• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1548-1555
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• 2006

Bujeonghangam-tang(BHT) has been used as an anticancer agent in oriental medicine, but the mechanism by which it induces cell death in cancer cells is still unclear. To investigate cell death mechanism by BHT in cancer cells, the activities of apoptosis signaling pathway were tested in human neuroblastoma cell line LAN5. Viability of LAN5 cells was markedly decreased by treatment of the water extract of BHT in a dose-dependent manner. BHT induced cell death was confirmed as apoptosis characterized by chromatin condensation. We tested whether the water extract of BHT affects the anti-apoptotic protein such as Bcl-2 and Bcl-XL, and the pro-apoptotic protein such as Bax. Both Bcl-2 and Bcl-XL were gradually decreased but Bas was increased in a time-dependent manner after the addition of the water extract of BHT. Cleavage of Bid by activation of caspase-8 protease was also observed in LAN-5 cells by the treatment of the water extract of BHT. Taken together, these results suggest that the water extract of BHT exerts anti-cancer effects on human neuroblastoma LAN-5 cells by inducing the apoptotic death via down-regulation of anti-apoptotic proteins such as Bcl-2 and Bcl-XL, up-regulation of pro-apoptotic protein such as Bax, and activation of intrinsic caspase cascades.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.7 no.3
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• pp.82-94
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• 2008

Airport GIS is a comprehensive information system to improve security and efficiency of airport. At the initial stage to make it real, the current status of domestic and international regulations along with relevant standardization bas been reviewed. Gimpo Airport becomes a test-bed to get some ideas about how to bring the airport GIS into workflow by building service model and basic design based on current status and demand analysis of the airport. The 6 service models primarily brought into the project are as follows: (1) Local vehicles safety management in airside, (2) Intelligent traffic control between flights and vehicles at main cross points, (3) Dynamic safety management against FOD in airside and breakage on pavement, (4) Special support vehicle management such as deicing remotely controlled, (5) Response and support for fire vehicles and ambulances of signatory institutions in emergency. The upcoming research topic aims at drawing a specific design and building integrated system in the future.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.28 no.1
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• pp.93-98
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• 2010

Recently, as digital photogrammetry bas been widely used in various fields including construction, it is also being applied to several industries. It is essential for interior orientation to determine accurate focal length of camera, lens distortion, location of principal point in order to apply high quality digital camera to digital photogrammetry. In this study we conducted interior orientation for zoom lens camera with regular time and zoom factors and analyzed change of radial distortion parameters and location of principal point to evaluate interior orientation stability. As a result, radial distortion parameters($k_1,k_2$) are converged into zero by increasing zoom factors. There are correlation between the change of location of point and zoom factors. The displacement of $x_p$, $y_p$ increase as zoom factors rise high.

• Steel and Composite Structures
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• v.26 no.2
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• pp.197-211
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• 2018

The study presents the earthquake performance of the Bosphorus Bridge under multi-point earthquake excitation considering the spatially varying site-specific earthquake motions. The elaborate FE model of the bridge is firstly established depending on the new considerations of the used FEM software specifications, such as cable-sag effect, rigid link and gap elements. The modal analysis showed that singular modes of the deck and the tower were relatively effective in the dynamic behavior of the bridge due to higher total mass participation mass ratio of 80%. The parameters and requirements to be considered in simulation process are determined to generate the spatially varying site-specific ground motions. Total number of twelve simulated ground motions are defined for the multi-support earthquake analysis (Mp-sup). In order to easily implement multi-point earthquake excitation to the bridge, the practice-oriented procedure is summarized. The results demonstrated that the Mp-sup led to high increase in sectional forces of the critical components of the bridge, especially tower base section and tensile force of the main and back stay cables. A close relationship between the dynamic response and the behavior of the bridge under the Mp-sup was also obtained. Consequently, the outcomes from this study underscored the importance of the utilization of the multi-point earthquake analysis and the necessity of considering specifically generated earthquake motions for suspension bridges.

• Journal of the Korean Society of Costume
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• v.19
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• pp.175-194
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• 1992

Le Proche-Orient est le pays de la Bible, Le peuple He breu ancien, appartenant la race des S mits s mi-nomades, est venu avec Abraham, de m sopotamie en Palestine, terre de Canaan. Nous avons consid r les v tements du peuple des anciens H breux en nous basant sur la Bible et en observant des peintures murales et des bas-reliefs des divers payes de l'ancienne poque, Pour comprendre l' volution des v tements des gens de la pr sente r gion palestinienne, nous avons tudi les v tements traditionnels de la race b douine qui m nent jusqu' maintenant une vie nomade dans le m nent jusqu' maintenant une vie nomade dans le d sert, parce que nous n'avons pas pu connaitre le processus d' volution des v tements apr s l'ancienne poque la suite d' v nements historiques compliques. En conclusion, nous pouvons nous r sumer comme suit: 1) Nous pensons que la kimlah, costume important du peuple h breu ancien est devenu abajeh, manteau des B douins, puisque ces v tements servent prot ger le corps lors des changments de temps, et la nuit on les utilise comme couverture et comme sac pour y mettre des objets, et comme tente lors su travail. en un mot, les fonctions de la Simlah et celles de l'abajeh sont les memes l' poque ancienne et maintenant. 2) Nous pensons que la forme et l'utilisation de la Kethoneth ayant une forme de tunique et de la thob des B douins sont presque semblable. La kethoneth et la thob sont la tuniqu importante que portent jusqu' maintenant tous les peuples du Proche-Orient. 3) Comme on le voit dans la Bible, les femmes du peuple h breu et celles des B douins utilisent le voile pour couvrir la e te, et se servent d'accessoires pour d corer leur corps. A l'avenir, les vVtements des Palestiniens, dans une recherche pous approfondie, feront l'objet de a 2 me partie de l' tude des costumes du Proche-Orient.

