• Bulletin of the Korean Chemical Society
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• 제31권9호
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• pp.2656-2664
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• 2010

We have synthesized a series of push-pull porphyrins containing both donor and acceptor substituents at the mesopositions and have examined their spectral and biological properties. The push-pull porphyrins containing both strong donor $NH_2$ and acceptor $NO_2$ at meso-positions, in which donor group condensed with the ligand, (2,6-bis(4-methylpiperazine-1-yl-methyl)-4-formlyphenol (L) to form imine linkages with porphyrin. The Schiff base ligand 5-[4-(2,6-bis(4-methylpiperazine-1-yl-methyl)-4-iminomethylphenol)phenyl]-10,15,20-tris(4-nitrophenyl) porphyrin [$an_3$(TPP)L] can be synthesized from 2,6-bis(4-methylpiperazine-1-yl-methyl)-4-formylphenol (L) and 5-(4-aminophenyl)-10, 15,20-tris(4-nitrophenyl)porphyrin. The push-pull porphyrin [$an_3$(TPP)L] was metallated to get copper, nickel and zinc complexes. The spectral, electrochemical, antibacterial, antifungal and cytotoxicity properties of all the donor- acceptor push-pull porphyrins and their complexes were characterized and studied.

• 한국환경생태학회지
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• 제33권1호
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• pp.116-123
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• 2019

본 연구에서는 생태학적 관점에서 biomimicry를 생태모방으로 정의하며, 생태모방에 대해 다학적 분야에서 정의되는 개념들을 비교하였다. 생태모방은 생물 생태특성에 대한 분류 및 조사 원리분석을 통해 얻어진 정보와 아이디어를 공학 및 기술 분야에 응용이 되는 개념으로 정리하였다. 또한 생물학, 생태학 및 공학적 관점에서 생태모방 연구와 기술개발을 진행하는 Biology Push(생물특성기반 생태모방)와 Technology Pull(기술문제기반 생태모방)방법을 비교하며, Biology Push를 생태학적 관점에서 시작하는 '생물특성기반 생태모방', Technology Pull을 기술필요에서 시작하는 '기술문제기반 생태모방'으로 정의하였다. 생태모방 연구동향을 살펴보면 안정적이고 친환경적인 원천 재료를 생물 생태 특성에서 찾아 기술개발에 초점이 맞춰진 사례가 대부분이나, 앞으로 생태모방 연구주제가 생물 생태 특성에서 비롯된 아이디어에서 착안되어 시작될 수 있는 연구분야의 잠재력에 대한 무한성을 시사하고자 한다. 향후 지속가능한 발전에 기여할 수 있는 생물생태학적 기반에 근거한 더 많은 연구와 기술개발이 필요함을 제시하고 있다.

• 대한의용생체공학회:의공학회지
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• 제38권4호
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• pp.143-152
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• 2017

The main purpose of this research was to examine the EMG characteristics of driver's upper limb and driving performance for operating accelerator and brake pedal by using four types of left hand control devices(Push/Pull, Push/Right angle, Push/Rock, Push/Twist) during simulated driving. The persons with disabilities in the lower extremity have problems in operation of the vehicle because of functional impairments for controlling accelerator and brake pedal. Therefore, if hand control device is used for adaptive driving controls in persons with lower extremity loss, the disabled people could improve their quality of mobility life by driving a car. Twenty subjects were involved in this research to assess driving performance and EMG activities for operating accelerator and brake pedal by using four types of left hand controls in driving simulator. We measured EMG responses of six muscles(posterior deltoid, middle deltoid, biceps, triceps, extensor carpi radialis, and flexor carpi radialis) during pulling and pushing movement with four types of left hand controls for acceleration and braking. STISim Drive 3 program was used for evaluation test of four types of left hand control devices in straight lane course for time to reach target speed and brake reaction time. While operating the four types of left hand controls for acceleration, EMG activities of posterior deltoid in normal subjects were significantly increased(p < 0.05) compared to the disabled subjects. It was also found that EMG responses of triceps and posterior deltoid were significantly increased(p < 0.05) when using the Push/Right angle type than Push/Pull type. While operating the four types of left hand controls for braking, EMG activities of flexor carpi radialis and triceps in subjects with disability were significantly increased(p < 0.05) compared to the normal subjects. It was shown that muscle responses of posterior deltoid, middle deltoid and triceps were significantly increased when using the Push/Right angle type than Push/Rock type. Time to reach target speed and brake reaction time in subjects with disability was increased by 2.5% and 4.6% on average compared to normal subjects. The person with disabilities showed a tendency to relatively slow performance in acceleration at the straight lane course.

• 한국미생물·생명공학회지
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• 제52권3호
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• pp.233-254
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• 2024

The microorganisms that live under extreme conditions on Earth are known as extremophiles. They possess an extraordinary capability to endure extreme conditions, including salinity, temperature variations, pH, desiccation, and nutrient scarcity, among others. These organisms, including a vast array of bacteria, eukarya, and archaea, have evolved specialized structural and functional adaptations that make them capable of thriving in extremely selective environments in such a way that they showcase remarkable adaptations that push the limits of what we consider habitable. This capability results in valuable compounds with great potential for developing novel pharmaceuticals and biotechnological innovations. The present review paper aims to summarize current knowledge on the diversity of extremophilic microorganisms and the adaptive strategies employed to face such a range of extreme conditions. Particular attention will be given to temperature, salinity, pH, and desiccation adaptation. The review also highlights their potential applications, specifically focusing on pharmaceutical and biotechnological applications.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1995년도 춘계학술대회
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• pp.19-22
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• 1995

