• 한국산학기술학회논문지
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• 제22권6호
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• pp.413-419
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• 2021

본 연구의 목적은 확장 스펙트럼 𝛽-락타마제(ESBL) 항생제가 그람 음성 세균에 의한 감염을 치료하고 예방하는데 사용하고 있으며 임상에서 심각한 감염을 치료하는데 선택하는 마지막 옵션 역할을 한다. 미생물의 확장 스펙트럼 𝛽-락타마제(ESBL) 및/또는 카르바페네마제(Carbapenemase) 내성에 대한 보고는 전 세계적으로 확산되는 것으로 보고되며 항생제 치료에 많은 제한을 주는 요인으로 다약재 내성과 관련이 있기 때문에 보건 서비스에 큰 관심을 가지고 있다. 본 연구는 국내 시장에서 구매하여 분리한 육류로부터 세균을 분리 동정하여 항생제 저항성 테스트인 디스크 확산법을 사용하여 내성균을 분리 실험하였고, PCR과 DNA 시퀜싱방법을 수행아였다. 결과는 PCR을 수행하여 항생제 내성유전자와 유전자를 생산하는 ESBL의 존재를 검출하고 결과를 얻었다. 총 36개의 샘플 육류로부터 181개의 각각 분리된 세균을 추출하여 실험결과을 얻었다. 결과는 PCR과 DNA 염기서열을 분석하여 항생제내성 유전자로 blaVIM, blaBIC, blaKPC, blaSIM으로 나타났다. 분리한 육류 속의 박테리아는 별도 유전자 서열분석으로 4개의 다른 박테리아가 확인되었다. 이러한 결과는 소매되는 육류에서 발견되는 박테리아에 ESBL 내성유전자인 blaVIM, blaBIC, blaKPC, blaSIM를 가진 박테리아 균주가 있을 수 있으며 이는 특수 확장 스펙트럼 𝛽-락타마제(ESBL) 및/또는 카르바페네마제(Carbapenemase) 내성유전자가 확산될 수 있다는 것을 시사한다.

• Journal of Veterinary Science
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• 제25권2호
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• pp.23.1-23.15
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• 2024

The widespread use of antimicrobials causes antibiotic resistance in bacteria. The use of butyric acid and its derivatives is an alternative tactic. This review summarizes the literature on the role of butyric acid in the body and provides further prospects for the clinical use of its derivatives and delivery methods to the animal body. Thus far, there is evidence confirming the vital role of butyric acid in the body and the effectiveness of its derivatives when used as animal medicines and growth stimulants. Butyric acid salts stimulate immunomodulatory activity by reducing microbial colonization of the intestine and suppressing inflammation. Extraintestinal effects occur against the background of hemoglobinopathy, hypercholesterolemia, insulin resistance, and cerebral ischemia. Butyric acid derivatives inhibit histone deacetylase. Aberrant histone deacetylase activity is associated with the development of certain types of cancer in humans. Feed additives containing butyric acid salts or tributyrin are used widely in animal husbandry. They improve the functional status of the intestine and accelerate animal growth and development. On the other hand, high concentrations of butyric acid stimulate the apoptosis of epithelial cells and disrupt the intestinal barrier function. This review highlights the biological activity and the mechanism of action of butyric acid, its salts, and esters, revealing their role in the treatment of various animal and human diseases. This paper also discussed the possibility of using butyric acid and its derivatives as surface modifiers of enterosorbents to obtain new drugs with bifunctional action.

• 한국컴퓨터정보학회논문지
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• 제6권1호
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• pp.7-13
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• 2001

VLSI의 집적도가 증가함에 따라 설계와 제조과정에서 기존의 논리 테스트 방법으로는 검출하기 어려운 고장들이 발생하고 있다. 최근에는 이러한 고장을 검출하기 위한IDDQ 테스팅 방법의 중요성이 증대되고 있다. 본 논문에서는 CMOS 회로내에서 IDDQ 값을 검사하여 고장의 유무를 검사하는 전류 테스팅 기법에 사용될 수 있는 새로운 전류감지기를 제안한다. 본 논문에서 제안된 전류감지기는 자기저항 소자 MR 전류감지기, 레벨변환기, 비교기로 구성되어 있으며 자동으로 고장을 검출할 수 있다.

