• Journal of the Korean Society for Precision Engineering
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• v.23 no.4 s.181
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• pp.176-182
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• 2006

Although several artificial disc designs have been developed for the treatment of discogenic low back pain, biomechanical changes with its implantation were rarely studied. To evaluate the effect of artificial disc implantation on the biomechanics of functional spinal unit, a nonlinear three-dimensional finite element model of L4-L5 was developed with 1-mm CT scan data. Biomechanical analysis was performed for two different types of artificial disc having constrained and unconstrained instant center of rotation(ICR), ProDisc and SB Charite III model. The implanted model predictions were compared with that of intact model. Angular motion of vertebral body, forces on the spinal ligaments and facet joint, and stress distribution of vertebral endplate for flexion-extension, lateral bending, and axial rotation with a compressive preload of 400N were compared. The implanted model showed increased flexion-extension range of motion compared to that of intact model. Under 6Nm moment, the range of motion were 140%, 170% and 200% of intact in SB Charite III model and 133%, 137%, and 138% in ProDisc model. The increased stress distribution on vertebral endplate for implanted cases could be able to explain the heterotopic ossification around vertebral body in clinical observation. As a result of this study, it is obvious that implanted segment with artificial disc suffers from increased motion and stress that can result in accelerated degenerated change of surrounding structure. Unconstrained ICR model showed increased in motion but less stress in the implanted segment than constrained model.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.6
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• pp.633-641
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• 2017

The aim of this study is to investigate the effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and ER stress of the cardiac muscle in high fat diet-induced obese middle-aged rats. We induced obesity over 6 weeks of period in 40 male Sprague-Dawley rats around 50 weeks old, and were randomly divided into four experimental groups: chow, HFD, exercise+HFD, and exercise+chow. The exercising groups underwent high-intensity intermittent training using a ladder-climbing and weight exercise 3 days/week for a total of 8 weeks. High-fat diet and concurrent exercise resulted in no significant reduction in body weight but caused a significant reduction in visceral fat weight (p<0.05). Expression of $PPAR{\delta}$ increased in the exercise groups and was significantly increased in the high-fat diet+exercise group (p<0.05). Among the ER stress-related proteins, the expression levels of p-PERK and CHOP, related to cardiac muscle damage, were significantly higher in the cardiac muscle of the high-fat diet group (p<0.05), and were significantly reduced by intermittent ladder-climbing exercise training (p<0.05). Specifically, this reduction was greater when the rats underwent exercise after switching back to the chow diet with a reduced caloric intake. Collectively, these results suggest that the combination of intermittent ladder-climbing exercise training and a reduced caloric intake can decrease the levels of ER stress-related proteins that contribute to cardiac muscle damage in obesity and aging. However, additional validation is required to understand the effects of these changes on mitochondrial biogenesis during exercise.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.37 no.4
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• pp.72-81
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• 2014

Even though two-hands lifting/lowering activity of manual materials handling tasks are prevalent at the industrial site, many manual materials handling tasks which require the worker to perform one-hand lifting/lowering are also very common at the industrial site, forestry, farming, and daily life. The objective of this study was to compare one-hand lowering activity to lifting activity in terms of biomechanical stress for the range of lowering heights from knuckle height to 10cm above floor level with two workload 7.5kg and 15.0kg. Eight male subjects with LMM were asked to perform lifting/lowering tasks using both a one-handed (left-hand and right-hand) as well as a two-handed technique. Spinal loading was estimated through an EMG-assisted free-dynamic biomechanical model. The biomechanical stress of one-hand lowering activity was shown to be 43% lower than that of one-hand lifting activity. It was claimed that the biomechanical stress for one-hand lifting/lowering activity is almost twice (194%) of the one for two-hands lifting/lowering activity. It was also found that biomechanical stress by one-hand lowering/lifting activity with the half workload of two-hands lowering/lifting activity was greater than that of the two-hands lowering/lifting activity. Therefore, it might be a risk to consider the RWL of one-hand lowering/lifting activity to simply be a half of the RWL of two-hands lowering/lifting activity recommended by NIOSH.

