• Geomechanics and Engineering
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• 제30권3호
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• pp.273-280
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• 2022

A certain amount of random vibration excitation to subway track is caused by subway operation. This excitation is transmitted through track foundation, tunnel, soil medium, and ground building to the ground and ground structure, causing vibration. The vibration affects ground building. In this study, the results of ANSYS numerical simulation was used to establish back-propagation (BP) neural network model. Moreover, a back-propagation neural network model consisting of five input neurons, one hidden layer, 11 hidden-layer neurons, and three output neurons was used to analyze and calculate the vertical Z-vibration level of New Capital's ground buildings of Qingdao Metro phase I Project (Line M3). The Z-vibration level under different working conditions was calculated from monolithic roadbed, steel-spring floating slab roadbed, and rubber-pad floating slab roadbed under the working condition of center point of 0-100 m. The steel-spring floating slab roadbed was used in the New Capital area to monitor the subway operation vibration in this area. Comparing the monitoring and prediction results, it was found that the prediction results have a good linear relationship with lower error. The research results have good reference and guiding significance for predicting vibration caused by subway operation.

• 한국의료질향상학회지
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• 제10권2호
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• pp.216-231
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• 2003

Objectives: To develop a model that predicts a death probability of acute myocardial infarction(AMI) patient, and to evaluate a performance of hospital services using the developed model. Methods: Medical records of 861 AMI patients in 7 general hospitals during 1996 and 1997 were reviewed by two trained nurses. Variables studied were risk factors which were measured in terms of severity measures. A risk model was developed by using the logistic regression, and its performance was evaluated using cross-validation and bootstrap techniques. The statistical prediction capability of the model was assessed by using c-statistic, $R^2$ as well as Hosmer-Lemeshow statistic. The model performance was also evaluated using severity-adjusted mortalities of hospitals. Results: Variables included in the model building are age, sex, ejection fraction, systolic BP, congestive heart failure at admission, cardiac arrest, EKG ischemia, arrhythmia, left anterior descending artery occlusion, verbal response within 48 hours after admission, acute neurological change within 48 hours after admission, and 3 interaction terms. The c statistics and $R^2$ were 0.887 and 0.2676. The Hosmer-Lemeshow statistic was 6.3355 (p-value=0.6067). Among 7 hospitals evaluated by the model, two hospitals showed significantly higher mortality rates, while other two hospitals had significantly lower mortality rates, than the average mortality rate of all hospitals. The remaining hospitals did not show any significant difference. Conclusion: The comparison of the qualities of hospital service using risk-adjusted mortality rates indicated significant difference among them. We therefore conclude that risk-adjusted mortality rate of AMI patients can be used as an indicator for evaluating hospital performance in Korea.

• Journal of Preventive Medicine and Public Health
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• 제31권3호
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• pp.384-394
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• 1998

In order to investigate the effect of the urinary excretion of sodium and potassium on the change on blood pressure over 3 years, 668 adolescents aged 13 years living in Kangwha area were investigated in a longitudinal follow-up study. Two measurements were taken on each blood pressure (diastolic, systolic) and the average of the two readings was used in the analysis. Sodium and potassium intake were estimated by the determination of those electrolytes in 24hr urine. The mixed model regression analysis was used to identify the effect of urinary sodium and potassium on the change of blood pressure after controlling for BMI of each age. On simple bivariate analysis no relationship was found between urinary sodium excretion and systolic or diastolic blood pressure among both male and female, however, a significant positive association between urinary potassium excretion and systolic blood pressure among male. The results of mixed regression analysis showed that the body mass index (BMI) were more influential that urinary electrolytes among this study subjects. It suggested that risk factors observed from the adults, may not be identical with that of the growing aged population. After control of the BMI and age, significant association between sodium and diastolic BP among male, and association between potassium and systolic BP among female, were found. In summary, the results indicate that growth has been more influential than dietary factor on blood pressure for growing aged population.

