• 동의생리병리학회지
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• 제17권1호
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• pp.151-156
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• 2003

This study was carried out to investigate the optimal mixed extract with Bambusae Caulis in Liquamen in order to strengthen anti-diabetic effects on the hyperglycemia induced by streptozotocin in mice. The original Bambusae Caulis in Liquamen filtered and refined. The effects of Bambusae Caulis in Liquamen and Mixed extracts(Bamboo Juice) with Bambusae Caulis in Liquamen were administered to mice for 4weeks and its anti-diabetic effect examined. Mice used in this experiment were divided into three groups and saline(control), Bamboo Juice mixed with refined Bambusae Caulis in Liquamen(BJ＋BCL.D) and distrilled water mixed with refined Bambusae Caulis in Liquamen(DW＋BCL.D) were given orally for 28days respectively. And then, experemental groups were observed in terms of blood sugar, creatinine, BUN and GPT. The amount of glucose was significantly decreased in the Bambusae Caulis in Liquamen and Mixed extracts(Bamboo Juice) with Bambusae Caulis in Liquamen-treated groups compared with the control group(P<0.01). The amount of creatinine, BUN and GPT did not show any differences among Control, BJ＋BCL.D and DW＋BCL.D groups. In conclusion. it was found that Bambusae Caulis in Liquamen and Mixed extracts(Bamboo Juice) with Bambusae Caulis in Liquamen were nontoxic to kidney and liver and also effective on murine hyperglycemia induced with STZ. Mixed extracts(Bamboo Juice) were more effective for decreasing blood glucose than Bambusae Caulis in Liquamen D. BJ＋BCL.D can be used as optimal mix material with Bambusae Caulis in Liquamen D for control Diabetes.

• 동의생리병리학회지
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• 제18권2호
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• pp.457-462
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• 2004

Bambusae Caulis in Liquamen has been used as a herbal medicine for the treatment of heat, paralysis of the hands or feet, or hemiplegia. In the present study, we investigated the effect of Bambusae Caulis in Liquamen to the phenylephrine (PE) induced contraction of isolated rat aorta Contractile force was measured with force displacement transducer under 1.5 g loading tension. Contractions evoked by PE 0.1 μM were significantly increased by low dosage of Bambusae Caulis in Liquamen, decreased by high dosage of Bambusae Caulis in Liquamen. L-NNA, ODQ and propranolol significantly altered the effect of Bambusae Caulis in Liquamen, but indomethacin did not change the relaxation of Bambusae Caulis in Liquamen. These results suggest that Bambusae Caulis in Liquamen can relax EP induced contraction of isolated rat aorta and that this decreasing contraction related to sympathetics.

• 대한의생명과학회지
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• 제11권3호
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• pp.343-347
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• 2005

Bambusae caulis in Liquamen is one of the important herbal medicine produced by heating bamboo indirectly and is used for treatment of stroke, hypertension, and diabetes etc. Recently the mechanism of clinical effects on Bambusae caulis in Liquamen has been studied. This experiment was conducted to confirm the clinical effects of Bambusae caulis in Liquamen on type 1 diabetes and its related mechanism. We divided C57BL/6 mice into 3 groups and induced them to be type 1 diabetes by injection of streptozocin into peritoneum. The dosage of each group was 150 mg/kg once only, 140 mg/kg once only and 40 mg/kg for 5 days respectively. The two groups injected streptozocin for once took orally Bambusae caulis in Liquamen after the induction of diabetes, and the other one group was given Bambusae caulis in Liquamen during the diabetes inducing period. As the result, the two diabetes-induced groups showed blood glucose decreasing effect by Bambusae caulis in Liquamen on an average, but they didn't show the signiftcant differences statistically. But Bambusae caulis in Liquamen showed the anti-diabetic effect suppressing blood sugar rising trend during the diabetes inducing peried (P<0.05). The anti-oxidative effect of Bambusae caulis in Liquamen was measured with the hypoxanthine/xanthine oxidase (HX/XOD) system. The quantity of ROS was measured using DCFDA reagent indirectly. As the result, $10\%$ solution of Bambusae caulis in Liquamen showed anti-oxidative effect by scavenging $93.4\%$ superoxide as compared with control group. It is suspected that the anti-oxidative effect of Bambusae caulis in Liquamen suppressed the increase of blood glucose in the diabetes-inducing group. These results could be useful data to understand the effect of Bambusae caulis in Liquamen on type 1 diabetes and type 1 diabetes developing because ROS were closely connected with the induction and complications of diabetes.

