• Applied Microscopy
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• v.31 no.4
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• pp.375-383
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• 2001

To understand the fine structure of Korean bat livers , the authors investigated the liver of four Korean bats; Rhinolephus ferrumequinum korai, Myotis macrodactylus, Myotis dauhentonii ussrinesis, and Murina leucogaster intermedia by transmission electron microscopy. The hepatocytes of Rhinolophus ferrumequinum korai had large-sized mitochondria and many peroxisomes. In the Myotis macrodactylus, juctional completes, especially desmosomes, were well developed. The Myotis daubentonii ussrinesis had many glycogen particles in the cytoplasm. Also, the space of Disse and sinusoidal spare was filled with amorphous materials. In the Murina leucogaster intemedia, basement membrane was prominent in the sinusoid, and no Kupffer and Ito cells were observed These results suggest the characteristic differences in the liver ultrastructure among Korean bats.

• The Korean Journal of Physiology and Pharmacology
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• v.8 no.3
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• pp.117-127
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• 2004

The heterodimeric amino acid transporter family is a subfamily of SLC7 solute transporter family which includes 14-transmembrane cationic amino acid transporters and 12-transmembrane heterodimeric amino acid transporters. The members of heterodimeric amino acid transporter family are linked via a disulfide bond to single membrane spanning glycoproteins such as 4F2hc (4F2 heavy chain) and rBAT $(related\;to\;b^0,\;^+-amino\;acid\;transporter)$. Six members are associated with 4F2hc and one is linked to rBAT. Two additional members were identified as ones associated with unknown heavy chains. The members of heterodimeric amino acid transporter family exhibit diverse substrate selectivity and are expressed in variety of tissues. They play variety of physiological roles including epithelial transport of amino acids as well as the roles to provide cells in general with amino acids for cellular nutrition. The dysfunction or hyperfunction of the members of the heterodimeric amino acid transporter family are involved in some diseases and pathologic conditions. The genetic defects of the renal and intestinal transporters $b^{0,+}AT/BAT1\;(b^{0,+}-type\;amino\;acid\;transporter/b^{0,+}-type\;amino\;acid\;transporter\;1)$ and $y^+LAT1\;(y^+L-type\;amino\;acid\;transporter\;1)$ result in the amino aciduria with sever clinical symptoms such as cystinuria and lysin uric protein intolerance, respectively. LAT1 is proposed to be involved in the progression of malignant tumor. xCT (x-C-type transporter) functions to protect cells against oxidative stress, while its over-function may be damaging neurons leading to the exacerbation of brain damage after brain ischemia. Because of broad substrate selectivity, system L transporters such as LAT1 transport amino acid-related compounds including L-Dopa and function as a drug transporter. System L also interacts with some environmental toxins with amino acid-related structure such as cysteine-conjugated methylmercury. Therefore, these transporter would be candidates for drug targets based on new therapeutic strategies.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.2
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• pp.34.1-34.1
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• 2016

The ultra hard X-ray band (14-195 keV) provides an important and unbiased way to understand black hole growth and relationship to the host galaxy. The Burst Alert Telescope (BAT) instrument on the Swift satellite has surveyed sky to unprecedented sensitivity, improving the number of known hard X-ray sources by more than a factor of 20 to 836 nearby AGN. The BAT AGN Spectroscopic Survey (BASS) is a study for the first large (N>600) and complete sample of ultra hard X-ray selected AGN with optical spectroscopy. In this talk, I present the observed relationship between black hole mass, bolometric luminosity, and Eddington ratio with optical emission line ratios. We show that [NII]/Ha ratio exhibits a significant correlation with Eddington ratio. We propose that the [NII]/Ha ratio is a useful indicator of Eddington ratio with 0.6 dex of scatter, and that it can be used to measure Eddington ratio and thus black hole mass from the measured bolometric luminosity, even for high redshift obscured AGN.

• BMB Reports
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• v.53 no.3
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• pp.142-147
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• 2020

Lipid accumulation in white adipose tissue is the key contributor to the obesity and orchestrates numerous metabolic health problems such as type 2 diabetes, hypertension, atherosclerosis, and cancer. Nonetheless, the prevention and treatment of obesity are still inadequate. Recently, scientists found that brown adipose tissue (BAT) in adult humans has functions that are diametrically opposite to those of white adipose tissue and that BAT holds promise for a new strategy to counteract obesity. In this study, we evaluated the potential of sinapic acid (SA) to promote the thermogenic program and lipolysis in BAT. SA treatment of brown adipocytes induced the expression of brown-adipocyte activation-related genes such as Ucp1, Pgc-1α, and Prdm16. Furthermore, structural analysis and western blot revealed that SA upregulates protein kinase A (PKA) phosphorylation with competitive inhibition by a pan-PKA inhibitor, H89. SA binds to the adenosine triphosphate (ATP) site on the PKA catalytic subunit where H89 binds specifically. PKA-cat-α1 gene-silencing experiments confirmed that SA activates the thermogenic program via a mechanism involving PKA and cyclic AMP response element-binding protein (CREB) signaling. Moreover, SA treatment promoted lipolysis via a PKA/p38-mediated pathway. Our findings may allow us to open a new avenue of strategies against obesity and need further investigation.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.47 no.2
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• pp.51-60
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• 2010

This paper proposes a new scheme to obtain enhanced 3D shape information rapidly for WLPSI(White Light Phase Shifting Interferometry). WLPSI is a convenient method to measure the height of the micro products. First we propose an effective method of limiting search interval for detecting the peak of the visibility function in order to obtain 3D shpae information rapidly. Second we propose an automatic base level decision method basad on image processing and a correction algorithm using the least square approximation method to overcome the global tilt problem of the conventional WLPSI algorithms. Third we propose an adaptive filtering method to remove the distortion known as bat-wing effect which appears near the step discontinuity. Experimental results show that the proposed overall technique is fast and provides more enhanced 3D shape information compared with the conventional WLPSI algorithms.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.12
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• pp.5785-5804
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• 2019

