• Journal of Ginseng Research
• /
• v.27 no.4
• /
• pp.171-177
• /
• 2003

Previously we have reported that administration of Korean red ginseng water extract (KRG-WE) plays both preventive and therapeutic roles in testicular toxicity of guinea pigs exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Further study was carried out to verify the beneficial role of Korean red ginseng in TCDD-induced testicular toxicity with different animal species by different route of administration. Korean red ginseng crude saponin (KRG-CS) was prepared by Diaion HP-20 adsorption chromatography. One hundred twenty rats (Sprauge Dawley, 200${\pm}$10 g) were divided into 6 groups. The normal control group (NC) received vehicle (i.p.) and saline (p.o.). Predetermined dosage of TCDD (40 $\mu\textrm{g}$/kg b.w., i.p.) was administered to single TCDD-treated (TT) and test (CS) groups. KRG-CS was admin-istered (p.o.) at daily doses of 5 (CS5), 10 (CS10),20 (CS2O) and/or 40 mg/kg b.w. (CS40) for 5 weeks, starting 1 week before the TCDD-exposure. Body weight gain, organ weights, and sperm quality were investigated. Decrease in body weight gain induced by TCDD was greatly attenuated by KRG-CS in a dose-dependent manner. Testicular weight, sperm head counts and ratio of sperm with progressive movement in TT group decreased significantly but those parameters were improved by the treatment of KRG-CS in a dose-dependent manner. This result led us to conclude that crude saponin might be the active ingredient of Korean red ginseng that attenuates the testicular toxicity induced by TCDD.

• The Journal of Pediatrics of Korean Medicine
• /
• v.24 no.2
• /
• pp.126-136
• /
• 2010

Objectives The purpose of this study was to investigate the antiallergic and antioxidative effects of Chaenomeles Sinensis (CS). Methods CS pretreatments inhibited anti-DNP IgE in RBL-2H3 mast cells for an hour. we measured cell viability, $\beta$-hexosaminidase release, IL-4, TNF-$\alpha$ secretion, and IL-4, TNF-$\alpha$ mRNA expression CS pretreatments inhibited DNP-HSA($10\;{\mu}g/ml$) for ten minutes, we measured Dicholrodihydrofluorescein(DCF) and DPPH radical-scavenging activity in 0.5 mM 1,1-diphenyl-2-picrydrazyl(DPPH) radical solution, 0.1ml, 99% ethanol 0.8ml, and CS 0.1 ml mixed solution. Results 0, 1, 2, 3, 4, 5 mg/ml CS treatments were not affect on cell viability and inhibited b-hexosaminidase release, IL-4, TNF-$\alpha$ secretion, CS treatments also decreased IL-4, TNF-$\alpha$ mRNA expression in RBL-2H3 cells. CS treatments inhibited reactive oxygen species(ROS) and DPPH radical-scavenging activity. Conclusions These results suggest that CS may be useful for the prevention or treatment of allergic disease.

• The Bulletin of The Korean Astronomical Society
• /
• v.43 no.1
• /
• pp.45.2-45.2
• /
• 2018

CS molecule is known to be adsorbed onto dust in cold dense cores, causing its significant depletion in the center region of cores. This study is aimed to investigate the depletion of CS molecule with optically thin $C^{34}S$ molecular line observations, including significance of its differentiation depending on the evolutionary status of the dense cores. We mapped five evolved starless cores, L1544, L1552, L1689B, L694-2 and L1197 using two molecular lines, $C^{34}S$ (J=2-1) and $N_2H^+$ (J=1-0) with NRO 45 m telescope. The $H^2$ column density and temperature structures of each targets were obtained by SED fitting for Herschel continuum images and the internal number density profiles by model fitting. All of the integrated intensity maps of $C^{34}S$ show depletion holes and 'semi-ring-like' distribution, indicating that the depletion of CS is clear and general. The radial profiles of CS abundance also show significant decrease towards the core center, while $N_2H^+$ abundance is almost constant or enhanced. We find that the more evolved cores with higher $H^2$ density tend to have a stronger depletion of CS. Our data strongly support claims that CS molecule generally depletes out in the central regions of starless dense cores and such chemical differentiation is closely related to their evolution.