• 동의생리병리학회지
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• 제16권6호
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• pp.1253-1259
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• 2002

This study was carried out to investigate the effects of Bambusae Caulis in Liquamen from different production process on blood sugar of the diabetic mice induced with Streptozotocin(STZ). The original Bambusae Caulis in Liquamen filtered and refined. Bambusae Caulis in Liquamen D(H-BCL.D) extracted at high temperature(1000℃), Bambusae Caulis in Liquamen A(L-BCL.A) and Bambusae Caulis in Liquamen B(L-BCL.B) extracted at low temperature (250～450℃) were administerd to mice for 4weeks and its anti-diabetic effect examined. Mice used in this experiment were divided into four groups(Control, H-BCL.D, L-BCL.A and L-BCL.B). Experemental groups were observed in terms of blood sugar, Creatinine, BUN and GPT. The amount of glucose was significantly decreased in the Bambusae Caulis in Liquamen-treated groups compared with the control(P < 0.05). The amount of Creatinine did not show any differences among four groups. The amount of Blood Urea Nitrogen did not show any differences in the L-BCL.A and B-treated groups, but did show slightly decrease(P<0.05) at H-BCL.D-treated group. The amount of GPT did not show any differences among four groups. In conclusion, it was found that Bambusae Caulis in Liquamen from extracted at high or low temperature were effective on murine hyperglycemia mice induced with STZ respectively.

• 대한한의학원전학회지
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• 제26권2호
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• pp.121-132
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• 2013

Objective : Bambusae Caulis in Liquamen has been used by East Asian doctors who approved efficient clinical effects of it since the early stage of medical history. It is commonly used for lifestyle related diseases including stroke in recent days thanks to the increasing number of manufacturers. However, products from pharmaceutical companies as well as food companies are not classified as Bambusae Caulis in Liquamen but Bamboo vinegar. This study aims to discern disparate manufacturing process. Methods : In this study, original texts were searched to corroborate the correct method to produce Bambusae Caulis in Liquamen. It is essential to inspect the original texts thoroughly in the course of modernizing traditional knowledge. Result : Discrimination between the two substances starts from manufacturing process; Bambusae Caulis in Liquamen is made under the temperature of less then $170^{\circ}C$, containing mild fragrance and sweet taste, and the Bamboo vinegar over $170^{\circ}C$ upto $400^{\circ}C$, carrying strong smoky scent and acidness. Although some researches show conforming clinical actions of both products, still there is a possibility that closer clinical study would reveal their discrepancy. Conclusion : Current use of Bambusae vinegar needs speculation. Authenticity in proper manufacturing process can be attained through passed-on medical texts.

• 동의생리병리학회지
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• 제17권1호
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• pp.177-182
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• 2003

This study was carried out to understand the effects of Bambusae Caulis in Liquamen on blood sugar in the db/db mice. Refined Bambusae Caulis in Liquamen C. D(BCL.C. D)manufactured by high temperature production process and Bambusae Caulis in Liquamen(H-BCL) manufactured & distributed by HANLIM PHARM.COM., LTD were used. The Bambusae Caulis in Liquamen extracted from bamboo charooal manufacturing process was filtered and refined. The effects of Bambusae Caulis in Liquamen were administered orally to mice for 6weeks and its anti-diabetic effect examined. The effects of BCL.C. D and H-BCL were observed in terms of blood sugar. creatinine. BUN and GPT in db/db mice. The results were as follows : The amount of glucose was slightly decreased (P<0.05) in the B CL.C-treated groups compared with the control. The amount of glucose was significantly decreased (P<0.01) in the BCL.D and H-BCL-treated groups compared with the control. The amount of creatinine did not show any differences among four groups. The amount of blood urea nitrogen did not show any differences in the case of BCL.C-treated groups. but observed significant decrease in the case of BCL.D and H-BCL-treated groups. The amount of GPT did not show any differences in the case of BCL.D-treated groups. but observed significant increase in the case of BCL.C and H-BCL-treated groups.