• 한국전자파학회:학술대회논문집
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• 한국전자파학회 2005년도 종합학술발표회 논문집 Vol.15 No.1
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• pp.235-240
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• 2005

This paper presents a dual band circularly polarized microstrip patch antenna. The antenna consists of two corner truncated patches implemented in one plane and single feed point. The input signal is directly excited to the patch 2 and the patch 1 is fed from patch 2 by coupling between two patches. The antenna is operated at 900 MHz and 2.45 GHz bands and has the right hand circularly polarized radiation pattern at all. The measured gains of the antenna are 2.95 dBic at 900 MHz band and 4.6 dBic at 2.45 GHz band.

• Journal of the Korean Statistical Society
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• 제28권3호
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• pp.371-387
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• 1999

For possibly nonstationary autoregressive moving average, modeling based on the original observations rather than the differenced observations is considered. Under this scheme, sample autocorrelation functions, parameter estimates, model diagnostic statistics, and prediction are all computed from the original data instead of the differenced data. The methods and results established under stationarity of data are shown to naturally extend to the nonstationarity of one autoregressive unit root. The sample ACF and PACF can be used for ARMA order determination. The BIC order is strongly consistent. The parameter estimates are asymptotically normal. The portmanteau statistic has chi-square distribution. The predictor is asymptotically equivalent to that based on the differenced data.

• 응용통계연구
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• 제22권4호
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• pp.687-695
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• 2009

The Bayesian multiple change-point estimation has been applied to the daily means of ozone and PM10 data in Seoul for the period 1999. We focus on the detection of multiple change-points in the ozone and PM10 bivariate vectors by evaluating the posterior probabilities and Bayesian information criterion(BIC) using the stochastic approximation Monte Carlo(SAMC) algorithm. The result gives 5 change-points of mean vectors of ozone and PM10, which are related with the seasonal characteristics.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 학술대회 논문집 전문대학교육위원
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• pp.179-182
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• 2007

The Design and Optimization of a low-profile antenna for the Satellite Digital Audio Radio System(SDARS) using a Non-Dominated Sorting Genetic Algorithm(NSGA) is presented. a fairly omni-directional elevation gain pattern over 60 degrees < q <60 degrees are obtained. The average value of the LCP gain pattern is approximately 2 dBic. The heights of the antennas are less than 0.251. The cross polarized signal level is approximately 12 dBic less than the co-polarized signal level.

• Clinical and Experimental Pediatrics
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• 제59권sup1호
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• pp.157-160
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• 2016

Coexistence of paroxysmal kinesigenic dyskinesia (PKD) with benign infantile convulsion (BIC) and centrotemporal spikes (CTS) is very rare. A 10-year-old girl presented with a 3-year history of frequent attacks of staggering while laughing and of suddenly collapsing while walking. Interictal electroencephalogram (EEG) revealed bilateral CTS, but no changes in EEG were observed during movement. The patient's medical history showed afebrile seizures 6 months after birth, while the family history showed that the patient's mother and relatives on the mother's side had similar dyskinesia. Genetic testing demonstrated that the patient had a heterozygous mutation, c.649_650insC, in the PRRT2 gene. To our knowledge, this constitutes only the second report of a patient with PKD, BIC, CTS, and a PRRT2 mutation.

• 응용통계연구
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• 제16권2호
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• pp.365-376
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• 2003

본 연구에서는 비정규 시계열 자료에 관한 다양한 회귀모형을 고찰하고, 이들 모형의 선택 기준에 관하여 연구해 보았다. 모형 선택의 기준으로는 AIC (Akaike information criterion), BIC (Baysian information criterion) 그리고 우도비 검정을 확장 적용하였다. 또한, 실제의 Polio 자료분석을 통해 이를 적용해보았다.

• 한국환경보건학회지
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• 제35권3호
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• pp.191-200
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• 2009

We investigated a trait of odor and the relationship between odor unit and odorous compounds using multiple regression analysis based on data compiled from Sihwa (SIC), Banwol (BIC), Banwol plating (BPIC) and Poseung industrial complex (PIC). These areas are odor control areas in Gyeonggi province. It was revealed that $NH_3$ and styrene concentrations in SIC and BPIC were relatively higher and $H_2S$ concentration especially in mc was more than five times higher than other areas. As a result of regression analysis using SAS, intensity of odor unit was highly related to concentrations of $H_2S$, TMA, styrene and n-valeraldehyde in SIC, $H_2S$, acetaldehyde, and butyraldehyde in BPIC and $NH_3$ in BIC.