• 한국한의학연구원논문집
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• 제13권2호통권20호
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• pp.149-155
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• 2007

Objective : Using a spontaneously hypertensive rat (SHR) model of essential hypertension, this study investigated whether electroacupuncture (EA) could reduce early stage hypertension by examining whether EA increased nitric oxide (NO) levels in plasma, which compensates for elevated blood pressure (BP). Methods : EA was applied to the acupoint, Baekhoe (GV20), and to a non acupoint in the tail at 10 Hz and an intensity of 1 mA for 10 minutes on the first and fourth day of the week for three weeks under isoflurane anesthesia. In conscious SHR and normotensive Wistar Kyoto (WKY) rats, blood pressure was determined the day after EA treatment by the tail cuff method using an automatic BP monitoring system. We also measured NO concentration of blood serum in SHR and WKY. Results : Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were lower after 3 weeks of GV20 treatment than in non EA treated or non acupoint treated SHR rats. The NO level of plasma was significantly lower in hypertensive SHR than in normotensive WKY. EA prevented the augmentation of blood pressure, and also increased NO concentrations from $7.91{\pm}0.42$ ${\mu}M$ to $11.50{\pm}0.93$ ${\mu}M$ in SHR serum. Conclusions : We suggest that acupuncture may be an early intervention to delay the development of hypertension and enhance NO/NOS activity.

• 한국통신학회논문지
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• 제21권12호
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• pp.3265-3276
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• 1996

문자인식에 대한 연구는 주로 한글인식에 대해서만 이루어져 왔는데, 대부분의 문서는 한글 뿐만 아니라 여러 종류의 문자가 포함되어 있다. 따라서, 본 논문에서는 다중 크기, 다중 활자체, 다자종 문자가 포함되어 있는 한글문서를 인식할 수 있는 문자인식 시스템을 구현하였다. CombNET 구조를 갖는 신경회로망을 자종별로 구성하여, 문자인식시에 문자를 구별하지 않고 인식하는 방법을 제안하였다. CombNET 구조의 상단부를 차지하는 Kohonen의 SOFM 신경망을 이용하여 한글과 한자는 36개, 영숫자는 16개의 유형으로 분류하고 각 유형에 대해서 CombNET 구조의 하단부에 있는 BP 네트워크를 이용하여 문자인식을 수행하였다. 실험결과 학습 데이타에 대해서는 95.6%의 인식율을 나타내었고, 실제문서에 대해서도 92.6%의 인식율과 초당 10.3자의 인식속도를 보임으로써 제안된 인식 시스템의 유효성을 입증하였다.

• BMB Reports
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• 제38권5호
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• pp.571-576
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• 2005

Cytokines are proteins produced by many different cells of the immune system and play a significant role in initiating and regulating the inflammatory process. In this research, an important cytokine, interleukin-10 (IL-10) gene, has been identified and characterized from zebrafish (Danio rerio) genome database. Zebrafish IL-10 is located within a 2690 bp fragment and contains five exons and four introns, sharing the same organization with mammalian IL-10 genes. An open reading frame of 543 bp was found to encode a putative 180 amino acid protein with a signal peptide of 22 amino acids, which shares 29.7-80.9% homology with amino acid sequences of other known IL-10. The signature motif of IL-10 is also conserved in zebrafish IL-10. The predicted transcript was finally confirmed by sequencing of cDNA clones. Multi-tissue reverse transcriptase PCR (RT-PCR) was performed to examine the tissue distribution and expression regulation of this gene in seven organs of normal and lipopolysaccharide (LPS) stimulation zebrafish. The results demonstrated that this gene was expressed slightly in normal kidney, gill and gut, no expression was detected in other four tissues. The expression was clearly upregulated after LPS stimulation. Using the ideal zebrafish model, further study of IL-10 characterization and function may provide insight on the understanding of the innate immune system.

• 생명과학회지
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• 제27권5호
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• pp.524-529
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• 2017

본 연구에서는 zebrafish에 인간의 KCNE1 유전자가 삽입된 형광단백질 vector를 microinjection하고, 그 발현 여부를 확인하고자 하였다. 먼저 양 말단에 제한효소(EcoRΙ, BamHΙ) site를 넣어 제작한 primer들로 genomic DNA에서 KCNE1 유전자를 분리하였다. 그 결과는 약 402 bp 크기의 DNA band였고 이 PCR 산물을 형광단백질 vector인 pPB-CMVp-EF1-GreenPuro 속에 클로닝하여 pPB-CMVp-hKCNE1-EF1-GreenPuro plasmid를 제작하였다. 이렇게 준비된 형광 vector를 zebrafish 수정란에 microinjection하였고, 부화된 치어에서 RT-PCR과 DNA sequencing을 통해 GFP 및 hKCNE1의 발현을 최종 확인하였다. 본 연구는 향후 QT 연장증후군(LQTs)에 대한 동물 모델로써 신경자극 전도, 유전자 치료, 유용 유전자 클로닝을 위한 기술 개발에 응용될 수 있을 것으로 기대된다.