• Journal of the Ergonomics Society of Korea
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• v.32 no.5
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• pp.413-420
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• 2013

Objective: The objective of this study was to compare one-hand and two-hands lowering activity in terms of biomechanical stress for the range of lowering heights from knuckle height to 10cm above floor level. Background: Even though two-hands lifting/lowering activity of manual materials handling tasks are prevalent at the industrial site, many manual materials handling tasks which require the worker to perform one-hand lifting/lowering are also very common at the industrial site and forestry and farming. Method: Eight male subjects were asked to perform lowering tasks using both a one-handed as well as a two-handed lowering technique. Trunk muscle electromyographic activity was recorded while the subjects performed the lowering tasks. This information was used as input to an EMG-assisted free-dynamic biomechanical model that predicted spinal loading in three dimensions. Results: It was shown that for the left-hand lowering tasks, the values of moment, lateral shear force, A-P shear force, and compressive force were increased by the average 6%, as the workload was increased twice from 7.5kg to 15kg. For the right-hand lowering task, these were increased by the average 17%. For the two-hands lowering tasks, these were increased by the average 14%. Conclusion: Even though the effect of workload on the biomechanical stress for both one-hand and two-hands lowering tasks is not so significant for the workload less than 15kg, it can be claimed that the biomechanical stress for one-hand lowering is greater than for two-hands lowering tasks. Therefore, it can be concluded that asymmetrical lowering posture would give greater influence on the biomechanical stress than the workload effect for one-hand lowering activity. Application: The result of this study may be used to provide guidelines of recommended safe weights for tasks involved in one-hand lowering activity.

• Molecules and Cells
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• v.43 no.3
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• pp.264-275
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• 2020

Reactive oxygen species (ROS) play a significant role in intracellular signaling and regulation, particularly when they are maintained at physiologic levels. However, excess ROS can cause cell damage and induce cell death. We recently reported that eIF2α phosphorylation protects hepatocytes from oxidative stress and liver fibrosis induced by fructose metabolism. Here, we found that hepatocyte-specific eIF2α phosphorylation-deficient mice have significantly reduced expression of the epidermal growth factor receptor (EGFR) and altered EGFR-mediated signaling pathways. EGFR-mediated signaling pathways are important for cell proliferation, differentiation, and survival in many tissues and cell types. Therefore, we studied whether the reduced amount of EGFR is responsible for the eIF2α phosphorylation-deficient hepatocytes' vulnerability to oxidative stress. ROS such as hydrogen peroxide and superoxides induce both EGFR tyrosine phosphorylation and eIF2α phosphorylation. eIF2α phosphorylation-deficient primary hepatocytes, or EGFR knockdown cells, have decreased ROS scavenging ability compared to normal cells. Therefore, these cells are particularly susceptible to oxidative stress. However, overexpression of EGFR in these eIF2α phosphorylation-deficient primary hepatocytes increased ROS scavenging ability and alleviated ROS-mediated cell death. Therefore, we hypothesize that the reduced EGFR level in eIF2α phosphorylation-deficient hepatocytes is one of critical factors responsible for their susceptibility to oxidative stress.

• Journal of agricultural medicine and community health
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• v.37 no.3
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• pp.156-166
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• 2012

Objectives: This study aimed to identify the relationship among health-related quality of life of the Cheon-nam region elderly with low back pain. Methods: Data were obtained from cross-sectional surveys conducted as a part of the Community Health Survey 2008. The final analysis included data from 7,003 of the 7,070 elderly participants (aged over 65 years), as 67 responses were excluded since they were inaccurate. Data were analyzed with SPSS for Windows (ver. 19.0), using a ${\chi}^2$-test, a t-test, an ANOVA, and multiple liner regression. The significance threshold was set as p<0.05. Results: Factors related to the health-related quality of life of the elderly were low back pain, age, education level, occupation, subjective health status, subjective stress, drinking status, number of chronic diseases, and sleep duration. Further, health-related quality of life was significantly lower in elderly adults with low back pain. Conclusions: In order to improve health-related quality of life of the elderly and the development of the program for the management of low back pain will be needed to determine, it is considered necessary to study more to follow through the various analysis of in the elderly and health-related quality of life.

