• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1901-1906
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• 2012

Background: The discovery that microRNA (miRNA) regulates metastasis provide a principal molecular basis for tumor heterogeneity. A characteristic of solid tumors is their heterogenous distribution of blood vessels, with significant hypoxia occurring in regions (centers of tumor) of low blood flow. It is necessary to discover the mechanism of breast cancer metastasis in relation to the fact that there is a differential distribution of crucial microRNA in tumors from centers to edges. Methods: Breast tissues from 48 patients (32 patients with breast cancer) were classified into the high invasive and metastatic group (HIMG), low invasive and metastatic group (LIMG), and normal group. Samples were collected from both the centers and edges of all tumors. The first six specimens were detected by microRNA array, and the second ten specimens were detected by real-time qRT-PCR and Western blot analyses. Correlation analysis was performed between the miRNAs and target proteins. Results: The relative content of miR-20a and miR-20b was lower in the center of the tumor than at the edge in the LIMG, lower at the edge of the tumor than in the center in the HIMG, and lower in breast cancer tissues than in normal tissues. VEGF-A and HIF-1alpha mRNA levels were higher in the HIMG than in the LIMG, and levels were higher in both groups than in the normal group; there was no difference in mRNA levels between the edge and center of the tumor. VEGF-A and HIF-1alpha protein levels were higher in the HIMG than in the LIMG, and protein levels in both groups were higher than in the normal group; there was a significant difference in protein expression between the edge and center of the tumor. Correlation analysis showed that the key miRNAs (miR-20a and miR-20b) negatively correlated with the target proteins (VEGF-A and HIF-1alpha). Conclusions: Our data suggest that miR-20a and miR-20b are differentially distributed in breast cancer, while VEGF-A and HIF-1alpha mRNA had coincident distributions, and VEGF-A and HIF-1alpha proteins had uneven and opposing distributions to the miRNAs. It appears that one of the most important facets underlying metastatic heterogeneity is the differential distribution of miR-20a and miR-20b and their regulation of target proteins.

• 한국연소학회:학술대회논문집
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• 2003.05a
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• pp.223-227
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• 2003

The method of flame hole dynamics is demonstrated as a mean to simulate turbulent flame extinction. The core of the flame hole dynamics involves derivation of a random walk mapping for the flame holes, created by local quenching, between the burning and quenched states provided that the dynamic characteristics of flame edges is known. Then, the random walk mapping is projected to a background turbulent field. The numerical simulations are carried out with the further simplifications of flame string and unconditioned scalar dissipation rate. The simulation results show how the chance of partial quenching is influenced by the crossover scalar dissipation rate. Finally, a list of improvements, necessary to achieve more realistic turbulent flame quenching simulation, are discussed.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 1999.10a
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• pp.159-173
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• 1999

본 논문은 교차로에 설치된 영상검지기로부터 들어온 교통정보 중 공간교통정보에 해당하는 차량 대기길이를 측정을 하는 방법으로 각 차선(lane)별 검지영역에 대하여 웨이브렛 변형(Wavelet Transforms)을 하여 차량을 검지하고, 검지영역 내에서 차량의 대기길이를 측정하는 알고리즘을 제안한다. 기존의 방법으로는 차량 윤곽선 추출(edge detection)을 이용한 대기길이 측정 방법이나 배경(background)정보를 사전에 입수한 후 임계값 이상의 변화가 있을 때 차량을 검지하여 대기길이를 측정하는 방법 등이 연구되어 왔으나 이러한 방법들은 영상의 노이즈에 대하여 크게 영향을 받는다는 문제점이 있다. 그러나 본 알고리즘은 영상의 노이즈에 대하여 크게 영향을 받지 않을 뿐만 아니라 시간대 변화에 따른 도로의 명암값(intensity or gray level)을 추정할 필요가 없다는 특징이 있다. 특히, 야간 영상인 경우 차량 헤드라이트로 인한 검지오류도 감소할 수가 있다. 본 논문에서 실험은 주간, 야간 각각 1개 차선의 80개 표본크기로 실험을 하였으며, 대기길이는 정지 대기길이(standing queue length)와 이동 대기길이(moving queue length)로 나누어 측정을 하였다. 그 결과 주간, 야간의 경우 정지 대기길이는 2.14%, 2.24%, 이동 대기길이는 2.59%, 2.74%의 오차율로 측정이 되었다.

• Journal of Korea Society of Digital Industry and Information Management
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• v.9 no.3
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• pp.13-20
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• 2013

In this paper, we propose a multi-scale crack detection method. This method uses decomposition, composition, and shape properties. It is based on morphology algorithm, crack features. We use a morphology operator which extracts patterns of crack. It segments cracks and background using opening and closing operations. Morphology based segmentation is better than existing integration methods using subtraction in detecting a crack it has small width. However, morphology methods using only one structure element could detect only fixed width crack. Thus, we use decomposition and composition methods. We use a decimation method for decomposition. After decomposition and morphology operation, we get edge images given by binary values. Our method calculates values of properties such as the number of pixels and the maximum length of the segmented region. We decide whether the segmented region belongs to cracks according to those data. Experimental results show that our proposed multi-scale crack detection method has better results than those of existing detection methods.

