• 한국안전학회지
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• 제19권4호
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• pp.1-7
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• 2004

This study investigated the effects of aging on the transformation behavior of $Ti-50.1at\%$ Ni alloy by means of differential scanning calorimetry. It was found that aging in the temperature range of $350^{\circ}C\~550^{\circ}C$ induced complex transformation behavior, involving the R-phase and multiple-stage martensitic transformation. Usually aged Ni-rich NiTi alloys undergo martensitic transformation on cooling from high temperatures in two step : B2 to R and then R to Bl9'(normal behavior). But under certain ageing conditions, the transformation can also occur in three or more step(unusual multiple step behavior). In the present study we use differential seaming calorimetry(DSC) for a systematic investigation of the evolution of transformation behavior with ageing temperature and time.

• 혜화의학회지
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• 제15권2호
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• pp.193-199
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• 2006

The literatural study on the effect of acupuncture for tinnitus was studied from the viewpoint of acupuncture effect. The conclusions are as follows. 1. The ear manages kidney, it relates with the heart meridian of hand soeum, kidney meridian of foot soeum, lung meridian of hand taeeum, spleen meridian of foot taeeum, stomach meridian of foot yangmyeong, gallbladder meridian of foot soyang, triple energizer meridian of hand soyang, small intestine meridian of hand taeyang. 2. According to classification of meridian in acupuncture treatment of tinnitus triple energizer meridian of hand soyang 18.0%, gallbladder meridian of foot soyang 16.6%, bladder meridian of foot taeyang 16.6%, small intestine meridian of hand taeyang 9.7%, large intestine meridian of hand yangmyeong 8.3%, stomach meridian of foot yangmyeong 5.5%, spleen meridian of foot taeeum 4.1%, pericardium meridian of hand gworeum 4.1%, lung meridian of hand taeeum 2.8%, heart meridian of hand soeum 2.8%, kidney meridian of foot soeum 2.8%, liver meridian of foot gworeum 2.8%, conception channel 2.8%, governor channel 2.8% have been used much in turn. 3. In the general points GB2 24times, TE3 22times, TE17 22times, SI19 20times, TE21 20times, KI 3 19times, BL23 17times, LI4 15times have been used much in turn.

• The Korean Journal of Physiology and Pharmacology
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• 제19권3호
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• pp.269-274
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• 2015

Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown to have anti-inflammatory effects in aged experimental animals. We reported on the long-term treatment of daumone, a synthetic pheromone secreted by Caenorhabditis elegans in an energy deficient environment, extends the life-span and attenuates liver injury in aged mice. The present study examined whether late onset short-term treatment of daumone exerts anti-inflammatory effects in the livers of aged mice. Daumone was administered orally at doses of 2 or 20 mg/kg/day for 5 weeks to 24-month-old male C57BL/6J mice. Increased liver macrophage infiltration and gene expression of proinflammatory cytokines in aged mice were significantly attenuated by daumone treatment, suggesting that short-term oral administration of daumone may have hepatoprotective effects. Daumone also dose-dependently suppressed tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$ )-induced nuclear factor-${\kappa}B$ (NF-${\kappa}B$) phosphorylation in HepG2 cells. The present data demonstrated that short-term treatment of daumone has anti-inflammatory effects in aged mouse livers possibly through suppression of NF-${\kappa}B$ signaling and suggest that daumone may become a lead compound targeting aging and age-associated diseases.

• IMMUNE NETWORK
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• 제19권1호
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• pp.3.1-3.17
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• 2019

Aging is a complex process associated with dysregulation of the immune system and low levels of inflammation, often associated with the onset of many pathologies. The lacrimal gland (LG) plays a vital role in the maintenance of ocular physiology and changes related to aging directly affect eye diseases. The dysregulation of the immune system in aging leads to quantitative and qualitative changes in antibodies and cytokines. While there is a gradual decline of the immune system, there is an increase in autoimmunity, with a reciprocal pathway between low levels of inflammation and aging mechanisms. Elderly C57BL/6J mice spontaneously show LGs infiltration that is characterized by Th1 but not Th17 cells. The aging of the LG is related to functional alterations, reduced innervation and decreased secretory activities. Lymphocytic infiltration, destruction, and atrophy of glandular parenchyma, ductal dilatation, and secretion of inflammatory mediators modify the volume and composition of tears. Oxidative stress, the capacity to metabolize and eliminate toxic substances decreased in aging, is also associated with the reduction of LG functionality and the pathogenesis of autoimmune diseases. Although further studies are required for a better understanding of autoimmunity and aging of the LG, we described anatomic and immunology aspects that have been described so far.

