• Toxicological Research
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• 제28권3호
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• pp.159-164
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• 2012

Allergic skin inflammation such as atopic dermatitis (AD) is characterized by edema and infiltration with various inflammatory cells such as mast cells, basophils, eosinophils and T cells. Thymic stromal lymphopoietin (TSLP) is produced mainly by epidermal keratinocytes, as well as dermal fibroblasts and mast cells in the skin lesions of AD. Omega-3 polyunsaturated fatty acids in fish oil can reduce inflammation in allergic patients. Fermentation has a tremendous capacity to transform chemical structures. The antiinflammatory effects of fish oil have been described in many diseases, but the beneficial effects by which fermented olive flounder oil (FOF) modulates the allergic response is poorly understood. In this study, we produced FOF and tested its ability to suppress the various allergic inflammatory responses. The ability of FOF to modulate the immune system was investigated using a mouse model of AD. The FOF-treated group showed significantly decreased immunoglobulin E (IgE) and histamine in serum. Also, the increased TSLP expression was significantly inhibited in the FOF group; the FOF-treated group was not appreciably different from the hydrocort cream treatment group. In addition, FOF treatment resulted in a smaller spleen size with reduced the thickness and length compared to the induction group. Splenocytes from mice treated with FOF produced significantly less IFN-${\gamma}$, IL-4, T-box transcription factor (T-bet) and GATA binding protein 3 (GATA3) expression compared with the induction group. These results suggest that FOF may be effective in treating the allergic symptoms of AD. 5.

• 상하수도학회지
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• 제29권3호
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• pp.407-414
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• 2015

The effect of activated carbon particle diameter (i.e. US sieve No. $8{\times}10$ ($d_p{\approx}2.19mm$), $18{\times}20$ ($d_p{\approx}0.92mm$), $50{\times}60$ ($d_p{\approx}0.27mm$) and $170{\times}200$ ($d_p{\approx}0.081mm$) on caffeine adsorption is investigated. BET surface area was increased with decreasing particle diameter ($d_p$), and caffeine adsorption rates increased with decreasing $d_p$. Moreover, pseudo-second order model is predicted the experimental data more accurately than pseudo-first order model, and the fastest rate constant ($k_2$) was $1.7g\;mg^{-1}min^{-1}$ when $d_p$ was 0.081 mm. Surface diffusion coefficient (Ds) was decreased with decreasing $d_p$ based on the minimum sum of square error (SSE). Practically, certain ranges of Ds are acceptable with high reliability ($R^2$) and it is determined that the effect of $d_p$ on Ds is unclear. The effect of pH on caffeine adsorption indicated the dependency of m/L ratio (mass liquid ratio) and $pH_{pzc}$. The $pH_{pzc}$ (i.e. $7.9{\pm}0.2$) was not affected by $d_p$. The higher caffeine adsorption at pH 4 and pH 7 than at pH 10 is due to $pH_{pzc}$, not $pk_a$ of caffeine.

• Korean Chemical Engineering Research
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• 제44권6호
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• pp.644-649
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• 2006

본 연구에서는 다양한 조건에서 기체상태의 오존처리된 활성탄소를 이용하여 수용액 상태에서의 Cr(VI)의 흡착특성에 대하여 고찰하였다. 오존처리된 활성탄소의 표면특성의 변화는 pH, 산도-염기도, FT-IR을 이용하였으며, $N_2$/77K 등온 흡착특성은 BET식, Boer의 t-plot, 그리고 Horvath-Kawazoe의 slit pore model을 이용하여 확인하였다. 또한, 총 Cr의 흡착량은 ICP-AES를 이용하여 확인하였다. 실험 결과, 오존처리는 활성탄소의 표면에 산소를 함유한 극성 관능기를 증가시켰으며, 이로 표면산도 또한 증가되었다. 한편, 오존처리의 영향으로 보이는 활성탄소의 비표면적과 미세기공 부피의 감소가 관찰되었지만, 활성탄소의 총 Cr 흡착량은 오존처리 시간이 증가할수록 비례적으로 증가하였다. 이는 활성탄소의 Cr 흡착특성이 비표면적보다 상대적으로 표면에 형성된 극성 관능기의 영향을 크게 받는 것으로 판단된다.

