• Journal of the Korean Society for Geothermal and Hydrothermal Energy
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• v.6 no.1
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• pp.23-28
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• 2010

The objective of this study is to develope ground heat exchanger using PHC pile used to building foundation, and it's element technology. So we made PHC piles into ground heat exchanger and evaluate it's performance. First, we studied PHC pile type, heat exchanger pipe, grouting materials, and present apartment house's foundation condition for PHC ground heat exchanger. As a result we designed BIGS(Building Integrated Geothermal System) prototype. Second, we applied BIGS to apartment houses' utility building in Osan built by Daelim. Third, we monitored heating performance of winter season. 1be result of heating performance was so good to apply to heat & cooling system in building.

• KASI NEWSLETTER
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• s.78
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• pp.6-6
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• 2008

• KASI NEWSLETTER
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• s.76
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• pp.6-6
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• 2008

• KASI NEWSLETTER
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• s.79
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• pp.6-6
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• 2008

• KASI NEWSLETTER
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• s.74
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• pp.6-6
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• 2008

• KASI NEWSLETTER
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• s.73
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• pp.6-6
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• 2008

• Journal of Marine Life Science
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• v.7 no.1
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• pp.15-20
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• 2022

Glioblastoma is one of the highly aggressive central nervous system tumors and it is difficult to treat owing its anatomical location. Peptides are novel class of drugs which has the potential to cross the blood brain barrier and exerts its anti-tumor activity. Here, we discovered a novel peptide from abalone (Haliotis discus hannai) next generation sequencing (NGS) data and tested its anticancer effect on glioblastoma cell line SNU-489. The anticancer activity was measured using a cytotoxicity assay in a time and dose-dependent manner. A concentration and time dependent increase in the cytotoxicity was seen in cells treated with the novel peptide. The highest cytotoxicity rate of about 67% was observed in SNU-489 cells treated with 200 µM peptide for 48 hrs. However, the cytotoxic effect was not or less observed in a normal skin cell line HaCaT at similar concentration, thus, evident of peptide's cell specific anticancer activity. In addition, the gene expression level of necroptosis-related genes was analyzed by qRT-PCR to elucidate the anticancer mechanism of the novel peptide. RIPK3 expression was significantly increased by 9.6-fold in 200 µM of novel peptide treatment group, and MLKL expression level was significantly elevated by 2-fold in 100 µM treated group compared to the control group. Therefore, this study confirmed that the novel abalone-derived peptide has anticancer potency, and it causes cancer cell death through the necroptosis mechanism. Collectively, these results suggest that the novel peptide could be candidate anticancer agent for the treatment of glioblastoma in the future.

• KASI NEWSLETTER
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• s.66
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• pp.6-6
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• 2007

• KASI NEWSLETTER
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• s.56
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• pp.26-27
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• 2006

• KASI NEWSLETTER
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• s.67
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• pp.6-6
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• 2007