The information of localization is a fundamental requirement in wireless sensor network (WSN). The method of distance vector-hop (DV-Hop), a range-free localization algorithm, can locate the ordinary nodes by utilizing the connectivity and multi-hop transmission. However, the error of the estimated distance between the beacon nodes and ordinary nodes is too large. In order to enhance the positioning precision of DV-Hop, fast triangle flip bat algorithm, which is based on curve strategy and rank transformation (FTBA-TCR) is proposed. The rank is introduced to directly select individuals in the population of each generation, which arranges all individuals according to their merits and a threshold is set to get the better solution. To test the algorithm performance, the CEC2013 test suite is used to check out the algorithm's performance. Meanwhile, there are four other algorithms are compared with the proposed algorithm. The results show that our algorithm is greater than other algorithms. And this algorithm is used to enhance the performance of DV-Hop algorithm. The results show that the proposed algorithm receives the lower average localization error and the best performance by comparing with the other algorithms.

• Journal of the Korean Society for Railway
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• v.18 no.3
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• pp.241-251
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• 2015

Compared with ballasted track (BT), ballasted asphalt track (BAT) has been increasingly adopted in many countries due to its more greatly reduced reinforced roadbed thickness and smaller cumulative plastic deformation, and its advantages in terms of maintenance. In this respect, the authors' previous research includes analysis of BAT sections that show performance similar to that of BT sections of the present specifications; reliability verification of the analysis results through real-sized static and dynamic train-load tests were performed. Based on previous research, this paper estimates the track lifetime using the strain of the lower roadbed according to reinforced roadbed thickness; using probabilistic LCC analysis, this paper presents a BAT section that satisfies the design lifetime and that has performance similar to or higher than that of BT.

• Phonetics and Speech Sciences
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• v.9 no.2
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• pp.69-76
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• 2017

The current study investigated whether Korean learners' English-learning environments, especially target English accent (General American English (GAE) vs. Southern British English (SBE)) and English-language experience affected their production of English vowels. Thirty six EFL learners, 27 ESL-US learners, and 33 ESL-UK learners produced 8 English vowels with a bVt frame (beat, bit, bet, bat, bought, bot, boat, boot). The learners' productions were acoustically analyzed in terms of F1 and F2 frequencies. The overall results revealed that the learners' target accent had an effect on their production of some English vowels. The EFL and ESL-US learners' (especially, female learners') production of bought, bot, boat, and boot, which show characteristic differences between the GAE and SBE accents, was closer to that of the native American English (AE) speakers than the native British English (BE) speakers. In contrast, the ESL-UK learners' production of bought and bot demonstrated the opposite pattern. Thus, the impact of target accent was not demonstrated across the board. The effect of the learners' different English-language experience was also rather limited. This was because the EFL learners' production was not much different from the ESL-US learners' production, in spite of the ESL-US learners' residence in the US for more than 9 years. Furthermore, the Korean learners, irrespective of their different English-language experience, tended to produce bit and bat with lower F1 than the native AE and BE speakers, thus resulting in bit and bat to be produced similarly to beat and bet, respectively. This demonstrates the learners' persistent L1 effects on their English vowel production despite the learners' residence in the English speaking countries or their high English proficiency.

• Applied Microscopy
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• v.30 no.1
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• pp.21-44
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• 2000

This study was carried out to investigate sperm storage, and the fate of spermatozoa in the female reproductive tract during hibernation in Korean greater horseshoe bat, Rhinolophus ferrumequinum korai. (1) Numerous sperm occurring in uterine lumen and glands were engulfed, and disappeared by the polymorphouclear leucocytes during the hibernation. (2) The stored sperm present in caudal isthmus of oviduct only, the heads of sperm toward the oviductal epithelial cells. Therefore, the projected sperm during the mating season are only alive in the caudal isthmus of oviduct in the long hibernation. The present result suggests that the caudal isthmus of oviduct may play an important role as the principal storage site in capacitation of sperm. (3) In March, the sperm do not occur in the caudal isthmus of oviduct. It suggests that the stored sperm in the caudal isthmus of oviduct should migrate to the ampulla of the site of fertilization to meet ovum in the period of ovulation. The results of this experiment consider that prolonged sperm storage, fate of sperm and sperm migration in the long hibernation have a kind of mechanism for the fertilization.

• Journal of Information Processing Systems
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• v.14 no.3
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• pp.569-589
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• 2018

Cloud computing, also known as "country as you go", is used to turn any computer into a dematerialized architecture in which users can access different services. In addition to the daily evolution of stakeholders' number and beneficiaries, the imbalance between the virtual machines of data centers in a cloud environment impacts the performance as it decreases the hardware resources and the software's profitability. Our axis of research is the load balancing between a data center's virtual machines. It is used for reducing the degree of load imbalance between those machines in order to solve the problems caused by this technological evolution and ensure a greater quality of service. Our article focuses on two main phases: the pre-classification of tasks, according to the requested resources; and the classification of tasks into levels ('odd levels' or 'even levels') in ascending order based on the meta-heuristic "Bat-algorithm". The task allocation is based on levels provided by the bat-algorithm and through our mathematical functions, and we will divide our system into a number of virtual machines with nearly equal performance. Otherwise, we suggest different classes of virtual machines, but the condition is that each class should contain machines with similar characteristics compared to the existing binary search scheme.