesting and meaningful to the students and the medical college. Greater effort and support to developing a new paradigm and to enlarge the scope of the program for making global doctors are required in the future.

• Korean Journal of Remote Sensing
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• v.26 no.3
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• pp.347-359
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• 2010

Ortho-photos provide valuable spatial and spectral information for various Geographic Information System (GIS) and mapping applications. The absence of relief displacement and the uniform scale in ortho-photos enable interested users to measure distances, compute areas, derive geographic locations, and quantify changes. Differential rectification has traditionally been used for ortho-photo generation. However, differential rectification produces serious problems (in the form of ghost images) when dealing with large scale imagery over urban areas. To avoid these artifacts, true ortho-photo generation techniques have been devised to remove ghost images through visibility analysis and occlusion detection. So far, the Z-buffer method has been one of the most popular methods for true ortho-photo generation. However, it is quite sensitive to the relationship between the cell size of the Digital Surface Model (DSM) and the Ground Sampling Distance (GSD) of the imaging sensor. Another critical issue of true ortho-photo generation using high resolution satellite imagery is the scan line search. In other words, the perspective center corresponding to each ground point should be identified since we are dealing with a line camera. This paper introduces alternative methodology for true ortho-photo generation that circumvents the drawbacks of the Z-buffer technique and the existing scan line search methods. The experiments using real data are carried out while comparing the performance of the proposed and the existing methods through qualitative and quantitative evaluations and computational efficiency. The experimental analysis proved that the proposed method provided the best success ratio of the occlusion detection and had reasonable processing time compared to all other true ortho-photo generation methods tested in this paper.

• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.400-400
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• 2015

기후변화로 인해 예측하기 어려운 강우패턴의 변화와 도시화로 인한 불투수면의 증가로 도심지는 매년 침수위험에 노출되어 있다. 배수시설의 개선은 인구밀도가 높고 유동인구가 많은 도심지에서 이루어지기 쉽지 않은 상황이며, 강우패턴의 변화는 예측과 대처가 어려운 상황이다. 이러한 이유로, 침투증진을 통해 직접유출수를 줄이는 연구 중 LID(Low Impact Development)에 대한 관심이 높아지고 있다. LID기법은 도시화로 증가된 불투수면을 투수면으로 대체하여 저류, 침투, 여과, 증발산을 유도하여 물 순환 회복에 기여할 수 있는 방법으로 옥상녹화, 투수성포장, 침투 트렌치 등의 기술요소가 있다. LID 기술요소에 대해 국외의 경우 설치방안과 평균적인 저감효과를 메뉴얼로 제시하고 있지만, 강우 및 토지의 지역적 편차가 큰 국내에 적용하기에는 어려운 상황이다. 또한, LID 모델링의 경우 유역 내 적용 면적에 따른 유출저감효과를 제시하는 연구결과는 다수 제시되고 있지만, 적용 면적과 지점에 따라 효율성을 제시하는 점에서는 다소 미흡한 상황이다. 따라서 LID 기술요소 별 설계 사례와 GIS를 바탕으로 유역 내 적용 지점과 면적을 산출하고, 적용 지점 및 면적에 따른 저감 효율을 분석하는 것이 필요하다. 본 연구는 SWMM모형을 이용하여 LID 기술요소 중 옥상녹화를 적용하여, 강우 강도와 적용지점 및 면적에 따른 유출저감 효율을 분석하고자 한다. 연구지역은 청계천 유역으로 총 면적의 75% 이상이 주거지, 상업지, 교통시설 등을 포함한 불투수면으로 이루어져있는 도시 지역이다. 강우자료는 10년, 30년, 80년 빈도 확률강우량을 적용하였으며, 옥상녹화를 적용하기 위한 지점과 면적은 GIS를 기반으로 산정하였다.