• Korean Journal of Chemical Engineering
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• 제35권12호
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• pp.2384-2393
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• 2018

Porous alginate-based hydrogel beads (porous ABH) have been prepared through a facile and sustainable template-assisted method using nano-calcium carbonate and nano-$CaCO_3$ as pore-directing agent for the efficient capture of methylene blue (MB). The materials were characterized by various techniques. The sorption capacities of ABH towards MB were compared with pure sodium alginate (ABH-1:0) in batch and fixed-bed column adsorption studies. The obtained adsorbent (ABH-1:3) has a higher BET surface area and a smaller average pore diameter. The maximum adsorption capacity of ABH-1:3 obtained from Langmuir model was as high as $1,426.0mg\;g^{-1}$. The kinetics strictly followed pseudo-second order rate equation and the adsorption reaction was effectively facilitated, approximately 50 minutes to achieve adsorption equilibrium, which was significantly shorter than that of ABH-1:0. The thermodynamic parameters revealed that the adsorption was spontaneous and exothermic. Thomas model fitted well with the breakthrough curves and could describe the dynamic behavior of the column. More significantly, the uptake capacity of ABH-1:3 was still higher than 75% of the maximum adsorption capacity even after ten cycles, indicating that this novel adsorbent can be a promising adsorptive material for removal of MB from aqueous solution under batch and continuous systems.

• 한국지반공학회논문집
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• 제37권5호
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• pp.47-63
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• 2021

최근 디지털 트윈 관점의 3차원 지하공간 지도의 수요 및 유관분야의 연계 활용 요구가 증대되고 있다. 그러나 전국단위의 지반조사 자료의 방대함과 이를 활용함에 있어 공간적/추계학적 기법 적용의 불확실성으로 인해 신뢰도 높은 지역적 지반특성화 연구와 그에 따른 최적화 모델 제시에 어려움이 있다. 따라서 본 연구에서는 서울지역 3차원 지하공간의 공학적 지층분류를 위해 다층 퍼셉트론(MLP) 기반의 최적 학습모델을 구축하였다. 먼저, 서울지역에 분포하는 시추공별 층상구조 및 3차원 공간좌표를 표준화 서식에 따라 지반정보 데이터베이스로 구축하고 기계학습을 위한 결측치 보정, 정규화 등의 데이터 전처리를 하였다. MLP 모델의 파라미터 최적화와 정밀도 및 정확도 관련 모델 성능 평가를 통해 최적의 피팅 모델을 설계하였다. 이후 3차원 지반 공간레이어 구축을 위한 수치표고모델 기반 격자망을 구성하고, 단위격자별 MLP기반 예측모델 적용을 통한 층상구조를 결정하고 이를 가시화하였다. 구축된 3차원 지반모델은 범용적인 지구통계학적 공간보간 기법의 적용 결과 및 지질도의 표토층 성상과 비교하여 그 성능을 평가하였다.

• Carbon letters
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• 제24권
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• pp.82-89
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• 2017

In this study, composite PAN-based ACNFs embedded with MgO and $MnO_2$ were prepared by the electrospinning method. The resultant pristine ACNFs, ACNF/MgO and $ACNF/MnO_2$ were characterized in terms of their morphological changes, SSA, crystallinity and functional group with FESEM-EDX, the BET method, XRD and FTIR analysis, respectively. Results from this study showed that the SSA of the ACNF/MgO composite ($1893m^2g^{-1}$) is significantly higher than that of the pristine ACNFs and $ACNF/MnO_2$ which is 478 and $430m^2g^{-1}$, respectively. FTIR analysis showed peaks of 476 and $547cm^{-1}$, indicating the presence of MgO and $MnO_2$, respectively. The FESEM micrographs analysis showed a smooth but coarser structure in all the ACNFs. Meanwhile, the ACNF/MgO has the smallest fiber diameter ($314.38{\pm}62.42nm$) compared to other ACNFs. The presence of MgO and $MnO_2$ inside the ACNFs was also confirmed with EDX analysis as well as XRD. The adsorption capacities of each ACNF toward $CH_4$ were tested with the volumetric adsorption method in which the ACNF/MgO exhibited the highest $CH_4$ adsorption up to $2.39mmol\;g^{-1}$. Meanwhile, all the ACNF samples followed the pseudo-second order kinetic model with a $R^2$ up to 0.9996.

