• The Korean Journal of Physiology and Pharmacology
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• v.16 no.6
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• pp.379-386
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• 2012

The purpose of this study was to evaluate whether berberine (BER) administration could attenuate depression- and anxiety-like behaviors and increase corticotrophin-releasing factor (CRF) and tyrosine hydroxylase (TH) expression following chronic morphine withdrawal in rats. Male rats were exposed to chronic, intermittent, escalating morphine (10~50 mg/kg) for 10 days. After the last morphine injection, depression- and anxiety-like beahvior associated with morphine discontinuation persisted for at least three days during withdrawal without any change in ambulatory activity. Daily BER administration significantly decreased immobility in the forced swimming test and increased open-arm exploration in the elevated plus maze test. BER administration also significantly blocked the increase in hypothalamic CRF expression and TH expression in the locus coeruleus (LC) and the decrease in hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression. Taken together, these findings demonstrated that BER administration significantly reduced morphine withdrawal-associated behaviors following discontinuation of repeated morphine administration in rats, possibly through modulation of hypothalamic CRF and the central noradrenergic system. BER may be a useful agent for treating or alleviating complex withdrawal symptoms and preventing morphine use relapses.

• International journal of advanced smart convergence
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• v.12 no.4
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• pp.20-25
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• 2023

Increasing demand for increasing higher data rate in order to solve computationally tasks timely and connecting many user equipment simultaneously have requested researchers to develop novel technology in the area of mobile communications. Intelligent reflecting surface (IRS) have been enabling technologies for commercialization of the fifth generation (5G) networks and the sixth generation (6G) systems. In this paper, we investigate a bit-error rate (BER) analysis on IRS technologies for non-orthogonal multiple access (NOMA) systems. First, we derive a BER expression for IRS-NOMA systems with Rician fading channels. Then, we validate the BER expression by Monte Carlo simulations, and show numerically that BER expressions are in good agreement with simulations. Moreover, we investigate the BER of IRS-NOMA systems with Rician fading channels for various numbers of IRS elements, and show that the BERs improve as the number of IRS elements increases.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.2
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• pp.183-192
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• 2018

Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear circuit. The present study measured several anxiety-related behavioral responses to examine the effects of berberine (BER) on symptoms of anxiety in rats after single prolonged stress (SPS) exposure, and to determine if BER reversed the dopamine (DA) dysfunction. Rats received BER (10, 20, or 30 mg/kg, intraperitoneally, once daily) for 14 days after SPS exposure. BER administration significantly increased the time spent in the open arms and reduced grooming behavior during the elevated plus maze test, and increased the time spent in the central zone and the number of central zone crossings in the open field test. BER restored neurochemical abnormalities and the SPS-induced decrease in DA tissue levels in the hippocampus and striatum. The increased DA concentration during BER treatment may partly be attributed to mRNA expression of tyrosine hydroxylase and the DA transporter in the hippocampus, while BER exerted no significant effects on vesicular monoamine transporter mRNA expression in the hippocampus of rats with PTSD. These results suggest that BER had anxiolytic-like effects on behavioral and biochemical measures associated with anxiety. These findings support a role for reduced anxiety altered DAergic transmission and reduced anxiety in rats with PTSD. Thus, BER may be a useful agent to treat or alleviate psychiatric disorders like those observed in patients with PTSD.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.6 no.10
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• pp.2493-2508
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• 2012

The performance of a MIMO system with adaptive modulation (AM) and space-time coding over Ricean fading channels for perfect and imperfect channel state information (CSI) is presented. The fading gain value is partitioned into a number of regions by which the modulation is adapted according to the region the fading gain falls in. Under a target bit error rate (BER) constraint, the switching thresholds for AM are given. Based on these results, we derive the calculation formulae of the theoretical spectrum efficiency (SE) and average BER. As a result, closed-form SE expression and accurate BER expression are respectively obtained. Besides, using the approximation of complementary error function, a tightly closed-form approximation of average BER is also derived to simplify the calculation of accurate theoretical BER. Computer simulation shows that the theoretical SE and BER are in good agreement with the corresponding simulation, and the approximate BER is also close to the accurate one. The results show that the AM scheme in Ricean fading channel provides better SE than that in Rayleigh fading channel due to the direct-path propagation, and has performance degradation in SE and BER for imperfect CSI.