A biomechanical study was made to demonstrate the superior mechanical performance of the newly designed Miniplate staple to the conventional Coventry staple in high tibial osteotomy(HTO). Using twenty fresh porcine tibiae, the fixational strengh of the two different types of staple in HTO was compared. To minimize the error due to the specimen-to-specimen individuality, the bone mineral density of the tibiae was measured with a bone densitometry (Dual photon absorptionometer, Luner, USA) and those with $0.8\;{\sim}\;1.2\;gm/cm^2$ at the proximal tibia was used in the biomechanical test. Testing was performed on a material testing system (Autogram ET-5, Shimatzu, Japan) with aid of a commercial data processor (IBM 80386/ ASYST). Using two differant loading modes, 'pull-out' and 'push-out', the maximum resistant force required to release the staple from the substrate bone was recorded. In the pull-out test, ten non-osteotomized specimens were used and the staple was pullout by subjecting an axial tension on the head of the staple inserted. While in the pull-out test where ten tibiae osteotomized in the usual way of HTO were used, the staple was not directly loaded. In this testing, as a mimic condition of the natural knee, the distal part of the specimen tibia was pushed horizontally in order for the staple to be pulled out while the proximal tibia was fixed. The pull-out strength of Coventry staple and miniplate staple were found to be $27.88\;{\pm}\;5.12\;kgf$ and $182.47\;{\pm}\;32.75\;kgf$, respectively. The push-out strength of Coventry staple and miniplate staple were $18.40\;{\pm}\;4.47\;kgf$ and $119.95\;{\pm}\;19.06\;kgf$, respectively. The result revealed that miniplate staple had the pull-out/ push-out strength at least fivetimes higher than Coventry staple. Based on the measured data, it was believed that the newly designed miniplate staple could provide much better postoperative fixation in HTO. The postoerative application of long leg casting may not be needed after HTO surgery.

• 대한의용생체공학회:의공학회지
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• 제23권5호
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• pp.385-390
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• 2002

오늘날 의료기기의 국산화 연구가 활발히 진행되고 있는 가운데 본 연구에서는 적추용 fusion device를 새롭게 개발하고자 시도하였다. 일반적으로 사용되고 있는 삽입형과 나사형을 기본 대상으로 하되 수술 시 뼈를 보다 적게 제거하여 삽입할 수 있게 하는 데 .) 주안점을 두고 형상 개발을 시도하였다. 아직 그 실효성을 논하기는 어려우나 고안된 척추용 fusion device의 형상을 중심으로 소개하고자 한다. 본 연구에서 경첩형과 분리삽입형을 고안하게 되었다. 그러나 경첩형은 기존 형상의 절반 크기로 삽입되는 장점은 있으나 핀의 강도해석과 안정된 잠금 장치의 개발에 더 연구가 요구되어 일단 본 연구에서는 분리삽입형을 중심으로 시제품과 3차인 유한요소 모델을 제작하여 그 역학적 해석을 행하였다. 그 결과 척추에 작용하는 기본 하중에 대한 역학적 안전성은 인정되나 아직 실용화되기까지는 보조 수술장비의 개발이 필요하다고 사료된다.

• Food Science and Biotechnology
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• 제14권5호
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• pp.566-571
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• 2005

Process of screw-pumping system (SPS) was optimized for mass production of encapsulated bifidus. SPS entrapment device was composed of feeding component, with optimized nozzle size and length of 18G (0.91 cm) and 4 mm, respectively, screw pump, and 37-multi-nozzle. Screw component had five wing turns [radius (r)=26 to 15 mm] from top to bottom of axis at 78-degree angle from middle of the screw, and two wings were positioned at screw edge to push materials toward nozzle. For nozzle component, 37 nozzles were attached to 20-mm round plate. Air compressor was attached to SPS to increase productivity of encapsulated bifidus. This system could be operated with highly viscous (more than 300 cp) materials, and productivity was higher than $1128\;{\pm}\;30\;beads/min$. Viability of encapsulated bifidus was $5.45\;{\times}\;10^8\;cfu$/bead, which is superior to that of encapsulated bifidus produced by other methods ($2.51{\times}10^8\;cfu$/bead). Average diameter of produced beads was $2.048\;{\pm}\;0.003\;mm$. Survival rate of SPS-produced encapsulated bifidus was 90% for Simulator of the Human Intestinal Microbial Ecosystem test and 88% in fermented milk (for 14 days). These results show SPS is effective for use in development of economical system for mass production of viable encapsulated bifidus.

• 대한의용생체공학회:의공학회지
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• 제13권4호
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• pp.269-274
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• 1992

In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.raph.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.249-252
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• 1997

A study on static and dynamic socket pressure distributions on a trans-femoral amputee with a suction socket was performed in order to assess an optimal socket fitting and function. Even for the amputee's static neutral position, pressure concentrations were observed in the lateral, medial, and posterior planes of the socket. During free walking, a significant movement of pressure concentration areas was observed. Large socket pressure was observed in the lateral, medial-anterior and posterior walls during mid-stance or push-off period. Socket pressure measurement will be one of the good tool to determine the optimal socket-limb interface.

• 대한의용생체공학회:의공학회지
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• 제18권2호
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• pp.133-146
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• 1997

In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases, each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO with plethysmograph.raph.