• IMMUNE NETWORK
• /
• v.23 no.3
• /
• pp.29.1-29.23
• /
• 2023

Cholesterol (CL) is required for various biomolecular production processes, including those of cell membrane components. Therefore, to meet these needs, CL is converted into various derivatives. Among these derivatives is cholesterol sulfate (CS), a naturally produced CL derivative by the sulfotransferase family 2B1 (SULT2B1), which is widely present in human plasma. CS is involved in cell membrane stabilization, blood clotting, keratinocyte differentiation, and TCR nanocluster deformation. This study shows that treatment of T cells with CS resulted in the decreased surface expression of some surface T-cell proteins and reduced IL-2 release. Furthermore, T cells treated with CS significantly reduced lipid raft contents and membrane CLs. Surprisingly, using the electron microscope, we also observed that CS led to the disruption of T-cell microvilli, releasing small microvilli particles containing TCRs and other microvillar proteins. However, in vivo, T cells with CS showed aberrant migration to high endothelial venules and limited infiltrating splenic T-cell zones compared with the untreated T cells. Additionally, we observed significant alleviation of atopic dermatitis in mice injected with CS in the animal model. Based on these results, we conclude that CS is an immunosuppressive natural lipid that impairs TCR signaling by disrupting microvillar function in T cells, suggesting its usefulness as a therapeutic agent for alleviating T-cell-mediated hypersensitivity and a potential target for treating autoimmune diseases.

• The Bulletin of The Korean Astronomical Society
• /
• v.39 no.1
• /
• pp.62.1-62.1
• /
• 2014

We present preliminary results on the chemical differentiation of two dense gas tracers CS and $N_2H^+$ in five 'evolved' starless cores, L1544, L1552, L1689B, L694-2 and L1197, using our mapping observations in $C^{34}S$(J=2-1) and $N_2H^+$(J=1-0) with Nobeyama 45-m telescope. We compared the intensity maps of two molecular lines with 850 ${\mu}m$ continuum data which precisely trace the density distribution of the dense cores, finding that all of our targets show the central depletion holes in CS distribution, but the similar distribution in $N_2H^+$ to the one in dust continuum. Our data confirm the claim that CS molecule generally deplete out in the central region in starless cores, while $N_2H^+$ keep abundant as they get evolved. The detailed quantitative analysis on CS depletion in the dense cores, for example, the size of CS depletion area and radial (or gas density) dependence of CS depletion, is underway and will be presented in the meeting.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2017.06a
• /
• pp.196-196
• /
• 2017

Oilseed crop Camelina (Camelina sativa L.) is a suitable for biodiesel production that has high adaptability under low-nutrient condition like marginal land and requires low-input cost for cultivation. Enhanced abiotic stress tolerance of Camelina is very important for oil production under the wide range of different climate. CsRCI2s (Rare Cold Inducible 2) are related proteins in various abiotic stresses that predicted to localized at plasma membrane (PM) and endoplasmic reticulum (ER). These proteins are consist of eight-family that can be divided into tail (CsRCI2D/E/F/G) and no-tail (CsRCI2A/B/E/H) type of C-terminal. However, it is still less understood the function of C-terminal tail. In this study, CsRCI2D/H genes were cloned through gateway cloning system that used pCB302-3 as destination vector. And we used agrobacterium-mediated transformation system for generation of overexpression (OX) transformants. Overexpression of target gene was confirmed using RT-PCR and segregation ratio on selection media. We analyzed physiological response in media and soil under abiotic stresses using CsRCI2D and CsRCI2H overexpression plant. To compare abiotic stresses tolerance, wild type and CsRCI2D/H OX line seeds were sown on agar plate treated with various NaCl and mannitol concentration for 7 days. In the test of growth rate under abiotic stress on media, CsRCI2H OX line showed similar to NaCl and mannitol stress. In the other hand, CsRCI2D OX line showed to be improved stress tolerance that especially increased in 200mM NaCl but was similar on mannitol media. In greenhouse, WT and CsRCI2D/H OX lines for physiological analysis and productivity under abiotic stresses were treated 100, 150, 200mM NaCl. Then it was measured various parameters such as leaf width and length, plant height, total seed weight, flower number, seed number. CsRCI2H OX line in greenhouse did not show any changes in physiological parameters but CsRCI2D OX line was improved both physiological response and productivity under NaCl stress. Among physiological parameters of CsRCI2D OX line under NaCl stress, leaf length and width were observed shorter than WT but it were slightly longer than WT in 200mM NaCl stress. Furthermore, total seed weight of CsRCI2D OX line under stress displayed to decrease than WT in normal condition, but it was gradually raised with increasing NaCl stress then more than WT relatively. These results suggested CsRCI2D might be contribute to improve abiotic stress tolerance. However, function of CsRCI2H is need to more detail study. In conclusion, overexpression of CsRCI2s family can generate various environmental stress tolerance plant and may improve crop productivity for bio-energy production.