• ETRI Journal
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• v.29 no.6
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• pp.707-715
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• 2007

In-phase/quadrature (I/Q) imbalances, which are generated by non-ideal transceiver components, are inevitable physical phenomena that cause the performance of practical communication systems to be degraded. In this paper, we provide a new closed-form expression for the bit error rate of hierarchical M-ary phase shift keying with I/Q phase and amplitude imbalances and analyze the effect of I/Q imbalances on BER performance over an additive white Gaussian noise channel.

• International Journal of Internet, Broadcasting and Communication
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• v.13 no.4
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• pp.39-47
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• 2021

Lempel-Ziv coding is one of the most famous source coding schemes. The output of this source coding is usually a non-uniform code, which requires additional source coding, such as arithmetic coding, to reduce a redundancy. However, this additional source code increases complexity and decoding latency. Thus, this paper proposes the optimal maximum a-posteriori (MAP) receiver for non-uniform source non-orthogonal multiple access (NOMA) with symmetric superposition coding (SSC). First, we derive an analytical expression of the bit-error rate (BER) for non-uniform source NOMA with SSC. Then, Monte Carlo simulations demonstrate that the BER of the optimal MAP receiver for the non-uniform source improves slightly, compared to that of the conventional receiver for the uniform source. Moreover, we also show that the BER of an approximate analytical expression is in a good agreement with the BER of Monte Carlo simulation. As a result, the proposed optimal MAP receiver for non-uniform source could be a promising scheme for NOMA with SSC, to reduce complexity and decoding latency due to additional source coding.

• International Journal of Internet, Broadcasting and Communication
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• v.14 no.2
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• pp.23-29
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• 2022

To improve spectrum and energy efficiency in the fifth generation (5G) wireless channels, intelligent reflecting surface (IRS) transmissions have been envisioned, possibly towards the sixth generation (6G) networks. In this paper, we analyze the bit-error rate (BER) performance of intelligent reflecting surface (IRS) assisted non-orthogonal multiple access (NOMA) systems. First, we derive a closed-form expression of the BER in terms of Q functions. Then we analyze the BER improvement of the IRS NOMA system over the conventional NOMA system with respect to the power allocation. Furthermore, we also demonstrate numerically the BER improvement of the IRS NOMA network over the conventional NOMA network in respect of the number of reflecting devices.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.5
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• pp.951-957
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• 2005

The bit error probability of UWB Time-Hopping(TH) multiple access communication systems combined with BPSK is calculated with a high accuracy including the multiple user interference(MUI). This paper finds that with some manipulations, the TH-BPSK UWB signal can be modified to the similar form of the DS-CDMA signal. The MUI in the system is explained by the characteristic function technique. Above two descriptions have been bases on the derivation of the exact BER expression of the system. We also propose the approximate expression for the BER, which has enough accuracy compared with the expression from the Gaussian approximation of the MUI. The comparison of the results from the proposed expressions with the simulation results gives the confirmation for the validity and accuracy of the proposed expressions.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.5
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• pp.881-888
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• 2020

In this paper, in order to improve the degraded BER performance of the stronger channel user in non-orthogonal multiple access(: NOMA) with interactive mobile users, we propose the negative correlation bit-to-symbol(: B2S) mapping. First, the closed-form expression for the BER of the negative correlation B2S mapping receiver is derived, and then it is shown that the BER of the negative correlation B2S mapping receiver is improved, compared with those of the ideal perfect successive interference cancellation(: SIC) receiver and positive correlation receiver. Additionally, based on the analytical expression, signal-to-noise(: SNR) gain is calculated, and the superiority of the negative correlation B2S mapping receiver is validated.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.5
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• pp.865-872
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• 2020

In the fifth generation (5G) mobile networks, non-orthogonal multiple access (: NOMA) has been considered as a promising technology, to increase the channel capacity. In NOMA, the multiple users share the channel resources and multiplex simultaneously. Recently, for the stronger channel user, it was reported that the bit-error rate (: BER) performance with interactive mobile users is degraded, compared to the BER of non-interactive users. In this paper, in order to improve such degraded BER performance, we propose the maximum-likelihood (: ML) receiver. First, the closed-form expression for the BER of the ML receiver is derived, and then it is shown that the BER of the ML receiver is improved, compared with the BER of the ideal perfect successive interference cancellation (: SIC) receiver. Additionally, based on the analytical expression, Monte Carlo simulations validates the above-mentioned results.