• Journal of Korean Society of Archives and Records Management
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• v.1 no.1
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• pp.177-200
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• 2001

The causes which affects the deterioation of paper arc paper structure, papermaking process, temperature and rative humidity, light and biological agents. Paper made from cllulose fibers by the wood and the nonwood, This paper structure is further hydrolyzed by acidic additive such as the sizing agents during the manufacturing process. These additives leave residual acids in the paper, which break the cellulose clown to simper molecules. The results is weak paper and bas caused most of the damage to book. This study was carried out to investigate the presevation and the deacidification for the permanenece by the book. The deacidification and the chemical agents aims to nutralized the aicd in paper and add alkaline to it as a buffer to withstand future acid attacks. By applying the system to the acid paper with a pH of 4.5 neutralized a pH of 8.5. The expected of alkaline reserved paper extend about 2times and 3times than acidic paper.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.2 no.3
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• pp.119-127
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• 1990

Wave directional spectrum estimation methods for irregular waves were considered in this study. Until now, the Longuet-Higgins Method (LHM) initiated by Longuet-Higgins et al. (1963) has been widely used, but resolutions of the estimation were found to be low. Kobune's Maximum Entropy Method (MEM) for the estimation of wave directional spectrum, bas-ed on the entropy Principle showed higher resolutions comparing with the LHM . If the wave directional spectrum is of Delta functions, the MEM is exact in its estimation. It was also found that for a unimodal spectrum, if the Mitsuyasu's spreading coefficient is above 5, the estimation resolutions were high. In bimodal spectrum, as the angle difference between the two peaks increased, the resolution improved. The energy seems to transfer to the smoother peak in the smoothing of peak's peakedness. LHM has a tendency to estimate bimodal spectrum as a unimodal spectrum ； thus, except for its computational speed, the resolution of LHM falls far below that of MEM.

• Journal of the Korean Chemical Society
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• v.30 no.1
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• pp.118-125
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• 1986

A small scale combustion unit was built to evaluate the CO suppression effects by various chemical additives added to coal briquettes. Among the additives tested comprising various transition metal compounds with catalytic activities, natural minerals and oxidizing agents, the copper component has shown the best CO suppression effect, and in particular, copper oxide dispersed on porous supports such as ${\gamma}-Al_2O_3$ was most effective. For instance, 0.5% of copper added to coal briquettes in this way bas exhibited 1.4 % CO in the combustion gas at the ignition and beginning stage of combustion and 0.3 % CO at the final stage. The effects of calcium compounds on the fixation of sulfur in coal were also evaluated to reduce the contents of sulfur compounds in the combustion gases.

• Journal of the Korea Society for Simulation
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• v.28 no.2
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• pp.119-129
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• 2019

Although line production systems with finite buffers have been studied over several decades, except for some special cases there are no explicit expressions for system performances such as waiting times(or response time) and blocking probability. Recently, a max-plus algebraic approach for buffer-sharing systems with constant processing times was introduced and it can lead to analytic expressions for (higher) moment and tail probability of stationary waiting. Theoretically this approach can be applied to general processing times, but it cannot give a proper way for computing performance measures. To this end, in this study we developed simulation models using @RISK software and the expressions derived from max-plus algebra, and computed and compared blocking probability, waiting time (or response time) with respect to two blocking policies: communication(BBS: Blocking Before Service) and production(BAS: Blocking After Service). Moreover, an optimization problem which determines the minimum shared-buffer capacity satisfying a predetermined QoS(quality of service) is also considered.

• Steel and Composite Structures
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• v.43 no.2
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• pp.271-278
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• 2022

Buckling is one of the most critical phoneme in the design of steel structures. Lateral torsional buckling (LTB) is particularly significant for slender beams generally subjected to loading in plane. The web distortion effects on LTB are not addressed explicitly in standards for flexural design of steel I-section members. Hence, the present study is focused to predict the influence of the web distortion on the elastic (L_r) limiting lengths given in American Institute of Steel Construction (AISC) code for the lateral torsional buckling (LTB) behavior of steel beams due to no provision in the code for consideration of web distortion. For this aim, the W44x335 beam is adopted in the buckling analysis carried out by the ABAQUS finite element (FE) program since it is one of the most critical sections in terms of lateral torsional buckling (LTB). The strain results at mid-height of the web at mid-span of the beam are taken into account as the monitoring parameters. The web strain results are found to be relatively greater than the yield strain value when L/L_r is equal to 1.0. In other words, the ratio of L/L_r is estimated from the numerical analysis to be about 1.5 when the beam reaches its first yielding at mid-span of the beam at mid-height of the section. Due to the effect of web distortion, the elastic limiting length (L_r) from the numerical analysis is obtained to be considered as greater than the calculated length from the code formulation. It is suggested that the formulations of the limiting length proposed in the code can be corrected considering the influence of the web distortion. This correction can be a modification factor or a shape factor that reduces sectional slenderness for the LTB formulation in the code.