• Proceedings of the Optical Society of Korea Conference
• /
• 2001.02a
• /
• pp.224-225
• /
• 2001

3차 비선형 광학 현상을 이용한 파장변환에 대한 연구는 1960년대 초 비선형 광학 연구가 시작된 이래 최근까지 연구자들로부터 큰 관심을 끌지 못하였다. 1963년 Terhune 등이 방해석을 이용한 3차 조화파 발생의 첫 연구결과를 보고하였으나, 일반적으로 직접적인 3차 파장변환 효율은 2차의 경우에 비해 현저히 낮기 때문에, 2차 파장변환 과정을 두 번 이용하여 3차에 해당하는 파장변환을 얻는 방법이 널리 활용되어 왔다. (중략)

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.26 no.8B
• /
• pp.1070-1077
• /
• 2001

본 논문은 여러 배경잡음에서 높은 성능을 나타내는 8 kbps CS-ACELP 부호화기의 음질개선방법에 관한 것이다. 파형정합방법을 이용하는 기존의 CELP 부호화기가 순수한 음성신호에 대해서는 우수한 음질을 제공하지만, 배경잡음에 대해서는 큰 음질저하를 가져온다. 따라서 본 논문에서는 음성신호뿐만 아니라 이러한 배경잡음에 대해서도 우수한 음질을 달성하는 에너지정합방법을 소개한다. 이 방법은 부가적인 비트를 요구하지 않으면서 효과적으로 음질을 개선한다. 실험 결과, 객관적 평가에서는 MSEGSNR이 0.01∼1.1dB 증가하였고, 주관적 평가에서는 MOS 점수가 평균 0.2, 최대 0.5점까지 증가하는 것으로 나타났다. 따라서 PPS 알고리즘을 적용한 부호화기의 음질이 최대 12%까지 향상되는 것으로 확인되었다.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.39A no.12
• /
• pp.746-755
• /
• 2014

Compressive sensing (CS) has drawn much interest as a new sampling technique that enables signals to be sampled at a much lower than the Nyquist rate. By noting that the block-based compressive sensing can still keep spatial correlation in measurement domain, in this paper, we propose a novel encoding technique for measurement data obtained in the block-based CS of natural image. We apply discrete wavelet transform (DWT) to decorrelate CS measurements and then assign a proper quantization scheme to those DWT coefficients. Thus, redundancy of CS measurements and bitrate of system are reduced remarkably. Experimental results show improvements in rate-distortion performance by the proposed method against two existing methods of scalar quantization (SQ) and differential pulse-code modulation (DPCM). In the best case, the proposed method gains up to 4 dB, 0.9 dB, and 2.5 dB compared with the Block-based CS-Smoothed Projected Landweber plus SQ, Block-based CS-Smoothed Projected Landweber plus DPCM, and Multihypothesis Block-based CS-Smoothed Projected Landweber plus DPCM, respectively.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.48 no.12
• /
• pp.82-90
• /
• 2011

A novel class AB current subtracter(CS) and its application to Norton amplifier(NA) for low-power current-mode signal processing are designed. The CS is composed of a translinear cell, two current mirrors, and two common-emitter(CB) amplifiers. The principle of the current subtraction is that the difference of two input current applied translinear cell get from the current mirror, and then the current amplify through CB amplifier with ${\beta}$ times. The NA is consisted of the CS and wideband voltage buffer. The simulation results show that the CS has current input impedance of $20{\Omega}$, current gain of 50, and current input range of $i_{IN1}$ > $i_{IN2}{\geq}4I_B$. The NA has unit gain frequency of 312 MHz, transresistance of 130 dB, and power dissipation of 4mW at ${\pm}2.5V$ supply voltage.