• Journal of Microbiology and Biotechnology
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• 제30권11호
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• pp.1777-1784
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• 2020

To increase the availability of microalgae as producers of valuable compounds, it is necessary to develop novel systems for gene expression regulation. Among the diverse expression systems available in microalgae, none are designed to induce expression by low temperature. In this study, we explored a cold-inducible system using the antifreeze protein (AFP) promoter from a polar diatom, Chaetoceros neogracile. A vector containing the CnAFP promoter (pCnAFP) was generated to regulate nuclear gene expression, and reporter genes (Gaussia luciferase (GLuc) and mVenus fluorescent protein (mVenus)) were successfully expressed in the model microalga, Chlamydomonas reinhardtii. In particular, under the control of pCnAFP, the expression of these genes was increased at low temperature, unlike pAR1, a promoter that is widely used for gene expression in C. reinhardtii. Promoter truncation assays showed that cold inducibility was still present even when pCnAFP was shortened to 600 bp, indicating the presence of a low-temperature response element between -600 and -477 bp. Our results show the availability of new heterologous gene expression systems with cold-inducible promoters and the possibility to find novel low-temperature response factors in microalgae. Through further improvement, this cold-inducible promoter could be used to develop more efficient expression tools.

• 정보처리학회논문지B
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• 제10B권5호
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• pp.553-560
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• 2003

웨이블릿 변환(Wavelet Transform)된 비디오는 주파수와 해상도가 다근 부대역으로 분해되므로 전송 오류가 발생한 패킷의 위치에 따라 복원된 프레임 간 화질 편차가 크게 된다. 복원된 프레임의 화질 변화가 클수록 사용자가 느끼는 비디오의 화질은 떨어진다. 특히, 움직임 예측을 이용한 웨이블릿 비디오의 경우, 특정 부대역에서 발생한 오류는 같은 프레임의 다른 부대역 뿐 아니라 이후 프레임의 화질에도 지속적인 영향을 미치게 된다. 본 논문에서는 웨이블릿 기반 비디오를 네트워크로 전송하기 위해 패킷화론 수행할 때, 오류발생 패킷의 위치에 관계없이 일정한 화질을 유지하며 오류 은닉이 쉬운 블록기반 패킷화 기법인 BDP(Block based Dispersive Packetization)를 제안한다. 본 논문은 MRME(Multi-Resolution Motion Estimation)글 적용하여 압축된 비디오와 무선 네트워크에서의 오류 발생 모델을 이용하여 성능평가를 수행하였다. 실험결과 제안된 기법은 프레임을 일정한 블록으로 분할하여 순차적으로 패킷화하는 BP나 픽셀단위로 분산하는 DP기법에 비해 주ㆍ객관적인 성능 모두 뛰어남을 알 수 있었다.

• 산업진흥연구
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• 제2권2호
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• pp.1-6
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• 2017

한국전력의 전력을 생산, 수송, 공급하는 3가지 업무분야 중 수송부분을 관리하는 서울전력관리처에 SCADA (Supervisery Control And Data Acquisition) System이 1980년 처음 도입된 후 중앙급전소, 지역급전소, 변전소 업무를 EMS, SCADA, RTU 컴퓨터 설비 3계층의 1:N 식 방사상 형태로 구성하여 HARRIS 6000, BSC, HDLC, L&N, 도시바 등 5개 Protocol로 1200 bps와 9600 bps로 Data Link를 이용하여 왔다. 본 연구는 OSI표준네트워크패킷흐름을 도시하여 DataLink와 Network Layer를 분석하고, 네트워크 3계층을 사용하는 X.25 고속 통신망으로 구성된 한국전력 SCADA 네트워크 모델을 제시하였으며, 통신망을 시험 평가하였다. 현재의 스카다 통신구조를 개선한 미래 스카다 통신구조를 제시하고, SCADA DB 구조를 정의하고, 스카다 기능 구조에 원격 SCADA 게이트웨이 개념을 도입 표준 통신프로토콜을 적용 하였다. 따라서 데이터 전송시간 제약완화, 타지역 타 설비에서의 감시 및 제어의 다중화 및 통신 개방성을 확보하도록 하였다.