• 대한약침학회지
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• 제11권3호
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• pp.113-122
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• 2008

Objective: The purpose of this study was to invigorate the use of infrared thermal imaging apparatus as a diagnostic tool in Oriental medicine by providing standard temperature on specific acupoints. Methods: Subjects for the study was recruited through an advertisement in the school homepage(www.sangji.ac.kr) explaining the objectives and methods. 100 volunteers agreeing to terms were selected and measured the full body thermal image. Common acupoints used in the clinical surrounding were chosen and final 63 acupoints were selected for the measurement. Male/female and right/left readings were obtained for the analysis. Results: Following results were obtained from analyzing the body temperature of 50 male subjects and 50 female subjects 1. Subjects participating in the study ranged from 19 years of age to 44 years. Median male age at $26.86{\pm}6.02$ and female age at $22.88{\pm}2.74$, respectively. 2. For all acupoints, no significant differences were witnessed between the gender and right, left side of the body. 3. 10 acupoints from the facial region(18 bilateral), 8 acupoints from the chest/abdomen region(10 bilateral), 6 acupoints from the back region(11 bilateral), 17 acupoints from the upper extremity(34 bilateral), and 22 acupoints from the lower extremity(44 bilateral) were chosen. 4. In the facial region, BL2 showed the highest temperature and GV26 showed the lowest. 5. In the chest/abdomen region, CV22 showed the highest temperature and CV6 showed the lowest. 6. In the back region, GV14 showed the highest temperature and BL23 showed the lowest. 7. In the upper extremity region, jianqian(extra point) showed the highest temperature and baxie(extra point) showed the lowest. 8. In the lower extremity region, KI1 and bafeng(extra point) shoed the highest temperature and BL40 showed the lowest. Conclusions: Based on the standard body temperature measured on specific acupoints throughout the body, we hope these findings can trigger further studies on applications of infrared thermal imaging and clinical usage in the field of oriental medicine.

• 대한한방종양학회지
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• 제4권1호
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• pp.159-175
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• 1998

1. 연구배경 최근 놀라운 과학기술의 발전에 힘입어 난치병이라고 생각되어 오던 질환들이 하나씩 정복되어 가고 있으나 평균수명의 연장, 생활수준 향상으로 인한 고지방식, 스트레스 및 과학기술발전의 부작용 등을 이유로 새로운 질환들이 나타나고 있는 실정이다. 종양도 이런 대표적인 질환중 하나로 최근 경제적, 시간적으로 많은 투자를 해왔으나 아직까지 그 발생원인이나 성장기전 등이 자세히 밝혀지지 않았다. 이에 본 연구는 효후(哮吼)를 치료하는 청상보하환(淸上補下丸)을 이용하여 흑색종의 폐전이 억제능과 이에 의한 면역증강에 관하여 연구하고자 하였다. 2. 연구결과 B-16 세포를 이용한 C57BL/6계 마우스에 있어서의 폐전이 억제능을 측정한 결과 청상보하환(淸上補下丸) 투여군이 대조군에 비해 검액처리 7일후에는 52.70%, 14일후에는 19.43%의 유의성있는 억제율을 보였으며, 청상보하환(淸上補下丸)의 B-16 세포에 대한 직접적인 항암작용을 알아 보기 위한 시험관내 세포독성 실험에서는 청상보하환(淸上補下丸)의 용량이 $5{\mu}g/well$, $2.5{\mu}g/well$, $1.25{\mu}g/well$, and $0.625{\mu}g/well$인 경우 유의성있는 효과를 얻을수 있었으며 생존율에 의한 $IC_{50}$은 $2.17{\mu}g/well$이었다. NK-activity를 측정한 결과 청상보하환(淸上補下丸) 투여군이 작동세포와 표적세포의 비율이 100:1, 50:1의 경우에 있어서 $72.63{\pm}5.17%$, $26.94{\pm}2.43%$를 보여 대조군에 비하여 각각 31.12%, 43.68% 유의성있는 증가를 보였다. IL-2의 생산능을 측정한 결과 청상보하환(淸上補下丸) 투여군은 $1392.00{\pm}22.31pg/ml$을 보여 대조군에 비해 4.04%의 유의성 있는 증가를 보였다.