• Molecules and Cells
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• 제41권4호
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• pp.290-300
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• 2018

Using an in vitro model of intestinal organoids derived from intestinal crypts, we examined effects of indole-3-carbinol (I3C), a phytochemical that has anticancer and aryl hydrocarbon receptor (AhR)-activating abilities and thus is sold as a dietary supplement, on the development of intestinal organoids and investigated the underlying mechanisms. I3C inhibited the in vitro development of mouse intestinal organoids. Addition of ${\alpha}$-naphthoflavone, an AhR antagonist or AhR siRNA transfection, suppressed I3C function, suggesting that I3C-mediated interference with organoid development is AhR-dependent. I3C increased the expression of Muc2 and lysozyme, lineage-specific genes for goblet cells and Paneth cells, respectively, but inhibits the expression of IAP, a marker gene for enterocytes. In the intestines of mice treated with I3C, the number of goblet cells was reduced, but the number of Paneth cells and the depth and length of crypts and villi were not changed. I3C increased the level of active nonphosphorylated ${\beta}$-catenin, but suppressed the Notch signal. As a result, expression of Hes1, a Notch target gene and a transcriptional repressor that plays a key role in enterocyte differentiation, was reduced, whereas expression of Math1, involved in the differentiation of secretory lineages, was increased. These results provide direct evidence for the role of AhR in the regulation of the development of intestinal stem cells and indicate that such regulation is likely mediated by regulation of Wnt and Notch signals.

• 한국산학기술학회논문지
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• 제1권2호
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• pp.85-92
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• 2000

Warrant란 소유자에게 일반회사채의 권리에 일정한 기간내에 일정한 가격으로 정해진 수의 발행회사 주식을 매입할 수 있는 권리인 신주인수권을 함께 부여한 사채로서 금융파생상품의 하나이다. Warrant는 콜옵션과 동일한 성격을 가지면서도 투자자가 아니라 기업에 의해서 발행된다는 점이 콜옵션과 상이하다. 이러한 warrant의 특징은 특히 배당(dividend)을 지급하는 경우 블랙ㆍ숄즈 옵션가격 모형으로 평가하는데 문제가 있다. 또한 신주인수권의 행사는 발행주식의 수를 증가 시킴으로써 기업의 자산과 이익이 희석화(dilution) 된다. 본 연구는 OPM 대신에, 다변량 분석기법중의 하나인 다중회귀분석을 통하여 warrant가격에 영향을 미치는 주요 변수를 분석함으로써 warrant 가격결정 문제를 해결하고자 한다. 이를 위하여 1995년과 1996년의 일본동경주식시장의 300여개 warrant 자료를 토대로 실증분석 함으로써 warrant 가격결정 주요변수와 warrant 가격 예측 모형을 검토하였다.

• 전자공학회논문지
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• 제49권12호
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• pp.226-233
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• 2012

본 논문에서는 고속 인터페이스 비트오류율(BER, Bit Error Rate)의 수학적 모델을 기반으로, 간단하고 정확하게 시간마진을 추정할 수 있는 '선형 근사화 추정법(linear approximation method)'을 제안하였다. 기존의 Q-factor를 이용한 추정법과 제안한 선형 근사화 추정법을 이용하여 $10^{-13}$ 이하의 BER을 얻기 위한 시간마진을 추정한 결과는 실측한 값과 비교할 때 약 0.03UI 정도의 작은 오차를 갖는다. 이 중 선형 근사화를 이용한 가속 자가내장측정법(built-in self test)을 내부 BERT(BER Tester)를 포함한 하드웨어로 구현하였다. 3Gbps, 95% 신뢰 수준에서 $10^{-13}$ BER 기준의 시간마진을 직접 측정하는데 소요되는 시간이 약 5.6시간인데 반해, 가속 자가내장측정법은 0.6초 이내에 유사한 정확도로 시간마진을 추정한다. 시간마진 추정치는 시간마진을 내부 BERT로 직접 측정한 값과 0.045UI 이하의 작은 오차를 보였다.

• 한국대기환경학회지
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• 제26권4호
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• pp.443-448
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• 2010

The objective of this study was to assess the catalytic activities of manganese oxide (MnO, $MnO_2$, $Mn_2O_3$, and $Mn_3O_4$) catalysts for odors (acetaldehyde and propionaldehyde) removal. We used a fixed bed reactor as the experimental apparatus and the catalytic performance were carried out over the temperature range of $200{\sim}470^{\circ}C$. The properties and performance of catalysts were characterized by the X-ray diffraction (XRD) and Brunauer Emmett Teller (BET). The catalytic activities of manganese oxide catalysts for acetaldehyde combustion were in the order of MnO < $MnO_2$ < $Mn_2O_3$ < $Mn_3O_4$, and it is similar to that of propionaldehyde combustion. We also confirmed that the reactions have well followed the kinetic model of Power-Rate Law and the reaction order (n) is 1 for both of the acetaldehyde and propionaldehyde combustion. In addition, the reaction activation energy of acetaldehyde and propionaldehyde combustion over $Mn_3O_4$ were found to be $72.42\;kJmol^{-1}$ for 487~503 K and $51.14\;kJmol^{-1}$ for 473~533 K, respectively.