• 동의생리병리학회지
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• 제19권1호
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• pp.152-158
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• 2005

This study was carried out to understand the physiological properties and the effects of Bambusae Caulis in Liquamen manufactured by three different production process on blood glucose of the mice induced with streptozotocin. Original, filtered and refined Bambusae Caulis in Liquamen manufactured by three different production process were used. The physiochemical properties of original, filtered and refined Bambusae Caulis in Liquamen manufactured by three different production process were compared. Furthermore, the effects of original, filtered and refined Bambusae Caulis in Liquamen were observed in terms of blood glucose, BUN, ALT in the mice induced with streptozotocin. The results were as follows : The range of the pH manufactured by three different production processes was $2.28{\sim}3.17$ Concentration of methanol and phenolic compounds which are related to toxicity were lowest in filtered Bambusae Caulis in Liquamen(L-BCL [E] B) manufactured by using electric furnace at $215{\circ}C$ during 8.10/hour. The blood glucose contents was decreased in the experimental groups compared with the control. The amount of BUN and ALT did not show any differences between control and experimental group.

• 동의생리병리학회지
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• 제17권5호
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• pp.1217-1223
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• 2003

This study was carried out to understand the effects of Bambusae Caulis in Liquamen manufactured by different production process mixed with Silk Worm Powder on blood sugar in the db/db mice. Refined Bambusae Caulis in Liquamen D(L-BCL.D and H-BCL.D) manufactured by low or high temperature production process and original Bambusae Caulis in Liquamen producted by Hanlim pham Co. (BCL) and Silk Worm Powder were used. The effects of L-BCL.D+Silk Worm Powder, H-BCL.D+Silk Worm Powdr and BCl+SWP were observed in terms of blood sugar, creatinine, BUN, GPT in db/db mice. The amount of glucose was significantly decreased (P < 0.01) in the expremental groups compared with the control. The amount of Creatinine did not show any differences among four groups. The amount of blood urea nitrogen observed significant decrease in the case of BCL group. The amount of GPT did not show any differences among four groups.

• 동의생리병리학회지
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• 제17권3호
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• pp.742-745
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• 2003

This study was carried out to investigate the optimal mixed extract with Acanthopanax Chiisanensis Nakai in order to strengthen anti-diabetic effects on the hyperglycemia induced by streptozotocin in mice. The original Bambusae Caulis in Liquamen filtered and refined. The effects of Acanthopanax Chiisanensis Nakai with Bambusae Caulis in Liquamen were administered to mice for 4weeks and its anti-diabetic effect examined. Mice used in this experiment were divided into two groups and distrilled water(control), Acanthopanax Chiisanensis Nakai mixed with refined Bambusae Caulis in Liquamen(AC+BCL.D) were given orally for 28days respectively. And then, experimental groups were observed in terms of blood sugar, creatinine, BUN and GPT. The amount of glucose was significantly decreased compared with the control group(P < 0.01). The amount of creatinine was decreased compared with the control group(P < 0.05). The amount of GPT did not show any differences between two groups.

• 동의생리병리학회지
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• 제18권5호
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• pp.1456-1462
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• 2004

This study was carried out to understand the effects of Bambusae Caulis in Liquamen manufactured by different production facilities on blood glucose of the mice induced with streptozotocin. Filtered Bambusae Caulis in Liquamen manufactured by two different facilitiesproduction process were used. The physiochemical properties of filtered Bambusae Caulis in Liquamen manufactured by two different facilities(300L×300W×400H and 700L×700W×800H electric furnace) were compared. Furthermore, the effects of filtered Bambusae Caulis in Liquamen were observed in terms of blood glucose, BUN and AL T in the mice induced with streptozotocin. The results were as follows : The pH value was the highest in L-BCL(E)B(pH 2.83) between manufactured by two different facilities. The L-BCL(E)B which observed low values of Hunter's color values show decreased concentration of methanol and phenolic compounds. The blood glucose contents was decreased in the experimental groups compared with the control. The amount of BUN and ALT did not show any differences between control and experimental group.