• The korean journal of orthodontics
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• v.28 no.4 s.69
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• pp.563-580
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• 1998

This study was designed to analysis the displacement and stress distribution of individual tooth by orthodontic force during distal on masse movement of the maxillary dentition. In this study, three dimensional finite element analysis was used. Author made the finite element model of maxillary teeth, periodontal ligament, alveolar bone and bracket with anatomic and physiologic characteristics on computer. Author analysed and evaluated the displacement and stress distribution of individual tooth when extraoral force, Class II intermaxillary elastics, ideal arch wire, MEAW and tip back bend were used for distal on masse movement of the maxillary dentition. These analyses were also applied in the case of the maxillary second molar were not extracted. Author compared the results of the cases which maxillary second molar were extracted or not. The results were expressed quantitatively and visually. Author obtained following results, 1. When anterior headgear was applied, the posterior translation, posterior tipping, and vertical displacement of teeth were produced more in the anterior segment of the dentition. 2. When Class II intermaxillary elastics were applied in the ideal arch wire, the teeth displacement were usually produced in the anterior segment. But when tip back bend were added in the ideal arch wire, the orthodontic force produced by elastics were transmitted to the posterior segment. As increasing the tip back bend, posterior translation and lingual tipping of anterior teeth were decreased, posterior translation and tipping displacement of posterior teeth were increased, and extrusion of anterior teeth by Class II elastics were decreased 3. When MDAW and Class II elastics were applied, the teeth movement were sir flu with the case of ideal arch wire and Class II elastics, but more small and uniform teeth displacement were produced Compared with the ideal arch wire, posterior tipping of the posterior segment were more produced than lingual tipping displacement of the anterior segment. 4. When the maxillary second molar without orthodontic appliance existed, the displacement of maxillary first molar were decreased.

• The Journal of Engineering Geology
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• v.19 no.1
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• pp.43-50
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• 2009

A 3-D numerical analysis was carried out to observe potential effects of orientation of inherent weak zones to tunnel behaviors and stress distributions during tunnel excavation. Weak zones used for the analysis were placed at the upper 1D part from crown, on the crown and on the center of face, using orientations derived from the 6th RMR parameter for assessment of joint orientation effect on tunnel. Mechanical properties of rock mass were derived through a in-situ displacement measurement-based back analysis. Finally, a classification chart for crown settlement with five ranks based on orientation and location of weak zones is suggested.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.09a
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• pp.539-545
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• 2010

The field plate test has a good potential for determining since it measures both plate pressure and settlement. The deformation modulus of rock mass is differently measured for status of structures. The values of deformation modulus are obtained from laboratory test (uniaxial and triaxial test) and field test (pressuremeter test). Plate load test should be conducted by different loading plate sizes for geological structure of rock mass and scale of structures. In this paper, large plate load tests were performed to predict of structure's behavior and evaluate the ultimate bearing capacity of the foundation on soft rock. Simultaneously, deformation modulus of rock mass was estimated by back analysis of stresses measured in field test under rock mass. Finally, we verified the validation of deformation modulus of rock mass through result of large plate load test and numerical simulation.

• Structural Engineering and Mechanics
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• v.38 no.4
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• pp.443-457
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• 2011

The loss of strength in a structure as a result of cyclic loads over a period of life time is an important phenomenon for the life-cycle analysis. Service loads are accentuated at the areas of stress concentration, mainly at the connection of components. Structural components unavoidably are affected by defects such as surface scratches, surface roughness and weld defects of random sizes, which usually occur during the manufacturing and handling process. These defects are shown to have an important effect on the fatigue life of the structural components by promoting crack initiation sites. The value of equivalent initial flaw size (EIFS) is calculated by using the back extrapolation technique and the Paris law of fatigue crack growth from results of fatigue tests. We try to analyze the effect of EIFS distribution in a multiple site damage (MSD) specimen by using the extended finite element method (XFEM). For the analysis, fatigue tests were conducted on the centrally-cracked specimens and MSD specimens.