• Proceedings of the IEEK Conference
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• 2005.11a
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• pp.363-366
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• 2005

In this paper, for detecting human faces under variations of lighting condition and facial expression, distance ranking feature and detection algorithm based on the feature are proposed. Distance ranking is the intensity ranking of a distance transformed image. Based on statistically consistent edge information, distance ranking is robust to lighting condition change. The proposed detection algorithm is a matching algorithm based on FFT and a solution of discretization problem in the sliding window methods. In experiments, face detection results in the situation of varying lighting condition, complex background, facial expression change and partial occlusion of face are shown

• Journal of The Korean Astronomical Society
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• v.49 no.6
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• pp.239-253
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• 2016

We determined the warp parameters of 192 warped galaxies which are selected from 340 edge-on galaxies using color images as well as r-band isophotal maps. We derive the local background density (${\Sigma}_n$) to examine the dependence of the warp amplitudes on the galaxy environment. We find a clear trend that strongly warped galaxies are likely to be found in high density regions where tidal interactions are supposed to be frequent. However, the correlation between ${\alpha}_{\omega}$ and ${\Sigma}_n$ is too weak for weakly warped galaxies (${\alpha}_{\omega}$ < $4^{\circ}$) and the cumulative distributions of weakly warped galaxies are not significantly different from those of galaxies with no detectable warps. This suggests that tidal interactions do not play a decisive role in the formation of weak warps.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2016.06a
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• pp.33-34
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• 2016

본 논문에서는 HVS(human visual system)의 특성을 고려한 새로운 스케일러블 코딩방법을 제안한다. 제안된 방법은 먼저 영상 내에서 관심영역(saliency map)을 찾고 관심영역을 제외한 부분에 에지 보존 필터를 적용한다. 그 영상은 정해진 양자 파라미터 값으로 인코딩 되어 제안된 코딩 시스템의 베이스 층(base layer)이 된다. 기존 스케일러블 코딩 표준에서의 베이스 층과 다르게 본 논문의 베이스 층은 관심 있는 중요영역(foreground)을 보존하고 또한 배경(background)의 에지 성분도 보존한다. 기본 층이 전송되면 개선층(enhancement layer)은 원 영상과 복원된 베이스 층 영상간의 차분 영상에서 관심영역 순으로 보내진다. 실험은 HEVC 를 바탕으로 수행되었고 스케일러블 코딩 표준인 SHVC 와 관심영역에서 비교를 했을 때 제안된 알고리즘이 더 높은 PSNR 을 가지는 것을 확인하였다. 또한 전체적으로 지각적인 품질(perceptual quality) 또한 향상되었음을 확인하였다.

• Journal of radiological science and technology
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• v.7 no.1
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• pp.13-21
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• 1984

Subtraction is an essential technic to improve imaging quality in various radiological procedures. The limitations of subtraction, however, are well known. Blurred under-subtraction (BUS) method has been suggested to overcome and compensate these limitations. Ten cases of angiography were subtracted by conventional subtraction and BUS technic. Results of this study revealed that BUS method is simple to perform and imaging quality obtained by BUS is excellent. Comparing to conventional subtraction, BUS method has advantages. For example, BUS need no mask film or no immobilization of patient during examination. Improvement of imaging Qualify is achieved by edge enhancement, homogeneous blurring of background density and increasing contrast. With emphasis of its simplicity in technic, we would report that BUS method is a useful adjunct imaging technic in various radiological procedures.

• International Commerce and Information Review
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• v.12 no.1
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• pp.327-352
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• 2010

3PL is the alternative for the corporation seeking to increase its logistics efficiency and effective implement of organization development. This study is to establish effective management method of the logistics companies and suggest further research direction by looking through theoretical background, applications, organization knowledge, international and domestic condition and problems of the 3PL which concludes to policy making. This study suggests corporation’s policy on technology oriented, management participation and knowledge on organization is used to secure competitive edge on logistics service. Close cooperation between departments is needed to acquire technology oriented information from 3PL human resource pool.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.5 no.6
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• pp.1169-1174
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• 2001

A new approach for determining global threshold value of binary image is proposed in this paper. In the proposed algorithm, bit-plane information which involve the shapes of original image is used for dividing image into two parts; object and background. Optimal threshold value are selected based on difference values of average between two regions, which is considered in global binary thresholding. Proposed method is no need to set a initial value, and consequently, it is relatively simple as well as robust. Experimental results showed a good performance in preserving edge not only continuous tone images but also document image.