• 동의생리병리학회지
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• 제19권3호
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• pp.696-704
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• 2005

This experiment examined the effect of Samultang-gamibang (SGB) on hair growth in spontaneous alopecia areata C57BL/6N mice. We first investigated hair growth effect of SGB compare to control groups after apply to oral administration for 10 weeks and regional treatment in skin for last 4 weeks. We second investigated the number of hair follicle and mast cells after treatment of SGB in spontaneous alopecia areata C57BL/6N mice for 10 weeks. We third investigated immunoreactive density of neuropeptides in skin of spontaneous alopecia areata C57BL/6N mice by immunohistochemical methods. The results were as follows : Hair growing effect of experimental group was observed from 7 weeks after administration of SGB (87.5%). In experimental group, the number of mast cells and eosinophils was significantly decreased compare to control group. Immunoreactive density of substance P and corticotropin releasing factor (CRF) in skin of experimental group was weakly stained in epidermis and subcutaneous tissue compare to control group. Immunoreactive density of CRF-receptor (CRF-R), CRF-binding protein (CRF-BP) in skin of experimental group was increased in epidermis, sebaceous gland, inner root sheath, outer root sheath and secondary hair germ epithelium compare to control group. These results suggest that SGB may be used in treatment of alopecia areata.

• 천문학회보
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• 제41권2호
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• pp.60.2-60.2
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• 2016

We present recent results of very long baseline interferometry (VLBI) observations of gamma-ray bright active galactic nuclei (AGNs) using Korean VLBI Network (KVN) at 22, 43, 86, and 129~GHz bands, which are part of a KVN key science program; Interferometric Monitoring of Gamma-ray Bright AGNs (iMOGABA). We selected a total of 34 radio-loud AGNs of which 30 sources are gamma-ray bright AGNs, including 24 sources monitored by the Fermi Gamma-ray Space Telescope using the Large Area Telescope on board. The selected sources consist of 24 quasars, 7 BL Lacs, and 3 radio galaxies. In this talk, we summarize recent results of the iMOGABA, including results of single-epoch multi-frequency VLBI observations of the target sources, conducted during a 24-hr session on 2013 November 19 and 20. All observed sources were detected and imaged at all frequency bands with or without a frequency phase transfer technique which enabled to detect and image 12 faint sources at 129 GHz, except for 0218+357 which was detected for only one baseline at all frequency bands.

• 대한의생명과학회지
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• 제19권3호
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• pp.206-212
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• 2013

The herbal composition Gyeongshingangjeehwan 18 (GGEx18), which is composed of three herbs, Laminaria japonica Aresch (Laminariaceae), Rheum palmatum L. (Polygonaceae), and Ephedra sinica Stapf (Ephedraceae), has been used as an anti-obesity drug in Korean local clinics. Thus, we investigated whether GGEx18 regulates obesity by suppressing appetite in high fat diet-induced obese C57BL/6J mice. Administration of GGEx18 to obese mice for 9 weeks significantly decreased body weight gain, epididymal adipose tissue weight, and food efficiency ratio. GGEx18 also caused a significant decrease in the circulating levels of leptin, which were increased by about 450% in obese control mice compared with normal lean mice. Concomitantly, GGEx18 decreased mRNA levels of a potent appetite-stimulating hormone neuropeptide Y, but increased an appetite-suppressing hormone pro-opiomelanocortin mRNA levels. These results suggest that GGEx18 may prevent obesity through regulating appetite in nutritionally obese mice.

• 한국임상수의학회지
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• 제19권2호
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• pp.207-210
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• 2002

The effects of electroacupuncture on gastric motility in dogs were investigated in this study. The acupoints used in this experiment were Zu San Li (ST-36), Feng Long (ST-40), Jie Xi (ST-41), and Li Dui (ST-45) which belong to stomach meridian, Wei Shu (BL-21) which belongs to urinary bladder meridian, and Zhong Wan (CV-12) which belongs to conception vessel meridian. The animals were stimulated with 2-4 volt and 5 Hz for 20 min. Electroacupuncture at Zu San Li and Wei Shu acupoint increased the gastric motility, but Zhong Wan decreased the motility. There were no change in gastric movement after electrostimulation at Feng Long, Jie Xi and Li Dui acupoints. It was considered that electroacupuncture at Zu San Li and Wei Shu acupoints to promote the gastric movement, and at Zhong Wan acupoint to depress the movement might be effective in veterinary practice.